Slicing and Stacking Builds Stronger Collagen Scaffolds

Dec-28-12 Researchers have developed a new slice/stack/role technique that allows for the creation of more durable collagen scaffolds for implants.

The method, called bioskiving, involves first decellularizing the tendons using a specialized detergent, leaving intact only the extracellular collagen matrix intact and its bundles of aligned collagen nanofibers. The tendons were then sliced into very thin sheet and stacked 10 slices thick, crisscrossing in a way so that the fibers in each sheet ran perpendicular to the one above an below.


To build a tubular scaffold, the sheets were layered so that the fibers ran the length and circumference around Teflon-coated glass rods, creating structures stronger than those made of reconstituted collagen. The structures also maintained their precise alignment, and the natural qualities of the collagen were not diluted in the process.

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