Method for the Treatment of Ischemia Reperfusion Injury

The invention is in the field of thrombosis, haemostasis, cardiology, medicinal chemistry and/or pharmacology. More particularly, it relates to the use of a mutant activated protein C (APC) for the treatment of ischemia reperfusion injury. A method is provided for treating or preventing reperfusion injury following an ischemic event that comprises administering to a subject a pharmaceutical preparation comprising a mutant APC or a precursor thereof. Compositions for use in the present invention include S360A APC or a precursor thereof and an acceptable pharmaceutical carrier.

Attached files:
WO 2009115548.jpg

Patents:
WO 2,009,115,548

Inventor(s): NICOLAES GERARDUS ANNA FRANCISCUS [NL]; ROSING JAN [NL]; CATE TEN HUGO [NL]; DAHLBAECK BJOERN ULFSON [SE]

Type of Offer: Sale



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