Method and Composition for Inhibiting Multi-drug Resistance By Hyaluronan Oligomer

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for treating multi-drug resistant cell. ; SOLUTION: The pharmaceutical composition includes a competing agent of hyaluronan interaction with an effective dosage in order to reduce the cellular tolerance against a pharmacologic agent. As the competing agent of hyaluronan interaction, hyaluronan binding protein is exemplified, more specifically hyaluronidase which digests a hyaluronan polymer to a hyaluronan oligomer is cited. The composition includes a competing agent (CHI) of HA interaction occurring in vivo. For example, CHI is a ligand of an HA receptor or is a decoy capable of uniting to HA. ; COPYRIGHT: (C)2010,JPO&INPIT

Patents:
JP 2,010,116,410

Inventor(s): TOOLE BRYAN P; GHATAK SHIBNATH; MISRA SUNITI

Type of Offer: Licensing



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