Novel Hetero Pyrrole Analogs Acting on Cannapinoid Receptors
Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or CB2 cannabinoid receptors. Aspects disclose hetero pyrrole analogs acting as CB1 and/or CB 1 receptor antagonists, having selectivity for the CB 1 or CB2 receptor, acting as neutral antagonists, acting preferentially on CB 1 receptors located in the peripheral nervous system, and/or acting as nitric oxide donors. Pharmaceutical preparations employing the disclosed analogs and methods of administering therapeutically effective amounts of the disclosed analogs to provide a physiological effect are also disclosed.
Patents:WO 2,010,104,488
Inventor(s):
MAKRIYANNIS ALEXANDROS [US]; VEMURI VENKATA KIRAN [US]; THOTAPALLY RAJESH [IN]; OLSZEWSKA TERESA [PL]
Type of Offer:
Licensing
« More Pharmaceutical Patents