Novel Hetero Pyrrole Analogs Acting on Cannapinoid Receptors

Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or CB2 cannabinoid receptors. Aspects disclose hetero pyrrole analogs acting as CB1 and/or CB 1 receptor antagonists, having selectivity for the CB 1 or CB2 receptor, acting as neutral antagonists, acting preferentially on CB 1 receptors located in the peripheral nervous system, and/or acting as nitric oxide donors. Pharmaceutical preparations employing the disclosed analogs and methods of administering therapeutically effective amounts of the disclosed analogs to provide a physiological effect are also disclosed.

Patents:
WO 2,010,104,488

Inventor(s): MAKRIYANNIS ALEXANDROS [US]; VEMURI VENKATA KIRAN [US]; THOTAPALLY RAJESH [IN]; OLSZEWSKA TERESA [PL]

Type of Offer: Licensing



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