Affinity Control of Tagging Noise

Analytical methodology is disclosed in which a trace analyte in a sample is tagged to increase its signal strength for measurement, and an affinity substance is used at least after the tagging step (late in the method) to separate the tagged analyte from tagging noise, wherein the affinity substance is directed at the reactive part of the tag, at the reagent-reacted part of the tag, or at a nonreactive part of the analyte. This method includes the case where exposure of the sample to the affinity substance begins prior to and continues after the tagging reaction. The affinity substance comprises an affinity reagent such as an immobilized antibody (immuno- affinity chromatography). This late use of an affinity substance (after the tagging reaction) is particularly important for methods in which trace analytes are reacted with a charge tag (tag possessing a charge) prior to detection by mass spectrometry.

Patents:
WO 2,009,105,082

Inventor(s): GIESE ROGER W [US]

Type of Offer: Licensing



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