Synergistic Induction of Humoral and Cellular Immunity By Combinatorial Activation of Toll-like Receptors

Described herein are compositions that include a selected antigen, a TLR4 ligand and a TLR7/TLR8 ligand, wherein the antigen and TLR ligands are encapsulated in nanoparticles. Co-administration of both a TLR4 ligand and a TLR7/TLR8 ligand results in the synergistic induction of humor and cellular immunity as evidenced by an increase in pro-inflammatory cytokine production, an increase in the number of CD8+ T effector and T memory cells, an increase in titer of antigen-specific antibodies, an increase in antibody affinity, an increase in the proliferation of na?ve B cells and/or a significant enhancement in the persistence of antibody and T cell responses. The compositions and methods provided herein can be used to stimulate an immune response such as an immune response to a pathogen or a tumor.

Patents:
EP 2,303,236

Inventor(s): PULENDRAN BALI [US]; KASTURI SUDHIR [US]; MURTHY NIREN [US]

Type of Offer: Licensing



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