Synergistic Antibiotic Combinations and Derivatives

Improved antibiotic analogs, and synergistic combinations of antibiotics designed based on structural crystallographic analysis, are provided as well as pharmaceutical compositions comprising the improved analogs and the synergistic combinations, and methods for their production and use. The synergistic combinations target neighboring sites in the ribosome demonstrating the importance of the corresponding ribosomal sites for development of clinically-relevant synergistic antibiotics.

Patents:
WO 2,011,080,739

Inventor(s): YONATH ADA [IL]; DAVIDOVICH CHEN [IL]; ZIMMERMAN ELLA [IL]; BASHAN ANAT [IL]; AUERBACH TAMAR [IL]; BELOUSOFF MATTHEW [IL]; XIONG

Type of Offer: Licensing



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