Nanomolar [beta]-lactamase inhibitors

New carboxyphenyl-glycylboronic acid transition-state analog inhibitors, representative of a class of compounds effective against class C [beta]-lactamase AmpC. The new compounds improve inhibition by over two-orders of magnitude compared to analogous glycylboronic acids, with Ki values as low as 1 nM.

Patents:
US 7,928,129

Inventor(s): HOICHET BRIAN K [US]; PRATI FABRIO [IT]

Type of Offer: Licensing



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