New Application for Vitamin D

Invention A new application / Use for Calcitriol - It was demonstrated, in vitro, that calcitriol and some of its synthetic analogs have the potential to reduce the damage inflicted to normal tissue by accepted anti-cancer therapy. Vitamin D offers protection from programmed cell death to cells in culture, reduces the synthesis and secretion of metalloproteinases (proteolytic enzymes that cause damage to tissues when in excess) and decreased the secretion of chemokines (pro-inflammatory mediators) The Need Most, if not all the therapeutic anti-cancer modalities, are accompanied by adverse side effects that exacerbate patients’ suffering and lead in many cases to non-completion of treatment protocols. It is therefore not surprising that much effort is dedicated to the search of agents to reduce these undesirable effects, while maintaining the efficacy of the anti-cancer treatment.

It should be stressed that to date there is no treatment proved to be efficient in the amelioration of the above-mentioned adverse side effects accompanying cancer therapy
Potential Applications A supplement drug for current anti-cancer therapy
Advantages Have the potential to reduce the damage inflicted to normal tissue by accepted anti-cancer therapy. Enables increasing the doses of anti-cancer drugs due to decreased side effects. Does not reduce the efficacy of the anti-cancer therapy and may even increase it.
Stage The first clinical trial to test this putative beneficial effect of vitamin D analogs in cancer patients is due to start Tech Transfer Officer Dr. Tamar Raz Office: +972-3-6406580 Fax: +972-3-6406675 Mail: [email protected]

Inventor(s): Amiram Ravid, Ruth Koren

Type of Offer: Licensing



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