Collagomers - Widely Applicable Drug Delivery Technology

Invention Collagomers are bioadhesive micro and macro particles generated by linking a phospholipid to collagen. Collagomers entrap a wide range of molecules and release them slowly over long periods of time. They bind with high affinity to cells providing an efficient, widely applicable drug delivery system.
The Need Current particulate systems for drug delivery such as cell microspheres, viral envelopes and liposomes suffer from disadvantages such as stability and biocompatibility problems, low encapsulation efficiency and poor targeting capabilities. Novel drug delivery systems that adequately address these issues are desperately required in fields as diverse as cancer therapy, diagnostic imaging and gene therapy. Potential Applications Collagomers may be used for:

o Implants for localized slow drug release: Treatment of solid tumors (including prostate, brain and breast tumors)

o Diagnostic imaging: Encapsulation and delivery of a radioactive isotope or fluorescent tracer

o Gene delivery: For short term gene expression in a target organ

o Immunization and vaccination
Advantages o High-efficiency encapsulation of large molecules

o Bioadhesive - adhering to collagen binding proteins and receptors – providing active targeting

o Very slow release, providing for sustained or controlled drug release

o Components are naturally occurring and are therefore expected to be non-toxic

o Several potential modes of administration including s.c. and i.m.
Stage Two basic types of Collagomers have been synthesized and characterized: disk-shape macroparticles and vesicular-shaped microparticles. Both types entrap small drugs and markers, as well as large proteins and nucleic acids. Doxorubicin-entrapping Collagomers demonstrated efficacy in vitro, overcoming MDR in tumor cells. Moreover, implantation of Collagomer disks into mice, did not illicit an immune response.
Patent Pending Tech Transfer Officer Dr. Nissim Chen Office: +972-3-6406121 Fax: +972-3-6406675 Mail: [email protected]

Inventor(s): Rimona Margalit, Dan Peer

Type of Offer: Licensing



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