Monoclonal Antibody 2F12, Anti-ITK

Summary Monoclonal antibody to the T cell signaling protein ITK (Tyrosine kinase), developed by Heather Wilcox in Dr. Leslie Berg's lab, in the department of Molecular and Cell Biology, Harvard. These monoclonal antibodies were raised against a GST fusion protein comprising the first 26 amino acids of murine ITK. The clone is 2F12, an IgG1, and it works for immunoprecipitation and Western blot. It apparently works for intracellular staining. It recognizes a single protein of 72kDa. The clone has been grown as ascites. There is cross-reactivity to human ITK, and possible cross-reactivity to species that show homology in the first 26 amino acids of the protein.

Applications Western blotting, immunoprecipitation, and immune complex kinase assays. Detection of ITK (Tyrosine kinase). For Further Information Please Contact the Director of Business Development Laura Brass Email: [email protected] Telephone: (617) 495-3067

Inventor(s): Wilcox, Heather M

Type of Offer: Licensing



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