A Rapid and Inducible Method for Repressing Gene Function

Summary The Struhl lab has developed a rapid and effective mean to inactivate a target gene, including genes involved in essential pathways. This invention allows the inducible degradation of the polypeptide product in addition to the repression of a targeted gene. In combination, this double shut-off provides for a thorough block to continued target gene function.

References:
Z. Moqtaderi, Y. Bai, D. Poon, P.A. Weil, K. Struhl, Nature 1996, 383, 188-191. Harvard's intellectual property portfolio includes the following patent: US 6,576,469 issued June 10, 2003.

Applications Various systems have been developed for the directed inactivation of a targeted gene in a eukaryotic cell but the study of genes essential for the viability of the cell remains difficult. The Cre/lox system allows for the inducible deletion of the targeted gene but the remaining mRNA and polypeptide products of the gene may only be slowly titrated out of the host cell. For Further Information Please Contact the Director of Business Development Katie Gordon Email: [email protected] Telephone: (617) 432-0920

Inventor(s): Struhl, Kevin

Type of Offer: Licensing



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