Surface-Bound, Bimolecular, Double-Stranded DNA Arrays

Summary The invention, developed at Harvard Medical School, achieves high array feature density and accurate feature production through enzymatic second-strand synthesis of immobilized single-stranded DNA on one or more solid- or semi-solid support structures. Efficient, high-fidelity production of surface-bound nucleic acid arrays and microarrays is desirable both in commercial manufacturing and in the research laboratory.

Selected advantages:

- Utilizes natural or synthetic first-strand DNA molecules

- Independent of the means of first-strand DNA deposition on the array support

- Does not require proprietary enzymes or other reagents

- Well adapted for use in DNA/protein binding studies (see also Harvard Case #1439)

The invention is protected by United States Patent No. 6,326,489 and is available for non-exclusive license in all fields of use.

Applications Genomics research; clinical diagnostic; food and environmental testing; drug development. For Further Information Please Contact the Director of Business Development Maryanne Fenerjian Email: [email protected] Telephone: (617) 432-0920

Inventor(s): Church, George M

Type of Offer: Licensing



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