Genetically Attenuated Microbial Vaccines

Summary The invention, covered by U.S. Patent No. 6,254,874, provides vaccines that comprise attenuated pathogens. It also encompasses methods for the creation of attenuated microorganisms useful in such vaccines. As claimed, attenuation of the organism against which the vaccine is to be directed in a recipient host is attributable to a combination of mutations. The first such mutation produces an auxotrophic condition, such that the microorganism requires a nutrient to proliferate, while a second mutation disables a mechanism specific for transport of that nutrient into the microorganism. While neither mutation alone attenuates the pathogenic microorganism, the two together render it incapable of causing disease in the vaccinated host.

U.S. Patent No. 6,254,874 is available on a field-exclusive basis for human and veterinary healthcare and on a non-exclusive basis for internal research use.

Applications Improved cell-based vaccines. For Further Information Please Contact the Director of Business Development Alex Szidon Email: [email protected] Telephone: (617) 495-3067

Inventor(s): Mekalanos, John J.

Type of Offer: Licensing



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