Novel Chemistry and Method to make Compounds Active Against Picornaviruses

Summary Picornaviruses are a large family of viruses responsible for many serious human and animal diseases, including hepatitis A, meningitis, diarrhea, summer flu, the common cold and polio. Several candidate antivirals have been shown to bind and inactivate picornaviruses. Current drugs active against these viruses are all derived from the same parent compound, identified via large scale random screening for activity against viral replication in vivo. Most of these are active against a limited spectrum of viruses within the family.

Harvard Medical School researchers have developed a novel combinatorial chemistry based approach for the synthesis of antiviral drugs against picornaviruses. This approach, used with a newly developed screen (part of Harvard Case #1417) has been validated by making chemical compounds active against viruses. These compounds have been evaluated in tissue culture bases systems, and block viral replication with IC50's in the micromolar range.

US Patent 6,416,762 issued 7/9/02 covering this technology

Applications COMMERCIAL POTENTIAL:

Antiviral drug discovery

Novel combinatorial Chemistry

ADVANTAGES:

Rapid generation of families of drugs that address a broad range of picornaviruses For Further Information Please Contact the Director of Business Development Katie Gordon Email: [email protected] Telephone: (617) 432-0920

Inventor(s): Hogle, James M.

Type of Offer: Licensing



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