Stabilization of Taxane Formulations

The clinical development of taxanes has been hampered by poor aqueous solubility, which necessitates administration of the drug in a vehicle such as Cremophor EL mixed with ethanol. Unfortunately, the formulation vehicle causes a variety of adverse r eactions, including anaphylactic hypersensitivity reactions

This invention provides a method of stabilizing a taxane (e.g., paclitaxel) in a dispersed system by exposing the taxane to a molecule which improves the physical stability of the taxane in the dispersed system, thus allowing a higher taxane content to be achieved. Additionally, this invention provides a stable taxane-containing liposome preparation comprising a liposome containing one or more taxanes present in the liposome in an a mount of less than 20 mol % total taxane to liposome, wherein the liposome is suspended in a glycerol:water composition having at least 30% glycerol.

6,348,215

Patents:
US 6,348,215

Type of Offer: Licensing



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