MUC7 12-mer-D isomer: novel and promising antimicrobial agent

This invention encompasses isomeric peptide derivatives of a naturally occurring protein found within the human body. These isomeric derivatives have been shown to possess potent antifungal activity comparable to that of currently used antifungal ag ents but with far less toxicity. The microbes used within those studies include but are not limited to C. albicans, C.glabrata, and C. krusei. These derivatives have been optimized for both size and charge and were specifically designed to resist t he action of proteolytic enzymes thereby enhancing their stability. The potential applications for this technology are broad:
* Therapeutic agent for the treatment of fungal infections
* Component of artificial saliva for immunocompromised p atients and/or those suffering from salivary dysfunction
* Topical antimicrobial
* Oral rinse
* Disinfectant/antiseptic for use in food or surface preparation
* Preservative to control food spoilage

Categories: Therapeutic and Vaccines

Patents:
US 7,271,239

Type of Offer: Licensing



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