Anti-tumor compounds

Members of the inhibitor of apoptosis protein (IAP) protein family are often expressed at high levels in cancer cells. It is thought that high expression of IAP proteins leads to a disruption in the apoptotic pathway (programmed cell death). This d isruption allows for continuation of the cell cycle and thus proliferation of tumor cells. XIAP and survivin are two members of the IAP protein family. It is thought that drugs or compounds that inhibit such proteins will allow for the cell to retu rn to a normal cellular apoptotic pathway and prevent cancerous cell growth. Using molecular modeling techniques from the crystal structure of XIAP, researchers at the University at Buffalo and Roswell Park Cancer Institute have developed and tested compounds that inhibit cell growth in prostate cancer and breast cancer cell lines.

Categories: Therapeutic and Vaccines

Type of Offer: Licensing



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