Transgenic mouse model for neurodegenerative diseases

The study of neurodegenerative diseases such as Parkinson’s Disease (PD) and the subsequent development of therapeutic agents to combat these diseases rely upon accurate non-human models that mimic the pathogenesis of their human counterparts. As th e current PD models fail to simulate all of the pathogenic, histological, biochemical and clinical features of the disease, their value remains limited.

A researcher at the University at Buffalo has developed transgenic mice that mimic not only the neurodegenerative process but also the underlying mechanisms of PD. In addition, other findings related to this invention suggest that this model may also be used to study both depression and obesity. This model may serve as a means to rapidly advance both the study of neurodegenerative diseases and development of pharmacotherapeutics to treat them.

These transgenic mice show:
(1) spontaneous neurodegeneration similar to that observed in nonheriditary (predominant) form of PD (advantag e over synuclein or parkin models of rare genetic forms of PD)
(2) progressive neurodegeneration similar to that human PD.

Categories: Genomics, Research Tool

Type of Offer: Licensing



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