1, 2, 4 - Trioxanes Having Antimalarial Activity

Because of the widespread incidence of malaria in certain parts of the world and because of the increasing parasite resistance to standard anti-malarial drugs, there is an urgent need for new and effective anti-malarial drugs. A wide variety of anti-malarial compounds have been proposed for use. One such compound is qinghaosu (also called QHS or antemisinin). See Klayman, Science (1985) 228 1049-1055. This compound is a sesquiterpene lactone which bears a peroxide group and, unlike most other anti-malarials, lacks a nitrogen-containing heterocyclic ring system. Description (Set) Proposed Use (Set) The present invention relates to a novel group of 1,2,4-trioxane compounds which demonstrate useful anti-malarial activity Patent (Set) 5,225,437

Patents:
US 5,225,437

Type of Offer: Licensing



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