Enhancing Nerve Regeneration

Compounds have been identified which can stimulate neuronal growth by inhibiting the neuronal inhibitory activity of myelin-associated glycoprotein (MAG). Specifically, complex carbohydrates have been identified which will bind to MAG, thereby inhibiting the MAG-mediated inhibiting mechanism so that nerve cell axons may regenerate after injury. This invention also provides a method to identify molecules or compounds which inhibit MAG inhibition of axonal outgrowth of injured nerve cells. Description (Set) Proposed Use (Set) Compounds are identified for potential treatment strategies for stimulating nerve growth after injury and methods of identifying such compounds based on their inhibition of the neuronal inhibitory activity of MAG are proposed.

Patent (Set) 5,962,434; 6,114,126

Patents:
US 5,962,434

Inventor(s): Yang, Lynda

Type of Offer: Licensing



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