Use of Recombinant Bacteriophages to Monitor Ion Channel Receptor Expression im Mammalian Cells

The present invention concerns a novel method for detecting cell surface proteins utilizing a modified virus. This method combines peptide display technology and traditional immuno-amplification strategy to provide an economical detection system. In contrast to traditional approaches, both specificity and affinity can be either coarsely modified or subtly tuned to achieve more resistance to changes of temperature and pH. These physical properties allow the viral or nonviral peptides to register at specific targets in vivo, which is a process vital for both drug and gene delivery. Description (Set) Proposed Use (Set) 1. New detection assays more versatile and economical than the traditional immunoassays. 2. Development and targeting of pharmaceutical reagents to speicific tissues and cell types. 3. Development of reporting assays
Patent (Set) 6,190,856;

Patents:
US 6,190,856

Inventor(s): Li, Min

Type of Offer: Licensing



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