Semaphorins

The semaphorin gene family consists of a large family of conserved proteins several members of which have been shown to function in inhibitory and repulsive axon guidance. In addition, semaphorins may influence neural regeneration in vertebrates. It is herein reported that neuropilin a type 1 transmembrane protein implicated in neurodevelopment is a Sema III receptor. Neuropilin was previously identified as a membrane-associated protein expressed in many populations of neuron, but its function has been unclear until now. This receptor is likely to function during neurodevelopment and also during regeneration of the nervous system. Furthermore, a neuropilin overexpressing mouse has the same phenotype as a mouse knockout of Sema III supporting the observation that neuropilin I is the receptor for Sema III.
Patent (Set) 6,428,965

Patents:
US 6,428,965

Inventor(s): Ginty, David D.

Type of Offer: Licensing



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