Method for producing diverse libraries of encoded polymers
With our reagents, libraries of drug-like molecules are rendered in a format where they can be subjected to evolution. This enables processing of libraries that are about 10 orders of magnitude more diverse than those typically used in high-throughput screens. Such diversity makes it probable that libraries will contain lead compounds for virtually any target, while a library's ability to undergo evolution makes it trivial to identify lead compounds. In addition, simple techniques within the capabilities of a single skilled individual are employed for library synthesis and processing, and thus our reagents could drastically reduce the cost of drug development as well as the time of development. Beyond providing the diversity and screening power needed to easily identify molecules that inactivate or modulate a specified target (irrespective of target choice), the reagents generate libraries predisposed towards desirable-therapeutic properties such as membrane permeability, bioavailability and biostability. Moreover, retro-fitting a lead compound with improved medicinal characteristics should be possible. Because libraries are evolved, families of related molecules are identified, and nonessential elements within a family are easily located. Subsequently, during child-library synthesis, such elements can be replaced by compounds having new property profiles. Again, augmentation can be performed on libraries of staggering complexity making it likely that any coveted property can be appended to a lead compound. Description (Set) Proposed Use (Set) Target independent identification of new therapeutics.Inventor(s): Merryman, Charles Everett
Type of Offer: Licensing
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