Molecular Switches and Methods for Making and Using the Same Involving the Circular Permutation of DNA

The invention provides molecular switches which couple external signals to functionality and to methods of making and using the same. The switches according to the invention can be used, for example, to regulate gene transcription, target drug delivery to specific cells, transport drugs intracellularly, control drug release, provide conditionally active proteins, perform metabolic engineering, create molecular sensors, and modulate cell signaling pathways. Libraries comprising the switches and expression vectors and host cells for expressing the switches are also provided. These libraries involve the circular permutation of DNA. Description (Set) Proposed Use (Set) Protein molecular switches engineered by the methods of this invention have a wide variety of potential applications in, for example, (a) the regulation of gene transcription, (b) the modulation of cell signaling pathways, (c) targeted drug delivery, (d) drug transport, (e) the creation of conditionally active toxic proteins, (f) metabolic engineering, and (g) the creation of novel biosensors.

Inventor(s): Ostermeier, Marc

Type of Offer: Licensing



Next Patent »
« More Pharmaceutical Patents

Share on      


CrowdSell Your Patent