Inhibiting Binding of Inducible Nitric Oxide Synthase to Cyclooxygenase-2 to Treat Inflammation

Cyclooxygenase (C0X2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Inducible NOS specifically binds to C0X2 and S-nitrosylates it, enhancing C0X2 catalytic activity. Selectively disrupting iN0S-C0X2 binding prevents NO-mediated activation of C0X2. The synergistic molecular interaction between two inflammatory systems permits assays for developing anti-inflammatory drugs. Patent (Set) WO 2006/116702

Inventor(s): Snyder, Solomon H.

Type of Offer: Licensing



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