Anti-inflammatory agents
The invention provides compounds, pharmaceutical compositions and uses of compounds and salts thereof of general formula (I), for the preparation of a medicament for treatment of an inflammatory disorder,
but excluding (S)-3-(1'-methylcyclohexylcarbonylamino)-caprolactam; wherein z is 1,2,3 or 4; A is -CO- or -SO2-; Q is alkyl, alkenyl, alkynyl, alkoxy, oxyalkyl, aminoalkyl, alkylamino, alkylaminoalkyl haloalkyl, optionally substituted aryl or tert-butoxycarbonylamino; T<1> and T<2> together constitute a cycloalkyl, cycloalkenyl or polycycloalkyl radical composed of n additional carbon atoms, where n is between 2 and 7; and each hydrogen atom bonded to the carbon atoms in the ring generated by T<1> and T<2> may be independently be substituted by a group R<1>, where R<1> is independently selected from an alkyl, haloalkyl, alkoxy, haloalkoxy, alkenyl, alkynyl or alkylamino radical of 1 to 20 carbon atoms; or each R<1> is independently selected from fluoro, chloro, bromo, iodo, hydroxy, oxyalkyl, amino, aminoalkyl or aminodialkyl radical. In addition, (S)-3-(3'-hydroxy-1'-adamantanecarbonyl)aminocaprolactam is also disclosed as an example.
Attached files:
Patents:
GB 2,430,674
Inventor(s):
GRAINGER DAVID JOHN [GB]; FOX DAVID JOHN [GB]
Type of Offer:
Sale
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