Methods for Identification

The invention relates to methods for the discovery of new chemical entities and pharmaceutical compositions with broad-spectrum chemokine inhibitor (BSCI) activity, together with the use of such agents as anti-inflammatory medicaments. In one aspect the method for the identification of a compound or agent with BSCI activity comprises the steps of : (a) firstly one or more candidate compounds or agents are screened for binding to a GPCR neuroreceptor known to be expressed on leukocytes; then (b) compounds or agents which show binding to the chosen GPCR neuroreceptor are tested for BSCI activity in a functional assay; and (c) compounds or agents which show binding to the chosen GPCR neuroreceptor are tested for classical agonist activity in a functional assay, where step (a) is completed first, but steps (b) and (c) are performed in any order, or simultaneously.

Patents:
WO 2,010,097,591

Inventor(s): GRAINGER DAVID JOHN [GB]

Type of Offer: Sale



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