Combinations Comprising Epothilone Derivatives and Alkylating Agents and Pharmaceutical Compositions Comprising Them

The invention relates to a pharmaceutical combination which comprises (a) an alkylating agent and (b) an epothilone derivative of formula (I) wherein A represents O or NRN, wherein RN is hydrogen or lower alkyl, R is hydrogen or lower alkyl, and Z is O or a bond. Said combination can be useful for the treatment of a proliferative disease, especially a tumor disease.

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Patents:
IL 163,774

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