« Patents

Patents for Sale or License

Medical Devices PATENTS

Medical Devices

The following Medical Devices patents, intellectual property and technologies are offered for sale or license. Viewing these patents and technologies for sale is a free service of IdeaConnection.com. You can post as many patented technologies as you like at no charge. Click on the headings below for more information on each patent.



Skin patch instrument for treating pain

A therapeutic patch for treating pain capable of compressing a tender area up to a boundary thereof and/or an entire induration with metallic grains or crushed stones by a treatment method in accordance with a classification determined after clarifying a site of pain by pressing a skin with a pressing bar or fingers (first to fourth fingers) to classify the cause of pain, thereby finding the presence of a geographical tender area and/or the presence of an induration on a skin as the cause of pai
...

Folding Urine Specimen Cup Holder

Designed to easily and sanitarily collect urine samples specifically for, but not limited to, obese, pregnant, elderly and injured persons. A foldable urine collection device which holds any size urine sample cup, unfolds and holds the sample cup over any standard toilet seat for easy and clean urine sample collection. This is a single use item. We call this the PUSCH - Personal Urine Specimen Cup Holder. Request for potential revenue information. Limited competition in the market place.
...

MC2 Folding Rescue Stretcher

The present invention provides a foldable rescue stretcher having an open position for transporting a patient and a storing position for storing the foldable rescue stretcher. The foldable rescue stretcher includes a rigid supporting frame having a plurality of sections, a protective barrier, and an inflatable collar. Methods of using the foldable rescue stretcher are also provided. Watch online video at: https://www.youtube.com/watch?v=Ay6UL3ETPLY Publication number US20140082844 A1 Publ
...

Methods for resection of a luminal structure

Provided is a method of resecting a luminal structure, such as a colon. A first luminal structure and a second luminal structure are defined by severing the original luminal structure. The second luminal structure is secured to the distal end of an elongate body disposed within the second luminal structure. Refraction of the elongate body forms a circumferential fold in the second luminal structure and isolates a tissue mass between the circumferential fold and the distal end of the elongate bod
...

Asymmetric Disc Distracting Cage

An inter-vertebral cage with a wedge shape eccentrically located on the leading end of the cage. The ectopically shaped leading edge of this embodiment facilitates easier interbody spacer placement with less risk of nerve injury, as well as with likely decreased risk of destruction of the end plate during the distraction process when the interbody cage is impacted.
...

Tractal Erectile Device

Male Erectile Dysfunction (ED) is a condition that affects many men and can have a negative physical and psychological impact on their lives. Stimulation of the penis may be difficult for men suffering from ED, and although attempts have been made to treat ED, those attempts have failed to provide a safe and effective non-drug related treatment. Health clinic research has revealed that starting an erection with a partial vacuum can be a simple and effective way of reducing the impact of male
...

Digital Video & Music Belt Buckle-WEARABLE TECHNOLOGY

I think the timing for my patent to be leveraged is NOW, sans the industry up-tick in this paradigm of the white-out WEARABLE TECHNOLOGY DEVICE space. Below is patent, and these recent articles discussing the space and providing the hard DD for the model. I think a proper deal would be to license and or sell to a multi-national like an Intel, the military and or the medical community,...or a hybrid of the the tech company(Intel) and the MILITARY SECTOR and medical arena. It would just become a d
...

Shoe sole sanitizing device and associated method for eradicating microorganisms from an exterior surface of a shoe sole

A shoe sole sanitizing device preferably includes a portable platform including a pair of shoe sole-receiving sections including open bottom surfaces respectively. Each of the shoe sole-receiving sections may be adapted to receive the exterior sole of the shoe thereon. The portable platform may further include a plurality of disposable transparent stratums removably positioned on the open bottom surfaces respectively. A plurality of ultraviolet light emitting sources are aligned beneath the shoe
...

MagnaStone, sinusoidal magnetic field therapy, alternative medicine.

MagnaStone US patents 7648454, 7803104, 8202192, 7915846, 8050059, 8257242, 8469872 is a instrument designed to generate a sinusoidal magnetic field that has been proven to have therapeutic value. This therapy has been effective in the field of orthopedics and depression. This is believed to stimulate cellular repair by concentrating the hemoglobin (the blood protein that carries oxygen) to the cellular damaged area. The exact mechanism of how it works is not fully understood. The design of t
...

Vaginal cream applicator.

The new Gentle-Comfort vaginal cream applicator is easier to use, more comfortable to use, safer to use and more hygienic for women to use than the standard syringe type applicator is. Details of this device may be viewed at http://www.gentlecomfort.com US D457,627S, a United States Design Patent covering this device is also available for sale, or license with royalties, as are: US 7,172,573 B1, a US patent for a vaginal tablet applicator; US 7,815,593 B2, a device for inserting vaginal
...

Disposable speculum with included light and mechanisms for examination and gynecological surgery

The disposable speculum with included light and complementary mechanisms for examination and gynecological surgery is a device used for medical and surgical procedures in the vagina, neck level and the uterus. It has two separate sheets joined in their own handles; the upper sheet has three cuts to evacuate the gases and smoke produced on the surgery area. It also has a light bulb to give clarity on the surgery area, to optimize the visibility with aluminum reflexive cover; the lower sheet has t
...

Joint Heat

An electric heating device that is constructed in a unique fashion that allows it to be drapeable so that its three-dimensional, `scoop-like` shape fits the curvature of a relaxed shoulder, a crooked knee, crooked elbow, fetal-positioned hip or ankle and is held in place by an adjustable strap whose ends are attached to the device. The heating element configuration that is contained within a singular, sealed, water-tight vinyl envelope that is produced as one piece, with the three panels briefly
...

Quick-E Emergency ECG Electrode Chest Pad

A disposable ECG electrode chest pad that has pre-wired electrodes in the proper positions which can be applied in one step and easily connected to nearly any ECG machine with pre-existing adapters. It can be used in any setting an ECG would be used, in addition to being used to monitor patients in the hospital setting by easily removing the unnecessary V leads. It can also be adapted with defibrillator pads for emergency situations.
...

Fluid Delivery Micropump

Infu-Disk™ , developed and manufactured by Med-e-Cell, is a commercially available fluid administration pump currently used in a variety of applications particularly veterinary medicine, toxicology/pharmacokinetic studies, and preclinical research, with the exception of human use. Infu-Disk™ fluid delivery pumps are a unique group of accurate, single use pumps, operating at any flow rate between 0.03 and 4.0 mL/hour. The flow rate is factory set. Infu-Disk™ is a totally autonomous, dis
...

Biodegradable Self-Expanding Drug-Eluting Prosthesis

Implantable radially expandable medical prostheses for treatment of vascular diseases through percutaneous deployment.
...

Device for stopping abnormal electric activity in the brain causing epilepsy

Epilepsy is a condition in which there are repeated attacks of seizures resulting from epileptogenic focus in the brain. This focus once activated from time to time causes abnormal electric activity leading to hyperexcitation of cerebral centers precipitating seizures. There are several means of antiepileptic therapy including drugs and electronic devices. Concerning drugs, they have side effects which may sometimes result in mental and physical disability. For devices to work they need be
...

Polyp Screen

US Patent # 7,488,312 Polyp Screen - this is a multiple product patent for screens that insert into existing mucous traps by Medline, Busse, etc. We have one actual product that has been manufactured for Medline Mucous Traps, so we have a mold and inventory. The polyp screens fits into the trap and keeps 99% of polyp specimens in the trap. If the trap is flushed incorrectly there is a possibility of losing the specimen. This is mainly used for colonoscopies.
...

Composition in the Form of Liquid for Maintenance of Contact Lenses and Medical Materials

The invention relates to a composition, particularly in the form of liquid to be used externally as a rinsing contact lenses, containing nanocrystalline photocatalyst active in visible light, and optionally hydrogen peroxide. Titanium dioxide based materials are commonly known as photocatalysts of environmental and biomedical relevance.Photoactive TiO2 irradiated with ultraviolet light shows antiseptic, fungicidal, disinfecting and odour-neutralizing properties. It can be used for production
...

“Deep” needle holder

Introduction: A number of open urological procedures demand deep and narrow surgical fields. This fact in correlation with special circumstances (like hemorrhage) makes many times the manipulation of a curved needle with a conventional needle holder very difficult, even for an experienced surgeon. This invention is designed in purpose to increase the flexibility and safety in grasping and suturing with a curved needle in difficult circumstances, where the conventional needle holders are ins
...

Nasal Cleaning Insert

January 14, 2013 Nasal Cleaning Insert Patent -USA 5,895,408 A device is used as a daily nasal cleaning insert. Use to clean remotes areas in nasal cavities. Is intended to use a daily hygiene to dialog Nasal cavities from mucus substances and germs as the same time reaching farther areas that could not be reached by other cleaning devises. Is a device that is designed to use with different substances to kill germs inside nasal cavities. One of the objects is to avoid germs to penetra
...

Special Bed for Self Induced Traction / Decompression

Please go to ebpocorp.com and read the article on Reverse Exercise which explains fully the lead up to this invention. The author believes that regular Traction in low doses is needed from early stages of one's growth years for healthy joints all through life. The invention describes a bed on which one comfortably lies down, - restrains one's feet and (VERY CAREFULLY) the chin or shoulders and self induces a LOW DOSE of decompression (traction) in self's full body. One may lie in this posture
...

Special Bed for prevention of Bedsores

It is a BED for the totally INVALID person prone to BED SORES. The paraphrased abstract reads as follows: A specialized bed will prevent bedsores, heal existing bedsores, with no repositioning of person required. The bed is provided with a series of BANDS that can be made to be TAUT and horizontal, or relaxed to be LIMP and shaped like a downward arc. The person is supported on the bands that are taut. Alternate bands are taut and the others are limp. After a brief period, the the bands
...

Lined Balloon Mounted Stent

A stent that is implanted by catheter to narrow or occlude the lumen of any vessel in a graded reversible pattern as needed. May be used to perform patent ductus arteriosus closure in neonates, pulmonary artery banding, reverisble control or occlusion of bleeding aneurysms..etc in all age groups.
...

Lockable Specimen Transporter

Patent Number: US6354104 Portable Medical Device: Suited for the collection of Urine and Blood Specimens both inner office and in field. Industry: Health/Medical fulfilling World Health Organization, Center for Disease Control and Health and Human Services guidelines specific to Chain of Custody in specimen collections. Market: Drug Testing Industry, Blood Banks, Hospitals, Specimen Collections sites, etc.
...

ULTRASOUND FOR LOCATING ANATOMY OR PROBE GUIDANCE

A hand-held apparatus can be used to assist in guiding a probe or locating a particular anatomical target in a subject. The apparatus can include an ultrasonic transducer located on or within a housing and configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. In an example, the apparatus can include a motion tracking circuit configured to provide information indicati
...

NON-INVASIVE SYSTEMS AND METHODS FOR IN-SITU PHOTOBIOMODULATION

Products, compositions, systems, and methods for modifying a target structure which mediates or is associated with a biological activity, including treatment of conditions, disorders, or diseases mediated by or associated with a target structure, such as a virus, cell, subcellular structure or extracellular structure. The methods may be performed in situ in a non-invasive manner by application of an initiation energy to a subject thus producing an effect on or change to the target structure dire
...

Hip joint orthosis for e.g. supporting musculature of patient after hip joint implantation, has electro stimulation device for generating electro stimulation, where beginning and ending of stimulation

The orthosis has a hip belt including three parts in the form of shell elements (1), which are movably arranged and fixed on a flexible anti-rotation cable. An orthosis joint (5) includes an adjustable, progressive resistance, which works against movement of a patient at an extreme position. An electro stimulation device (3) is attached to the shell elements for generating electro stimulation, where beginning and ending of the stimulation is controlled by a switch e.g. hand switch, such that mus
...

Bite guard splint i.e. lower jaw bite guard splint, for keeping open of respiratory tract at asleep of patient, has fastening elements provided for connection element to piercing-like implant at regio

The splint (13) has fastening elements (14) e.g. hooks (15), for a connection element (17) e.g. fastening lug, to a piercing-like implant at a region of a tongue body of a patient. The fastening elements are arranged at the lower jaw bite guard splint, and are provided at interior sides of the lower jaw bite guard splint, and the hooks are made of surgical stainless steel, titanium or titanium alloy. The fastening lug is attached and detached at the fastening elements and at the implant, and is
...

MAGNETICALLY MOUNTED ARTIFICIAL JOINT

The invention relates to a prosthesis for replacing a joint compound in the same magnetic fields of joint head 10, socket 12 and pivot collar 14 can be superimposed so that the repulsive forces produce a state of suspension of the joint head 10 in the bearing and the damping effect is maximal.The invention also provides a method for replacing a bone connection of a mammal in which the prosthesis is attached to the bones in the joint and cause repulsive forces to a state of levitation, the joint
...

REPOSITIONING DEVICE FOR THE HANDLING OF DISTAL RADIUS FRACTURES BY MEANS OF A T-SHAPED OSTEOSYNTHESIS PLATE

The invention relates to a repositioning device for the handling of distal radius fractures by means of a T-shaped osteosynthesis plate, comprising a long leg and a short leg, disposed in a T-shaped and angular manner in relation to said long leg, wherein the short, distal leg has a face that comes into contact with the distal fracture fragment and a number of openings for bone screws and the long, proximal leg is intended for making contact with the proximal bone near the body.; To improve the
...

Device for ventilating the middle ear, has stent having hollow cylinder which has funnel-shaped expansion at two ends, where inner diameter of hollow cylinder lies in certain range

The device has a stent (10) having a hollow cylinder (12) which has a funnel-shaped expansion (18) at two ends (14,16). The inner diameter of the hollow cylinder lies in the range of 0.5 millimeter to 10 millimeter. The stent has a length in the range of 1 centimeter to 5 centimeter along the longitudinal axis. The stent consists of a biocompatible elastomer. A cladding (20) of the hollow cylinder has a notch in the area of the funnel-shaped expansion. The biocompatible elastomer is silicon or p
...

DEVICE FOR IN SITU MILLING OF JOINT SURFACES

The invention relates to a device for in situ milling of joint surfaces, comprising a milling device (20 24) and a joint clamping device (10). The invention further relates to a use of a corresponding device and to a method for in situ milling of joint surfaces. The joint clamp device (10) of the device according to the invention is designed to be inserted between two joint components forming a joint, particularly bones (1, 3), and for pushing the joint components (1, 3) apart with a predetermin
...

METHOD FOR DETERMINING THE CLAMPING FORCE ON A MECHANICAL JOINT CONNECTION CONNECTING AT LEAST TWO COMPONENTS

The invention relates to a method for determining the clamping force on a mechanical joint connection connecting at least two components by coupling sound waves into the joint connection. The invention is characterized by the combination of the following method steps: exciting the mechanical joint connection in order to generate oscillation, capturing the oscillations made by the joint connection due to the excitement, and analyzing the oscillations of the joint connection on the basis of refere
...

Device for testing endurance limit of medical device, has two fixing devices at end cross sections of medical device, and two actuators which are coupled with fixing devices

The device (1) has two fixing devices (3,4) at the end cross sections of a medical device, and two actuators which are coupled with the fixing devices. The device has a guiding element (10) at which the medical device is formed or shaped. A deformation kinematic of the medical device is recreated at a certain application site by rotational movement of the guiding element. An independent claim is also included for a method for testing the endurance limit of a medical device.
...

Medical implant i.e. flexible hollow implant, for ventilation of middle ear in head of human, has flexible peristalsis elements assigned to implant and causing pressure balance between openings on imp

The implant i.e. flexible hollow implant (5), has peristalsis elements flexible over entire length and assigned to the flexible hollow implant and causing pressure balance between distal and proximal openings on the flexible hollow implant by peristalsis movements. The peristalsis elements are designed as tubes running in longitudinal direction of the flexible hollow implant. The tubes are formed out one-piece with the hollow implant. The tubes are arranged in relation to an axial plane and coil
...

MEDICAL IMPLANT FOR TREATING ARTHRITIS IN JOINTS OF THE HUMAN OR ANIMAL BODY

The invention relates to a medical implant for treating arthritis in joints of the human or animal body, in particular in the knee joint of a patient. In order to prevent extensive means for inserting stable plates in the gap of the knee joint, the invention provides two magnet bodies (9, 10; 20) that can be inserted in two opposite joint parts (1, 2), wherein the polarity of the magnetic body (9, 10; 20) associated with a joint is of the same name.
...

DEVICE AND METHOD FOR MEASURING TIBIAL TRANSLATION

The invention relates to a device and a method for measuring tibial translation in mammals under loading. The device has at least a first and a second splint, which can be fastened laterally to the upper and lower leg and have an overlapping region in the area of the knee joint. The displacement of the first and second splints in the overlapping region allows the tibial translation to be calculated directly and/or indirectly. The device according to the invention can also be used advantageously
...

SUTURE ANCHOR SYSTEM

The invention relates to a suture anchor system for fixing sutures to bone, having a screw, an adjacent anchor, a cannulation in the anchor, and a thread, wherein the anchor comprises two opposite indentations at which the cannulation terminates at each end. In order to provide a suture anchor system wherein the thread can easily be inserted into the cannulation, the anchor (3) comprises a slit (10) on the cannulation (6) extending parallel to the cannulation (6) and inclined relative to the end
...

ORGANIZATION AND SECURITY SYSTEM FOR FUNCTIONAL CONNECTIONS

The invention relates to a device for separating functional connections, in particular in the medical field, for example infusion and perfusion lines, but also to cable connections from and to medical devices and/or surgical instruments, for example endoscopes or heart catheters. The invention is characterized in that an existing space divider enables organization of the functional connections.
...

CELL COATED IMPLANTABLE DEVICE

The present invention relates, in general, to a cell-coated implantable medical device and, in particular, to an implantable medical device the blood-contacting surfaces of which are coated with endothelial progenitor cells (EPCs). In a preferred embodiment, the medical device is a titanium or titanium alloy-based medical device.
...

APPARATUS FOR OCCIPITO-CERVICAL FIXATION ENABLING SUPPLEMENTAL OCCIPITAL BONE FIXATION

An apparatus for stabilization of a patient's head relative to the patient's neck joint includes an occi-cervical base member having a "C '-shaped central part and first and second attachment rods respectively connected to and extending transversely from free ends of the central part. An occiput attachment has a first end slideably engaged to the central part and a flat, straight second end that extends radially outwardly relative to the first end. First and second polyaxial screw heads are adap
...

TRANSLATIONAL MANIPULATION POLYAXIAL SCREW HEAD

A novel surgical screw is presented as a polyaxial, multiaxial, or monoaxial screw. The polyaxial screw allows versatile angulation between a bone anchor section and a screw body and allows the surgeon to attach a rod to the invention in a top-loading manner and manipulate the rod to accommodate a patient's body and the surgical goals. The screw uses a rod saddle to seat a rod, and permits the surgeon to sagitally manipulate the rod. After implantation of the screw and insertion of the rod, a lo
...

Intracranial Catheter and Methods of Use

A catheter assembly for intracranial treatment of a subject that includes an outer tube that may be connected to an infusion or osmotic pump and delivered through a bendable catheter to the target brain site of the subject. The assembly facilitates regular accurate placement of drug or compound delivery at the tissue region without additional contact and minimizes trauma to the subject.
...

BLADDER DRAINAGE AID

Provided is a bladder drainage aid which attaches to the end of Foley Catheter and removes the need for a catheter bag. In a preferred embodiment, the device is a spring-loaded valve with an inflow tube and an outflow tube. The inflow tube connects to the external end of a catheter. The outflow tube can be aimed by the patient. When pressed, the valve opens, allowing the fluid to flow there through. When released, the piston of the valve cuts off fluid flow. The valve cap allows ease of use and
...

APPARATUS FOR OSTEOTOMY AND GRAFT PREPARATION

Surgical tools that increase surgical accuracy for orthopedic procedures involving long bone osteotomy with or without supplementation with allograft or autograft. Two clamps on the operative side are rigidly interconnected to one another with an adjustable rod that is locked into place, preserving length and rotation of the bone. A graft preparation device is used on the operative table. It enables alignment of the graft to preserve the desired mechanical and anatomic axes and to provide rigid
...

TRANS-ENDOSCOPIC HYDRAULIC BALLOON APPARATUS

A trans-endoscopic hydraulic balloon dilation apparatus includes a fluid reservoir containing a hydraulic fluid. A shaft has a lumen in fluid communication with a leading end of the fluid reservoir. A balloon is mounted on the shaft and an opening in the shaft enables hydraulic fluid to flow through the opening into or from the balloon. A piston secured to a leading end of a piston rod is slideably positioned within a lumen of the fluid reservoir. A hub secured to a trailing end of the fluid res
...

ENDOSCOPIC OVERTUBE

An over-tube was developed for receiving and guiding endoscopic instruments into a patient's anus, through the colon, and into the peritoneum. The over-tube has a flexible sheath adapted for insertion into the anus through the colon and out the peritoneum of a patient. A stiffened region is used to protect the colonic wall from injury during insertion of medical instruments through the patient's lower gastrointestinal tract. The proximal end of the over-tube is surrounded by two narrow inflatabl
...

Cervical plate system

An anti-subsidence, anti-translocation, fusion compression cervical plate system with interface visualization, drill guide and temporary pin is provided. In one embodiment the invention provides a vertebral plate for minimizing the ability of an inter-body cage, filled with bone (or BMP-soaked sponges, etc.), to telescope into the vertebral body and to minimize failure due to cages that telescope into adjacent vertebral bodies on a delayed basis after surgery, as well as creation of reverse lord
...

EMBOLECTOMY STROKE DEVICE

Devices and methods for removing an obstruction from a blood vessel are described. The devices are deployed in a collapsed condition and are then expanded within the body. The devices are then manipulated to engage and remove the obstruction. A system for removing an obstruction from a blood vessel includes an obstruction engaging element and an expandable capture element. The capture element preferably has a flexible cover and an expandable support structure. The engaging element engages the ob
...

PREDETERMINED PRESENTATION OF PATIENT DATA AT BEDSIDE

Techniques for presenting patient data at the patient's bedside include receiving predetermined presentation style data that indicates a subset of fewer than all parameters available from an electronic medical records (EMR) system and a first arrangement on a display device of related parameters in the subset. Without human intervention, the most recent values from the EMR system are received. The most recent values are associated in the EMR system with the particular patient for corresponding p
...

HOLDING DEVICE, BITE ELEMENT AND SYSTEM FOR INTRAORAL RADIOGRAPHY

The invention relates to a bite element, a holding device, a method, a computer program product and a system for creating and/or processing intraoral shadow images, in particular X-ray images. To this end, a holding device comprises a device base which is designed to define a determined or determinable position of a projection surface, in particular a planar projection surface, of a radiation detector relative to a radiation source; and a bite element which is located at the device base so as to
...

DEVICES AND METHODS FOR PERCUTANEOUS ACCESS, HEMOSTASIS, AND CLOSURE

The present invention provides methods and devices for obtaining percutaneous access, maintaining hemostasis, and providing closure of openings in tissues of the body. In particular, the present invention provides methods and devices for maintaining hemostasis and providing closure surgical incisions of the left ventricular apex of the heart..
...

FLUID CONTAINMENT APPARATUS

The invention relates to the treatment of wounds. In particular, the invention relates to systems, devices, and methods enabling pulse lavage irrigation of wounds in a non-controlled setting while providing containment of contaminated irrigation fluid, thereby preventing exposure of individuals and surfaces in proximity to the patient to infectious materials.
...

ABLATION DEVICES AND RELATED METHODS THEREOF

The present invention relates generally to devices for performing targeted tissue ablation in a subject. In particular, the present invention provides devices configured to deliver energy to a targeted tissue region without causing damage to untargeted tissue.
...

DEVICES FOR MATERIAL DELIVERY, ELECTROPORATION, AND MONITORING ELECTROPHYSIOLOGICAL ACTIVITY

The invention relates generally to devices for material delivery, electroporation and monitoring electrophysiological activity. In particular, the present invention provides devices and systems configured to deliver therapeutic compositions, to provide electroporation to increase therapeutic efficiency, and to monitor electrophysiological activity, for example, before and after treatment.
...

APPARATUS AND METHOD FOR AIRWAY PATENCY AND HEAD IMMOBILIZATION

A jaw-thrust device includes a base with an extension arm disposed on each side of a patient's head mounted on the base. A mandible rest is mounted on each extension arm such that the mandible rest may be deployed proximate to a patient's mandible. A chin pad and at least one connector connects the chin strap to at least one of the base or extension arm; whereby jaw thrusting pressure on the mandible rests causes rotational force on the chin straps such that the patient's mouth opens without sub
...

METHODS AND DEVICES FOR ARYTENOID REPOSITIONING

Methods and devices for repositioning the arytenoid cartilage of a human subject are disclosed.
...

AGR-MEDIATED INHIBITION AND DISPERSAL OF BIOFILMS

The present invention involves the use of activators of bacterial agr quoroum-sensing systems to block, inhibit or reverse biofilm formation. The biofilm may be located on an industrial or medical surface, or may be located in a subject, such as in a wound or infected organ, or on an in-dwelling medical device.
...

FASTENER DEPLOYMENT SYSTEM AND METHOD

This document discloses, among other things, a long reach, side ejecting fastener placement apparatus suitable for use in nasal septal surgery. A first linear member carries a fastener body and a second linear member delivers a fastener retainer or provides support for placement of the fastener body. In various examples, the fastener includes a single stud rivet or includes a two legged staple. A mechanical linkage coupled to the handle provides a linear force for placement and deployment of a f
...

TISSUE AND OBJECT RETRIEVAL DEVICE AND SYSTEM

The invention described herein provides a device for tissue and/or object retrieval constructed for use with minimally invasive medical procedures. By virtue of its construction and operation, the device of the invention can obtain a relatively large amount of tissue (or object) while reducing or minimizing the amount of trauma to the patient. The device of the invention further maintains reduced or minimal dimensions during insertion and access stages and utilizes a greater freedom of movement
...

TREATMENT AND PLACEMENT DEVICE FOR SINUSITIS APPLICATIONS

Devices, methods and kits which, when installed or used, access, aspire, dilate, insufflate, drain or deliver fluid medicaments to, or place a patency device within a sinus area, such as a maxillary sinus or a maxillary sinus ostium. The device can include a hollow catheter and probe, and can be configured to permit gradual and incremental probe extension. The device can be constructed to enhance the precision and maneuverability within the nasal and sinus passageways, while also accommodating t
...

IMPLANTABLE DEVICES FOR TREATMENT OF SINUSITIS

Devices, methods and kits which, when installed or used, urge or maintain patency of sinus ostia, such as the ostium between a nasal passageway and a maxillary sinus, while maintaining some function of cilia extending within or near the ostium. In various examples, the devices comprise a first portion, a second medial portion including a partially open cross-sectional configuration, and a third portion including one or more flexible and outwardly-biased projections. The partially open cross-sect
...

SPINAL PROBE WITH TACTILE FORCE FEEDBACK AND PEDICLE BREACH PREDICTION

A spinal probe (10) comprises a handle (18), a shaft (20) coupled to the handle and a force sensor (14) to detect forces applied to a tip of the shaft. A controller that executes a predictive algorithm to predict whether or not the tip of the shaft is going to breach a cortex of a pedicle based on the detected forces. The controller may be embedded within the spinal probe or external within a computer or other device coupled to the probe by a data acquisition component.
...

CATHETER INSERTION STERILIZATION

A device includes a sheath having a lumen defined by a wall. The wall has an outer surface that is configured to emit ultraviolet light in a direction substantially normal to the wall. The lumen has a distal end configured for percutaneous placement. The lumen has a proximal end configured to receive a catheter.
...

BIOACTIVE PEPTIDE FOR CELL ADHESION

Implantable devices for adhering eukaryotic cells and devices providing a substrate for eukaryotic cell growth and/or differentiation in vitro are described. Each device comprises a scaffold that is coated with a protein comprising an adhesive polypeptide that has at least 90% sequence identity to a specific peptide sequence within domain IV of perlecan. The devices adhere epithelial cells, epithelial stem cells, mesenchymal stem cells, and osteoblasts.
...

INTELLIGENT POWERED MOBILITY FOR INFANTS AND SPECIAL NEEDS CHILDREN

A powered mobility device for advancing cognitive, perceptual and motor abilities of a child lacking natural mobility is disclosed. The device includes a seat sized for the child to be secured therein and a motorized drive assembly coupled to the seat. A local operating instrument is operably coupled to the drive assembly for operating and steering the drive assembly. The local operating instrument is positioned to allow manipulation by the child seated in the seat. A processor is operatively co
...

DYNAMIC VIBRATIONAL METHOD AND DEVICE FOR VOCAL FOLD TISSUE GROWTH

Dynamic vibrational methods and devices for inducing differentiation of stem cells into vocal fold fibroblast-like cells or for generating vocal fold-like tissue from cultured cells. Also provided are matrices providing sustained release of growth factors, and bioreactors generating and delivering a high frequency vibration with in-plane shear stress to cultured cells.
...

Delivery System For Heparin-Binding Growth Factors

A device comprising a scaffold coated with a protein having at least 83% identity to the amino acid sequence of the core protein of domain I of a mammalian perlecan, wherein at least one glycosaminoglycan is attached to the protein is described. The device may be used in vitro or in vivo to induce replication and/or differentiation of connective tissue cells and to repair tissue.
...

IMAGE-BASED CONTROL SYSTEMS

Image-based control systems and methods automate the adjustment of medical devices. An image based-control system for an endoscope can include, in addition to the endoscope, a processing system and an actuator. The processing system can receive an image from an image capture device of the endoscope. Based on coordinates of a lumen in the image, the processing system can instruct the actuator to reorient the capture device to direct the capture device toward the lumen. The actuator can be coupled
...

TARGETING THERAPEUTIC AGENTS

Provided are devices, systems, and methods for targeted administration of therapeutic agents to a subject. For example, provided are devices, systems, and methods for targeting the administration of peri-urethral bulking agents.
...

DEVICES AND METHODS FOR MODULATING BRAIN ACTIVITY

Devices and methods for brain modulation are provided herein. A device may comprise a body and components for activating the brain. Such components include ultrasound transducers. The devices are used to provide ultrasound waves to brain structures in a subject wearing a device for methods to treat traumatic brain injury, affect postural control, affect wakefulness, attention, and alertness, to provide memory control, to alter cerebrovascular hemodynamics, to minimize stress, and to reinforce be
...

NEUROSTIMULATOR

Methods and devices of stimulating nerves are disclosed. In one embodiment adapted for stimulating excitable tissue, the invention includes drive circuitry (12), an acoustic transducer (14) and a pair of electrodes (28).
...

ROTATING NEEDLE DRIVER AND APPARATUSES AND METHODS RELATED THERETO

Featured is a medical instrument driver, a robotic apparatus embodying such a medical instrument driver and methods related thereto for inserting a medical instrument into tissue of a mammal (e.g., human). Such medical instruments include medical needles, biopsy needles, trocars, cutters and introducers. Such a medical instrument driver according to the present invention is configured and arranged so that medical instrument is rotated as it is being moved longitudinally for insertion into the ti
...

CYLINDRICAL ILLUMINATION CONFOCAL SPECTROSCOPY SYSTEM

A cylindrical illumination confocal spectroscopy system has a fluidic device having a fluid channel defined therein, an objective lens unit arranged proximate the fluidic device, an illumination system in optical communication with the objective lens unit to provide light to illuminate a sample through the objective lens unit, and a detection system in optical communication with the objective lens unit to receive at least a portion of light that passes through the objective lens unit from the sa
...

ARTICULATED DEVICE WITH VISUALIZATION SYSTEM

An articulated device may include a first steerable multi-linked mechanism and a second steerable multi-linked mechanism. The second steerable multi-linked mechanism may include a first link, a plurality of intermediate links and a second link movably coupled to a second one of the intermediate links A first one of the intermediate links may be movably coupled to the first link The articulated device may include a camera located within at least a portion of the second link and a protective shiel
...

INSERTABLE SURGICAL IMAGING DEVICE

A body-insertable imaging device includes a first camera that comprises a first image sensor and a first lens to pass incident light onto the first image sensor, a control interface to receive a remotely generated control signal, and an actuator communicatively coupled to the control interface and configured to support the camera and manipulate the camera about a pan axis, a tilt axis, and along a zoom direction in response to the control signal while the camera and actuator are within a body ca
...

SYSTEMS AND METHODS FOR INSERTING STEERABLE ARRAYS INTO ANATOMICAL STRUCTURES

Systems and Methods are provided for inserting a steerable array into an anatomical structure of the body. The system includes an insertion module for holding a proximal end of the steerable array and a force sensor configured to detect force on the steerable array and to produce force information. The system includes a position sensor configured to detect a position of the insertion module and to produce position information, the position information including a lateral position along an insert
...

INHIBITING STAPHYLOCOCCUS EPIDERMIDIS INFECTIONS

The invention relates to Staphylococcus epidermidis peptides, antibodies and nucleic acids that can inhibit Staphylococcus epidermidis infection of a mammalian subject and colonization of a medical device in the mammal.
...

Medical implant and method of its manufacture

The implant has an outer mantle layer consisting of a set of coils (10) movably arranged to each other in a longitudinal direction. A hollow space is provided between the coils, which exhibit conicity and differ in rotational directions. The spirals differ in its starting point and/or direction of the conicity. Geometry of the coils corresponds to a golden layer, and size and/or number of cavities increases at an outer surface of the mantle layer. An entire component volume of the implant is con
...

MEDICAL IMPLANTS, PROSTHESES, PROSTHESIS PARTS, MEDICAL INSTRUMENTS, DEVICES AND AUXILIARY CONTRIVANCES MADE OF A HALOGENIDE-MODIFIED MAGNESIUM SUBSTANCE

The use of a magnesium substance, whose corrosiveness is altered as a result of modification with halogenides, enables medical implants, prostheses or prosthesis parts and medical instruments, devices and auxiliary contrivances, especially surgical instruments or tools, for use in and on the human or animal body to be produced, whereby the degree of corrosion-resistance thereof can be adjusted to full corrosion-resistance.
...

FIXATION DEVICE AND METHOD FOR SOFT TISSUE GRAFTS

An expandable medical device for surgical implantation that secures the ends of a soft tissue graft in a tunnel made in bone, such as in ligament replacements. The graft material is positioned between the bone and the flexible portion of the fork component with intimate contact with the bone surface during the device expansion. Movement of a plug component into the fork component causes expansion of the device perpendicular to the bone tunnel. The device expansion is also perpendicular to the gr
...

ARRAYED DETECTOR SYSTEM FOR MEASUREMENT OF ANTI-VIRAL IMMUNE RESPONSE

A sensor chip for detecting an immune response against a virus, the sensor chip including a substrate having a surface and a plurality of virus-like particles or capsid fragments bound to discrete locations on the surface of the substrate. Detection devices containing the sensor chip and methods of detecting anti-viral immune responses are also described herein.
...

Device and method for disinfecting stethoscope heads

A device for disinfecting a head of a stethoscope has a receiver adapted to hold a supply of disinfecting agent. A dispenser that is mounted to reciprocate relative to the receiver has a receptacle for receiving the head of the stethoscope. The dispenser can communicate with the supply of disinfecting agent and deliver its disinfecting agent to the receptacle. By pressing the head of the stethoscope against the dispenser, disinfecting agent will pass from the receiver through the dispenser and o
...

DNA MICROARRAY HAVING HAIRPIN PROBES TETHERED TO NANOSTRUCTURED METAL SURFACE

A sensor chip and detection device are disclosed. The sensor chip includes a substrate, at least a portion of which is covered by a metal nanoparticle film; a first nucleic acid molecule that is characterized by being able to (i) self-anneal into a hairpin conformation and (ii) hybridize specifically to a target nucleic acid molecule, the first nucleic acid molecule having first and second ends, which first end is tethered to the metal nanoparticle film; and a first fluorophore bound to the seco
...

INTRAOCULAR PRESSURE REGULATING DEVICE

Systems and methods are described for implanting a device in a mammalian eye to raise intraocular pressure. In some embodiments, the device (54) includes an arcuate body that, when implanted, obstructs aqueous humor outflow from the anterior chamber (38) of the eye.
...

ARRAYED DETECTOR SYSTEM FOR MEASUREMENT OF INFLUENZA IMMUNE RESPONSE

A sensor chip for detecting an immune response against an influenza virus, the sensor chip including a substrate having a surface and a plurality of hemagglutinin polypeptides bound to discrete locations on the surface of the substrate, each hemagglutinin polypeptide having a hemagglutinin epitope. Detection devices containing the sensor chip and methods of detecting influenza immune responses are also described herein.
...

CMOS IMAGE SENSOR ON STACKED SEMICONDUCTOR-ON-INSULATOR SUBSTRATE AND PROCESS FOR MAKING SAME

Methods and apparatus for producing a CMOS image sensor result in a plurality of photo sensitive layers (A,B,C ); each layer including: a glass or glass ceramic substrate (102A, 102B, 102C) having first (102A-1, 102B-1, 102C-19 and second (102A-2, 102B-2, 102C-2) spaced-apart surfaces; a semiconductor layer (104A, 104B, 104C) disposed on the first surface of the glass or glass ceramic substrate; and a plurality of pixel structures formed in the semiconductor layer, each pixel structure including
...

SIMULTANEOUS AMBULATORY PULSE OXIMETRY AND PH MONITORING FOR THE DIAGNOSIS OF GERD-RELATED RESPIRATORY DISEASE

Respiratory diseases related to gastroesophageal reflux disease in a patient are diagnosed by detecting esophageal or pharyngeal impedance and pH in the patient, detecting oxygen saturation in the patient, and diagnosing the respiratory diseases from the esophageal or pharyngeal impedance, the pH, and the oxygen saturation.
...

NEEDLE SHIELD FOR INJECTIONS

A needle shield for hiding a needle from a patient during an injection is disclosed. The needle shield comprises an attaching portion for attaching the needle shield to a syringe and an opaque collapsible element extending from the attaching portion, the collapsible element having an orifice extending therethrough and being of a sufficient length to conceal a needle from view when the needle is disposed in the orifice, and wherein the collapsible element collapses and conceals the needle as the
...

TRANSCUTANEOUS MAGNETIC ENERGY TRANSFER DEVICE

Transcutaneous magnetic energy transfer to drive a VAD or other implanted medical device can be supplied through two spinning (or otherwise moving) permanent magnets, or a moving permanent magnet and a moving ferric material, or a moving permanent magnet and a coil or an array of coils, One part is implanted under the patient's skin, so that the skin does not have to be broken for a connection to take place.
...

GAS SYRINGE DEVICE

PROBLEM TO BE SOLVED: To provide a unit dose, gas-filled syringe which is filled with gas and packaged in a gas barrier material prior to use to increase shelf-life, that is, to minimize gas leakage and dilution of the contents of the syringe. ; SOLUTION: The syringe (12) is filled with a selected gas and sealed inside a container (10) made from a high gas barrier material. The container is also filled with the selected gas. The container material is selected to have a gas transmission rate suff
...

A SYSTEM AND METHOD FOR PATIENT SELF-ASSESSMENT OR TREATMENT COMPLIANCE

A system and method for transmission of alphanumeric messaging between mobile subscribers and an external system to send messages directly to the mobile subscriber's existing mobile phone to query them, for example, on the psychometric scale of interest. The resulting daily assessments may then be stored in a database that may be accessed via the internet to aid both the patient and a care provider in tracking the state and progress of the illness or symptoms which are being treated. It may allo
...

VERTEBRAL BODY REDUCTION INSTRUMENT AND METHODS RELATED THERETO

Featured is a reduction instrument being configured and arranged to allow correction of vertebral translation and applying distraction across a segment in an independent fashion. Such a reduction instrument embodies one or more identical modules that are configured as needed for correcting the deformity. In more particular embodiments, each of the one or more modules has two degrees of freedom (DOF) with uncoupled orthogonal translations. Such a reduction instrument allows the reorientation of t
...

NASAL AIRWAY MANAGEMENT DEVICE WITH INFLATABLE SUPRAGLOTTIC LARYNGEAL CUFF

An airway management device such as, for example, an nasal airway management device with inflatable supraglottic laryngeal cuff is provided. The airway management device includes an airway tube, an inflatable cuff, and an inflation passage. The airway tube defines a lumen extending between a proximal end and a distal end. At least the distal end of the airway tube is configured to be inserted through a patient's nasopharyngeal passageway. The inflatable cuff is attached at or near the distal end
...

METHOD OF MAKING 3-DIMENSIONAL NEURAL PROBES HAVING ELECTRICAL AND CHEMICAL INTERFACES

A method of fabricating a three-dimensional neural probe includes the steps of: growing thermal oxide layer; depositing a layer of Au/Cr on the thermal oxide layer; patterning the layer of Au/Cr; depositing a layer of parylene C; etching the thermal oxide layer to release a plurality of islands; and folding the islands onto one another in stacked relation. The layer of Au/Cr is formed by an evaporation process, and the layer of parylene C is deposited to a thickness of approximately 8 [mu]m. DRI
...

DEVICE FOR COLLECTION AND PRESERVATION OF TISSUE OR STOOL SAMPLES

An arrangement for collecting a tissue or stool sample has a sample vial and a source of preservative fluid. A fluid valve controls a flow of the preservative fluid from the source of preservative fluid to the sample vial. An air equalization vent tube is coupled to the source of preservative fluid and an air valve controls a flow of air through the air equalization vent tube, the air valve and the fluid valve being actuated simultaneously. A scoop for collecting the sample is coupled to the sam
...

Device and Method for Transfecting Cells for Therapeutic Use

This invention generally relates to devices and methods for transfection of living cells using electroporation, in particular high throughput microtluidic electroporation, and to therapeutic uses of the transfected cells.
...

INTRINSIC HAND STRENGTH MEASUREMENT DEVICE

A device for measuring intrinsic hand muscle strength comprising an adjustable restraint adapted to restrain at least a portion of a hand, a force transfer member adapted to fit on or around one or more digits of the hand, a force sensor connected to the force transfer member, and a processing unit connected to the force sensor is provided. Methods of measuring intrinsic hand strength are also provided
...

ELECTROCARDIOGRAM RECONSTRUCTION FROM IMPLANTED DEVICE ELECTROGRAMS

A method of reconstruction of the standard 12-lead surface EKG given values of the electrical potential from an implanted medical device is described. This implanted device can be oriented in an arbitrary fashion and reconstruction technique is obtained through physical measurement of the orientation of the implanted device or correlation with a standard 12-lead EKG obtained from the patient.
...

IMPLANTABLE DEVICE, SYSTEM INCLUDING SAME, AND METHOD UTILIZING SAME

An implantable device. The implantable device includes a computing device, a microelectromechanical system (MEMS) pH sensor connected to the computing device, and a communication system connected to the computing device.
...

ELECTRODE SYSTEMS, DEVICES AND METHODS

An electrode system include a flowable and cohesive surface contact element comprising a hydrophilic polymer swollen with an electrolyte fluid, the contact element having a Q' ratio (A) of at least 5 as defined by the equation wherein WG is the dry weight of the hydrophilic polymer and WW is weight of water in the sample after absorption of the electrolyte fluid comprising water and an electrolyte salt. The surface contact element can consist essentially of the hydrophilic polymer swollen by the
...

POWERED VEHICLE CONVOYING SYSTEMS AND METHODS OF CONVOYING POWERED VEHICLES

A vehicle convoy system for use in connection with a vehicle (for example a self-propelled wheelchair), wherein the vehicle includes at least one drive mechanism to impart drive to the vehicle, includes a first processor to effect control of the drive mechanism based upon data of the position of a leading vehicle in front of the vehicle so that the vehicle moves to follow movement of the leading vehicle and a physical or virtual linkage between adjacent vehicles (for example, a retractable rope
...

AN ECHO-SPECIFIC K-SPACE REORDERING APPROACH TO COMPATIBLE DUAL-ECHO ARTERIOVENOGRAPHY

A dual-echo sequence technique provided herein empowers simultaneous acquisition of both TOF MRA and BOLD MRV in a single MR acquisition. By this approach, an echo- specific K-space ordering scheme permits the adjustment of the scan parameters that are compatible for each of the MRA and MRV. The image quality in the MRA and MRV acquired by this compatible dual-echo arteriovenography (CODEA) technique is comparable to that for conventional, single-echo MRA and MRV. When the technique is integrate
...

AUTOMATED ASSESSMENT OF OPTIC NERVE HEAD WITH SPECTRAL DOMAIN OPTICAL COHERENCE TOMOGRAPH

A fully automated optic nerve head assessment system, based on spectral domain optical coherence tomography, provides essential disc parameters for clinical analysis, early detection, and monitoring of progression.
...

INTRACORPOREAL GAS EXCHANGE DEVICES, SYSTEMS AND METHODS

A system for intracorporeal gas exchange includes a flexible, rotatable shaft; a plurality of axially spaced agitation mechanisms positioned on the rotatable shaft, such that the rotatable shaft can flex between the axially spaced agitation mechanisms; a plurality of hollow gas permeable fibers adapted to permit diffusion of gas between intracorporeal fluid and an interior of the hollow fibers. The plurality of hollow fibers is positioned radially outward from the agitation mechanisms. A blood c
...

COILS FOR MAGNETIC RESONANCE SPECTROSCOPY AND IMAGING OF HUMAN BREAST

System(s) and method(s) for magnetic resonance imaging and spectroscopy, and magnetic resonance spectroscopic imaging (MRSI) are provided. A unified heteronuclear coil system includes a volume coil tuned to detect a first nuclei and a butterfly coil tuned to detect a second nuclei for simultaneous detection of both the first nuclei and the second nuclei signals from human breast tissue and perform MRIS. First nuclei and second nuclei each include 1H, 13C, 31P, 23Na, and 19F. The heteronuclear co
...

SYSTEM FOR AT-HOME EYE MOVEMENT MONITORING

An apparatus for monitoring eye movement in a patient, includes a frame structured to be worn on the head of the patient. An infrared illumination device structured to illuminate an eye of the patient is supported by the frame. A camera structured to capture images of the eye when illuminated by the infrared illumination device is also supported by the frame. A number of sensors structured to generate data relating to one or more characteristics of the user or environment is further supported by
...

ARTICULATING LARYNGOSCOPE

Articulating laryngoscope to aid in the intubation of patients by providing illumination of the oral cavity and trachea during the process having, for example, 'fingers' with fiber optic lights at the ends and at joints of the fingers, fingers spread open or 'flower' when the device is deployed, gently retracting and compressing soft tissues in the oral cavity and providing medical professionals with much better illumination of the passageway they are addressing, constructed from a malleable mat
...

JOINT BIOSCAFFOLDS

Provided herein are compositions and medical devices, and in particular, biodegradable scaffolds capable of repairing and replacing cartilaginous meniscuses. Also provided herein are methods of using scaffolds for treating degenerative tissue disorders. In certain embodiments, such scaffolds can promote tissue regeneration of a temporal mandibular joint (TMJ) meniscus.
...

Cortical Control of a Prosthetic Device

A methodology for using cortical signals to control a multi jointed prosthetic device for direct real-time interaction with the physical environment, including improved methods for calibration and training.
...

MAGNETIC DEVICE FOR GUIDING CATHETER AND METHOD OF USE THEREFOR

One or more external magnets that are suitable for placement on the back or front of a patient's neck and methods for using the external magnet(s) to guide a feeding tube containing one or more internal magnets through the esophagus are described herein. The external magnet is applied to the back or the front of the patient's neck and the feeding tube is inserted into the patient's nose and advanced within the patient's body. The magnetic field of the external magnet combines with the magnetic f
...

Paracorporeal respiratory assist lung

A paracorporeal respiratory assist lung (900), comprising a housing (920) having an outer body including an upper portion and a lower portion; an upper gas port (945) located on the upper portion; a lower gas port (940) located on the lower portion; an upper blood inlet (930) located on the upper portion; a blood outlet (935) located on the housing and disposed away from the upper blood inlet; a plurality of gas permeable fiber membranes configured to form a stationary fiber bundle (950) dispose
...

DETECTION AND QUANTIFICATION OF BIOMARKERS VIA A PIEZOELECTRIC CANTILEVER SENSOR

Quantification of a target analyte is performed using a single sample to which amounts of the target analyte are added. Calibration is performed as part of quantification on the same sample. The target analyte is detectable and quantifiable using label free reagents and requiring no sample preparation. Target analytes include biomarkers such as cancer biomarkers, pathogenic Escherichia coli, single stranded DNA, and staphylococcal enterotoxin. The quantification process includes determining a se
...

TWO-PIECE LIGHTWEIGHT LITTER SYSTEM

This invention is directed to a durable, compact, two-piece, light weight, load sustaining litter system for the transport of humans, animals or objects. The litter system comprises a litter frame, a fabric disposed between the structure of the frame, at least one hinge and at least one coupling mechanism. The litter system may be quickly assembled under adverse conditions and may be particularly beneficial in transporting individuals who are injured, disabled and/or incapable of movement under
...

METHODS AND DEVICES FOR

The 'Smart Tool' includes a 'Smart Tool Probe' and two processing modules. The Smart Tool Probe is a hand held, wired or wireless, device that a surgeon utilizes for interrogating and identifying a tissue site, such as the entrance to a pedicle. The processing units, an Electro-Optical Control (EOC) Module and a CDS Module, provide control and display capabilities enabling real-time tissue site (such as vertebra bone) interrogation. The Smart Tool Probe utilizes a system of optical fibers that c
...

APPARATUS FOR ATMOSPHERIC PRESSURE PIN-TO-HOLE SPARK DISCHARGE AND USES THEREOF

Disclosed herein are atmospheric pressure pin-to-hole pulsed spark discharge devices and methods for creating plasma. The devices include a conduit for fluidically communicating a gas, a plasma, or both, therethrough, portion of the conduit capable of being connected to a gas supply, and a second portion of the conduit capable of emitting a plasma; a positive electrode comprising a sharp tip; and a ground plate electrode. Disclosed are methods for treating a skin ulcer using non-thermal plasma i
...

APPARATUS AND METHODS FOR DETECTING INFLAMMATION USING QUANTUM DOTS

Apparatus and methods for detecting an a biomarker indicative of an inflammatory condition, including a capillary tube adapted for one or more biomarkers to adhere to an interior surface thereof, a light source for energizing quantum dots conjugated with the biomarkers within the capillary tube, and a detection system for detecting and quantifying fluorescent energy emitted by the quantum dots in one or more predetermined wavelength ranges, each wavelength range being correlated to one and only
...

INTRACRANIAL PRESSURE SENSOR

An intracranial pressure device for measuring CSF pressure in a skull includes a housing located between the scalp and the skull containing pressure device circuitry and a conduit extending downwardly from the housing to the vicinity of the CSF. A pressure sensor is coupled to the conduit and located in communication with the CSF wherein the pressure sensor directly senses the pressure of the CSF and provides a signal representative of the pressure of the CSF to the pressure device circuitry by
...

CERVICAL SPINE PROTECTION APPARATUS AND METHODS OF USE

The invention is directed to a cervical spine protection apparatus one or more composite bands attached to provide restraint of one or more motions of the cervical spine of a wearer. The apparatus is designed to protect a wearer from incurring cervical spinal injuries, and/or to reduce the severity of cervical spine injuries without substantially compromising the normal functional range of motion of the wearer's cervical spine.
...

ALL ELECTRIC PIEZOELECTRIC FINGER SENSOR (PEFS) FOR SOFT MATERIAL STIFFNESS MEASUREMENT

A PEFS (Piezoelectric Finger Sensor) acts as an "electronic finger" capable of accurately and non-destructively measuring both the Young's compression modulus and shear modulus of tissues with gentle touches to the surface. The PEFS measures both the Young's compression modulus and shear modulus variations in tissue generating a less than one-millimeter spatial resolution up to a depth of several centimeters. This offers great potential for in-vivo early detection of diseases. A portable hand-he
...

BALLOON-ASSISTED ANNULUS REPAIR

The present invention is directed to an inflatable annulus repair device (10) for sealing an annulus defect located in an annulus fibrosis of an intervertebral disc space. In use, the inflatable device is introduced, in a first non-expanded state, preferably via a cannula (100) into the annulus defect. After the inflatable device has been properly positioned, a filler material (11) is injected into the inflatable device to expand the device to a second expanded state. In the second expanded stat
...

DEVICES AND METHODS FOR DETECTING AND MONITORING HIV AND OTHER INFECTIONS AND DISEASES

Disclosed herein are bio-nanosensor devices and methods suitable for blood assays. The bio-nanosensors are based on thickness shear mode transducer capable of transmitting a shear wave into a biofluid adjacent to a bio-functionalized sensing interface of a piezoelectric crystal. The bio-functionalized sensing interface includes one or more antibodies and/or biomarker- specif?c ligands capable of sensing HIV. The disclosed bio-nanosensors are capable of defecting the presence of HIV virus at pico
...

STABILIZED ULTRASOUND CONTRAST AGENT

Provided is a particle-stabilized ultrasound contrast agentn (UCA) and methods of preparing same. Also provided is a method for preparing a lyoprotected UCA, a freeze-dried lyoprotected UCA, and a reconstituted freeze-dried lyoprotected UCA.
...

MULTIMODAL LASER SPECKLE IMAGING

A system for multimodal laser speckle imaging may include a first light source positioned to emit laser light toward a target, a second light source positioned to emit light toward the target, a camera positioned to receive light scattered from the target, and a processor. The processor may be programmed to receive from the at least one camera at least one image of the target as illuminated by the laser, obtain a laser speckle contrast image of the target from the at least one image of the targe
...

Wrist Mounted CPR Chest Compression Monitor

A chest compression monitor for measuring the depth of chest compressions achieved during CPR. A displacement detector produces a displacement indicative signal indicative of the displacement of the CPR recipient's chest toward the recipient's spine. A signaling mechanism provides chest compression indication signals directing a chest compression force being applied to the chest and a frequency of such compressions.
...

OPTIMIZED MRI STRIP ARRAY DETECTORS AND APPARATUS, SYSTEMS AND METHODS RELATED THERETO

Featured is a device for NMR or MRI signals from excited nuclei as well as related apparatus, systems and methods. The device includes a strip array antenna including one or more conductor and N reactive tuning components, where N is an integer>=1 at least one of the N reactive components is electrically coupled to each of the one or more conductors as well as to ground/virtual ground. The apparent electrical length of the conductors is tuned with the reactive tuning components so it is equal to
...

Devices and Methods for Treatment of Gastrointestinal Disorders

An implantation device for releasably holding implantable microstimulators can be used to guide one or more microstimulators to any site within the gastrointestinal tract for implantation. The device can further releasably hold one or more ligation clips for securing the one or more microstimulators in place within the implantation site(s) and/or for closing an incision in which a microstimulator is implanted. The device can be employed using open, laparoscopic, and endoscopic techniques.
...

SYSTEMS AND METHODS FOR TESTING VESTIBULAR AND OCULOMOTOR FUNCTION

The invention relates to systems and methods for testing vestibular and oculomotor function. One aspect of the invention provides a vestibular and oculomotor function testing device including a track supported by a plurality of bearings, an engine configured to selectively displace the track, and a head coupling component coupled to the track. The head coupling component is configured to convey a movement generated by the engine to a subject's head in one or more axes.
...

AUTOMATED SURFACE-BASED ANATOMICAL ANALYSIS BASED ON ATLAS-BASED SEGMENTATION OF MEDICAL IMAGING

A non-invasive imaging system, including: a non-invasive imaging scanner; a signal processing unit in communication with the imaging scanner to receive an imaging signal from a subject under observation; and a data storage unit in communication with the signal processing unit, wherein the data storage unit stores template data corresponding to a tissue region of the subject, and wherein the signal processing unit is adapted to generate a surface map to encode a property of a subvolume of the tis
...

VISUAL TRACKING AND ANNOTATION OF CLINICALLY IMPORTANT ANATOMICAL LANDMARKS FOR SURGICAL INTERVENTIONS

A visual tracking and annotation system for surgical intervention includes an image acquisition and display system arranged to obtain image streams of a surgical region of interest and of a surgical instrument proximate the surgical region of interest and to display acquired images to a user; a tracking system configured to track the surgical instrument relative to the surgical region of interest; a data storage system in communication with the image acquisition and display system and the tracki
...

SYSTEMS AND METHODS TO REDUCE POWER DEPOSITION IN TISSUE EXPOSED TO RADIO -FREQUENCY ELECTROMAGNETIC FIELDS

An apparatus for exposing a region of interest of an object, animal or person to an alternating magnetic field has a source of radio-frequency electromagnetic radiation arranged to provide the alternating magnetic field in an exposure volume defined by the apparatus, and a shield arranged between the source of radio-frequency electromagnetic radiation and the exposure volume. The shield includes a material that has a sufficient thickness and arrangement to reduce power deposition to at least reg
...

Surgical Instrument and Systems with Integrated Optical Sensor

A surgical instrument has a surgical tool that has a proximal end and a distal end, and an optical sensor that has at least a portion attached to the surgical tool. The surgical tool has a portion that is suitable to provide a reference portion of the surgical tool, and the optical sensor has an end fixed relative to the reference portion of the surgical tool such that the reference portion of the surgical tool can be detected along with tissue that is proximate or in contact with the distal end
...

LOW-COST IMAGE-GUIDED NAVIGATION AND INTERVENTION SYSTEMS USING COOPERATIVE SETS OF LOCAL SENSORS

An augmentation device for an imaging system has a bracket structured to be attachable to an imaging component, and a projector attached to the bracket. The projector is arranged and configured to project an image onto a surface in conjunction with imaging by the imaging system. A system for image-guided surgery has an imaging system, and a projector configured to project an image or pattern onto a region of interest during imaging by the imaging system. A capsule imaging device has an imaging s
...

ADIABATIC MULTI-BAND RF PULSES FOR SELECTIVE SIGNAL SUPPRESSION IN MAGNETIC RESONANCE IMAGING

A magnetic resonance imaging (MRI) system, comprising: a magnetic resonance imaging scanner comprising: a main magnet providing a substantially uniform main magnetic field B0 for a subject under observation; and a radio frequency (RF) coil configured to irradiate a radio frequency (RF) pulse into a region of interest of the subject under observation, wherein the RF pulse comprises a base pulse comprising an adiabatic pulse having a first bandwidth time product (BWTP), wherein the RF pulse select
...

IODINATED POLYMERS

The invention provides medical devices that comprise an iodinated polymer and that can be viewed using X-Ray imaging techniques. The invention also provides novel iodinated polymers that can be incorporated into or coated on medical devices.
...

METHOD FOR DETERMINING THE QUALITY OF HEPARIN

The invention relates to a method for determining contamination of heparin with other sulfated glycans, comprising the steps: incubating a predetermined amount of heparin together with a predetermined amount of an enzyme that specifically digests heparin for a predetermined duration, wherein the amount of the enzyme corresponds approximately to the amount of the enzyme that would completely degrade an approximately identical amount of contaminant-free heparin within the predetermined duration, o
...

IMAGE-BASED RISK SCORE-A PROGNOSTIC PREDICTOR OF SURVIVAL AND OUTCOME FROM DIGITAL HISTOPATHOLOGY

The present invention relates to an image-based computer-aided prognosis (CAP) system and method that seeks to replicate the prognostic power of molecular assays in histopathology and pathological processes, including but not limited to cancer. Using only a tissue slide samples, a mechanism for digital slide scanning, and a computer, the present invention relates to an image- based CAP system and method which aims to overcome many of the drawbacks associated with prognostic molecular assays (e.g
...

RADIOPAQUE POLYMERIC STENTS

The present invention relates to polymeric medical devices such as stents. More particularly the polymeric compositions disclosed herein comprise halogen-containing, tyrosine-derived diphenols, optionally in conjunction with other groups, such as dicarboxylic acids and/or poly(alkylene oxides), such that the medical devices made from these polymeric compositions are bioresorbable and inherently radiopaque, and exhibit physicomechanical properties consistent with the intended uses of such devices
...

BIOCOMPATIBLE POLYMERS FOR MEDIAL DEVICES

The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and copolymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio-opacity and are useful for medical device applications and controlled release therapeutic formulations.
...

COMPLIANT BIOCOMPATIBLE POLYMER COMPOSITIONS FOR MEDICAL USES

Phase-separated elastomeric biocompatible polymer compositions are disclosed that are bioresorbable and/or biodegradable, and are useful in a variety of medical applications in which a low modulus polymer is desired, such as in the fabrication of medical devices.
...

BIOCOMPATIBLE POLYMERS FOR MEDICAL DEVICES

The present invention relates to new classes of monomeric compounds, which may be polymerized to form novel biodegradable and bioresorble polymers and co-polymers. These polymers and co-polymers, while not limited thereto, may be adapted for radio- opacity and are useful for medical device applications and controlled release therapeutic formulations.
...

MULTI-USER SMARTGLOVE FOR VIRTUAL ENVIRONMENT-BASED REHABILITATION

A low-cost, virtual environment, rehabilitation system and a glove input device for patients suffering from stroke or other neurological impairments for independent, in-home use, to improve upper extremity motor function, including hand and finger control. The system includes a low-cost input device for tracking arm, hand, and finger movement; an open source gaming engine; and a processing device. The system is controllable to provide four types of multiple patient/user interactions: competition
...

VARIABLE RESISTANCE HAND REHABILITATION DEVICE WITH LINEAR SMART FLUID DAMPER AND DYNOMETER CAPABILITIES

A variable resistance hand rehabilitation device and corresponding system. Improvements over the prior art include: a new damping system or damper design, to reduce friction and increase maximum force output; a dynometer feature that enables converting the dynamic device to a static grip force measuring device; a closed-loop controller; and a new graphic user interface for the medical practitioner and new virtual reality game software that allow accurate and smooth operation of the device and in
...

PATIENT SPECIFIC ANKLE-FOOT ORTHOTIC DEVICE

The unique advantages of computer-controlled fabrication of a patient-specific orthotic device using an automated fabrication machine capable of following computer instructions to create 3D surface contours and new developments in non-invasive three-dimensional (3D) scanning have made it possible to acquire digital models of freeform surfaces such as the surface anatomy of the human body and to then fabricate such a patient-specific device with high precision. Such a patient-specific device brin
...

Apparatus And Method For Modulating Neurochemical Levels In the Brain

A treatment for Parkinson's Disease uses a stimulus electrode implanted in a subthalamic nucleus with a chemosensor implanted in a globus pallidus pars interna (GPi) of the subject. A level of a neurochemical is sensed with the chemosensor, and compared to a desired level. When the level of the neurochemical is less than desired, an electrical stimulation is provided to the stimulus electrode. In alternative embodiments, the neurochemical sensed is glutamate or dopamine. An alternative system us
...

SYSTEM AND METHOD FOR CALIBRATION FOR IMAGE-GUIDED SURGERY

A method of calibrating a transformation of ultrasound data in an imaging system from a first coordinate system into a second coordinate system, the method comprising applying a transformation having parameters. The parameters are calibrated by imaging a planar object, extracting points corresponding to ultrasound rays intersecting the planar object, and fitting the parameters such that the points when transformed by the transformation describe a planar surface in the second coordinate system.
...

ELECTRICAL IMPEDANCE SENSING BIOPSY SAMPLING DEVICE AND METHOD

A biopsy sampling device has an inner trocar having a sharpened tip and a sampling opening. The trocar is slideably engaged in a central cavity of an outer needle with its sharpened tip and sampling opening protruding from an end of the outer needle. Impedance measuring apparatus measures impedance between the inner trocar and the outer needle. In an embodiment, impedance is measured at multiple frequencies and spectral characteristics are determined therefrom. The inner trocar has an insulating
...

Systems And Methods For Combined Ultrasound And Electrical Impedance Imaging

A dual imaging probe 300 for obtaining both ultrasound and electrical impedance data is disclosed along with methods of using the dual imaging probe 300 to interrogate tissue. An electrical impedance imaging overlay 330 is adapted to be positioned on a transducer window 304 of an ultrasound probe 320, and may be integrally formed as part of the ultrasound probe 320 or as a modular adapter for coupling with, and optionally uncoupling from, an ultrasound probe 320 to form the dual imaging probe 30
...

ELECTROENCEPHALOGRAPHY MONITORING DEVICE HAVING A SELF-ADAPTIVE ANALOG-TO-DIGITAL CONVERTER

An EEG monitoring device, contains at least one electrode, a non-linear analog signal processor, a variable resolution analog-to-digital converter, a storage, and a power source. The non-linear analog signal processor receives a signal from the at least one electrode and determines whether the signal is within a significant category. The variable resolution analog-to-digital converter converts signals received from the non-linear analog signal processor into high-resolution digital signals if th
...

Biological Particle Collector, and Methods of Use Thereof

One aspect of the invention relates to the devices and methods for the collection of bioaerosols (such as viruses, bacteria, and proteins) from the exhaled breath of humans and/or animals, for the purpose of determining, for example, particle size, generation rate, diseases and interventions for particle release.
...

Organometallic-Polyisomonoolefin Block Copolymers

The present invention provides copolymers which include a plurality of constitutional units that correspond to at least one cationically polymerizable isomonoolefin species and a plurality of constitutional units that correspond to at least one anionically polymerizable monomer species selected from the group consisting of monomers of formula (I): wherein R1, R2, R3, R4, n, p, M, X, and L are defined herein. The present invention also provides methods for making and using (e.g., in articles of m
...

CERAMIC/STRUCTURAL PROTEIN COMPOSITES AND METHOD OF PREPARATION THEREOF

Ceramic/structural protein composites and methods of preparation are disclosed, including coatings and films. Ceramic/structural protein coatings can be fabricated on the surface of substrates, including the surface of implantable medical devices.
...

SHAPE MEMORY MAIN-CHAIN SMECTIC-C ELASTOMERS

Shape memory main-chain smectic-C elastomers are described, as are methods for their preparation and monomers used in such methods. The elastomers are prepared by hydrosilylation of a reaction mixture including a liquid crystalline diene, a crosslinking agent, and a bis(silyl hydride) compound. The elastomers exhibit shape-memory properties and spontaneously reversible shape changes. They are useful for fabrication of shape memory articles including, for example, implantable medical devices, con
...

IMPLANTABLE MEDICAL DEVICES

A medical device includes a balloon catheter having an expandable member, e.g., an inflatable balloon, at its distal end and a stent or other endoprosthesis. The stent is, for example, an apertured tubular member formed of a polymer and is assembled about the balloon. The stent has an initial diameter for delivery into the body and can be expanded to a larger diameter by inflating the balloon.
...

BLENDS OF AMORPHOUS AND SEMICRYSTALLINE POLYMERS HAVING SHAPE MEMORY PROPERTIES

Blends of amorphous and semicrystalline polymers having shape memory properties were prepared by blending a crystalline polymer such as poly(vinylidene fluoride), polylactide, poly(hydroxxybutyrate), poly(ethylene glycol) polyethylene, polyethylene-co-vinyl acetate, poly(vinyl chloride), poly(vinylidene chloride) and copolymers of poly(vinylidene chloride) and poly(vinyle chloride) and an amorphous polymer such as poly(vinyl acetate), poly methyl acrylate, poly ethyl acrylate, atactic poly methy
...

METHODS AND SYSTEM FOR CONFOCAL LIGHT SCATTERING SPECTROSCOPIC IMAGING

The present invention is generally directed to imaging methods and apparatus that employ angular and/or wavelength distribution of light backscattered from multiple portions of a sample in response to illumination by electromagnetic radiation to generate one, two or three dimensional images of the sample. In many embodiments, confocal imaging can be employed to detect the backscattered radiation, e.g., to measure spectral signals of layered samples (such as biological samples) through optical se
...

APPARATUS AND METHOD OF ANALYZING ARTERIAL PLAQUE

A method of identifying arterial plaque analyzes arterial plaque using one or more non-invasive tests to determine if the plaque has any of a plurality of hallmarks that are predictive of disruption. The one or more tests do, in fact, test the plaque for the plurality of the hallmarks. The method then formulates a vulnerability quantity as a function of the determined hallmarks. The vulnerability quantity identifies whether the plaque is vulnerable to disruption.
...

LABELED SKIN LESION BIOPSY PUNCH AND USES THEREOF

The present invention relates to a biopsy device, methods, kits and systems for marking the location of a biopsy site in order to later identify the location of a biopsy or surgery in a subject, where the marker is a dye or tattoo which is not visible to the naked eye under normal (white) light, but is visible under UV light. Some embodiments relate to marking a biopsy site for later visualization of the marker.
...

BIOLOGICAL CIRCUIT CHEMOTACTIC CONVERTERS

Described herein are novel biological circuit chemotactic converter that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for detecting and converting external inputs, such as chemoattractants, into outputs that allow for autonomous chemotaxis in cellular systems. Flexibility in these biological circuit chemotactic converter is provided by combining individual modular components, i.e., SIMMs and genetic toggle switches, together. These biol
...

BIOLOGICAL ANALOG-TO-DIGITAL AND DIGITAL-TO-ANALOG CONVERTER SWITCHES

Described herein are novel biological converter switches that utilize modular components, such as genetic toggle switches and single invertase memory modules (SIMMs), for converting analog inputs to digital outputs, and digital inputs to analog outputs, in cells and cellular systems. Flexibility in these biological converter switches is provided by combining individual modular components, i.e., SIMMs and genetic toggle switches, together. These biological converter switches can be combined in a
...

Fully automated control system for type 1 diabetes

An augmented, adaptive algorithm utilizing model predictive control (MPC) is developed for closed-loop glucose control in type 1 diabetes. A linear empirical input-output subject model is used with an MPC algorithm to regulate blood glucose online, where the subject model is recursively adapted, and the control signal for delivery of insulin and a counter-regulatory agent such as glucagon is based solely on online glucose concentration measurements. The MPC signal is synthesized by optimizing an
...

LOW COST DISPOSABLE MEDICAL FORCEPS TO ENABLE A HOLLOW CENTRAL CHANNEL FOR VARIOUS FUNCTIONALITIES

The present invention relates to an endoscopic biopsy forceps (10) with an open central channel. The forceps include a sheath (20) having a proximal end and a distal end, a housing (50) connected with the distal end of the outer sheath, an open channel actuator control means (30) having a proximal end and a distal end and passing through the sheath, an operating means attached to the proximal end of the open channel actuator means, an open channel actuator (60.) attached to a distal end of the o
...

Dermal punch device

A dermal punch for extracting skin or tissue samples. The dermal punch has a blade having a pair of walls. Each wall is convex and opens towards each other. The walls are connected to each other at a pair of mating edges. Each wall has a cutting edge. In a preferred embodiment, the ratio of the minor axis to the major axis of the opening created by the walls is between 1 to 3 and 1 to 4, wherein the major axis extends through the mating edges. The cutting edge is formed of a plurality of teeth a
...

BONE FIXTURE ASSEMBLY

An assembly for rigid bone fixation includes a plate and a screw. The screw can be rotated freely within the plate in a non not locking configuration to secure the plate against the bone. A locking mechanism is engaged to prevent the screw from moving relative the plate. In one embodiment, the plate includes a threaded portion and a non- threaded portion. The screw head rotates within the non- threaded portion to tighten the screw and pull the plate against the bone. The locking mechanism includ
...

MODULAR THERAPEUTIC PRESSURE APPLICATION DEVICES

The invention relates in some aspects to therapeutic pressure application devices and methods of manufacturing and using the same. In some aspects, the devices comprise a support structure shaped to conform to a portion of a body of an individual; a bladder having a port for the passage of a fluid, the bladder being supported by the support structure; a pump having a fluid outlet, the pump being secured to the support structure; and separable fluid connectors operably connecting the pump with th
...

SPECTROSCOPIC SENSORS

Disclosed herein are sensors that include: (a) a circuit board that includes an electronic processor; (b) a plurality of radiation sources, each source being attached to the circuit board; and (c) a spectral detector attached to the circuit board, the spectral detector being configured to analyze radiation derived from one or more of the plurality of radiation sources. During use, the sensors are configured to be worn on a portion of a body of a subject. The electronic processor is configured to
...

SUSPENSION/RETRACTION DEVICE FOR SURGICAL MANIPULATION

A device that can be delivered into a body cavity to manipulate tissue intracorporeally while being controlled extracorporeally and a method of using the device to perform a single-port laparoscopic or natural orifice surgery. The device is being capable of being passed through an interior diameter of a single port into the body cavity. The device comprises an anchor or suspension element that is attachable or mountable to the tissue intracorporeally, a guide element attached to the anchor or su
...

INTRAUTERINE FALLOPIAN TUBE OCCLUSION DEVICE

An intrauterine device for occluding orifices of fallopian tubes includes a resilient body having an elongated member with a first end and a second end. The elongated member further includes a first leg ending with the first end of the elongated member, a second leg ending with the second end of the elongated member and a connection member positioned therebetween. A first orifice plug is secured at the first end of the elongated member and a second orifice plug is secured at the second end of th
...

PARALLEL MAGNETIC RESONANCE IMAGING USING NONLINEAR GRADIENT ENCODING

In MRI by excitation of nuclear spins and measurement of RF signals induced by these spins in the presence of spatially-varying encoding magnetic fields, signal localization is performed through recombination of measurements obtained in parallel by each coil in an encircling array of RF receiver coils. Through the use of magnetic gradient fields that vary both as first-order and second-order Z2 spherical harmonics with position, radially-symmetric magnetic encoding fields are created that are co
...

VOLUME STATUS MONITOR: PERIPHERAL VENOUS PRESSURE, HYPERVOLEMIA AND COHERENCE ANALYSIS

Systems and methods are provided for monitoring changes in blood volume using waveforms in the peripheral vasculature. In particular, the systems and methods relate to detecting ventilation-induced variation (VIV) of waveforms in the peripheral vasculature. Advantageously, the systems and methods may relate to analyzing VIV in peripheral venous pressure (PVP). Thus, the VIV of PVP may be measured, wherein decreased VIV is indicative of decreased blood volume In exemplary embodiments, such as inv
...

Dynamic spine stabilizer

A dynamic spine stabilization device is provided that includes at least one force imparting member, e.g., a spring. The force imparting member is adapted to deliver a force of between about 150 lb/inch and 450 lbs/inch, and restrict the relative travel distance between said first and second pedicles to a distance of between about 1.5 mm and 5 mm. The spinal stabilization devices also have a minimal impact on the location of the center of rotation for the spinal segment being treated. By providin
...

Method of Assessing Blood Volume Using Photoelectric Plethysmography

A method and system for assessing blood volume within a subject includes generating a cardiovascular waveform representing physiological characteristics of a subject and determining blood volume of the subject by analyzing the cardiovascular waveform. The step of analyzing includes generating a first trace of the per heart-beat maximums of the cardiovascular waveform, which is representative of the systolic pressure upon the cardiovascular signal, generating a second trace of the per heart-beat
...

Bone Implant Device and Methods of Using Same

A bone implant device comprising a plurality of interconnected plate members, at least one plate member defining a plurality of apertures therein adapted for permitting bone growth there through from an interior portion of the bone in which the device is implanted for aiding in securing the device within the interior portion, and wherein the device is configured and adapted to minimize contact with an interior surface of the bone. The device is useful in applications including, but not limited t
...

ACCESS DEVICE

A device may include a hollow needle, a dilator mounted coaxially on the needle, and a sheath mounted coaxially on the dilator. The dilator may be slideably displaceable relative to the sheath.
...

METHOD FOR IMPLANTING INTRAOCULAR PRESSURE SENSOR

Methods of implanting an intraocular pressure sensor and systems tbr sensing intraocular pressure are disclosed. An intraocular pressure sensor, including, a top surface, may be placed through the sclera of an eye of a patient. The intraocular pressure sensor may be caused to be inserted into the sclera until the top surface of the intraocular pressure sensor is substantially flush with the exterior wall of the sclera. An implantation wand may be used to assist in the insertion process. The wand
...

UVEOSCLERAL DRAINAGE DEVICE

An ophthalmic shunt implantable in an eye having an elongate body (10) and a branched conduit (40) for conducting aqueous humor from an anterior chamber of the eye to the suprachoroidal space of the eye and the subconjunctival space, and a plate extending from an upper surface of the elongate body.
...

DEVICE FOR MEASURING AND ANALYSING THE COLOUR OF THE OUTER EAR AND EAR CANAL

The present invention concerns a device for measurement and analysis of the middle ear and ear channel colour. This device allows thus automatic patient middle ear colour measurement and intends to be auxiliary equipment for health professionals in the diagnosis of ear infections. The device is composed of a standard otoscope (1), modified to include two optical fiber (2a and 2b) : one for ear illumination and another which returns the reflected light. The electronic unit (3) can change linearly
...

SUPRAPUBIC INSTRUMENT USED SPECIFICALLY IN ENDOSCOPIC PROSTATE SURGERY

The invention relates to a single tool that complements the technique performed by a resectoscope (4), which combines puncturing and subsequently extracting the irrigation liquid and remains of the extracted tissues, optimising said processes and increasing the intervention time, being suitable for treating prostates or larger bladder stones. Said suprapubic instrument (1) includes a puncturing means (10), suitable for making a cut in the outer suprapubic area of the patient, coinciding with the
...

MAGNETIC HYPERTHERMIA APPLICATION DEVICE

Magnetic hyperthermia application device (1) to apply magnetic hyperthermia treatment to a sample, characterized as such because it includes: an LC resonant tank (3), consisting of a first coil (5) and a first condenser (6), connected to an alternating voltage power supply (2) of variable frequency and a control medium (4) connected to the LC resonant tank (3) and to the alternating voltage power supply (2), which controls the voltage that the alternating voltage power supply (2) applies to the
...

DEVICE FOR CLAMPING SAMPLES IN MECHANICAL TESTS ON SOFT TISSUE

The invention relates to a jaw-type device that can be used to clamp soft tissue samples, such as biological tissue, in order for traction tests to be performed on said tissues. The device can also be used to perform tests on these types of samples in submerged environments.
...

MICRO-STEREOSCOPIC RETINAL PHOTOGRAPHY METHOD

The invention relates to a micro-stereoscopic retinal photography method, characterised in that said method uses a combination of two axes, X and Y, manipulating the moving parts of a retinal scanner and positioning the lens thereof at the axial focal length on the retina in a primary position, followed by capturing images in two consecutive stereoscopic passes, top left and bottom right, viewing the result on a parallel viewer with interpupillary distance adjustment. Since retinal nerve fibres
...

DEVICE FOR APPLYING A CONTACT ANAESTHETIC

Device for applying a contact anaesthetic, such as those used mainly in superficial ophthalmological surgery for application of a local anaesthetic, characterized in that it consists of a porous strip of gelatine sponge which is flexible and preferably rectangular in shape with a small thickness, which is impregnated with a topical anaesthetic and is deposited on the surface to be treated, leaving it to act for a short period of time so that anaesthetic is released onto said zone, being discharg
...

FORENSIC IDENTIFICATION SYSTEM USING CRANIOFACIAL SUPERIMPOSITION BASED ON SOFT COMPUTING

The invention relates to a method and an automatic system for assisting a forensic anthropologist in the task of identification by means of craniofacial superimposition. First, the system automatically builds a three-dimensional model from a device providing partial views of the skull. Said model is then superimposed onto a photograph of the disappeared person, modelling the inherent uncertainty to the pairing of two separate objects: a skull and a face. Finally, the system emits a recommendatio
...

PORTABLE DEVICE FOR SELF-VIEWING BLOOD CELLS IN THE RETINA

The invention relates to a compact, portable instrument that is easy to use, enabling the patient to evaluate him/herself in a few seconds whether the blood circulation in his/her retina is correct, and to therefore self-detect pathologies such as vascular retinopathies, arteriosclerosis or diabetic retinopathy inter alia.
...

DEVICE FOR THORACOSTOMY

The invention relates to a device (1) for thoracostomy, in particular for relief of a (tension) pneumothorax, comprising a cannula (2) and a needle (3) slidingly sheathed m the cannula (2). A spring (13) resiliently couples the needle (3) to the cannula (2), at least during insertion of the device (1).
...

MICRONEEDLE INJECTING APPARATUS

A method of delivering a microneedle array to a substrate including the steps of propelling the microneedle array towards the substrate utilising a microneedle applicator device which propels the microneedle array towards the substrate at a speed of 0.5 m/s to 5 m/s, the device subsequently withdrawing the microneedle array from the substrate.
...

TOOLS FOR USE IN TREATMENT OF MALE URINARY INCONTINENCE.

A transobturator technique was developed for treating male urinary incontinence. This approach helped to design specific instruments to pass around the ischio-pubic branches of the male pelvis from inside to outside (i.e from the suburethral space to the thigh fold). The inside-out transobturator sling technique uses specific instruments and a polypropylene mesh with two arms that are passed inside to outside through the obturator foramens, pulled for compressing the bulbar urethra upward, and t
...

DEVICES FOR SURGICAL TREATMENT OF FEMALE URINARY INCONTINENCE

A variety of specifically designed surgical instruments to perform a new, quick, simple, efficient, safe, and reproductible surgical technique for the treatment of female urinary incontinence, in which the posterior urethra is suspended using a tape passed through the obturator orifices from inside (underneath the urethra) to outside (thigh folds).
...

A method and device for processing and presenting medical images

The present invention relates to a method for processing and presenting at least a first image and a second image, these images being digital medical images. A first step in the method is performing image registration between the first image and the second image to generate a pixel-level mapping between both images a second step is presenting the first image and the second image simultaneously on a display. A third step is presenting a first magnification of a region in the first image and a sec
...

METHODS AND SYSTEMS FOR ANALYSING RESUSCITATION

A system (100) for analysing resuscitation is described. The system comprises an input means (120) for obtaining a plurality of pressure values over time. It also comprises a tracheal pressure value processing means (140), and a clinical parameter determination means (150) for determining at least one clinical parameter based on said processed tracheal pressure values. A corresponding method is also described.
...

GDF15 AS MOLECULAR TOOL TO MONITOR AND ENHANCE PHENOTYPIC STABILITY OF ARTICULAR CHONDROCYTES.

The present invention relates to GDF15 as a molecular marker in in vitro assays determining phenotypic stability of articular chondrocytes and predicting the outcome of chondrocyte transplantation.
...

IMPLANTABLE SENSOR

A sensor is described for sensing a substance such as for example glucose. The sensor is implantable in the body of a living creature. The sensor comprises a photonic integrated circuit, e.g. silicon-photonics, based radiation processor for spectrally processing radiation interacting with the sample. A continuous monitoring system also is described using such a sensor.
...

COCHLEAR IMPLANT APPARATUS

The invention relates to cochlear implants and to improved methods of operating such implants. We describe cochlear implant apparatus comprising an audio signal processing unit with a wired or wireless coupling to an implantable cochlear stimulation device, wherein said audio signal processing unit has an audio input to receive an audio signal representing a sound, wherein said implantable cochlear stimulation device includes an electrical pulse generator coupled to an electrode array for intrac
...

Active Interface Device

An active interface device including a transducer or sensor array having a plurality of transducers or sensors arranged to transform a cell activity into an electrical signal, at least one detection unit for detecting the electrical signal(s), at least one recording unit for recording the electrical signal(s), comprising a plurality of recording channels arranged for being routed to the transducers or sensors, and at least one control unit. The control unit is arranged for addressing the transdu
...

Large Time Constant Steering Circuit and Instrumentation Amplifier Implementing Same

The present invention relates to a large time constant steering circuit for slowly changing a voltage on a node between at least two discrete voltage levels. The present invention further relates to a slow steering current DAC comprising said large time constant steering circuit. The present invention further relates to an instrumentation amplifier device comprising a current balancing instrumentation amplifier for amplifying an input signal to an amplified output signal and a DC servo-loop for
...

FLEXIBLE ENDOSCOPE DEVICE WITH VISUAL CONTROL AND PROCESS FOR STABILIZATION OF SUCH A DEVICE

A flexible endoscope device includes an elongated flexible body having an end segment bearing or defining the endoscope head, and provided with an optical system that can be curved or bent in at least two mutually perpendicular directions, the elongated body being functionally connected at the other end thereof to a control element capable of controlling at least the movements and/or the arrangement of the end segment. The device includes automatic flexion and positioning elements of the end seg
...

ADJUSTABLE CATHETER OR ENDOSCOPE STRUCTURE

The structure e.g. catheter (27), has a resiliently deformable longitudinal body (28) including a memory shaped actuator e.g. yarn (38), integrated longitudinal to the body that is in the form of an elongated cross-sectional blade. A heating unit longitudinally contracts the actuator by Joule effect to cause longitudinal bending of the body. The actuator extends over a polymer part with variable stiffness of the body. The actuator is incorporated in the blade, and extends along a longitudinal si
...

SURGICAL INSTRUMENT

The invention relates to a surgical instrument (1) comprising: an elongated arm (11; 307) according to a longitudinal axis and having a distal end (2; 305) mounted with a pivot joint on the elongated arm according to an axis substantially orthogonal to the longitudinal axis; a drive shaft (3) substantially coaxial with the elongated arm comprising means forming a universal joint facing the pivot joint; and, a distal tool (9) securely fastened on the drive shaft and rotatively mounted on and in t
...

DEVICE FOR MEASURING THE ACTIVITY OF THE SPINAL CORD OF A VERTEBRA

The invention relates to a device for measuring the activity of the spinal cord of a vertebra, characterized in that the device comprises at least one main probe (1) shaped so as to be attached to a spinous process (2) of a vertebra (3) and to maintain in position, on either side of the vertebra, at least one transmitter (6) for transmitting a wave capable of interaction with the spinal cord (7) and at least one associated receiver (8) for receiving the wave that interacted with the spinal cord
...

Assay device and method for chemical or biological screening

An assay device (1) comprises a base (2) and glass plate lid (3). The base (2) has an array of shallow microwells (4), each having a flat rim (9), all rims being co-planar. When the lid (3) is placed on the base (2) a thin capillary gap (10) is formed on each rim, acting as a liquid seal for a microwell chamber. The liquid is excess sample liquid and further excess is accommodated in overspill cavities (6) between the microwells (4). Because of the liquid seal and shallow configuration the benef
...

A device for treating tissue

An apparatus for use in carrying out a prophylactic or treatment procedure on tissue comprises a head piece 1 having a receiver 2 for receiving an instrument such as an endoscope 10 and a chamber 3 into which is drawn by vacuum. There are two electrodes 11 within the chamber 2 and two electrodes 25 located on opposite sides of the entrance 5 into the chamber. The voltage applied to the inner and outer electrodes 11, 25 can be varied independently and allows tissue underlying the device to be tre
...

A stent delivery system

A stent delivery balloon 1 is used to deploy a plurality of mini-stents 5 into a bodily lumen at a controlled spacing. The balloon 1 has formations 3 for retaining the stents in a designed position. The formations may comprise ridges 3, or retractable bridging elements, on the surface of the balloon 1 to control both the expansion of the multiple stents 5 from a single balloon 1 and also the coverage of the vessel wall following stenting. <Figure 23>
...

ENDOSCOPY SYSTEM WITH MOTION SENSORS

An endoscopy system (1) comprises an endoscope (2) with a camera (3) at its tip. The endoscope extends through an endoscope guide (4) for guiding movement of the endoscope and for measurement of its movement as it enters the body. The guide (4) comprises a generally conical body (5) having a through passage (105) through which the endoscope (2) extends. A motion sensor comprises an optical transmitter (7) and a detector (8) mounted alongside the passage (105) to measure the insertion- withdrawal
...

INTRAVASCULATURE DEVICES AND BALLOONS FOR USE THEREWITH

An inflatable device (1) for use within the vasculature of a body and having an expandable annular body (Ia) which is expandable by inflation of a series of inflation lumen (2) defined therein, the device having inflated (b) and non-inflated (a) states and inner (3) and outer (4) annular walls, the device being adapted so that inflationary pressure within the lumen moves the device from the non-inflated state toward the inflated state by radially outward expansion of both the outer and inner wal
...

Method and apparatus for imaging tissue topography

The present invention related to an optical device for imaging and measuring characteristics of an objects surface shape, surface spectral reflectance and structure of sub-surface layers. In particular, the invention related to imaging of topography of human skin and skin sub-surface layers and determination of concentration of skin constituents. The present invention has applications in areas such as skin care, dermatology, cosmetics, wound managemtn and tricology. The imaging device of the inv
...

METHOD AND SYSTEM FOR MONITORING SLEEP

A method of monitoring sleep comprises simultaneously recording a person's electrocardiogram (ECG) and photoplethysmogram (PPG), deriving a plurality of parameters from the recorded data, and providing an output indicative of a sleep characteristic based upon an analysis of the parameters. The ECG and PPG may be recorded using an apparatus which is a combination of a Holter monitor and a pulse oximeter, which is wearable in ambulatory manner.
...

A LATERAL FLOW ASSAY DEVICE FOR COAGULATION MONITORING AND METHOD THEREOF

The present invention is directed to a lateral flow assay device for the monitoring and measuring of coagulation and method thereof. Ideally, the invention is directed to a lateral capillary flow device for the monitoring and/or measurement of coagulation in a liquid sample wherein the device comprises a non-porous substrate with a zone for receiving a sample and a defined flow path zone wherein a clotting agent is deposited on at least part of the defined flow path zone to accelerate the coagul
...

VESSEL SUPPORT DEVICE AND METHODS FOR SUPPORTING A VESSEL

The present invention is directed to a vessel support member having opposing ends adapted to move in a circumferential plane, the support member configured for deployment in a substantially radial direction to support a substantial portion of the circumference of a vessel, the support member adapted to change between a first configuration and at least a second configuration, such that when in the first configuration, the support member is substantially linear or substantially planar, and as the
...

ORTHOPAEDIC DEVICE FOR THE TREATMENT OF SPINAL DISC DEGENERATION DISEASE

An orthopaedic device is provided for the treatment of spinal disc degeneration disease (DDD). The device comprises a vertebral body spacer capable of being placed between a first vertebral body and a second vertebral body of a human or vertebrate animal subject such that said vertebral body spacer forms or occupies an intervertebral space between the vertebral bodies, and wherein the vertebral body spacer comprises a body housing at least one tooth therein, where the, or each, tooth is adapted
...

METHOD, SYSTEM AND APPARATUS FOR VENTILATION

The invention relates to a ventilator for delivering fluid pressure to the lungs of a subject, the ventilator having; a pump in operative connection with a first pressure vessel for control of the peak inspiratory pressure (PIP) of the subject, wherein the volume of the first pressure vessel is substantially greater than the volume of the lungs of the subject.
...

RESPIRATORY AID DEVICE

A system is described for stimulating the chest wall of a subject to reduce breathlessness. The system includes a respiration sensor (3) operable to generate an output signal dependent on respiration of the subject; a stimulation device (7) operable to stimulate the chest wall of the subject; and a controller (5) arranged to monitor the output signal and to activate operation of the stimulation device dependent on the output signal. The system provides in-phase stimulation of intercostal muscles
...

A WIRELESS CODE GAME ENURESIS ALARM FOR THE TREATMENT OF ENURESIS

A system (10) and method for use by a subject with a sleep disorder, such as nocturnal enuresis. The system (10) comprises at least one sensor (11) that detects at least one attribute of the sleep disorder, for example urine, and outputs at least a first signal on or after detection of that attribute. The system (10) further comprises a control device (12) that comprises an arousal device (14), such as a loudspeaker, that activates on or after receipt of the first signal, an interactive device (
...

Pressure sensor for measuring intraocular pressure that can be worn on the eye.

A pressure sensor that can be worn on the eye of the user for measuring the intraocular pressure of the user. The pressure sensor may take the form of a strain gauge 24 which has a resistance element. The pressure measuring device may also be incorporated into a corneal contact lens, the contact lens may have a cavity which can hold or store medication for intraocular pressure. The contact lens may also have an outlet for the medication so it can be administered to the eye. The pressure sensor m
...

PHASE LOCK EVOKED RESPONSE AUDIOMETER

An evoked response audiometer method and apparatus in which a patient receives an auditory stimulus signal comprising a carrier frequency which is periodically amplitude modulated and frequency modulated whereby the stimulus is at least substantially frequency specific, the brain potential signals of the patient evoked by the auditory signal being sampled to determine whether phase locking to the modulated auditory signal has occurred, the auditory signal being selectively controlled to advance
...

METHOD AND APPARATUS FOR SENSORY FIELD ASSESSMENT

A method for assessing the function of at least one sensory field of a subject, and apparatus and systems for carrying out the method, the method comprising: using a display, presenting stimuli to selected locations of the sensory field, the selected locations being centred at points on a sampling grid spanning a portion of the sensory field, wherein the individual stimuli if presented simultaneously at the sampling grid points would overlap in the space defined by the sensory dimensions of the
...

NEURAL CIRCUITS AND STEREOTACTIC APPARATUS

Herein are disclosed: - solid or semi-solid implantable neural circuits conduit comprising an elongate polymer sheath and one or a plurality of neurons in the lumen of the sheath or embedded in the scaffold; - methods of manufacturing said implantable neural circuits; - a stereotactic syringe apparatus having a frame and a syringe support mounted on the frame, the syringe support having : (i) a translation stage on which a medical syringe is mounted, the syringe having a single cannula, the cann
...

DEVICES AND METHODS FOR DETECTING ss-HAEMATIN AND HAEMOZOIN

In the application, the change in the magnetic state of the haemoglobin caused by the malarial infection is exploited by detecting suitable properties of haemozoin which are dependent on the application of a magnetic field. Figure 1 shows apparatus, shown generally at (10), for performing magneto-optical detection using photo-acoustic techniques. The apparatus (10) comprises a light source (12), producing a beam of optical radiation (14) which passes through a polariser (16), a variable LC retar
...

MICROFLUIDIC APPARATUS AND METHOD FOR DNA EXTRACTION, AMPLIFICATION AND ANALYSIS

An integrated gel based microfluidic sample processing device An integrated gel based microfluidic sample processing device, suitable for forensic investigations at the scene of a crime,comprising a substrate having a plurality of micro-channels to form at least a DNA extraction chamber in fluidic cooperation with an amplification chamber which in turn is in fluidic cooperation with a separation and detection channel; said micro-channels containing a DNA extraction material and gel based reactio
...

Speech valve

The valve 10 comprises a generally cylindrical body 12, 14, 16 and a closure member 62 which is slidably movable within the body between a closed position and an open position. The valve body and the closure member 62 are formed of a rigid, smooth material which is resistant to the growth of biofilm, such as a ceramic. A particular suitable ceramic is partially stabilised zirconia. The valve body is provided with an outer sleeve 76 which is provided with radially outwardly extending annular flan
...

A SPEECH VALVE, A TOOL FOR FACILITATING INSERTION OF A SPEECH VALVE AND A TOOL FOR HOLDING A SPEECH VALVE

A tool (106) for facilitating insertion of a speech valve (10) with a flexible retention flange (56) into a fistula between the trachea and the oesophagus of a human patient, having a wall (108) curved to define a passage (116) having opposed open first and second passage ends and an axis extending therebetween, said wall (108) having an external surface (118) insertable into a fistula between the said trachea and oesophagus and defining a slot (110) which extends from the passage (116) to the e
...

TRANSPEDICULAR ACCESS TO THE INTERVERTEBRAL DISC SPACE FOR DISCECTOMY, END PLATE PREPARATION, AND INTERBODY FUSION

An insertion device is configured to access a disc positioned between adjacent vertebrae. The insertion device includes a cannula having a passage formed therein. The cannula has an exit aperture. An obturator is substantially positioned within the passage formed in the cannula. One end of the obturator has a probe and the other end of the obturator has a head. An impaction cap is in contact with the cannula and is positioned to cover the head of the obturator. The impaction cap is configured to
...

INSERTION ASSEMBLY FOR MINIMALLY INVASIVE SPINAL SURGERY

A telescopic insertion assembly is configured to insert a pedicle screw into a vertebral body. The insertion assembly includes an attachment fixture having one end configured to mate with the pedicle screw and another end having a ridged portion. A center tube is provided having one end slidably attached to the attachment fixture and another end having an internally ridged portion. A telescoping member has one ridged end configured to slidably attach to the center tube and another end having a y
...

PEDICLE SCREW ASSEMBLY HAVING A RETRACTABLE SCREW TIP FOR FACILITATING THE SECUREMENT OF THE PEDICLE SCREW ASSEMBLY TO A SPINAL VERTEBRA

A pedicle screw assembly has a retractable screw tip that facilitates the securement of the pedicle screw assembly to a spinal vertebra in a minimally invasive fashion during an orthopedic surgical procedure. The pedicle screw assembly includes a body portion including a head and a shank. The shank includes an outer surface with a thread provided thereon, an end having a cutting tip provided thereon, and a bore extending inwardly from the end and having an internally threaded region provided the
...

FIXATION ASSEMBLY HAVING AN EXPANDABLE INSERT

A fixation assembly having one or more insertions member that include one or more expandable and retractable anchoring inserts positioned along at least a portion of the insertion member and methods of use thereof are disclosed.
...

DIRECTIONAL SOFT TISSUE DILATOR AND DOCKING PIN WITH INTEGRATED LIGHT SOURCE FOR OPTIMIZATION OF RETRACTOR PLACEMENT IN MINIMALLY INVASIVE SPINE SURGERY

A soft tissue dilator for use in a surgical procedure includes a first dilator member that defines a first axis and a second dilator member that defines a second axis. The second dilator member is supported on the first dilator member such that relative rotational movement of the first and second dilator members causes eccentric movement of the first and second axes defined by the first and second dilator members. Additional dilators members may be sequentially supported on the first and second
...

PEDICLE SCREW ASSEMBLY HAVING A RETRACTABLE SCREW TIP FOR FACILITATING THE SECUREMENT OF THE PEDICLE SCREW ASSEMBLY TO A SPINAL VERTEBRA

A pedicle screw assembly has a retractable screw tip that facilitates the securement of the pedicle screw assembly to a spinal vertebra in a minimally invasive fashion during an orthopedic surgical procedure. The pedicle screw assembly includes a body portion including a head and a shank. The shank includes an outer surface with a thread provided thereon, an end having a cutting tip provided thereon, and a bore extending inwardly from the end and having an internally threaded region provided the
...

NEEDLE FOR DIRECTIONAL CONTROL OF THE INJECTION OF BONE CEMENT INTO A VERTEBRAL COMPRESSION FRACTURE

A needle for use in a surgical procedure includes an outer cannula including a shaft portion having a side wall and an end wall. A first aperture extends through the side wall of the outer cannula, and a second aperture extending through the end of the outer cannula. The needle also includes an inner cannula that is disposed within the outer cannula and includes a shaft portion having a bore extending therethrough. The inner cannula is selectively movable relative to the outer cannula between a
...

STERILIZATION OF MEDICAL DEVICES USING EXPANDED ORGANIC ACIDS

The present invention concerns a process for sterilizing biomedical devices using organic acids expanded by compressed gases to form an "expanded liquid". The term "expanded liquid" means, in the technical literature, an organic solvent that is liquid at room temperature and pressure, modified by dissolution therein of a compressed gas to modify the diffusivity and the surface tension of the liquid compound, while maintaining part of its original In the proposed process the diffusivity and the s
...

AIR CUSHION SENSOR FOR TACTILE SENSING DURING MINIMALLY INVASIVE SURGERY

A sensor is described for detecting the force applied to or by soft material, and that is thus able to measure the stiffness of a soft material. The sensor comprises a sensor body into which is supplied a fluid under pressure. At least one sensor members are provided that are arranged to project from the sensor body under the pressure exerted thereon by the fluid. A sensor member displacement detection system is also provided, that is preferably optically based using optical fibres to illuminate
...

APPARATUS AND METHOD FOR MEASURING BLOOD PRESSURE

The application relates to an apparatus and a method for estimating a central systolic blood pressure (cSBP) of a subject, in which a peripheral blood pressure waveform of the subject's pulse and at least two peripheral blood pressure measurements within the cardiac cycle of the subject are determined and the peripheral blood pressure waveform is manipulated with a transfer function to provide an estimate of the central blood pressure waveform of the subject's pulse. The at least two peripheral
...

CMYBP-C AND MLC2 AS DIAGNOSTIC MARKERS OF CARDIAC INJURY

The invention relates to markers for acute myocardial infarction (AMI), particularly markers that may be used in the rapid and accurate diagnosis of AMI or reinfarction. A method of diagnosing cardiac injury comprising identifying an elevated concentration of cardiac myosin binding protein C (cMyBP-C) or a fragment thereof or myosin regulatory light chain 2 (MLC2) or a fragment thereof in a sample obtained from a subject.
...

REVERSIBLY GELLING POLYURETHANE COMPOSITION FOR SURGICAL REPAIR AND AUGMENTATION

A new reversibly gelling polyurethane (RGP) polymer composition is described, as well as novel processes for its preparation, and its medical uses for filling spaces in tissue, or bulking tissue, or for restoring organ function. The novel RGP polymer forms a gel on standing, liquefies during shear and reversibly reforms a macroscopic gel on standing after being sheared. Methods of use include delivering the improved gel to a site on the body to fill voids or to augment local tissue bulk.
...

BIOACTIVE MATERIAL DELIVERY SYSTEMS COMPRISING SOL-GEL COMPOSITIONS

Implantable medical devices employing a sol-gel composition coatings that functions as a bioactive material reservoir, and the use of sol-gel composition coatings for improved adhesion of organic and inorganic substrates are disclosed.
...

MEDICAL TUBING SECUREMENT ASSEMBLY AND METHODS OF USE

A medical tubing securement assembly includes a base having a disc, and a retaining adapter removably and rotatably attached to the disc. The retaining adapter includes a longitudinal passage for receiving a locking adapter. The locking adapter includes a longitudinal passage for receiving a medical tube. Once the tube is inserted into the locking adapter, the locking adapter may be rotated within the retaining adapter, around the tube, to secure the tube within the securement assembly.
...

UNIVERSAL CATHETER SECUREMENT DEVICE

A universal securing device for holding catheters of various shapes and sizes and the like in place includes a base and cover. The cover may be connected to the base by a hinge which allows the cover to be lifted open or pushed down into a closed position, over a catheter fitting. The base may have locating elements configured and arranged to fit around catheter fittings of various sizes, and the locating elements prevent substantial movement of a catheter fitting and catheter in various dimensi
...

A DEVICE FOR DELIVERING MEDICAL TREATMENT

he present invention provides a medical device for the delivery of treatment fluid to body vessels, having a distal (21) and a proximal (20) end, comprising a self-expanding, hollow tubular member (9) and a delivery catheter (10) suitable for deploying a self-expanding, tubular member (9), wherein the tubular member (9) is configured to expand radially to form a central part (11) flanked by two annular ridges, which creates, in situ, an annular lumen for that can apply treatment fluid locally to
...

METHODS AND DEVICES FOR CONTINUOUS SUTURE PASSING

Described herein are suture passers for suturing tissue in a continuous manner by passing a suture attached to a suture shuttle through. A suture passer may include a first jaw, a second jaw, and a tissue penetrator that is retractable and extendable from the first jaw. The tissue penetrator may have a suture shuttle engagement region, and the second jaw may include a shuttle dock. The suture shuttle may be transferred between the first and second jaws as the tissue penetrator is extended from t
...

AMBULATORY AID WITH A POWER UNIT

A device comprising an ambulatory aid, the device comprising a distal end, a load, a first portion positioned at, or close to the distal end and adapted to allow the device to move along a surface, a second portion spaced apart from the first portion and the distal end and adapted to allow a user to be attached to, or hold the device, and a power unit operably connected to the first portion, the device having a deployed position in which the device is moveable, and is supported by the user, move
...

TARGET ACQUISITION SYSTEM

A targeting system and method for remotely controlling the zoom and pan features of a device for display in an operating room is provided. The invention generally relates to a system and method for allowing a controller in an operating room to control the zoom and pan features of one or more remote display terminals in the sterile area of the operating room; and more particularly, to a system and method for providing a graphical overlay at a control terminal for use in identifying and modifyi
...

STENT DELIVERY DEVICES, SYSTEMS & METHODS

The present invention relates to devices, systems and methods to maintain self- expanding stents in a compressed form during delivery and positioning at a treatment site. Such a device may comprise a cylindrically-shaped material with a plurality of slots which are spaced on said material to accept sections of a self-expanding stent wherein said material has a tensile strength that is sufficient to maintain said self-expanding stent in a compressed form when said accepted sections of said stent
...

IMPLANTABLE AND LUMEN-SUPPORTING STENTS AND RELATED METHODS OF MANUFACTURE AND USE

An implantable stent includes multiple circumferential segments that surround a bore and are connected in series along a length to form a tubular wall. Multiple adjacent alternating opposite facing crowns arranged along each segment's circumference are bridged by struts. The struts include a series of staggered arcuate edges with limited flats to provide a limited region of maximum width between significantly extended reducing diameter tapers at either end where they transition into the crowns.
...

SUTURE PASSING INSTRUMENT AND METHOD

A continuous suture passer device (10) may include a first jaw (20) and a second jaw (21 ); an actuator (15) including a jaw control which may manipulate at least one jaw; a tissue penetrator (50) which may be configured to form a pathway through a tissue which may be positioned between the first and second jaws (20 and 21) through which a suture shuttle (70) may be passed, wherein the suture shuttle (70) may be releasably secured to the tissue penetrator (50); and a suture shuttle retainer seat
...

SURGICAL ANTENNA

A surgical instrument (100) (e.g. scalpel) is disclosed which has an antenna arranged to emit a substantially uniform microwave radiation field (e.g. having a frequency of 5-100 GHz) at an edge of a cutting element (110) (e.g. blade). The emitted radiation can cauterise tissue e.g. broken blood vessels simultaneously with cutting. The antenna may be integral with the cutting element, e.g. a metallised piece of ceramic attachable at an end of a waveguide (120, 150) to receive radiation therefrom.
...

NEEDLE STRUCTURE AND METHOD OF PERFORMING NEEDLE BIOPSIES

A biopsy needle (80) having a longitudinal channel (84) formed within an inner conductor (86) of a coaxial antenna is disclosed. The coaxial antenna terminates in a rigid insertion tip (82) e.g. a ceramic cone that is insertable into biological tissue. Microwave energy (e.g. having a frequency of 1 to 100 GHz) delivered to the coaxial antenna is emitted at the insertion tip. The insertion tip may be arranged to match the impedance of the coaxial antenna to a predetermined tissue impedance. The e
...

MEDICAL DEVICES, APPARATUSES, SYSTEMS, AND METHODS

Apparatuses and systems for enabling electrical communication with a device positionable within a body cavity of a patient. Apparatuses and systems for magnetically positioning a device within a body cavity of a patient. Medical devices. Methods of use.
...

THERAPEUTIC METHODS USING CONTROLLED DELIVERY DEVICES HAVING ZERO ORDER KINETICS

An injectable or implantable medical device having orifice(s) on the surface that release an active agent with zero-order release kinetics is described herein. The device is a hollow matrix of any size or shape, which can be made from both metal and non-metal surfaces. The device comprises of a reservoir capable of releasing at least one therapeutic, diagnostic, or prophylactic agent via the orifices to the desired anatomical site. The developed device, due to its composite structure, has the ab
...

PHOTOKINETIC OCULAR DRUG DELIVERY METHODS AND APPARATUS

The present invention relates generally to transscleral and transocular delivery of biologically active substances through the tissues, blood vessels and cellular membranes of the eyes of patients without causing damage to the cellular surface, tissue or membrane. The invention provides compositions and methods for enhanced transscleral and transocular delivery of biologically active substances using pulsed incoherent light, and particularly the transcleral or transocular delivery of high molecu
...

APPARATUS FOR TREATING TISSUE WITH MICROWAVE RADIATION AND ANTENNA CALIBRATION SYSTEM AND METHOD

A calibration method and apparatus for surgical antennas which are arranged to deliver microwave radiation (e.g. having a treatment frequency of 500 MHz to 100 GHz) into biological tissue is disclosed. An emitting region of the antenna is exposed to a plurality of calibration standards each having a different complex impedance at the treatment frequency. In one embodiment the calibration standards are created in a short-circuit-terminated waveguide cavity of variable length. In another embodimen
...

OESOPHAGEAL TREATMENT APPARATUS

A probe and associated apparatus for treating oesophageal tissue with microwave radiation (e.g. radiation having a frequency of 5-60 GHz) are disclosed. The probe comprises a flexible substrate that expands and retracts between an access configuration, e.g. suitable for insertion through an endoscope, and a treatment configuration in which radiating elements, e.g. conducting patches, monopole antennas, slots in a conducting strip or the like, are brought into close proximity with tissue to be tr
...

ELECTRICAL WOUND HEALING SYSTEM AND METHOD

A wound healing system comprising an array of electrodes incorporated in a device for applying an electrical signal to a wound. The electrodes are configurable to form at least one composite electrode and the electrical signal is applied to the wound via the composite electrode(s). The system preferably includes means for determining the state of the wound, the electrode composition of the composite electrode(s) depending on the determined state of the wound. Advantageously, the electrode compos
...

SKIN MARKER

A skin marker for providing a reference point for a plurality of different medical imaging procedures, said marker incorporating one or more substances having one or more of radiance and/or hydration and/or radiopaque and/or radio luminescent and/or radioactive properties for detection by X-ray and/or Computer Tomography (CT) and/or MRI and/or Ultrasonic scanning processes and/or Positron Emission Tomography (PET), and one or more markings recognisable by an optical imaging process such as 3D su
...

AN INFANT INCUBATOR WITH RADIANT HEATER

An infant incubator comprises a radiant means (30) with an infrared heater (12). A infant bed (16) is provided under the radiant means (30) and includes a humidifier (7) and a second temperature controller (18). A transparent sphere cover (6) is mounted around the bed (16), and a cover board (28) for directing air, which includes an air outlet (32) and an air return inlet (33), and a volute casing (19 ) which includes a recirculating blower are provided under the bed (16). The second temperature
...

HARD TISSUE REGENERATION DEVICE

PROBLEM TO BE SOLVED: To provide a new hard tissue regeneration device using osteoblast. ; SOLUTION: The hard tissue regeneration device is a complex of an osteoblast and a honeycomb porous body having through-holes with 1 [mu]m-14 [mu]m pore diameter comprising calcium phosphate produced by the osteoblast and a non-water-soluble polymer. The device is used for a joint treatment and a hard tissue regeneration treatment with respect to the disease of a bone and cartilage, and urges the excellent
...

URINE COLLECTION DEVICE

A pad assembly for use with a urine collection device comprises an external layer (2), which is preferably an impermeable conformable material. The external layer (2) partially surrounds a filling material (3), which preferably comprises a single layer of open low-density material that does not appreciably resist the flow of urine nor retain urine. The pad assembly is preferably tapered and preferably is able to accommodate an end portion of a urine outlet tube (1) longitudinally within the boun
...

Device for supporting at least one arm of an operating person during a surgical or medical operation

A device for supporting at least one arm of an operating person during a surgical or medical operation comprises at least one supporting element for supporting the at least one arm of the operating person, the supporting element being arranged at a carrying structure for carrying the at least one supporting element. The carrying structure is configured such that the at least one supporting element can be lowered or raised for adjusting the height of the operating person's arm. The carrying struc
...

Heating system

A body part heating system (10) comprises a temperature sensor (28) adapted to measure the temperature of a body part, and a heater (34a, 34b) in communication with the temperature sensor (28). The heater (34a, 34b) is adapted to be activated to heat the body part in response to the temperature sensor (28) sensing the occurrence of a predefined thermal event such as a temperature drop below a predefined level. The heating system (10) may be in the form of a glove and may be used to treat the sym
...

MAGNETIC RESONANCE IMAGING OF LABELLED CELLS

A method and apparatus for obtaining a magnetic resonance image of a sample by applying a radio frequency signal to a sample containing magnetically labelled cells or tissues in order to heat the magnetically labelled cells or tissues and applying a sequence of radio frequency pulses to the sample to obtain magnetic resonance signals from the sample. Heating the magnetically labelled cells or tissues causes them to function as positive contrast agents providing positive image contrast in an imag
...

PRESSURE MEASUREMENT DEVICE

A non-invasive device adapted to measure intraocular pressure (IOP) comprising: a pressure sensor mounted on a soft contact lens to be worn on the eye of a subject, wherein the device is adapted such that, when worn on the eye, the pressure sensor is located at or near the transitional region of the cornea. The pressure sensor communicates wirelessly to an external controlling device through a magnetic field- based telemetry system that serves to power the pressure sensor and transmit the pressu
...

APPARATUS AND METHOD FOR THE MANIPULATION OF OBJECTS USING ULTRASOUND

A method and apparatus for manipulating particles. The apparatus comprising an ultrasound source for providing a variable ultrasound signal within a region of interest, and a controller connected to the ultrasound source such that it provides a control signal to the ultrasound source. The variable ultrasound signal creates a pressure field within the region of interest, the shape and/or position of which can be altered by changing the control signal input to the ultrasound source such that a par
...

APPARATUS AND METHOD FOR MINERALISING BIOLOGICAL MATERIALS

An apparatus and method for mineralising demineralised and hypo-mineralised biological material such as tooth or bone. The apparatus has a probe electrode for receiving a mineralisation agent and a counter electrode. It is also provided with means for controlling the electrical signal provided to the probe such that the extent of mineralisation of the biological material is controlled by modulating or changing the electrical signal provided by the probe based upon the measured output of the circ
...

METHODS FOR REDUCING FALSE HYPOGLYCEMIA ALARM OCCURRENCE

A system and method for reducing the number of hypoglycemic alarms presented to a user is presented. The system and methods include use of model based state estimation and variable-delayed threshold values to balance the risk of not presenting an alarm caused by an actual hypoglycemic state with the presentation of alarms caused by artifacts in the signals produced by a continuous glucose monitor.
...

Valve disc and combination filling device using the valve disc, and tube, pipe jointing device, connection port manufacturing device, and pipe jointing system

A tube (51,30) including a flow path (51) in the inside, at least a part of which is constituted by a flexible material, the tube (51,30) is provided with at least one inner slit along an axis of the tube in a closed state or an opened state that reaches an internal peripheral surface (72,302) thereof and does not reach an external peripheral surface (71) thereof, and the tube includes position indicating means (83,304) for indicating a position of the inner slit, and when a connection port (300
...

Automatic sample collector

This invention relates to an automatic sample collector for liquids which are discharged from a chromatographic column, a dialysis apparatus, or a reaction container, for example, and are consecutively collected at a give volume division, a method for collecting samples of a liquid in a predefined chronological sequence, and uses of the inventive sample collector. The volume is divided by assigning one or several gas-permeable liquid barriers ( 4, 5 ) to each collection container ( 3 ). The samp
...

MICRODIALYSIS CHAMBER SYSTEM WITH INCLUDED COLLOIDAL MATERIALS AND METHOD FOR THE MANUFACTURE THEREOF

The invention relates to a microdialysis chamber system comprising a base member (1) made of a solid material that does not swell in water, at least one cavity (4) functioning as a dialysis chamber, containing water soluble colloidal materials (5) and at least one asymmetrical composite membrane (3) as a dialysis membrane that covers the dialysis space and covers the base member on one or both sides. Optionally, a perforated plastic film is located between the base member and the composite membr
...

METHOD AND SYSTEM FOR THE INTEGRAL AND DIAGNOSTIC ASSESSMENT OF LISTENING SPEECH QUALITY

A method for determining a speech quality measure of an output speech signal with respect to an input speech signal, wherein the input signal passes through a signal path of a data transmission system resulting in the output signal, includes the steps of pre-processing the output signal; determining at least one of an interruption rate of the pre-processed output signal and a measure for an intensity of musical tones present in the pre-processed output signal; and determining the speech quality
...

Hand-held tattooing device for bringing e.g. medical active ingredient into e.g. human skin, has drives that are coupled to cutting blade for shifting blade in multiple cutting positions along cutting

The device (1) has a cutting blade (3) that is shiftable between multiple basic positions that are assigned to respective cutting depth. A liquid supplying device supplies liquid to be brought for entry in a cutting channel produced by the cutting blade. Two drives (4, 5) are coupled to the cutting blade for shifting the cutting blade in multiple cutting positions along a cutting path into the basic positions in a horizontal direction and a vertical direction. The cutting blade is formed at a ro
...

ANASTOMOSIS RING AND ANASTOMOSIS RING ASSEMBLY

The invention relates to an anastomosis ring and to an anastomosis ring assembly for connecting hollow organs made from human or animal tissue. The anastomosis ring includes a first support ring and a second support ring, which can be coupled with the first support ring for fixating the tissue, so that the support rings are essentially disposed fixated relative to one another. The anastomosis ring is at least partially made form a biofragmentable material which disintegrates after a predetermine
...

Polymerstent

The invention relates to a polymer stent with open ends at the longitudinal support structure which includes an interior that allows the passage flow of body fluid (eg blood) from an open longitudinal end to another longitudinal end open. According to the invention has the the interior surface facing the supporting structure of an educated microstructures microstructure, which is designed to cause a swirling of through the interior of flowing body fluid, which prevents the formation of stationar
...

ULTRASONIC DIAGNOSTIC APPARATUS

PROBLEM TO BE SOLVED: To provide an improved ultrasonic diagnostic apparatus to be used for diagnosing a bone including a healthy region and a diseased region. ; SOLUTION: An ultrasonic beam 40 for echo tracking is formed for a healthy region 52a of the bone 50 including healthy regions 52a and 52b and a fractured region 54. The echo tracking process is executed in the state in which a load F is not applied to the bone 50 and in the state in which the load F is applied to the bone, and the quant
...

BONE EXAMINATION SYSTEM

PROBLEM TO BE SOLVED: To easily position lower limbs in a bone examination system for executing an examination based on the deformation of bones by adding loads to the bones of the lower limbs. ; SOLUTION: A lower limb L of a subject P is mounted on a proximal supporting block 26 disposed on a rotary base 24 and a distal supporting block 28. The proximal supporting block supports the fibular head and the distal supporting block supports the lateral condyle or medial condyle in the tibial distal
...

ULTRASONIC PROBE SUPPORTING DEVICE

PROBLEM TO BE SOLVED: To move an ultrasonic probe along a kneecap to obtain ultrasonic echo information for the cartilage of a knee joint. ; SOLUTION: An attaching unit 16 is positioned by an attaching unit frame 58 to abut to the thigh with the knee in the bending state and a knee abutting part 62 to abut to the knee. The attaching unit has a probe support frame 60 for moving the ultrasonic probe along the kneecap. The probe support frame is rotated around the mechanical center of the knee join
...

KNEE ACOUSTIC MATCHING BOX FOR ULTRASONIC PROBE

PROBLEM TO BE SOLVED: To achieve acoustic matching between the kneecap and an ultrasonic probe when the ultrasonic probe is moved along the kneecap for obtaining ultrasonic echo information for the cartilage of a knee joint. ; SOLUTION: The acoustic matching box includes a water bag 64 filled with water and a water bag support frame 66 curved along the kneecap to hold and support the water bag from the left and right sides of the knee. The water bag is formed in a curved plate-like shape along t
...

BLOOD-PRESSURE SENSOR SYSTEM

There is provided a blood-pressure sensor system wherein a blood-pressure sensor including a plurality of structures which induces surface plasmon resonance on a light-receiving plane of a photoelectric conversion element is attached to an outer wall of a blood vessel, in which if the blood-pressure sensor is deformed according to expansion or contraction of the blood vessel, an interval of layout of the structure is changed (widened or narrowed), so that an incident form of light with respect t
...

SYSTEM FOR TRANSPORTING DRUGS AND MEDICAL MATERIALS IN HOSPITAL

Provided is a system for transporting drugs and medical materials in a hospital wherein drugs and medical materials required in each ward can be mounted previously on a tray which is a unit of transportation or use, and a plurality of trays can be set in a tray cart and kept in a transportation standby state on a tray cart basis, trays can always maintain a horizontal transportation position regardless of whether rails in a transportation section are horizontal or vertical, continuous traveling
...

Automated Vitrification System

Market Opportunity Cryopreservation of biological materials by vitrification has made significant inroads in displacing the more conventional slow-freeze process. However, technicians must conduct a laboriously manual and technique-driven process to vitrify biological materials. Manual vitrification is a non-scalable low-throughput process. Vitrification is practiced on small specimen volumes, (∼1 μL), limiting its application to discrete cells such as oocytes, embryos, and blastocysts
...

Device for High Efficiency Cell Encapsulation using Novel On-Demand Droplet Generation and Impedance-Based Detection

Tech ID: 21236 Brief Description Researchers have developed a novel microfluidic device that is capable of encapsulating cells at a very high efficiency. The device integrates impedance measurement with a novel on-demand droplet generation process to enable the selective generation of droplets that contain encapsulated cells only when a cell is present. This ensures that a high percentage of cells are encapsulated rather than droplets that do not contain cells. The device consists of two
...

Colloidal Self-Assembly of Droplets for High Density Microfluidic Micro-Reactor Arrays with High Throughput Functionality

Tech ID: 21274 Brief Description Researchers have developed a simple method for the rapid self-assembly of predictable high density droplet-reactor arrays for high throughput microfluidic applications in biology and chemistry. By controlling the ratio of the chamber height to droplet diameter, the resulting self-assembled 3D colloidal, lattice droplet pattern formations can be selectively tuned for optimal real-time and/or long-term 2D visualization and image capture of reactions occuring in
...

Microfluidic Device using Dielectrophoresis Separation of Heterogeneous Cell Populations

Tech ID: 21272 / UC Case 2011-181-0 Brief Description Researchers have developed an automated microfluidic device that traps different cell populations in different chambers based on the cells’ dielectric properties. The device consists of one main channel with individual sets of electrodes in three or more different chambers. Each set of electrodes generates a non-uniform electric field that traps and therefore separates a heterogeneous cell population at different frequency ranges due to
...

TIO2 Nanotubes - A New Cold Cathode for X-Ray Generation

Tech ID: 20909 Brief Description Researchers have shown that titanium dioxide (TiO2) nanotubes (NT) may be used as a cold cathode X-ray source. Full Description Researchers have shown that titanium dioxide (TiO2) nanotubes (NT) may be used as a cold cathode X-ray source. In contrast to CNTs, TiO2 nanotubes are comprised of a native oxide and adsorption or reaction with oxygen is not an issue. These TiO2 NTs are grown directly from titanium metallic sheets to insure a stable electical con
...

A Removal Esophageal Stent

Tech ID: 20908 Brief Description Physicians have developed a new esophageal stent that can be easily removed. Suggested uses This stent may be used to prevent or treat gastrointestinal leaks. Advantages Currently to remove an esophageal stent, endoscopy is performed to grasp the suture at the proximal aspect of the stent and the patient must be sedated. This method of removal is cumbersome, can be technically difficult and time consuming. This new stent can be removed easily without
...

Hydrostatic Pressure Pump and its use in Valving for Centrifugal Microfluidics

BRIEF DESCRIPTION Researchers have developed a hydrostatic pressure pump for centrifugal microfluidic applications. FULL DESCRIPTION In centrifugal microfluidics, the hydrostatic pressure pump is generated natively during rotation. In the design, when fluid from a main reservoir is propelled by centrifugal forces through a microchannel, the liquid encounters a resistance. This in turn causes localized pressure shifts to be seen along the microchannel. The phenomenon can thus be utilized a
...

Portable Ultrasound Bladder Monitor

“Proactive Bladder Health” through a wearable, non-invasive device for wireless monitoring of bladder volume. • Non-invasive operation ideal for systematic use, e.g. every night or all day • No wires between the patient and base station making it safe to use while sleeping • Motor and mechanics, inherent to the mechanical sector scan transducer, have been omitted, making the system less bulky and completely silent and free of vibrations • The transducers have been positioned
...

Portable, Foldable Mirror

The present invention relates generally to mirrors and, more specifically, to a portable mirror having a plurality of foldable mirror panels, each hingedly attached to a main mirror panel. A light fixture is provided and sits at the top of the device, flush with the folding panels when in the closed position. A sensor is provided between the main panel and the foldable mirror panels and is activated when the panels are moved to an open position. The device provides easy viewing of feet for peopl
...

Digital Staining for Histopathology

Background 99.9 % of cancer cases are diagnosed and monitored by histopathological assessment of a biopsy sample. The presence, concentration and distribution of biological molecules (such as nucleic acid, protein or lipids for example) can be determined by selecting a specific combination of chemical stains and fixatives. A commonly used stain in histopathology is hematoxylin and eosin (H&E) which detect nuclei and cytoplasmic components of tissue, respectively (Figure 1). A well-trained hist
...

Confocal Microscope with 2-D Array of LEDs

Background Confocal microscopes can provide 3-dimensional (3D) images with superior contrast and depth resolution compared to conventional wide-field microscopy because they reject the out-of-focus light. This makes them the tool of choice for advanced laboratory imaging, e.g. for life sciences or industrial inspection applications. In most confocal microscopes, illumination is provided by a scanning laser beam, requiring high-speed optomechanics that add significant complexity and cost to the
...

C-Pap Face Protector

A comfortable, moisture absorbant barrier between the face and the plastic of the c-pap mask. Helps to eliminate discomfort of sweating around the nose & mouth as well as helping to control skin problems due to that sweating.
...

Magnetic apparatus for the treatment of cataracts and other eye conditions

Cataract is the leading cause of blindness in the world today. More than 160 million people have visual impairment, with three quarters of the cases related to cataracts. Sixty per cent of world blindness occurs in China, India and Sub-Saharan-Africa; blindness numbers are estimated to be increasing at the rate of of more than 2 million cases annually; and as the population ages, the number of people older than 45 years is expected to double by the year 2020. Cataract is treated with surge
...

Portable Imperial College Surgical Assessment Device (pICSAD)

Background Dexterity is a crucial aspect of surgical competence. Technical ability to perform a procedure is considered to be crucial for a safe and effective outcome and is also an important aspect of surgical training. However, a lack of haptic feedback particularly in laparascopic surgery training is a major obstacle and there exists a need for the development of objective methods for surgical assessment. Invention This invention relates to a training package that aims to provid
...

Sutureless Chest Drain Dressing

Background Air or blood in the pleural cavity is a serious condition which can become life threatening. World-wide, it is estimated that 5 million chest drains are inserted annually. Currently, chest drains are secured in place using an arrangement of stitches, dressing pads and self-adhesive tape. However, there are no devices and dressings on the market, specifically designed for the fixation of chest drains or dressings that are suitable for visual wound inspection or simple re-adjustmen
...

Improved Tunneling Catheter

Annually, approximately 100,000 US patients suffer end stage renal disease and commence renal dialysis (1). All of these patients require an AV access. Over 70% of patients initiating chronic haemodialysis in the US have a tunnelled central venous catheter (CVC) as their first blood access device and even after 90 days, catheter is still the leading access type (2). Drawing blood from a central vein is technically challenging: • Removal of blood creates negative pressure around the access p
...

Post-Stroke Neuro-Rehabilitation Device

Stroke is one of the leading causes of adult disability in the world, with more than 15 million cases every year. Most stroke survivors suffer from hemiparesis, a paralysis of one side of the body, resulting in a severe decrease in their ability to perform typical activities of daily living. Rehabilitation centres will typically focus on regaining the ability to walk, as well as on shoulder and elbow function, often having only limited time to work on the hand and fingers. Additionally, physiot
...

Improved Endoscope

Current endoscopes fall into the categories of rigid optical endoscopes, flexible video endoscopes and flexible optical endoscopes. Rigid endoscopes are typically used in orthopaedic surgery or surgery in the large body cavities, and for imaging in rodent brains. They are not usually suitable for the study of internal organs because they are not flexible enough to be passed through internal pathways, small body cavities or vessels in live subjects, and they are typically of limited length. Fo
...

Oblique Selected Plane Microscopy For Optically Sectioned Imaging

Conventional optical microscopy provides high resolution images and has a huge range of applications. In many cases, it is desirable to obtain so-called ‘optically sectioned’ images, i.e. an image of only a thin axial slice through the sample. The conventional method for obtaining high quality optically sectioned images is confocal microscopy. Confocal microscopy involves scanning a point of illumination and detecting the reflected or fluorescent light back to a confocal point detector.
...

Novel Doppler Method

Recent advances have demonstrated the feasibility of molecular imaging using targeted microbubbles and ultrasound. However, one technical challenge is to selectively detect targeted bubbles from those freely flowing bubbles and surrounding tissue. Pulse Inversion Doppler (PID) is a known imaging technique which enables the selective detection of both static and moving ultrasound contrast agents. However, one disadvantage of PID is that a second pulse must be an identical but inverted copy of t
...

A Novel Attenuation Correction Technique for Ultrasound Contrast Agent Imaging

Quantification of tissue perfusion using ultrasound and contrast agents has great potential for various clinical conditions which involve changes of blood flow in tissue, e.g. tumours or myocardial infarction. However, the application of these techniques is limited by a lack of an effective correction technique that can satisfactorily estimate and correct for signal attenuation incurred during image formation. This can cause inaccuracies in the quantification of blood flow, resulting in a signi
...

Active Mobilization Shoulder Brace

Many types of shoulder injuries can be treated by positioning the arm in abduction (elevated sideways) and external rotation (twisting the arm outwards). This results in an extremely uncomfortable position for the patient and it is difficult for this position to be maintained. Furthermore, the inwardly rotated position of the shoulder when the arm is held in a sling for between three and six weeks is actually counterproductive to the healing of the lesions associated with anterior shoulder dislo
...

Modular Partial Knee Replacements

There is growing demand for surgical procedures to remedy pain caused by early stage arthritis in the knee, but due to physical wear and osteolysis, implants are not expected to last a patient’s life time. Younger, active individuals wanting to maintain their lifestyle or overweight people, who wear out their joints quicker, pose a particular challenge to orthopaedic surgeons. The solution is to use smaller, partial implant devices that conserve natural tissue and bone. Conserving natura
...

Hip Resurfacing Implants

In 2008, there were 378,865 hip replacement procedures in the US alone and the number of procedures is predicted to increase with a CAGR of 5.1 % from 2008 to 20151. All hip replacements currently are based upon the ball and socket principle. The acetabular socket component is a part sphere, typically just under a hemisphere, and the femoral head is also a part sphere, typically just over a hemisphere. In human anatomy, while the proportions are similar, the extent of each varies according to
...

Low Level Laser battery operated medical devise

Medical Device: A low level hand held battery operated medical laser device has been developed and clinically tried with proven good results on almost all medical conditions encountered in a medical office including diabetes, strokes uncontrolled pain obesity and many others. Easy to learn techniques for applications have been developed and used. In a complimentary manner utilizing ancient acupuncture principles the device can help in many problems where medications and other western medical
...

Device to Monitor Cardiac Tissue Viability

DESCRIPTION: The last decade of cardiac surgery has witnessed significant strides towards better understanding and management of previously lethal cardiac pathologies. It is now recognized that conditions of myocardial stunning and hibernation exist, in which the injured myocardium is only temporarily inhibited in its mechanical function. Such myocardial states give the appearance of infarcted or irreversibly damaged tissue (thus resembling total necrosis), but in fact are only transiently depre
...

Platform for Chemical and Biological Sensing by Surface Enhanced Raman Spectroscopy

BACKGROUND: Surface-Enhanced Raman Spectroscopy (SERS) is an optical analysis technique that can provide molecular identification and quantification by recording a spectrum that displays characteristic vibrational fingerprints of molecules or parts of molecules. SERS is potentially among the most sensitive analysis techniques with molecular identification capabilities and has the benefit of extraordinary sensitivity. In the past, however, SERS platforms have been highly technical preparations.
...

Epidermal Marking Pen for use in Surgical Marking and Cosmetics

The current use of surgical marking pens in the operating theater is quite common. However, these pens suffer from many drawbacks. These pens smear and despite the thinness of their tip, the ink spreads so that an initial thin line becomes wide as the skin absorbs the ink. Additionally, if the skin surface is greasy or has any blood or fluid on its surface the above problems are made even worse, but more commonly the pen will not even write. To correct these deficiencies Dr. Chasen has invent
...

Novel Microneedle and Micro-Blade Fabrication Technique for Biomedical Applications

This invention presents a novel needle fabrication technique for creating a sharp, beveled metallic microneedle. Using a SU-8 mold structure, needle tip geometry with beveled dimensions can be controlled in 3D. The same fabrication method can be adopted to create a micro-blade with controlled blade angle. Benefits Existing microneedle fabrication techniques are not able to control the needle tip geometry in 3D. The manufacturing method disclosed in this invention can produce a controlled sh
...

Wheelchair Advantage Mobility System (WAMS)

WAMS is a bolt-on system with hand-actuated levers and disc/caliper system to propel, brake and securely park a manual wheelchair. It incorporates a set of ergonomic handles that enables users with reduced grip strength to propel or stop the wheelchair. Other interesting features of the invention include a) a lever system that allow the use of larger muscle groups with greater pushing strength and better stamina b) a disc brake system that provides solid clamping power to lock the chair in pla
...

Releasable Safety Mechanism for Prosthetic Implants

Prosthetic implants for amputees contain a metal post surgically implanted into the bone that protrudes through the skin. Any torsional or bending force applied to the prosthetic may fracture the bone/implant interface. This technology describes a novel safety device to prevent damage to the bone-implant interface. If an excessive bending, torsional or tensile load is applied to the prostheses, the device will release while transmitting minimal torque to the anchor. <i>Benefits</i> Curren
...

Antimicrobial Contaminant Cap for Prosthetic Implants

This novel technology describes an antimicrobial contaminant cap for preventing infection at the implant-tissue interface for prosthetic implants. The cap is designed to slide along the pin, tube, post or any protruding material and would capture and contain antibacterial substances at the interface thereby preventing infection at the site. <i>Benefits</i> The technology is very novel and such a concept or device does not exist commercially. The contaminant cap described will be a novel m
...

Occipital-Cervical Plate for Spinal Fixation

Fixation of the skull to the cervical spine may be used to treat trauma to the neck, degenerative diseases such as rheumatoid arthritis, and congenital instability. Many current implantable devices designed to immobilize the skull with respect to the upper cervical spine are assemblies of several components which are not designed specifically for fusing the cervical spine to the skull, but instead are assembled from multiple components designed for other applications. Such assembly may prolong
...

Disposable Fluid Sensor

This technology is useful for determining the level of fluid in a container. An indicator such as a flashing light or an audible alarm is used to indicate when the fluid level in a container drops below a desired predetermined level. The sensor detects the change in fluid level by sending and receiving electromagnetic signals. <i>Benefits</i> *Medical and biomaterial devices, such as liquid levels in: 1. Intravenous feeding solutions 2. Saline solutions for providing pressure to the eye
...

Physiologically Motivated Control for Blood Pumps

Heart failure is one of the leading causes of death in America. Currently 4.7 million Americans suffer from congestive heart failure in different stages, with 954,000 people dying every year from some form of heart or vascular disease. While a heart transplant is still the preferred treatment plan, there is a shortage of donor hearts with only half of the need being met, underscoring the importance of a reliable artificial heart. A Ventricular Assist Device, or VAD, is designed to work as a b
...

Surgical Electric Blade Coated With Quasicrystalline Twin Films

Medical surgery is performed in all countries of the world ranging from very simple procedures involving flesh and bones in hands to very complex procedures on the brain. It is desirable to use surgical tools that are of high quality that do not cause unnecessary damage to the organ or tissue. Electric surgical blades coated with a thin film of quasicrystalline material, such as AlCuFe, offer superior mechanical and electrical performance when compared to conventional blades. The high hardness a
...

Catheter Tracking with Phase Information

Background Currently invasive cardiovascular procedures rely on x-ray angiography to navigate a cardiac catheter to a location of interest. Interventional cardiology would benefit from using MR guidance by exploiting MRI’s excellent soft tissue contrast. For example, MRI is able to distinguish between infarcted and healthy myocardium to identify an appropriate location for stem cell delivery. MRI is also able to distinguish between plaque and vessel walls which would ease the traversing of
...

Sampling and Toxicity Device

Aquatic and gaseous environments are often contaminated by a wide range of toxic chemicals. Monitoring of contamination requires the use of sampling and test methods that need to be selected based on the chemical properties of the contaminant being monitored. The complex matrix of many environmental samples can mask the presence of toxic substances and/or make identifying the target contaminants of interest impossible. Another difficulty lies in extracting and concentrating target contaminant
...

The TeleWatch Patient Monitoring System

The Johns Hopkins Medical Institutions, Division of Cardiology and The Johns Hopkins Applied Physics Laboratory have developed medical procedures and associated telehealth system capabilities for the home monitoring and disease management of high risk outpatients suffering from congestive heart failure. Effective management of congestive heart failure (CHF) is one of the most important challenges and opportunities confronting our health care delivery system. Despite landmark basic and clinical r
...

An Unclad Fiber Optic Sensor for Measuring Chromophoric Compounds in Human Blood and Amniotic Fluid

Yellow or brown tinged skin and eyes are the hallmarks of jaundice – seen most often in infants. The yellowing is a result of elevated levels of a substance called bilirubin in the blood (hyperbilirubinemia). Hyperbilirubinemia is commonly seen in 50-70 percent of newborn babies and is the most common reason for hospital readmission for newborns. In many cases, this jaundice appears about 2-5 days after birth, is a result of inadequate processing of normal red blood cell breakdown by the liver
...

Combined Chemical/Biological Agent Detection by Mass Spectrometry

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to analyze large amounts of protein data, or too costly for widespread use. The Johns Hopkins University Applied Physics Laboratory has invented and is patenting a mass spectrometer for combined chemical
...

Remote Monitoring and Relaying for Wrist Watch Alarm

Hearing loss can be a problem for many segments of the population. As the population gets older and the ability to hear high pitch sounds decreases, it may not always be possible to hear a watch alarm or cell phone ringing. It is common to see people use watch alarms to remind them to take medications. Often, if the person is active or the watch is under clothing, it is not possible for the person to hear the alarm. The detailed invention details an electronic device that would be worn close
...

Helmet System Including at Least Three Accelerometers and Mass Memory and Method for Recording in Real-Time Orthogonal Acceleration Data of a Head

Conventional devices which measure acceleration in a single direction, or from a single event, or only above a predetermined threshold, or in a way which does not permit use during performance of the actual sport do not provide the dynamics necessary to correlate exposure to forces to the injury caused by that exposure over a period of time. This is a system designed to measure and record in real time data relating to translational and angular acceleration of an individual's head during norm
...

Instrumented Model of the Human Torso for Ballistic Impact

Effective body armor minimizes injury by transferring the kinetic energy of a projectile over an extended time-scale or surface area. Body armor that accomplishes such energy transfer using lightweight materials that are comfortable to wear involves sophisticated technology and engineering. To better assess the quality of new body armor designs, new injury criteria are needed to quantify the damage of different non-penetrating munitions to the internal organs. Therefore there is a need for a hum
...

Time-of-Flight Mass Spectrometer Array (TOF Spectrarray)

Small devices that can rapidly and accurately analyze chemical and biological molecules are required by many industries. Homeland security and the medical community lead the list. Current instruments are either too large to be used as a first responder in the field, too slow in giving results to analyze large amounts of protein data, or too costly for widespread use. The Johns Hopkins University Applied Physics Laboratory has invented and patented a minimization of the TOF Mass spectrometer w
...

Method and System for Detecting Small Structures in Images

The potential difficulties and pitfalls of many automated detection techniques can be summarized as follows: a. Too little enhancement may preclude the detection of minor microcalcification peaks while too much enhancement may increase significantly the amplitude of small background structures (noise) and thus produce a large number of false detections. An acceptable compromise may not exist in some images, and in those images where it exists, it can change from image to image and can be difficu
...

Auscultation Diagnostic Support Device

Current medical training techniques rely on significant patient contact, resulting in high training costs and often not the expected outcomes. In a 1997 study published in The Journal of American Medical Association, researchers found that on average, internal medicine and family practice residents (all four years) recognized only 20% of the common cardiac problems that could be diagnosed using a stethoscope; the cardiac auscultation skills of 198 internal medicine and 255 family practice reside
...

Core Body Temperature Pill Technology

A multichannel circuit for telemetry signals representing physiological values from a point in a human body to a receiver (24) outside of the body. The two signals (S1, S2) other than the temperature signal (27') are used to provide two frequency modulated signals (14, 16) summed by an amplifier (18) with the summed FM signal then being applied to amplitude modulate (21) a carrier (8) whose frequency varies as a function of temperature. The resulting FM / AM signal (22) is telemetered inductivel
...

Non-invasive Fetal Heart Signature Monitor

Regardless of the monitoring technique, critical difficulties frequently arise when there is an emergent need to transfer the monitored patient from the labor area to the operating room. The monitors are usually detached during this critical interval with the mother and her fetus unmonitored during the transfer. Reattachment to monitors in the operating room (if at all) requires additional, possibly precious time and attention. Doppler transducers, if used, are inevitably in the operative field
...

Portable pH Data Collector

The present invention provides an apparatus for continuously recording physiological data. The invention includes a unique data mapping and compression technique, which allows relatively long-term data acquisition without compromising the data sampling rate. The present physiological data recorder has application in recording physiological data which is non-periodic and is characterized by "bursts" of rapid activity interspersed among relatively long periods during which there is little or no ac
...

NONINVASIVE TRANSCERVICAL TUBAL OCCLUSION (STERILIZATION) IN WOMEN

In 1985, Platia and Krudy reported the first successful transcervical catheterization of one obstructed fallopian tube in a woman with bilateral tubal obstruction. Since then a number of reports have documented successful retrograde tubal cannulation. From this preliminary work, the concept of a safe, cost effective, outpatient method of achieving tubal catheterization and intentionally causing obstruction has been developed. A team of investigators at Dartmouth -Hitchcock Medical Cen
...

SYSTEMS AND METHODS FOR COMBINED ULTRASOUND AND ELECTRICAL IMPEDANCE IMAGING

Ultrasound imaging provides good spatial resolution and can identify the borders of tissues, and possibly tumors, but the technique is unable to discriminate between benign versus malignant tissue. Electrical impedance imaging ("EII"), on the other hand, is a medical imaging technique that provides information on tissue types and pathologies. EII offers low cost, but also low resolution images. The strengths and weaknesses of ultrasound and EII complement one another such that they may be com
...

THERMAL TREATMENT SYSTEMS WITH ACOUSTIC MONITORING AND ASSOCIATED METHODS

Thermal treatment systems are used, for example, to ablate liver metastatic tumors, treat benign prostatic hyperplasia, ablate cardiac tissue for the prevention of arrhythmia, heat corneal tissue to correct myopia, treat urinary incontinence, treat sleep apnea and snoring, tighten ligaments within the joints, tighten collagen for cosmetic purposes, occlude the Fallopian tubes and for other therapeutic purposes. Despite a vast array of systems for treating different types of tissue, the
...

THE DARTMOUTH ACOUSTIC PLETHYSMOGRAPH: A NOVEL METHOD FOR MEASURING BREATHING IN VERY SMALL ANIMALS

As genetic modification of brain respiratory control processes becomes more advanced, there is great interest in measuring breathing and the development of respiratory control in neonatal mice and rats to evaluate the roles of the affected processes. Traditional methods for measuring breathing in animals do not work reliably in small rodents for a number of reasons. Head-out and barometric plethysmographic techniques have been used to measure breathing in small animals but each technique has pit
...

Improved Aneurysm Clips and Improved Aneurysm Clip Applicators

Cerebral Aneurysm Clips Prior art aneurysm clips are fabricated of metal (usually a cobalt metal alloy of steel or titanium). These metallic clips limit the usefulness of non-invasive imaging, i.e. Magnetic Resonance Imaging (MRI) and Computed Tomography Angiography (CTA) for patients that have been implanted with the prior art clips. Dartmouth inventors have designed and tested a non-metallic variation of an aneurysm clip that retains the spring portion of the clip as metal, but which u
...

Magnetic Proximity Sensor System and Associated Methods of Sensing A Magnetic Field

Magnetic Resonance Imaging (MRI) provides an unparalleled window into the human body and is highly regarded as a safe and effective medical technique. There is however a potential for interaction between the magnetic field generated by the MRI instrument and ferrous metal objects, either internal or external to the patient. External metal objects, in particular, may become projectiles capable of causing injury, and even death, to persons within the path of the accelerating object. In one well
...

SYSTEMS AND METHODS FOR tomographic IMAGE RECONSTRUCTION

Diffuse Optical Tomography (DOT) is a relatively new optical imaging modality that uses visible and near infrared radiation for the detection and diagnosis of surface and near-surface anomalies. Measuring and modeling of the attenuation and scattering of light in tissue allows for a determination of tissue density and chromophore concentration. These data may be used, for example, to detect and differentiate between tumors and cysts. Existing DOT systems, however, are subject to large noise c
...

Novel Method for Early Detection of Hypovolemia

Early detection of hypovolemia is clinically important because severe hypovolemia, blood loss of more than 1 liter, can lead to rapid decline and cardiovascular collapse. By the time the tachycardia or low blood pressure associated with severe hypovolemia is finally detected, the patient will already have sever medical complications. To date, the reliable clinical detection of hypovolemia requires a pulmonary arterial catheter while under mechanical ventilation, a procedure which has been associ
...

METHOD AND DEVICE FOR THE NON-INVASIVE DETECTION OF PRE-NEOPLASIA IN VIVO

Dartmouth has developed a system capable of measuring tissue optical properties in vivo. The fluorescence lifetime spectrometer (FLS) is a clinically compatible, portable, fiber based instrument capable of simultaneously measuring native tissue fluorescence and the corresponding emission lifetime in less than one second. This non-invasive optical measurement is compatible with existing flexible and rigid clinical endoscopes. The FLS design is highly flexible, allowing for user selectio
...

METHOD AND DEVICE FOR THE MEASUREMENT OF THE PARTIAL PRESSURE OF OXYGEN (pO2) IN VIVO, INCLUDING FOR ROUTINE USE IN CLINICAL SETTINGS INVASIVELY AND NON-INVASIVELY

We have developed a new system which, for the first time, makes it feasible to measure pO2 in the clinical setting with the accuracy, sensitivity, and repeatability needed for effective clinical use. The method measures at defined sites in the region(s) of interest and measurements can be made simultaneously at several sites. The existing methods for making experimental measurements of pO2 in cells and tissues, e.g., the Clark electrode, fluorescence quenching, O2 binding to myoglobin, chemilu
...

CRUTCH FOOT RESTER(FOOT RESTER ON CRUTCH)

I am an inventor with a new product that I invented “TITLED” CRUTCH FOOT RESTER(FOOT RESTER ON CRUTCH). I invented this product, which goes on the tip of a crutch, so that it will offer people who have cast on their leg due to an ankle or foot injure an opportunity to have a place to rest the injured leg while walking with a crutch, thereby avoiding the uncomfortable and difficulty of having to walk or leap on one leg, in order to avoid putting much pressure on the injured leg, and also dam
...

Implantable Biotelemetry System for Preterm Labor and Fetal Monitoring (ARC-14280)

Abstract: In 1993, The FTC established a relationship with Sensors2000! (S2K!) to adapt NASA's implantable biotelemetry devices to their monitoring needs of the human fetus and its uterine environment. One of their major goals was to measure intra-uterine pressure changes in order to monitor and treat preterm labor. S2K! used NASA's technology to design a system that could accurately measure intra-uterine pressure changes, body temperature, and the heart rate of the fetus. While the first syste
...

Insulin Receptor Knockout Mice

Description: The Insulin/IGF family of ligands and receptors controls mammalian growth, metabolism and reproduction, and insulin signaling at the insulin receptor is implicated in important signal transduction pathways. Interactions at this receptor can either amplify, diversify or terminate insulin action. One fruitful strategy for studying insulin receptor action is the creation of mouse models in which the gene encoding the insulin receptor has been ablated or knocked out.
...

Methods and Compositions for Inducing Brown Adipogenesis

Description: The most common fat cells are white adipose tissue (WAT) cells, which have a thin ring of cytoplasm surrounding a lipid or fat droplet. WAT is found underneath the skin and provides heat insulation, cushioning against shock and jarring, and energy reserves. An average lean person has roughly 20 to 40 billion WAT cells, and an obese person can have up to ten times more WAT than the average lean person. The less common fat cells are the brown adipose tissue (BAT) cells. Energy e
...

Exemer Ablation Within Bowman

Abstract (Set) Method and apparatus for laser ablation of the cornea to correct strabismus. The laser beam is controlled by a system of limiting shutters to cut prism lenses into the cornea. The ablation is to remain substantially within the Bowman's layer, keeping scarring to a minimum.
...

Corrections for Image Artifacts in MRI

A method for removing image artifacts in MRI created when data acquisition is synchronized to a physiological and therefore uneven intervals. The method simultaneously records both image data from the MRI scanner as well as the exact interval between each data acquisition. The image data is then modified according to the timing file to create a image data file free from signal variations and artifacts resulting from the uneven data sampling intervals.
...

New Inhibitor of Rotavirus

An anti-diarrheic product comprises a foodstuff and an anti-rotaviral agent such as human defatted fat globule membranes, the human milk macromolecular fraction, the milk mucin complex, the 46 Kd apparent MW glycoprotein, a polypeptide having the rotavirus-binding specificity of the 46 Kd apparent MW HMFG glycoprotein, or mixtures thereof, and optionally skim milk, curd, and/or whey. The product of the invention is provided also as an anti-diarrheal kit, with instructions for its use. the produc
...

New Surgical Instruments for Vocal Cord Repair

A device and method to lateralize, or alternatively medialize, the vocal cord is described that is adjustable so that the final position of the vocal cord can be adjusted to enhance the quality of the patient's voice following the procedure. The multi-component device preferably includes, in the case of lateralization, a collar, a translation bushing, and a piston having a grasping device which is inserted through the thyroid cartilage and activated to grasp the vocalis process region of the ary
...

Use of Botulinum Toxin for Treatment of Smooth Muscle Disorder

Direct injection of sphincteric botulinum toxin is disclosed as an effective, safe and simple method of treatment for disorders of gastrointestinal muscle or smooth muscles elsewhere in the body, with results that appear to be sustained for several months. Muscle disorders which are suitable for such treatment include achalasia, isolated disorders of the lower esophageal sphincter, gastroparesis, hypertrophic pyloric stenosis, sphincter of Oddi dysfunction, short-segment Hirschsprung's, anal fis
...

Endoscopic Cryospray Device

A cryoprobe instrument for endoscopic use has been provided that permits the delivery of liquid or gaseous cryogens in the form of a spray. In an embodiment, the cryoprobe instrument includes an elongated, flexible tube having a fluid passage defined therethrough; a proximal connector portion provided at the proximal end of the tube for coupling the tube to a pressurized source of cryogenic refrigerant; and a nozzle tip mounted to the distal end of the tube. The nozzle tip has an outlet orifice
...

Dosing Model

A drug dosage modeling system that simulates the effect of therapeutic agents in humans to allow accurate evaluation not possible using conventional methods. Description (Set) Proposed Use (Set) The pre-clinical drug development process could utilize this invention to more accurately evaluate the potential in-vivo effects of each candidate. This could shorten the development process saving money and other resources.
...

Bipolar Cautery Catheter

A bipolar electrocautery valvulotome in the form of an elongated catheter having a longitudinal axis, a proximal end for being held and manipulated by a user, and a distal end. The device is used to remove the valves in veins for peripheral by-pass surgery.
...

A Mouse Model of Hemophilia A

A transgenic mouse deficient in blood factor VIII has been developed. This mouse serves as a model of human hemophilia.
...

Adaptive and Reconfigurable Chip for DC Motor Control

Abstract (Set) An integrated chip for control of position/velocity and torque of DC motor is provided. The technique uses armature current feedback and on-chip position/velocity estimate from an incremental optical encoder to implement a closed loop mechanism that controls the motor. The chip is reconfigurable for different motor specifications. Description (Set) Proposed Use (Set) The chip is designed to provide high-performance feedback and control of small motors in space-constrained ap
...

Surface-Immobilized Antimicrobial Peptoids (28138)

Northwestern researchers have developed peptoid mimics of antimicrobial peptides that can be immobilized onto surfaces, rendering these surfaces capable of compromising the membranes of attached bacteria. ADVANTAGES: Peptoids afford promising alternatives to conventional antimicrobials because of their stability, ease of synthesis and low cytotoxicity. These agents present solutions to infections associated with implantable medical devices. SUMMARY: Surface-immobilized antimicrobial polym
...

Device and Method for Measuring Spinal Reposition Sense (20013)

Proprioception is used by the body to communicate position sense and appreciation of movement of body parts. Receptors located in muscles, ligaments, tendons, capsules, menisci and the skin provide proprioceptive input about the body's static and dynamic position sense in space. A growing body of research supports that injury or disease (degenerative disc disease, DDD) affecting the spine may disrupt spinal proprioception. In turn, the resulting proprioceptive impairment may further place spinal
...

Sandwich Holder

INVENTION: The Sandwich Holder enables patients with limited use of their hands to independently feed themselves. In contrast to currently available sandwich holders, the Sandwich Holder delivers the following: Secure grip Sleek and discrete design Minimal readjustments during a meal Ease of adjustment to various foods Intuitive to use The Sandwich Holder is the result of ongoing investigation by undergraduates in their work with disabled clients in Northwestern’s Institute for Design
...

List-mode Image Reconstruction Software for Positron Emission Tomography (PET) Imaging

Abstract (Set) The technology is software capable of performing accurate and efficient reconstruction of a high resolution PET scanner, namely the high resolution research tomography (HRRT). The software also includes state-of-the-art compensation capability. Description (Set) Proposed Use (Set) The technology outlines a list-mode reconstruction in which individual elements are one-by-one analyzed and directly included in the reconstruction task as well as motion compensation methods. The
...

Novel Calcitriol Analogs

Abstract (Set) Five to eight million people in the US and 125 million people worldwide have psoriasis. Current treatment of Psoriasis includes Maxacalcitol, an oxa analog of calcitriol which is a necessary regulatory steroid hormone. Scientists at JHU have rationally designed and easily synthesized eight new oxa analogs of the natural hormone calcitriol. Three of the new analogs are more antiproliferative in vitro and desirably less calcemic in vivo than the natural hormone. Of these three, one
...

Automate White Matter Parcellation Based on Diffusion Tensor Imaging

Brain white matter looks homogeneous in conventional MR. This makes it difficult to identify specific white matter regions (similar to locate a place in desert). DTI provides contrasts based on axonal fiber orientations, with which locations of specific white matter tracts can be visualized. This invention provides means to automatically parcellate the white matter based on this new contrasts. Description (Set) [1] Automated white matter tract reconstruction: 1) Choose a common anatomical temp
...

Biodegradable Polyphosphates for Controlled Release of Bioactive Substances

The present invention includes a series of polycationic biodegradable polymers, the process for making the polymers, and the process for making compositions contain polymers and bioactive ligands. The biodegradable polymers are capable of forming a complex with biological active substances which include but are not limited to DNA, RNA, proteins, and small molecule therapeutics. Furthermore, the polymers of the invention have groups that can facilitate the intraceullar delivery of the biological
...

Biofunctional Fibers

The present invention describes a method to functionalize polymeric fibrous scaffolds. Surface biofunctionalization is achieved by linking bio-functional ligands and growth factors onto polymeric biocompatible fibers. These biofunctional ligands are crucial for cell attachment, proliferation, and function. The biofunctional fibers within this invention can be either biodegradable or non-biodegradable. Furthermore, these fibers can be arranged into three dimensional scaffolds and can be used for
...

PECAM-1 Related Compositions and Associated Methods of Use

PECAM-l (CD 31), a member of the IG superfamily, is expressed strongly at endothelial cell junctions, leukocytes and platelets. PECAM-l has been suggested to play a role in angiogenesis, vasculogenesis and is critical in mediating the transendothelial migration of monocytes. This is an important first step in atherosclerosis as well as in inflammatory processes. However, similar reagents to abrogate cell adhesion and transendothelial migration are not available. Now, JHU scientists have designed
...

Improved Fitting Calculation For Diffusion Tensor Imaging

Diffusion tensor imging is a new MRI modality, which is becomig a very important technque to assess various tyes of brain diseases. However, this technque has one weakness; its extreme sensitivity to patient motions. The image is often corrpted by patient motions as small as cardiac pulsation of the brain. Even though this problem is ameliorated by employment of rapid imaging, we often fmd corrpted imges are included in the scans, which leads to substantial errors in tensor calculation. Curently
...

Transplantable Membrane Systems For Use In Ocular Tissue Repair

The present invention is a novel non-immunogenic collagen vitrigel membrane for use in ocular tissue repair. The unique properties of the collagen vitrigel permit it to be transplanted alone or as a supporting film for corneal epithelial, stromal, endothelial, or other ocular surface tissue. The membrane biomaterial increases the ease of implantation. The membrane may be modified with peptides and/or cell extracts in order to further promote cell growth and transplantation efficacy. Furthermore,
...

Mutant DISC1 Inducible Transgenic Mouse Model of Schizophrenia

Description (Set) Transgenic mice with inducible expression of mutant human DISC1 (hDISC1) limited to forebrain regions were generated. Proposed Use (Set) The mouse model could be used to study of aspects of the pathogenesis and preclinical experimental therapeutics of schizophrenia.
...

EmboGel / EmboClear Therapeutic Solution � Dissolvable radio-opaque alginate-based biomaterial for endovascular delivery and controlled therapeutic agent release

Johns Hopkins University is seeking licensees for EmboCaps and Emboclear. EmboCaps are an alginate matrix with controllable porosity that provides diffusion-controlled release of therapeutic agents. EmboClear is an alginate dissolving solution with minimal toxicity in vivo and enables erosion-controlled agent release from EmboCaps. Description (Set) Advantages: • Adjustable porosity of EmboCaps and control of delivery time and dosage of EmboClear after embolization gives clinicians unprece
...

Pull-Out Resistant Pedicle Screw for Osteoporotic Patients

This novel device is a pullout resistant pedicle screw that will provide enhanced stability and fixation in osteoporotic spine surgery patients. The use of the new pedicle screw may also be indicated in patients necessitating revision surgery due to the fact that it increases osseous fixation and pull-out strength compared to conventional pedicle screw systems. This technology facilitates surgical instrumentation, reducing the risk of surgical error.
...

A System and Method for Image Based MR Interventional Device Tracking and Scan Plane Guidance

The present invention is a method of using projection images for interventional device tracking. Specifically, the new tracking method involves acquisition, device detection on 2D projection images, reconstruction of the 3D device from its 2D projection, and selecting the plane of the device without the use of RF coils. Once the device plane is determined, it is utilized to guide the device towards a previously determined ?target plane? providing information for rotation and translation of the i
...

Platform for High-Quality 3D Elasticity Ultrasound

The Johns Hopkins University seeks a partner to commercialize a new platform for generating high-quality elasticity ultrasound images. The system uses a novel set of algorithms that integrate with traditional ultrasound machines to produce highly accurate and stable segmentation of areas with high or low tissue stiffness relative to the surrounding tissue. Click here to view high-quality marketing materials. Description (Set) • Ultrasound (US) elastography (strain imaging) suffers from a
...

Optimized MRI Strip Detectors

Strip MRI detectors offer the advantages over conventional detectors of minimal coupling and high-frequency operation as phased arrays. This invention is a method to optimize the SNR for MRI strip detector designs. The rules were determined by numerical electromagnetic Method of Moment (Mom) analysis and have been validated by fabrication and testing of model detectors. Description (Set) Proposed Use (Set) The purpose of the invention is to detect MRI signals with optimum SNR to convey to
...

A Novel Method for Programmed Release of Biomolecules

Johns Hopkins University seeks a partner to commercialize a novel method for programmed release of biomolecules and nanoparticles. This is a useful tool for the controlled delivery of drugs, DNA, proteins, viruses, and nanoparticles. This invention provides a method to release small quantities of the molecule over time or a mixture of multiple molecules. Click here to view high-quality marketing materials. Description (Set) • This device can be regenerated and reused multiple times, maki
...

Multi-Imager Compatible Robot for Image-Guided Interventions and Fully Automated Brachytherapy Seed Injector

The present technology is a robot designed for image based percutaneous needle intervention of the prostate gland. The robot is constructed of nonmagnetic and dielectric materials for complete MR compatibility. The system utilizes a pneumatic stepper motor (PneuStep) providing the precision required for needle insertion. Additionally, the robot is designed to accommodate various types of end-effectors for percutaneous interventions; however for this particular design the robot has a developed fu
...

A Method for the Efficient Functional Examination of Mammalian Noncoding Sequences in Transgenic Zebrafish

sequence conservation is recognized as a reliable indicator of both coding and non-coding functional sequences. Consistent with this hypothesis, coding sequences may be readily identified based on evolutionary conservation. However, of the 5% of the human genome that is predicted to be functional based on conservation alone, less than a third actually encodes protein. The remaining conserved non-coding sequences probably regulate temporal, spatial, and quantitative aspects of gene expression. Co
...

Microfluidic Device for High-throughput Cellular Gradient and Dose Response Studies

This invention is a microfluidic device made of a silicone elastomer (PDMS) that can be used for dose response, gradient detection, and chemostatic growth studies of most cell types, particularly non-adherent cells. The gradient is generated by the diffusion of molecules between two reservoirs of continuously replenished chemicals and nutrients. The gradient created is decoupled from the fluid flow, allowing for gradient studies on non adherent cells without the artificial attachment onto the s
...

Device for High-throughput Stimulation, Immunostaining, and Visualization of Single Cells

This invention exploits the high efficiency and exquisite control afforded by microfluidic devices by allowing a group of cells to be stimulated in a precise and dynamically regulated fashion and stained in parallel. The device is composed of a series of chambers in which cells are seeded and sustained. Sophisticated multiplex control of multiple inlets and outlets allows a variety of media to be applied to each of the chambers in a time varying fashion. This enables high-throughput immunofluor
...

Pneumatic Stepper Motor

The present technology is a new pneumatic motor, a pneumatic stepper motor that can be easily controlled for precise motion. Directional rotary motion of discrete displacement is achieved by sequentially pressurizing three ports of the motor. This is the first pneumatic stepper motor. The motor assembly includes a motor, gearhead, and position encoder. The motor accepts open-loop step operation as well as closed-loop control with feedback from the built in incremental encoder. Problem Solved/Bac
...

Image Guided Device for Rodent Brains

Stereotaxic device for rodent brains is widely used for various types of brain surgeries, injections, and other types of manipulations. The device is essential for many research labs in Universities and Chemical and Pharaceutical companies. For stereotaxic operations, precision is the key element. Available stereotaxic devices have great precision. However, coordinates of brain regions of interest remain guesswork. This computerized and image-guided stereotaxic device wil greatly improve the ac
...

Dual Vector Information via Audible Pulse Oximeter Signals

This invention allows anesthesia providers to audibly detect both a patient�s oxygen saturation and blood pressure. Currently, the pulse oximeter signal carries information about oxygen saturation (via frequency) and heart rate (via time between pules). Modifying the timbre of the audible signal provides another vector of information, in this case, systolic blood pressure.
...

Modified Pipette Tips for Plasma Collection

Description (Set) Blood collection is a common technique used in a variety of capacities ranging from human to mouse. In all cases, blood coagulation during and after collection can be fairly problematic. Scientists at Johns Hopkins University have invented a modified pipette tip designed to inhibit or prevent coagulation during collection and/or transfer of blood and plasma. With this invention plasma can be easily used and transferred in downstream applications for measurements of lipids, pro
...

A New Method for Co-registering PET and CT Images Acquired in Separate Dedicated Small Animal Scanners

Abstract (Set) Background - Positron Emission Tomography in dedicated small animal scanners is a very attractive imaging modality for many research applications due to the high sensitivity and potential for absolute quantification. However, PET images, although revealing valuable functional information, are of poor morphological detail. In addition, accurate absolute quantification requires attenuation correction of the emission data, a task that is challenging in these small animal scanners, w
...

Transcaval Mesenteric Venous Anastomosis and Access System

This device is used to create a percutaneous anastomosis between the Inferior Vena Cava (IVC) and the mesenteric/portal system. The subsequent anastomosis can be used to divert blood flow for the reduction of portal hypertension; and provide access into the mesenteric, portal, and splenic system for local drug or cellular delivery. The device is composed of a Nitinol based skeleton; therefore it provides feasibility for MR guided percutaneous access to the portal system. A transjugular intrahepa
...

IB3-1

Cystic Fibrosis bronchial epithelial cell line isolated from a patient with genotype ?F508 /W1282X. Cells were immortalized with adeno12SV0. Description (Set) Proposed Use (Set) This cell line will be useful for the identification of drugs that treat cystic fibrosis.
...

A Method of Assessing Vascular Reactivity Using Magnetic Resonance Imaging

precision, using magnetic resonance imaging. The most commonly used noninvasive technique for assessing arterial endothelial function employs ultrasound. There are several improvements using this invention. One problem with the ultrasound-based method is that shear rate during hypermia, the stimulus for dilation that is dependent on resistance vessel endothelial function, is either not measured, or is calculated based on assumptions that decrease accuracy. With JHU's invention, shear rate is mea
...

A "Wireless" Scleral Search Coil for the Measurement of Eye Movements

The present invention improves upon the existing scleral search coil system by introducing a new ?wireless? contact lens. The new system uses a similar scleral contact lens on the eye but without the connecting wire leading to the amplifier system. Additionally, the transmitter/receiver coils are proximal to the eye, and the associated electronics are in a portable standalone package, allowing natural freedom of movement. A benefit of the new system is that it eliminates restrictions on head and
...

Medical Device for Treatment of Ulnar Neuropathy

UlnarGuardTM is a non-invasive medical device used for treating pain and disability due to ulnar neuropathy. It is designed to worn under clothing so that patients can undergo treatment day and night. Background Ulnar nerve abnormalities are found in as many as 40% of adult Americans. Often due to excessive flexion (technology usage, sleeping habits) and pressure on the nerve as it crosses the outside of the elbow, ulnar neuropathy results in hand weakness and chronic burning pain. The condition
...

Point-of-care Mass Spectrometer

The invention is an apparatus for clinical diagnostics using a point-of-care approach to mass spectrometry technology to provide a single broad-based assessment of viral infection, HIV, and/or cancer. The approach records a survey mass spectrum that can be compared with patients' baseline data to determine changes in the patients to broader patient population databases, and to known antigens. In addition to initial diagnoses, the instrument and approach could be utilized in the assessment of dis
...

Disposable Sleep and Breathing Monitor

The apparatus consists of two parts, 1.) a calibrated flowmeter for measuring breathing and 2.) electrical sensors attached to the mask for measuring biomedical signals such as, but not limted to, oxygen saturation, head position as well as bioelectrical signals. The flow meter unit delivers a stable pre-calibrated airflow signal, which allows for the quantification of ventilation and obviates the need to perform laborious calibration routines prior to each measurement. The electrical sensor uni
...

Hypothermia Induction Device

JHU researchers have developed a device that cools the heart and brain from normal temperature to mild hypothermia (35-32?C) within a few minutes. The device cools blood extracorporealy. It requires only venous access and thus suitable for uses in an out-of-hospital environment. The device is not dependent on spontaneous circulation and can be used during resuscitation. The device withdraws a volume of venous blood, cools it and injects it back to the vein. It comprises of a heat exchange unit,
...

Modified 0.8 mm-tipped Laparoscopic Dissecting Clamps used to Aid in Cavernous Nerve Preservation During Nerve-Sparing Laparoscopic Radical Prostatectomy

Laparoscopic radical prostatectomy has recently been proposed as a less invasive technique as compared to conventional open radical prostatectomy for the surgical management of prostate cancer. Preservation of the cavernous nerves during radical prostatectomy is a delicate surgical technique that is crucial in reducing the incidence of postoperative impotence in men suffering from prostate cancer. In efforts to refine the laparoscopic instrumentation to replicate nerve-sparing technique in open
...

The Cysteine Noose of the Attachment Protein of Respiratory Syncytial Virus Inhibits the Effects of the Endotoxin and the Innate Immune Response

Both endotoxin and RSV protein F stimulate CD14/TLR4 receptor in monocyte/macrophages resulting in a strong inflammatory response. In the case of endotoxin, this response has a direct pathogenic role in septic shock, autoimmune diseases, HIV, and asthma. And, it is the first response of the immune system against many pathogens and also a critical mechanism of disease for numerous processes. JHU Researchers have found, that within the conserved region of the protein G present in all wild type iso
...

Interventional Devices for Chronic Total Occlusion Recanalization Under MRI Guidance

Recanalization of chronic total occlusion (CTO) is a chanllenging clinical procedure traditionally conducted under x-ray guidance to improve blood flow to patients with symptomatic ischemia. X-ray guidance generally does not provide satisfactory imaging nor geometric information about the artrtial contours, and in the absence of a lumen to fill with radiographic contrast, the recanalization procedure is hazardous. Devices inadvertrntly can exit the native vascular lumen leading to perforation an
...

A System for Macro-micro Distal Dexterity Enhancement in Microsurgery of the eye

The system is a system for providing dexterity inside the eye for micro-surgical procedures. The system includes a remote center of motion unit (RCM) and a Macro-Micro Distal Dexterity (MMDD) unit. the MMDD unit is of several unique design variants that provide dexterity, deliver a micro robot close to the retina, includes a micro robot based on EAP Electro Active Polymers (Conjugated Conductive polymers), provides controllable light source inside the eye and micro dexterity for vein manipulatio
...

A Highly Accurate Ultrasound-Guided Interstitial Intervention

The Johns Hopkins University seeks a partner to commercialize a new approach to dramatically increase the accuracy of image-guided intervention systems, with the use of interstitial ultrasound. Click here for high-quality marketing materials. Description (Set) • Interstitial ultrasound (ISUS) is a minimally invasive tool that provides superior quality and details that magnetic resonance imaging (MRI) and computer tomography (CT) might miss it. • Anatomical motion artifact problems in
...

A New Ultrasound Imaging Method for Prostate Visualization

The Johns Hopkins University seeks a partner to commercialize a new method of ultrasound strain imaging for prostate therapies. Click here to view high-quality marketing materials. Description (Set) • A major problem in prostatic interventions and therapies is localizing and tracking of the prostate gland, as well as anatomical details and foreign objects within. • Prostate therapies typically guided with transrectal ultrasound (TRUS). TRUS has significant limitations in the followin
...

A Novel, Robust Method for Ultrasound Probe Calibration

Abstract (Set) The Johns Hopkins University seeks a partner to commercialize a novel, robust method for calibration of an ultrasound probe. The technique relies on a unique closed-form solution that provides real-time quality assurance for two-dimensional and three-dimensional ultrasound data. By utilizing in-vivo recalibration, the technique provides intra-procedural quality control. Click here to view high-quality marketing materials. Description (Set) • Discerns the unknown spatial t
...

A Synthetic Torso for Training and Evaluation of Laparoscopic Skills

We report the development a new synthetic torso for urologic laparoscopy training allowing the placement of animal organs in situs. The trainer, Lapman, has the exact shape of a human torso, presenting abdominal and thoracic cavities. Animal and/or synthetic models of the abdominal organs can be realistically placed in the abdominal cavity for the training operation. A disposable abdominal wall seals the cavity and can be replaced after repeated punctures with laparoscopic instruments. The thora
...

Method of Three-dimensional Video-oculography

JHU researchers describe a novel, inexpensive, method and apparatus for real time measurement of binocular three-dimensional rotational eye position and velocity. The method employs consumer grade digital video cameras to track an array of three fluorescent non-collinear markers affixed to each eye. A software element uses the positions of these markers before and after an eye rotation to construct a rotation matrix describing the eye rotation. The mathematical computation used to determine the
...

A Novel Robotic Five-Dimensional Ultrasound System

The Johns Hopkins University seeks a partner to commercialize a novel robotic five-dimensional ultrasound system that incorporates four-dimensional ultrasound imaging (three spatial dimensions and time) with strain data in a unique volume-rendering pipeline to provide highly accurate ultrasound imaging with five degrees of freedom. Click here to view high-quality marketing materials. Description (Set) • Utilizes new algorithms for ultrasound strain imaging to help identify the targeted l
...

A Radiometric Approach to Temperature Monitoring in the MR Scanner

The present invention offers a novel method of using the Magnetic Resonance (MR) scanner as a radiometer for measuring body temperature. This methodology utilized the radiated thermal noise to estimate the absolute body temperature by non invasive means. The methodology can be further extended to create a radiometric tomography reconstructing thermal maps of monitored objects or organs. Background A radiometer is a device used to measure the power in electromagnetic radiation. A typical setup fo
...

Using Wireless Electromyographic Data to Infer Hand Applied Forces

In an effort to quantify hand-applied forces without instrumentation of the object, we have developed a force measuring system that can wirelessly transmit force-related information to a data acquisition(DAQ) unit. This system includes using electromyography (EMG) measurements of forearm and other secondary muscle groups. EMG biopotentials from the muscle group, i.e. flexor carpi radialis, are transmitted via a wireless module to a receiver that integrates and rectifies the signal. These EMG rea
...

Genetically Engineered "Down Syndrome" Mice

We used chromosome engineering to create mice that have the extra genes in a ?critical region? proposed to cause Down syndrome. These mice can be assessed for mental retardation as well as problems that occur in the heart, gut, muscle, immune, and skeletal systems that occur in Down syndrome Description (Set) Proposed Use (Set) These mice can be used to test therapies for Down syndrome as well as investigate the underlying mechanisms that cause them.
...

MRI Flex Circuit Catheter Imaging Coil

The invention is a long, narrow, thin flexible piece of printed wiring board that can fit into an 8 French cardiac catheter that acts as a shielded coil useful for picking up magnetic lines of flux in a noisy electric field environment. The coil is deployed as a flat piece of flexible wiring through a catheter than can be deployed as a small loop once inside the heart. The loop is designed to optimally receive the time dependent magnetic induction field stimulated by the RF pulse sequences gener
...

MRI Compatible Positioning Arm

Scientists at Johns Hopkins have developed a family of passive positioning arms designed to carry a robot, instrument, or other tool at its distal end. The prototype has full six degrees of freedom (3 translation and 3 rotation) when unlocked, and the rigidity when locked to hold 100N at its fully extended length. A completely nonmetallic variation of the of the arm was also designed for positioning robotic effectors in the high magnetic field of Magnetic Resonance Imaging (MRI) machines. Desc
...

Process of Fiber Fabrication by Intrefacial Polyelectrolyte Complexation and the Encapsulation of Biological Materials Within Said Fibers

This invention includes a method of producing drug-loaded fibers using interfacial polyelectrolyte complexation for tissue engineering. Fibers are produced by pulling from the interface between two polyelectrolyte solutions at room temperature. Drugs, proteins, cells, genetic materials and bioactive agents are encapsulated into the fibers by dispersion of the bio-agents into the polyelectrolyte solution. These fibers can be further processed into knitted, braided, woven and non-woven fibers. St
...

Electroporation System for Enhancing Wound Healing Using Plasmid DNA Expression Vectors

We have invented a gene therapy protocol (system, kit) that enhances wound healing. Our approach is to combine the application of plasmids expressing growth factors and the technique of electroporation to enhance transfection efficiency of the plasmid transfection. The combination of these two approaches is the basis of the invention. Various growth factors have the potential to enhance cutaneous wound healing. Promising growth factors are Kertinocyte Growth Factor-1 (KGF-1). Platelet Derived Gr
...

A Chitosan-DNA Mucosal Vaccine For Respiratory Syncytial Virus Infection

A gene expression vaccine (GXV) comprising of a cocktail of pDNAs encoding nine immunogenic antigens was developed in the form of chitosan-DNA nanospheres. This GXV was tested in a BALB/c model of RSV infection. Results demonstrate that an intranasal GXV is safe and effective against RSV and significantly attenuates pulmonary inflammation induced by RSV infection. Description (Set) Proposed Use (Set) Prophylactic and therapeutic vaccine Patent (Set) 7,118,888; WO 03/028759
...

Miniaturized Sample Scanning Mass Analyzer

This mass spectrometer is being developed as a compact analytical instrument capable of handling large sample arrays, such as the 96 and 384 microtiter sample formats. It is aimed at both research and high throughput screening applications. Description (Set) Proposed Use (Set) Protein research, proteomics, drug discovery, analytical instrumentation Patent (Set) WO 03/086589; 7,015,463
...

Device, Method, and System For Needle Insertion Inside a Medical Imager, From Within Body Cavity

The Invention is a device, computerized system, and methods for entering a needle into the body inside a medical imager such as a MRI scanner, CT, X-ray fluoroscopy, and ultrasound imaging, from within a body cavity (such as the rectum, vagina, or laparoscopically accessed cavity). A three degree-of-freedom mechanical device translates and rotates inside the cavity and enters a needle into the body, and steers the needle to a target point selected by the user. The device is guided by real-time i
...

Adjustable Remote Center of Motion Robotic Module

The invention is a robotic module that can be used to orient an end-effector about two axes intersecting at a fixed geometric point located distal to the mechanism materializing a pivot point or a Remote Center of Motion (RCM). A robotic tool (or end-effector) mounted on an RCM module will rotate about the RCM point, which can be conveniently located on the end-effector since this point is remote from the robotic module. The module presents two rotational degrees-of-freedom (DOF) with coincident
...

Noninvasive System for Assessing Cardiac Filling Pressure

Abstract (Set) The invention is a system for assessing cardiac filling pressure noninvasively. It consists of a device and method that can be used at the bedside, in clinic, in the emergency department, an intensive care unit, or at home. It can be used repeatedly and conveniently, and is inexpensive to operate. Description (Set) The invention consists of a photoplethysmography (PPG) transducer and a pressure transducer that are connected to a central processor. The clinician places the PPG t
...

Combination device and solution for efficient removal of insect from the ear canal

Abstract (Set) Johns Hopkins University is seeking a licensee for a combination solution and device for efficient removal of insects from the ear canal. A JHU Emergency department study showed that insects were found in 85% of adults with ear foreign bodies. The hard outer shell and legs of an insect in the ear become wedged against the eardrum and walls of the ear canal. Struggling of the insect can damage the ear and is extremely painful for the individual. Current extraction methods involve
...

Ambulatory Raynaud's Monitor

Monitoring a person?s response to cold by recording their skin temperature is a key physiological response parameter for identifying Raynaud?s. This device would provide the means for physicians to definitively diagnose the disease without having to rely solely on a patient?s subjective feedback. According to the NIH, recent surveys show that Raynaud's phenomenon may affect 5 to 10 percent of the general population in the United States. The original application of this miniature finger monitor i
...

System For Refibrillation of the Heart For Treatment of Post Countershock Pulseless Electrical Activity and Asystole

A method and/or system for inducing ventricular fibrillation (VF) of the heart for treatment of post-countershock pulseless electrical activity (PEA) or asystole. In certain example embodiments, it has been found that reinduction of ventricular fibrillation, followed by restoration of blood flow with cardiopulmonary resuscitation (CPR), can make subsequent countershocks more successful in restoring a heart rhythm associated with blood flow
...

A Multiple-projection DXA Scanner for Improved Accuracy and Precision in the Measurement of Bone Cross-sectional Geometry and Body Composition

Osteoporosis and a number of other diseases and conditions alter the mechanical strength of the skeleton such that bones fracture easily. A number of treatments exist that can mitigate the loss of bone strength, hence accurate diagnosis and assessment of the effects of treatment are critical. Bone-weakening conditions are most commonly assessed and diagnosed with a dual energy x-ray absorptiometry (DXA) scanner that can measure mass of bones by their mineral content. Bone mass measurements most
...

Laser-based CT and MR Registration

A simple method for robot and precise instrument registration in computer tomography and magnetic resonance imaging systems. The method uses the laser markers readily available on any CT or MR scanner. It does not require imaging thus eliminating radiation exposure in the CT case. Its accuracy is inherited from the laser positioning system. This approach does not require additional hardware, laser alignment being performed on scanners without flouo-CT capability. Unlike the manual approach, the
...

Design and Fabrication of High Performance AFM Cantilivers

High performance cantilevers with optimal combinations of high resonant frequency and low force constant are provided. AFM cantilevers with spring constants in the range 1-10-6 N/m with fundamental resonant frequencies in aqueous solutions of 0.1-100 MHz are provided. The high performance cantilevers allow faster scanning, increase the temporal resolution of force measurement, improve measurement sensitivity by reducing cantilever noise, and improve sensitivity by reducing cantilever spring cons
...

Accessing the Scala Media of the Inner Ear with Robot Assistance

Accessing the scala media of the cochlea would permit the delivery of drugs, growth factors, gene therapy vectors and cells in order to treat hearing loss of cochlear origin. Many forms of hearing loss begin with trauma to the acoustic hair cell receptors, which in turn, initiates a downstream cascade of events that damages the neurons conducting signals into the brain. The goal of this invention is to facilitate treatment at the hair cell-neuron junction. This sensorineural hearing loss is the
...

Clinician's Portable, Digital, Intelligent Assistant (Pain Informatics Program)

The input devices are mobile pen-based computers and palm pad systems that will emulate and expand the clinician's present paper patient system. The system will provide for semi-automation of the collection, archiving, and retrieval of patient information. The Pain Informatics system provides medical personnel with an organized, efficient and reliable method of completing all patient information electronically. This system can improve the accuracy and reliability of patient data collection and a
...

The Cardiac Ausculatory Recording Database (CARD): an Internet-based software Program and Digital Heart Sound Recording Database for Teaching and Study of Cardiac Auscultation

The Cardiac Auscultatory Recording Database (CARD) was also developed. Developed using the Microsoft Access relational database program, CARD is available online through the World Wide Web. CARD contains digitized heart sound recordings collected from patients at the Pediatric Cardiology Echocardiography Laboratory at the Johns Hopkins Outpatient Center. To date, the database contains over 2500 individual recordings from over 350 patients, representing 300 unique heart murmurs. At least one thir
...

Analysis of Cardiac MR Relaxation Time Images with Application to Quantifying Myocardial Perfusion Indexes

The present invention is a method and apparatus for semi-automatically registering low signal to noise ratio relaxation-time images, with particular application to tracking motion in moving organs and quantifying myocardial perfusion reserve. For each image acquired in a time series, a corresponding high signal to noise ratio image is extrapolated from the collected data. The high signal to noise ratio images are registered to track motion, and the resulting registration data is copied onto the
...

Controllable Motorized Device for Accurate Percutaneous Needle Placement in Soft Tissue Target

The invention is a motorized controllable needle driver for percutaneous delivery of needles and devices of circular cross section profile to soft tissue targets inside the body. The device can be used with flouroscopy, X-ray or CT (CAT-scan, or computed tomography) guidance in image guided surgery, biopsy, as well as interventional therapy.
...

Auscultation Diagnostic Support Device

This invention is a screening tool for heart and lung aliments. Advanced signal processing techniques have been applied to heart and lungs sounds as an aid to diagnoses. A database containing patient demographics, relevant health information, physical exam results, ECG traces, echocardiograph diagnoses, and auscultatory findings obtained with a traditional stethoscope are all linked together with digitized recordings of patient data. Included are recordings from five (5) standard auscultatory ar
...

Near-field Radio Frequency Planar Strip Array Antenna for NMR Imaging

A device for detecting electromagnetic signals, more specifically, the magnetic resonance signals from excited nuclei as well as related apparatuses, systems and methods is provided. This detection device includes a planar strip array antenna including a plurality, and in more particular embodiments, a multiplicity of parallel conductors (e.g., 4, 16, 32 or more of conductors). The length of the conductors is adjusted to substantially reduce the coupling of a signal in one conductor to an adjace
...

Transgenic Mice Expressing a Truncated Mutant of Rat Cardiac Troponin

Stunned myocardium is a reversible contractile failure secondary to coronary artery disease. It has been found that selected proteolysis of the protein troponin is associated with stunned myocardium and this effect has been modeled using transgenic mice expressing the major degradation product of troponin. The same type of troponin proteolysis occurs in ischemic human cardiac muscle, thus these mice can be used as a model in the evaluation of therapeutics targeting this cause of heart failure.
...

Circumferential Pulmonary Vein Ablation using a Laser and Fiberoptic Balloon Catheter

The purpose of this invention is to deliver near-infrared laser radiation radially from a diffusing optical fiber through an optically transparent distendable balloon to create complete circumferential thermal lesions at the pulmonary vein ostia or orifice. Electrical isolation of the pulmonary veins from the left atrium of the heart may be necessary for effective catheter ablation of paroxysmal atrial fibrillation, a common cardiac arrythmia. Description (Set) Proposed Use (Set) Catheter-
...

Gastric Reduction Endoscopy

Methods and devices for partitioning or plicating a region of a hollow body organ are described herein. These methods and devices relate generally to medical apparatus and methods and more particularly to devices and methods for affecting a change in the function of a hollow body organ, particularly a stomach, intestine or gastrointestinal tract. These changes can include reducing the volume capacity of the hollow body organ, disrupting or altering the normal function of the organ, functionally
...

Transgastric Peritoneoscopy

A novel approach to diagnostic and therapeutic interventions in the peritoneal cavity is described. More specifically, a technique for accessing the peritoneal cavity via the wall of the digestive tract is provided so that examination of and/or a surgical procedure in the peritoneal cavity can be conducted via the wall of the digestive tract with the use of a flexible endoscope. As presently proposed, the technique is particularly adapted to transgastric peritoneoscopy. However, access in additi
...

A Flexible Retinal Vessel Cannulation Device

A microcatheter system that allows for vascular infusion into retinal veins for extended periods of time. The microcatheter system includes a flexible cannula that is inserted into the retinal vein lumen and that remains stably within the retinal vein lumen without being held by a robot, micromanipulator or similar holding devices. The microcatheter system is particularly suitable for the treatment of retinal venous occlusive disease. Description (Set)
...

Method for Parallel Spatial Encoded Magnetic resonance Imaging

In a MR imaging system spins in a selected slice of the object are excited by RF excitation pulse and the signal is then received by an array of RF detectors. The phases of signals from multiple channels are uncorrelated and a Fourier-Hilbert Transform method analytically restores the phase coherence among the signals from different channels, preserving the spatial encoding information. For the phase coherent parallel, acquired data set, one dimension of the spatial frequencies is encoded by MRI
...

Intraoperative Microsurgical Ultrasound Device

Featured is a device that provides a mechanism for imaging structure and/or tissue of a surgical site during and after performing a microsurgical procedure such as ophthalmic surgical procedures. Also featured are methods and systems related thereto. In the imaging method of the present invention using such a device includes positioning a high frequency ultrasonic signal transmitting and receiving apparatus imaging mechanism in close proximity to the area to be scanned/imaged (e.g., surgical si
...

Surgical Device for Enhanced Perception

Featured are surgical devices that provide enhanced perceptual feedback to a medical practitioner in the form of e.g. tactile sensations or auditory feedback, and methods of use of the devices. The devices and methods of the present invention are particularly suitable for microsurgery applications including ophthalmic or neurosurgical procedures. Use of the present devices and methods will enhance user feedback, allowing for improved perception, thereby increasing performance, speed, and accurac
...

Cardiac Sock Electrode and Implantable Defibrillator System

An object of this invention is to provide an implantable cardioverter defibrillator (ICD) system and/or method that is less painful to a patient than one or more conventional ICD systems/methods. Another object of this invention is to provide a flexible array including a plurality of electrodes for surrounding at least a portion of the heart, for use in an ICD system/method. In certain embodiments, individual electrodes in the array are selectively coupled to one another so that the electrodes m
...

Non-traumatic Infusion Cannula

In preferred aspects, the present invention features a non-traumatic cannula for use in connection with eye surgery, such as retinal tear and/or detachment surgery. The non-traumatic cannula of the present invention is particularly configured so as to minimize or avoid the potential for damage to the retina when infusing air or a gas therein. Related methods are also disclosed for infusing air during eye surgical procedures e.g. for treating a retinal tear or detachment and macular hole surgery.
...

Injectable Bag Intraocular Lens System

Featured is an injectable intraocular lens system including an insertion and injection device and an injectable intraocular lens. In its broadest aspects, the injectable intraocular lens is a deflated flexible bag that is disposed within the insertion and injection device prior to insertion into the eye. In use a portion of the insertion and injection device is inserted into the eye and the flexible bag is deployed out from an aperture in the inserted portion into the eye. Following deployment,
...

MR Safe Coaxial Cables

This invention is a novel coaxial cable design that will reduce the induced currents and hence the risk of excessive heating or burns in MR scanner. Compact resonance circuits/structures are placed along the length of a coaxial cable with short intervals in a way that an external field could not induce current on the cable. Example designs and related calculations are given in this patent. Description (Set) Proposed Use (Set) In all MRI scanners, possibility of burns or excessive heating d
...

A Surgical Needle Probe for Electrical Impedance Measurements

An electrical impedance probe constructed within a surgical needle. The probe consists of a two-part trocar needle designed to acquire impedance measurements at its point. Since the impedance of cells varies by cell type, the new probe may be used to confirm needle position in a desired anatomical target or to identify the nature of cells surrounding the tip of the needle Description (Set) Proposed Use (Set) In urology this sensor is used for confirming the needle insertion into the urinar
...

Brain Stimulation as a Treatment for Seizures

The present invention includes adaptive technologies to detect and treat brain seizures. Neural networks or other mathematical methods which model seizure patterns are used to detect the seizures. A number of methods for simulation are suggested which include increasing the output of inhibitory structures, decreasing excitation, stimulating targets that would block epileptogenic activity, and interfering with the synchronization of the ictal firing pattern. Different pulse sequences and/or DC sh
...

Tympanic Membrane Prosthesis with Mechanical Fixation

Perforations of the tympanic membrane result from many different processes such as infections of the middle ear, direct trauma to the eardrum, or poor post-operative healing. They usually do not present an immediate danger to the patient?s hearing apparatus, but they can lead to symptoms of decreased hearing, autophony (hearing an echo of one?s own speech), or pain secondary to infection. They can be sub-categorized based on the duration of the perforation (acute vs. chronic) and the presence of
...

Passive Intraocular Pressure Sensors & Patient-Worn Monitorying Recorder

A device for passively measuring intraocular pressure of a patient including an in vivo sensor and an instrument external to the patient for remotely energizing the sensor, thereby permitting the instrument to determine the intraocular pressure. The device directly and continuously measures the intraocular pressure of a patient. The in vivo sensor in the intraocular pressure monitor includes a capacitive pressure sensor and an inductive component. An instrument, external to the patient, measures
...

Eye Fixation Monitor and Tracker

The eye fixation monitor can non-invasively and remotely detect when a human eye looks directly at it. The apparatus illuminates the eye with infrared light energy, uses a photodetection system to analyze polarization-related changes in the light reflected by the fundus of the eye, and identifies the unique pattern or signature produced when the fovea of the eye is directed toward the center of the photodetection system. All functions can be performed remotely, at a distance of several meters, w
...

Friction Transmission with Axial Loading

As a common characteristic of friction rotational-translational transmissions, the force generating the friction was oriented radial with respect to the rotational shaft of the transmission. Our approach differs in this orientation of the friction loading. To the best of our knowledge, such an approach has never been implemented or presented in the mechanics literature or patents. The transmission converts rotational to translational mechanical power or vice-versa. The power is transmitted throu
...

Method to Objectively Quantify the Level and Density of a Neural Blockade

Electromyogram (EMG), temperature, and heart rate measurements, which correlate to the dermatomal level and density of neural blockade, are obtained in a passive manner, i.e., the patient is not stimulated or exposed to any sensor that requires an active conduction in order to make a measurement and no active patient participation or response is required. Measurements obtained provide objective and quantitative indications of epidural blockade with local anesthetics, thus allowing objective real
...

Device forTranstracheal Insufflation in Treating Obstructive Sleep Apnea

A novel ventilatory support system which controls the flow of breathing gas to a patient based upon the physiological need of the patient is disclosed. Gas pressure in the trachea of the patient is monitored to control breathing gas delivery to the patient. The breathing gas flow rate (Vin) to the patient is reduced or terminated when an established tracheal gas pressure limit (Plim) is reached. Flow is resumed after a predetermined delay period or upon sensing of an appropriate tracheal gas pre
...

Method for Assessing Cardiac Contractility and Cardiovascular Interaction that may be Applied to Non-Invasive Clinical Practice

It has been found that E.sub.N (t.sub.N) curves are surprisingly similar among hearts, particularly during early contraction. Based on this observation, the present invention provides an arrangement (method and apparatus) for determining a good approximation of ESPVR using pressure, volume and timing data easily obtained from a single cardiac cycle. Our arrangement identifies both resting and acute changes in the ESPVR, is minimally sensitive to load, and yields a better estimate of directly mea
...

A Method for Designing Non-Linear Field Reflectrons

This is an approach to the design of reflectron time-of-flight mass analyzers that utilizes a cylindrical geometry to achieve nearly-quadratic retarding and reflecting fields without employing a set of resistively-coupled lenses. The mass analyzer consists of a simple grounded cylinder capped with a high voltage retarding electrode, and is thus known as an ?endcap reflectron?. The intent is to provide high resolution focusing in a miniaturized instrument. Description (Set) Proposed Use (Set
...

Transcatheter, Non-surgical Left Ventricular Assist Device

The invention comprises a method and device for draining blood from the left atrium of the heart by utilizing a cannula and catheter in which a guide wire and a needle assembly are positioned axially. The guide wire and the needle assembly can be extended alternately through the distal catheter orifice. A cannula is positioned over the catheter (and can slide thereover) and is inserted into a blood vessel with the catheter. This axial configuration of all the system elements obviates the need fo
...

Cryo Filter Exchanger

This device maintains parallelism between diffracting crystals while allowing the crystals to continuously travel through high to low take-off angles. A central shaft that rotates by one half of the value of the take-off angle drives the device. The central shaft allows for variable collimation to track the beam path between the two crystals. Description (Set) Proposed Use (Set) Spectrometers Neutron & X-ray Patent (Set) 7,099,437 B2; WO 2004/036174
...

Virtual Instrument & Permeability System

This camera-based system provides improved water permeability measurement over prior LED methods. Rather than tracking air bubbles by sensing light transmisson, this system uses a camera and virtual instrument to capture the bubble images. The software uses a pattern recognition algoriithm to identify the bubble and assigns a Y-Y coordinate location. At specified time intervals, the virtual instrument collects images from the contiuous input and identifies the new position. The program calculate
...

Copper-Based Probes for Determining Nucleic Acid Structure In Vitro and In Vivo

The present invention is related to a novel method for splitting nucleic acids at specific points on a complementary nucleic acid segment using a trinuclear copper-based compound of formula (I). Additionally, the present invention is related to a novel treatment of cancer, tumors, and cancer cells using a trinuclear copper-based compound of formula (I) or a naked ligand of formula (II).
...

Multi-Band Image Analysis

Computation of contrast, which includes computation of gradient and zero-crossings, has been used in computer vision as one of the primary methods for extracting grayscale and color features. It seems plausible, therefore, that the correct way to compare versions of the same image in terms of feature information is through their contrast content. Contrast, however, is defined a priori only for grayscale images, so it is hard to readily compare multiband images amongst themselves or multiband ima
...

Miniature Immuno-Optical Rapid Analyte Sensor Platform

A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereby extracting the analyte. The affinity column is then rinsed to remove any other chemicals that may fluoresce. The rinsed affinity column is then eluted with a known volume of elution fluid causing th
...

Apparatus and Method for Exercising and Measuring Strength of a Patient's Limb

An apparatus for measuring the strength of and for performing physical therapy exercises to strengthen a patient's limb. The device includes a pair of pivot clamps each having a end for connecting the pivot clamps to a solid object such as a physical therapy table or hospital bed. A second end of each pivot clamp adjustably receives a first frame member of a conventional traction or load frame. This arrangement enables rotational and translational movement of the first frame member retained by t
...

Polarization Lens

The present invention pertains to a polarization viewer. The polarization viewer comprises a mechanism or means for forming a broadview image having a spectral width preferably greater than 2 angstroms and 0.50.degree. based on polarization information of a scene, although it can be used in that range. The polarization viewer is also comprised of a mechanism or means for providing polarization information to the forming mechanism or means. The providing mechanism or means is in communication wit
...

Skills Trainer for Robotic Surgery

Robotic surgery is becoming increasingly popular with the advent of robotic technology in medicine. With this, there arises a need to extensively train the surgeons to effectively use these devices. Surgeons using these robotic systems need to be tra ined for a large number of procedures before being considered proficient. There is a large time and monetary cost involved with such training and therefore there is a need to reduce time spent on training on these systems. Currently commercially opt
...

CPAP titration using artificial neural network

For 18 million Americans suffering from Obstructive Sleep Apnea (OSA) this is as frustrating as a dog chasing its tail. Lack of proper sleep can lead to severe health problems and increased risk of accidental death. Continuous Positive Airway Press ure (CPAP) provides effective treatment. However, determining the CPAP pressure for treatment involves multiple steps and guess work which drives up cost and delays treatment. This invention eliminates much of the guess work. The sleep technician obta
...

Intestinal Coupling Device

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments involve extensive surgery which can have lifelong effects on the patient and a significant mortality risk. Described within is a novel method and device that could be used as a minimally invasive metho d
...

Esophageal Coupling Rings

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments involve extensive surgery which can have lifelong effects on the patient and a significant mortality risk. Described within is a novel method and device that could be used as a minimally invasive metho d
...

Esophageal Coupling Device

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments involve extensive surgery which can have lifelong effects on the patient and a significant mortality risk. Described within is a novel method and device that could be used as a minimally invasive metho d
...

Catheter for endovascular intervention

A University at Buffalo radiologist has developed novel stent vascular devices for the treatment of cerebral aneurysms. The nature of these neurovascular stents and other devices like them make deployment a real challenge. In addition to the stents , a truly novel and revolutionary deployment device has been designed to overcome this deployment challenge. The device allows for precise longitudinal and azimuthal positioning. Further, the design enables easy navigation of the tortuous vessels o f
...

Non-Invasive Screening Device for Upper Aerodigestive Tract Neoplasia

Diagnostic medical equipments are probably one of the most important paraphernalias of the medical field. This is because of the fact that in all the medical procedures, diagnosis is the first step towards combating diseases. It assumes critical impo rtance when the diseases are of the nature that requires early detection for their cure e.g.: Cancer, Diabetes etc. However it is seen that sometimes the disease matures to a higher stage because of the failure to detect its early onset. The present
...

Methodology for the Synthesis of fluoride (NaYF4) nanophosphors co-doped with Gd3+ and other rare-earth ions and its applications in security printing and bimodal (optical and MRI) imaging

Methodology for the Synthesis of fluoride (NaYF4) nanophosphors co-doped with Gd3+ and other rare-earth ions and its applications in security printing and bimodal (optical and MRI) imaging Categories: Materials & Chemicals, Imaging: Medical Imaging
...

Skills Trainer for Robotic Surgery

Robotic surgery is becoming increasingly popular with the advent of robotic technology in medicine. With this, there arises a need to extensively train the surgeons to effectively use these devices. Surgeons using these robotic systems need to be tra ined for a large number of procedures before being considered proficient. There is a large time and monetary cost involved with such training and therefore there is a need to reduce time spent on training on these systems. Currently commercially opt
...

Catheter for endovascular intervention

A University at Buffalo radiologist has developed novel stent vascular devices for the treatment of cerebral aneurysms. The nature of these neurovascular stents and other devices like them make deployment a real challenge. In addition to the stents , a truly novel and revolutionary deployment device has been designed to overcome this deployment challenge. The device allows for precise longitudinal and azimuthal positioning. Further, the design enables easy navigation of the tortuous vessels o f
...

CPAP titration using artificial neural network

For 18 million Americans suffering from Obstructive Sleep Apnea (OSA) this is as frustrating as a dog chasing its tail. Lack of proper sleep can lead to severe health problems and increased risk of accidental death. Continuous Positive Airway Press ure (CPAP) provides effective treatment. However, determining the CPAP pressure for treatment involves multiple steps and guess work which drives up cost and delays treatment. This invention eliminates much of the guess work. The sleep technician obta
...

Non-Invasive Screening Device for Upper Aerodigestive Tract Neoplasia

Diagnostic medical equipments are probably one of the most important paraphernalias of the medical field. This is because of the fact that in all the medical procedures, diagnosis is the first step towards combating diseases. It assumes critical impo rtance when the diseases are of the nature that requires early detection for their cure e.g.: Cancer, Diabetes etc. However it is seen that sometimes the disease matures to a higher stage because of the failure to detect its early onset. The present
...

Intestinal Coupling Device

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments involve extensive surgery which can have lifelong effects on the patient and a significant mortality risk. Described within is a novel method and device that could be used as a minimally invasive metho d
...

Esophageal Coupling Rings

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments involve extensive surgery which can have lifelong effects on the patient and a significant mortality risk. Described within is a novel method and device that could be used as a minimally invasive metho d
...

Esophageal Coupling Device

Esophageal atresia with tracheal esophageal fitula occurs in approximately 1 in 1500-5000 newborns. This is a congenital defect in which the esophagus does not form a continuous connection to the stomach and instead ends in a pouch. Without treatme nt, the condition is fatal. Current treatments involve extensive surgery which can have lifelong effects on the patient and a significant mortality risk. Described within is a novel method and device that could be used as a minimally invasive metho d
...

Stent Vascular Intervention Device and Method Modification

A team of University at Buffalo researchers has developed novel stent vascular devices for the treatment of cerebral aneurysms. The new stents can be deployed by a conventional balloon-catheter and a single stent could replace the use of multiple emb olic coils resulting in reduced procedure duration and cost. The stents may be used for all types of aneurysms, including wide neck and giant aneurysms, and for aneurysms located at vessel bifurcations and near areas of vessel curvature. Categor
...

Stent Vascular Intervention Device and Method Modification

A team of University at Buffalo researchers has developed novel stent vascular devices for the treatment of cerebral aneurysms. The new stents can be deployed by a conventional balloon-catheter and a single stent could replace the use of multiple emb olic coils resulting in reduced procedure duration and cost. The stents may be used for all types of aneurysms, including wide neck and giant aneurysms, and for aneurysms located at vessel bifurcations and near areas of vessel curvature. Categor
...

Cell and Microparticle Separator Employing Patterned Grooves

Introduction Microscale enrichment and separation are important for various research, biomedical, and industrial uses. Conventional means for these processes typically require specific labels— either inherent to the structure or appended to it. Unfortunately, not every important substrate has a convenient label of its own, such as stem cells, and it costs additional time and money to develop and append appropriate and effective labels, such as antibody tags and magnetic beads. Sometimes, all
...

Nanobioelectronics: Building functional hybrid nanoelectronic/cell circuit elements

Summary Background: The determination of electrophysiological properties is important for understanding signal propagation through individual neurons and neuronal networks as well as muscle tissue. However, previously existing technologies are relatively crude: micropipette electrodes poked into cells are invasive and harmful, and microfabricated electrode arrays are too bulky to detect activity at the level of individual cells or in the case of neurons, discrete axons and dendrites. Novel T
...

"MoleProbe": A Real-Time Molecular Diagnostic Device

Summary A novel engineering method for generation of freestanding 2-D and 3-D tissue structures. Biopolymers (proteins, carbohydrates, lipids, nucleic acids or combinations thereof) are deposited onto a transitional polymer surface with a patterning technique that allows for nanometer-to-millimeter-scale spatial positioning. In one example, the transitional polymer layer dissolves or switches states to release the biopolymer structure(s). The free-standing biopolymer structure(s) is then seeded
...

Torque-Actuated Valves for Microfluidics

Summary Background: A number of active and passive valves for microfludic systems, based on bubbles, pneumatics, electrokinetic, and other mechanical solutions, have been developed. So far these solutions have not been adequate enough and the lack of inexpensive and efficient valves has been one of the main reasons why microfluidic devices have not yet realized its full commercial potential. The most commonly used valves have a number of disadvantages: 1) they require constant pressure and th
...

Enhanced Nanoparticle-Based Molecular Imaging via MRI

Summary Enhanced Nanoparticle-Based Molecular Imaging via MRI Elevator pitch: For biotech and pharmaceutical companies who need to track drug effectiveness in the drug discovery and for MRI facilities, hospitals and physicians who seek to diagnose and treat specific diseases through molecular imaging, the novel nanoparticle imaging agents are MRI contrast agents that enable MRI imaging at high resolution. Compared to alternatives, our NIAs can be produced at a lower cost, improve patient saf
...

Compounds and Methods for Tumor-Specific Targeting

Summary A novel strategy for developing cancer-homing drugs has been developed by Dr. Amin Kassis that combines Enzyme-Mediated Cancer Imaging and Therapy (EMCIT) with radionuclides (see figure below). This powerful method achieves a multimodal effect, since it can be exploited for therapeutic efficacy as well as tumor imaging. The technology exploits molecular database mining, chemistry, and biology to generate accumulation of radionuclides only at sites of tumor growth. EMCIT capitalizes on th
...

Biological Computers: In Vivo Autonomous Doctors that Diagnose and Treat Disease

Summary Background: The promise of computers made from biological molecules lies in their potential to operate within the biochemical environment of a living organism and to interact with that environment through inputs and outputs with other biological molecules. For example, a biomolecular computer might act as an autonomous "doctor" within a cell. It could sense signals from the environment indicating disease, process them using its preprogrammed medical knowledge, and output a signal for the
...

Slowing Down Light for Enhanced Detection of Biomolecules

Summary Allows for optical sensing and chemical and biological detection using extremely small and highly-sensitive devices. Also allows for fabrication of exceptionally small lasers for applications in displays and telecommunications, quantum optical devices, and barcoding. Applications The photonic crystal device is a novel method for localizing and trapping light, where the light can be utilized for a wide-variety of chemical, biological, and optical applications. Traditional chemical and
...

Robust and inexpensive actuator to generate motion in small-scale devices

Summary Innovation and Advantages: The invention is a novel design and fabrication of a millimeter scale SMA actuator used to generate motion. In addition, the researchers have developed a novel system for annealing shape memory alloys (SMA). This system allows for the creation of a spring that has discrete contraction lengths, as opposed to the “all or nothing” contraction of current SMA springs. Unlike existing techniques, our method is robust and can create accurate contraction le
...

New Nitrate Measurement Method

Summary By employing novel filtration methods, this semi-continuous ambient particulate nitrate monitor measures the concentration of particulate ammonium nitrate (NH4NO3) contained in PM2.5. The device consists mainly of an inlet, filter, heater and detector. In 10-minute cycles, nitrates are collected with a PTFE membrane filter, subsequently volatilized via thermal desorption in a two zone heater, and finally, measured using chemiluminescent detection. The Limit of Detection is better tha
...

Torque-Actuated Valves for Microfluidics

Summary Background: A number of active and passive valves for microfludic systems, based on bubbles, pneumatics, electrokinetic, and other mechanical solutions, have been developed. So far these solutions have not been adequate enough and the lack of inexpensive and efficient valves has been one of the main reasons why microfluidic devices have not yet realized its full commercial potential. The most commonly used valves have a number of disadvantages: 1) they require constant pressure and th
...

Nanobioelectronics: Building functional hybrid nanoelectronic/cell circuit elements

Summary Background: The determination of electrophysiological properties is important for understanding signal propagation through individual neurons and neuronal networks as well as muscle tissue. However, previously existing technologies are relatively crude: micropipette electrodes poked into cells are invasive and harmful, and microfabricated electrode arrays are too bulky to detect activity at the level of individual cells or in the case of neurons, discrete axons and dendrites. Novel T
...

An Ultra Low Power System Architecture for Sensor Network Applications

Summary Ultra-low-power chip for sensor network applications Application and Benefits: Wireless sensor networks (WSNs) are used in a wide variety of applications including environmental monitoring, vehicle tracking, health-care, and business supply-chain management. Often such networks must provide continuous sensing for long periods of time, resulting in a need for inexpensive, long-lasting, highly reliable devices. Power consumption is usually the most important design constraint, as energ
...

Controlled Synthesis of Millimeter-Long Silicon Nanowires with Uniform Electronic Properties

Summary Background Single-walled carbon nanotubes (SWCNTs) and semiconducting nanowires (NWs) are attractive building blocks for fabricating numerous functional nanodevices such as FETs, light emitting diodes, laser diodes, and biological sensors. Even though very long SWCNTs have been achieved, dramatic change in electrical properties accompanying the change of chirality and diameter impedes control over their electrical properties along the tubes. Millimeter-long SiNWs and oxide NWs have al
...

Smart Balloon Catheters for Diagnosis and Therapy of Narrowing Lumen

Summary Modern techniques for the diagnosis and treatment of narrowing of lumen can use dilating balloon catheters. A common risk with such procedures -- for instance, in the case of peptic and non-peptic strictures, or the sweeping of ducts -- is the improper dilation of the balloon catheter. In the case of under-dilation, the effect of the catheterization on an obstruction may be insufficient, while in the case of overdilation, the over-expanded balloon catheter can cause cracks on the lumen,
...

A Novel Color Filter Array Design

Summary Background In digital imaging applications, data are typically obtained via a spatial subsampling procedure implemented as a color filter array (CFA). CFA assigns a separate primary color to each pixel by placing a filter of that color over the pixel. The most well known CFA is the Bayer pattern which uses a checkerboard pattern with alternating rows of filters. The Bayer filter has twice as many green pixels as red or blue and takes advantage of the human eye’s tendency to see
...

Device and Method for Restoration of Sight through Patterned Thalamic Microstimulation.

Summary This technology aims to restore sight in people who are blind due to disease or injury by placing an electrode implant in a part of the vision system known as the lateral geniculate nucleus (LGN). Unlike other visual prostheses in development, this new approach could make it possible to treat blindness even when the entire eye is damaged. The investigators showed that microstimulation of the dorsal LGN of the thalamus can generate localized visual percepts in alert monkeys. To assess ele
...

Target-locking Confocal Microscope System

Summary Eliminating tumors via a non-invasive target-locking technology Markets/Needs Addressed: Many tumors occur in parts of the body that are difficult to locate and image dynamically (e.g., colon, stomach or lung tumors) because a patient’s breathing can causes the entire area to move several millimeters each second. These types of tumors are therefore inaccessible to non-invasive radiative methods, such as the gamma knife. Harvard’s PLuTARCTM technology, when integrated w
...

Biological Computers: In Vivo Autonomous Doctors that Diagnose and Treat Disease

Summary Background: The promise of computers made from biological molecules lies in their potential to operate within the biochemical environment of a living organism and to interact with that environment through inputs and outputs with other biological molecules. For example, a biomolecular computer might act as an autonomous "doctor" within a cell. It could sense signals from the environment indicating disease, process them using its preprogrammed medical knowledge, and output a signal for the
...

Novel way of brain mapping to be used in pre-surgical planning

Summary Innovation and Advantages: Harvard researchers have developed a method for mapping the organization of a patient’s brain for pre-surgical planning by using functional MRI, but without requiring performance of specific task. With this system, a patient would lie in an MRI scanner, at rest with their eyes open or closed. The procedure could also be performed if the patient is under anesthesia or during sleep. The technology might be used to test language lateralization prior to epil
...

Slowing Down Light for Enhanced Detection of Biomolecules

Summary Allows for optical sensing and chemical and biological detection using extremely small and highly-sensitive devices. Also allows for fabrication of exceptionally small lasers for applications in displays and telecommunications, quantum optical devices, and barcoding. Applications The photonic crystal device is a novel method for localizing and trapping light, where the light can be utilized for a wide-variety of chemical, biological, and optical applications. Traditional chemical and
...

Robust and inexpensive actuator to generate motion in small-scale devices

Summary Innovation and Advantages: The invention is a novel design and fabrication of a millimeter scale SMA actuator used to generate motion. In addition, the researchers have developed a novel system for annealing shape memory alloys (SMA). This system allows for the creation of a spring that has discrete contraction lengths, as opposed to the “all or nothing” contraction of current SMA springs. Unlike existing techniques, our method is robust and can create accurate contraction le
...

New Delivery Device for Protein Therapeutics and Vaccines

Summary Harvard's researchers have developed a new device for protein and gene delivery. It makes use of the unique ability of unicellular organism protozoa to infect a host, evade their immune defense, and target specific tissues. Protozoa are single-celled, independently living eukaryotic organisms. Some of these species are pathogenic while others have no detectable adverse effects or pathologies. Protozoa spread from one host to another through a variety of methods. In the United States, app
...

Animal Model of Diabetes and Obesity: Cross-bred JNK1 KO/JNK 2 KO Mice

Summary Mice with the JNK 1 and JNK2 genes knocked out were crossed with the obese mouse line (ob/ob) to create a mouse model of diabetes and obesity. These mice exhibit many of the hallmark metabolic pertubations characteristic in diabetes and obesity. Nature: Vol 420, Nov 21, 2002, pp 333-336 Applications These mice are a research tool that can be used to screen therapeutic compounds for efficacy in diabetes and obesity. For Further Information Please Contact the Director of Business De
...

Elucidating Novel Protein Interactions Using MALDI-MS and a Self-Assembled Monolayer Chip

Summary The ability for real-time identification of protein binding from whole cell lysates is a challenge for protein microarrays. This invention uses MALDI-MS to analyze complex biological mixtures using a protein or small molecule microarray, which is characterized by a self-assembled monolayer on gold contacts. Specialized surface chemistry enables efficient creation of both small molecule and protein microarray chips. For protein attachment to the chip, self-assembled monolayers of alkaneth
...

Enhanced Nanoparticle-Based Molecular Imaging via MRI

Summary Enhanced Nanoparticle-Based Molecular Imaging via MRI Elevator pitch: For biotech and pharmaceutical companies who need to track drug effectiveness in the drug discovery and for MRI facilities, hospitals and physicians who seek to diagnose and treat specific diseases through molecular imaging, the novel nanoparticle imaging agents are MRI contrast agents that enable MRI imaging at high resolution. Compared to alternatives, our NIAs can be produced at a lower cost, improve patient saf
...

Nanobioelectronics: Building functional hybrid nanoelectronic/cell circuit elements

Summary Background: The determination of electrophysiological properties is important for understanding signal propagation through individual neurons and neuronal networks as well as muscle tissue. However, previously existing technologies are relatively crude: micropipette electrodes poked into cells are invasive and harmful, and microfabricated electrode arrays are too bulky to detect activity at the level of individual cells or in the case of neurons, discrete axons and dendrites. Novel T
...

Crosslinkable Hole Transporting Materials for Organic Lightemitting Diodes

Introduction High-performance organic or polymer light-emitting diodes comprise multilayer configurations having hole-transporting, emissive and electron-transporting layers to balance the injection and transport of both holes and electrons. In general, holetransporting material is the first applied layer onto the anode upon sequential layerby- layer fabrication of a device. This hole-transporting layer (HTL) plays a very important role in the efficiency of multilayer PLEDs. Technology descripti
...

Non-toxic protocol to establish paraoxonase 1 (PON1) status

Introduction Paraoxonase 1 (PON1) is a member of a three-gene family localized on human chromosome 7. Due to its role in the metabolism of both lipids and organophosphorus (OP) compounds, genetic variability in PON1 has been examined by many research groups as a risk factor for vascular and other diseases as well as for OP exposure. A simple, high throughput, two-substrate assay/analysis system determines both PON1 levels as well as the functional PON1192 allo form(s) present in plasma (PON1 St
...

Use of Adhesion Molecules as Shear-Induced Nanoscale Binding Switches

Introduction Methods, compositions, and devices for using shear-dependent binding switches in a variety of applications would be extremely useful in biomedical and other fields. Applications for this technology include the following: 1) as a non-invasive probe for force fields; 2) to control the aggregation of ionic and molecular scavengers; 3) to fabricate devices for particle and cell sorting; 4) to allow for the assembly of molecules, particles, and micro- or nanosystems into novel materials
...

Optical Coherence Tomography: High-Resolution Balloon Catheter Imaging, Dispersion Management, and Lateral-Priority Real-TimeImaging and Focus Tracking

Introduction Optical coherence tomography (OCT) is an imaging technique that uses light to acquire three-dimensional images of biological tissue. This non-invasive technique generates highquality images in real time and easily integrates with existing endoscope technologies. It is commonly used to image intravascular and intraluminal spaces. Technology Description Professor Li at the University of Washington has developed an optical coherence tomography (OCT) device that incorporates a balloon c
...

A Microfluidic Device and Methodology for Rapid, Quantitative Determination of Analyte Concentration in a Fluid Sample

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, especially for biosensors and environmental monitoring. One recent area of interest is point-of-care diagnostic devices. These devices provide fast, accurate, and inexpensive sample analysis. Recent advances have enabled a universal platform that is adaptable to a potentially limitless array of analytes and could lead to affordable health care devices, including for the developing worl
...

Localization Wire for Surgical Excision of Breast Lesions

Introduction With the introduction of screening mammography, the median tumor size has decreased considerably, and approximately half of breast cancers in surgical practice are non palpable and amenable to breast conserving surgery. Traditionally, non palpable lesions are excised with a wire or wires as guiding tools, which are critical for defining the extent of the abnormal tissue. The two wire shapes that are currently used are the J-shaped and the barbed. The J-shaped, often referred as the
...

Novel Gadolinium nanoparticles for Magnetic Resonance Lymphatic Imaging

Introduction Gadolinium (Gd3+) is chelated with diethylenentriaminepentaacetyl (DTPA) to provide contrast in magnetic resonance (MR) imaging to identify pathogenic tissues. Unfortunately, the Gd3+-DTPA complexes approved for clinical use are cleared within a few minutes and do not provide sufficient concentrations or time in lymphoid tissues. Many pathogenic conditions, including the spread of cancer, require high-resolution lymphoid tissue images. Technology description Rodney Ho’s laboratory
...

Platelet Clotting Force Array

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will enable faster, cheaper, and more accurate patient evaluation for a wide array of parameters. One such parameter is the coagulation capacity of blood, for abnormalities in which can be indicative of a wide variety of pathologies. The ability to more quickly and easily assess platelet function would grea
...

Tissue-Engineered Urinary Bladder Using Autologous Cells

Introduction There is a variety of reasons that a person’s bladder may fail or require removal, including bladder acontractility, cancer, and cystitis. Unfortunately, conventional artificial bladders tend to suffer from critical complications, such as inadequate performance, infection, and adverse host response. Ideally, a new bladder could simply be formed from the patient’s own cells. Technology Description Professor Ratner at the University of Washington has developed a technique to creat
...

Advanced Biomimetic Surfaces for Surface-Enhanced Raman Spectroscopy (SERS)

Introduction Raman spectroscopy characterizes molecules by their Raman scattering. As incoming light scatters off a molecule, most does so elastically, neither gaining nor losing energy, and this is known as Rayleigh scattering. Some of this light, however, about 1 in 10 million photons, is the subject of an energy exchange with the molecule and scatters inelastically, possessing more or less energy than it started with, and this is known as Raman scattering. Raman scattering acts as a vibration
...

Networked Surgical Robot Control System

Introduction The individual soldier remains the most valuable asset of the military and in spite of the current emphasis on the threat of weapons of mass destruction, and biological warfare, attending to the soldier's needs when they become a casualty remains a top priority. There is a significant opportunity to save the lives of soldiers by using forward deployed telesurgical capabilities to control the consequences of abdominal vascular injury. The surgical robots now being deployed and FDA ap
...

A Staged Balloon-Tipped Overtube for Endoscopic Peritoneal Access

Technology description Researchers at the UW have developed a staged balloon-tipped overtube for improved peritoneal access, particularly applicable to trans-gastric endoscopic surgery. The field of minimally invasive surgery has recently focused on the use of natural body lumens as a point of entry for endoscopic surgery within the peritoneal cavity. Current research in translumenal surgery shows potential to minimize scarring, while reducing patient pain and recovery time. Gastric access is ch
...

Evanescent Wave Coupling Sensor for Shear/Pressure Measurement

Introduction Lower limb complications associated with diabetes include the development of plantar ulcers that can lead to infection and subsequent amputation. Several authors have postulated that shear stress is an important component of ulcer development. While it is known from force plate analyses that there are medial/lateral and anterior /posterior shear components of the ground reaction force, there is little known about the actual distribution of this force during daily activities, nor abo
...

Novel Spherical Mechanism for Minimally

Introduction Minimally invasive surgical instruments coupled with robotics are being used in a vast array of modern surgeries to minimize patient trauma and reduce recovery time. As these instruments progress in their capabilities, the need for smaller and more robust mechanical joints becomes increasingly urgent. Technology description Researchers at the UW have developed a spherical mechanism for minimally invasive surgical instruments. This mechanism is a novel approach to manipulator design
...

A Method and Design for Performing Rapid Parallel Microfluidic Molecular Affinity

Introduction Point-of-care diagnostic testing, or testing performed at the patient bedside, allows physicians to diagnose patients more rapidly than traditional laboratory-based testing. Rapid results can enable better patient management decisions, improved patient outcomes, and a reduction in the overall cost of care. Technology description UW researchers have developed a method and design for performing rapid molecular binding assays, including immunoassays, and in particular, sandwich immunoa
...

A Prosthetic Liner incorporating Shear & Pressure Sensors

Introduction Fitting prosthetic limbs for amputees is a time-consuming, tedious process that is more art than science, often requiring ten or more visits by the patient before the proper fit is achieved. Changes in the size and shape of the limb over time need to be monitored and adjustments made to ensure patient comfort and prosthetic functionality. Researchers at the University of Washington have developed a flexible sensor array to measure the pressure and shear force distribution at the int
...

Periarticular Plates

Introduction A bone plate is typically used to maintain different parts of a fractured bone substantially stationary relative to each other during and/or after the healing process in which the bone mends together. A bone plate which attaches to both a head and the shaft of the bone includes an elongate portion which attaches to the shaft of the bone and a flared portion which attaches to the head of the bone using a plurality of bone screws. It is quite common for the curvature of the flared por
...

Signal Amplification Method for SPR-based Chemical Detection

Introduction Surface plasma resonance (SPR) is a general spectroscopic method for sensing refractive index changes near the surface of a metal film. Its sensitivity to these changes provides a versatile platform for the observation and quantitation of chemical reactions and intermolecular binding at the metal/solution interface. The generality of the technique has led to its application to a variety of chemical systems, including biological interactions and reactions. Technology description Rese
...

Interactive 3D Registration of Ultrasound and Magnetic Resonance Images based on a Magnetic Position Sensor

Introduction Accurate guidance and localization of the surgical tool within the brain is essential for the success of various neurosurgical procedures, such as biopsy or tumor resection. Stereotactic systems provide guidance to the surgeon based on preoperative tomographic images, such as CT and MRI. Recently, intraoperative ultrasound (US) images have been integrated with stereotactic systems. Although comparison of these corresponding US and MR/CT images provides the surgeon with easier visual
...

Microfabricated multiplexed devices for sample application and sample delivery to a microelectrospray-mass spectrometer

Introduction The most conclusive and reliable protein identification method is based on correlating collision-induced dissociation (CID) mass spectra of peptides with sequence databases. CID spectra of peptides are most frequently generated by electrospray ionization tandem mass spectrometry (ESI-MS/MS) on triple quadrupole or ion trap mass spectrometers. This technology has reached a level of sensitivity which permits the identification of essentially any protein which is detectable by conventi
...

Wearable Low Vision Aids Using Retinal Light Scanning Technologies

Introduction Severe visual impairment (those persons classified as legally blind) affects over 1 million Americans currently. With the aging of the U.S. population, this visually impaired segment is expected to rise at 10 times the rate of general population growth. Technology description Researchers at the UW have developed a wearable low vision aid (WLVA). This new technology does not require bulky pixel arrays so there is high potential for miniaturization to a form factor compatible with the
...

Endoscopic Imaging Devices Using Micromotor Scanners

Introduction Endoscopes are increasingly involved in performing common surgical procedures and in diagnosing cancer and other medical conditions. New technologies can demonstrate significant cost savings by moving these procedures from an inpatient to an outpatient setting. Technology description Researchers at the UW have developed an ultrasonic micro scanner and new endoscopic optical imaging device capable of beam scanning and focus tracing using the micro scanners. The endoscopic imaging dev
...

Programmable Logic Controller Safety System for Surgical Robot

Introduction Surgical robotics is revolutionizing the way in which clinicians deliver health care. As the field of surgical robotics continues to evolve, it is important to keep patient safety in mind. A surgical robot presents a complex software and hardware system with strong requirements for safety. It is problematic to ensure safety of such systems as no known methods exist to prove correctness and robustness of complex control software. Technology description Researchers at the University o
...

Mobile Antiseptic Spraying Tube (MAST)

Introduction Pneumatic tube systems are integrated within the walls and ceilings of many biomedical facilities and allow for the rapid transport of important materials, such as lab specimens and blood and tissue samples. In such a system, contamination due to biohazards must always be a concern, and no matter how rare, an effective means of decontaminating the system after such an incident is essential. Technology Description At the University of Washington, a mobile antiseptic spraying tube (MA
...

Grasper Pad Sensing

Introduction Minimally invasive surgery is now being used routinely as one of the most preferred choices for various types of operations. Despite its many advantages, such as reduction of trauma, less pain, smaller injuries, faster recovery time, and reduction of postoperation complications, MIS decreases the tactile sensory perception of the surgeon during grasping or manipulation of biological tissues. Therefore, the corresponding diagnostic information is lost. Present-day commercial endoscop
...

Microfluidic Platform for Assessment of Blood Coagulation

Introduction Advances in microfluidic technology are constantly opening doors to new and exciting applications, such as point-of-care diagnostic devices. These microscale diagnostic platforms will enable faster, cheaper, and more accurate patient evaluation for a wide array of parameters. One such parameter is the coagulation capacity of blood, abnormalities in which can be indicative of a wide variety of pathologies. The ability to more quickly and easily assess this, especially in an ambulator
...

Active Contact Lens

Introduction The interstitial fluid in the eye over the cornea is in indirect contact with blood serum via capillaries in the eye and is a good target for biomarkers that signal certain health conditions. If sensors and data transmitters could be implanted in a contact lens, the health of the user could be monitored continuously. Technology description University of Washington researchers have developed the active contact lens, a multifunctional chip integrating electronic, radio frequency, phot
...

Programmable Ultrasound Back-End System Using Multi-Core Processor

Introduction Ultrasonography is a noninvasive medical imaging technique, which utilizes ultrasonic waves to visualize soft tissue within the body, and advances in this technology have led to various therapies, including those that utilize high-intensity focused ultrasound (HIFU) capable of rapidly heating small areas of tissue deep within the body. Ultrasound offers a real-time, inexpensive, and noninvasive alternative to complex imaging techniques and to some surgeries. Unfortunately, ultrasou
...

Micro-Fabricated Thermal Conductivity Sensor for Biomaterials

Introduction Advances in microscale technology are constantly opening doors to new and exciting applications. Of special interest, novel microscale biosensors and other diagnostic devices promise to revolutionize patient care and biomedical research with point-of-care devices, personalized medicine, and in vivo monitoring. These devices provide fast, accurate, and inexpensive sample analysis, and they are adaptable to a potentially limitless array of analytes that could lead to affordable health
...

Design of Bio-Actuator for Medical Treatment Based on Ferromagnetic Shape Memory Alloy Helical Spring

Introduction FSMA (ferromagnetic shape memory alloy) materials provide fast speed of actuation using magnetic fields and large strain and stress capability. Technology description Researchers at the University of Washington have developed applications for FSMA devices in stents encapsulated with micro-bioactuators for removal of plaque accumulated in tube walls, not normally removed during a standard stent installation procedure. The helical spring removes plaque by oscillating at a frequency of
...

Polymer Solar Cells using Self-Assembled Monolayer modified Zinc Oxide/Metal as Cathodes

Introduction Conjugated polymer-based organic solar cells are considered an essential source of inexpensive renewable energy due to their advantages of being fabricated by low-cost and large-area printing and coating techniques on light-weight flexible substrates. Bulk heterojunction (BHJ) solar cells composed of a polymer:fullerene composite layer sandwiched between a transparent metal-oxide anode and a metallic cathode are one of the most successful types of polymer solar cells. However, the p
...

Safe last step

Introduction A common cause of injury among orchard workers in Washington state occurs when the user dismounts the ladder. The user often cannot accurately gauge the last step of the ladder because the line of sight is obscured by the apple bag when descending the ladder, with their back facing the ladder. The user may inadvertently step off the ladder at an upper rung causing falls that can be dangerous, especially with loaded fruit bags. Technology description Researchers at the University of
...

Fast Calibration for 3D Ultrasound Imaging and Multimodality Image Registration

Introduction Three-dimensional (3D) localization of two-dimensional (2D) ultrasound (US) images involves the determination of the position and orientation of a set of acquired 2D US images with respect to a given coordinate system. Accurate image localization is critical when US is used for the measurement of organ volumes and for the monitoring of anatomy shifts during surgical intervention. Calibration must be performed before US image localization is feasible, though existing calibration pro
...

Respiratory Detection System (RDS)

Introduction Respiration rates are an important indicator of cellular and metabolic states in cells ranging from mammalian to bacterial, from individuals to large populations. Unfortunately, conventional techniques have significant drawbacks: for instance, electrochemical techniques have low sensitivity and consume oxygen and optical techniques are difficult to integrate. With more effective monitoring techniques, the detection of microorganisms, the characterization of disease states, and the c
...

Episodic Monitor

Introduction Epilepsy affects over three million Americans and is characterized by recurring seizures, which typically involve problems with motor, sensory, and/or cognitive functions. These seizures may occur with or without loss of consciousness. One of the hazards of having a seizure, especially without notice or notification to caregivers, is the chance for the victim to become seriously injured. Epileptic seizures are often followed by vomiting where unattended, unconscious victims are at r
...

FEITER A NEW METHOD OF BRAIN SCANNING

BACKGROUND A number of techniques are available for brain scanning and imaging including CT scanners, MRI, fMRI and PET. All require large expensive fixed installations and cannot be made available in all hospitals. Their imaging speed does not allow measuring brain activity or functional responses in the millisecond region.. The University of Manchester is a Centre of Excellence in the field of industrial tomography and image reconstruction and has exploited these skills to develop fEITER (Func
...

An Innovative Implant for Treating Glaucoma

The Invention The Glaucoma Implant is a new shunt that eliminates the complications created by devices currently in use and it may eliminate the need for repeat surgeries. It is small in size, easy to implant and thus causes less discomfort for the patient and results in faster recovery time. For hospitals and HMOs, this means less OR time and more efficient use of resources. As the procedure is simple and with potentially fewer complications, the innovative Glaucoma Implant could also be used
...

DQF-MRI Strain Maps of Blood Vessel Walls

The Invention Two images that display a 2D map of a bovine coronary artery, unstressed (Left) and 55% elongated (Right). Strain maps of blood vessels walls, tissue composition and strain distribution are now possible through the use of DQF-MRI (Double Quantum Filtered-MRI). This innovative method is extremely powerful easily achieving images of distinct tissue layers, especially the tunica adventitia. The most significant feature is the additional spectroscopic dimension of the DQF-MRI w
...

Slice-Selective DQF-MRI of Connective Tissues

The Invention Reduced signal loss and the achievement of optimal contrast for imaging tendons and ligaments are made possible through the innovation of Slice-Selective Double Quantum Filter MRI (DQF-MRI). This new DQF-MRI is performed on a time scale shorter than any previous imaging sequence, making it possible for doctors to follow healing processes and treatments. As opposed to the histological gold-standard methods, the DQF-MRI is non-destructive and can monitor the healing process of rup
...

MRI Sequence for Macromolecule Characterization of Brain Tissue

The Invention Brain macromolecules can now be detected and identified according to contrasting macromolecular characteristics of the tissues, using this new MRI sequence. The dynamics and rigidity of a host of macromolecules can be identified, including proteins and lipid membranes. In the brain and spinal cord, the new MRI sequence gives an enhanced signal for the white matter - an invaluable tool in the detection of related diseases. The new MRI sequence may also track the amyloid plaques i
...

Real-time Diagnosis of Ovarian Malignancy

The Invention Automatic, non-invasive and immediate diagnosis of ovarian malignancy with an accuracy rate of over 90% is made possible through this innovative Real-time Diagnostic ultrasound package. The package includes two components, which together increase the likelihood of a highly accurate diagnosis. This new technology combines a computerized analysis of a B-scan Ultrasound, and an analysis of the Doppler Velocity Spectrum. The complex algorithms for automatic Doppler spectra analysis
...

Improving Speech Intelligibility for the Hearing Impaired

The Invention An improved method for processing audio inputs to hearing impaired, allowing them to better understand speech in a noisy environment The Need Most common speech enhancement techniques were designed and developed on the basis of cochlear psychoacoustical and physiological research. In the normal cochlea, there are about 10,000 outer hair cells (OHC). The most frequent cause of cochlear hearing loss is OHC loss. Since 1950 researchers have been developing cochlear models with rec
...

Drug-Eluting Bioresorbable Composite Fibers for Medical Applications

The Invention A novel class of bioresorbable, composite (core/shell) fibers loaded with bioactive agents (hydrophobic or hydrophilic) has been developed. These fibers have: excellent tensile mechanical properties (high strength and flexibility) desired controlled release profile. controllable porosity (10-85%) (for release of various molecules in a desired controlled manner and absorption of water). A unique fabrication process of the fibers has also been developed that preserves activi
...

Contrast Improvement in CT images

The Invention An improved algorithm for handling CT scan information which enables the display of all relevant anatomical features in a single image. The Need An important clinical problem in radiology is the inability to see abnormalities in tissues with marked differences between their X-ray attenuation coefficients in a single CT window. When viewed by a radiologist the same CT image slice must be examined four times, each time focusing on a different tissue's window. This process is ti
...

Passive accurate detection of elderly patient falling events

The Invention A very accurate method utilizing a combination of non-intrusive installed vibration detectors and microphones to detect the fall of humans in the domicile. The Need The elderly desire to remain independent as much as possible. This translates to living alone without constant supervision. However, there are many cases of the elderly falling in the house and being unable to call for help, sometimes for days. Current best-known solutions incorporate wearable transmitters, so tha
...

PRODUCTION OF NOVEL HUMAN COLLAGENS

BACKGROUND A powerful new platform technology for the production of human collagens is being developed in the Kadler Centre for Cell-Matrix Research within the Department of Life Sciences at the University of Manchester. The collagens most closely mimic human collagen structure, giving a far superior product to that produced by the harsh conditions necessary to extract animal collagens and can be tailored to incorporate binding sites for growth factors and cell attachment to promote integration
...

FEITER A NEW METHOD OF BRAIN SCANNING

BACKGROUND A number of techniques are available for brain scanning and imaging including CT scanners, MRI, fMRI and PET. All require large expensive fixed installations and cannot be made available in all hospitals. Their imaging speed does not allow measuring brain activity or functional responses in the millisecond region.. The University of Manchester is a Centre of Excellence in the field of industrial tomography and image reconstruction and has exploited these skills to develop fEITER (Func
...

A DEVICE FOR TREATING SWALLOWING PROBLEMS (DYSPHAGIA) AFTER STROKE

Swallowing problems after stroke are common, with over 40,000 patients annually in the UK suffering from dysphagia and its attendant consequences of aspiration pneumonia and malnutrition. This leads to longer hospital stays, increased demands on feeding resources, higher admissions to nursing homes and poorer survival costing the NHS an estimated £200 million per year. Based on the observation that many patients demonstrate gradual recovery of swallowing function over time in the absence of the
...

NOVEL ANTIMICROBIAL PEPTIDES

BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-microbial products, for out-licensing to healthcare companies across a range of sectors. THE TECHNOLOGY The core technology stems from research into a class of human proteins involved in innate immunity, whose role in fighting infection had not previously been identified. Specific regions of these pro
...

Methods of Identifying Lung Homing Molecules Using Membrane Dipeptidase

Methods of Identifying Lung Homing Molecules Using Membrane Dipeptidase 6,174,687; 6,232,287; 6,933,281; 6,784,153; 6,610,651;
...

Thryroid Hormone Receptor

Thryroid Hormone Receptor
...

Molecules that Home to a Selected Organ or Tissue In Vivo and Methods of Identifying Same

Molecules that Home to a Selected Organ or Tissue In Vivo and Methods of Identifying Same
...

Hybrid Automated/ Curated/ Peer-Reviewed Publication System

Hybrid Automated/ Curated/ Peer-Reviewed Publication System
...

High Affinity EPHB Receptor Binding Compounds and Methods of Use Thereof

High Affinity EPHB Receptor Binding Compounds and Methods of Use Thereof
...

Nucleic Acid Encoding Proteins Involved in Protein Degradation, Products and Methods Related Thereto

Nucleic Acid Encoding Proteins Involved in Protein Degradation, Products and Methods Related Thereto
...

PAAD Domain-Containing Polypeptides, Encoding Nucleic Acids, and Methods of Use

PAAD Domain-Containing Polypeptides, Encoding Nucleic Acids, and Methods of Use
...

Producing Energetic, Tunable, Coherent X-rays with Long Wavelength Light

A coherent X-ray source based on low power laser has been developed to replace traditional synchrotron as a radiation source. It is much cheaper to build and operate than a synchrotron and it is has also a much compact set up. This is achieved through the generation of high harmonic radiation with long wavelength light involving the use of a optical parametric amplifier. Photon energy can be increased by a factor of 2 to 4 when the wavelength of light field is increased by a factor of 2. When us
...

Quantitative Quantum Yield Measurements Using Flourescents Modulated Imaging

Background: Modulated imaging (MI) is a non-contact imaging modality that employs broadband, spatially modulated illumination capable of wide-field imaging, depth sectioning of turbid media, and the simultaneous extraction of the optical absorption (µa) and reduced scattering (µs') properties. The technique relies on extracting the depth and optical properties encoded in the spatial modulation transfer function of turbid media. Sinusoidal patterns of various spatial frequencies are used to il
...

High Sensitivity Optical Coherence Tomography

Background: Optical coherence tomography (OCT) is a non-invasive sub-surface optical imaging modality with high axial resolution and high signal to noise ratio compared to other imaging modalities such as ultrasound and MRI. Depending on the tissue's scattering and absorption, usually the imaging depth can be 1-2mm sub-surface in turbid tissue. A high sensitivity OCT system is desirable for better imaging depth and more imaging details. Technology: University of CA Researchers have developed
...

Flexible Endoscopic Tube

Background: In performing, through an anatomical channel inside the body, a diagnostic or surgical procedure, the surgeon or operator may need to rotate with precision the distal end inside the body, from the proximal end outside the body. Precise transfer of angular rotation from the proximal to the distal end, without loss, or amplification, of angular rotation, would give the surgeon, or operator, the ability to orient the distal end in space inside the body. That way, they can rotate the in
...

Intragastric Balloon for Treatment of Obesity

Background: The BioEnterics Intragastric Balloon System™ is a non-surgical, non-pharmaceutical alternative for the treatment of obesity. The balloon system is designed to provide loss therapy to reduce health risks related to obesity or risks prior to vital supervised weight loss program. Endoscopically placed and inflated with saline, the balloon system (made of high-quality silicone) partially fills the stomach to induce the feeling of fullness and support patients in reducing food intake a
...

Fabrication of Renewable RNA Microarrays and Methods

Background: Numerous methods and devices are available to detect and/or quantify target DNA in a test sample. In almost all of these methods, detection and/or quantification are performed utilizing a detectable label such as radiolabels, fluorescent and luminescent labels. Methodologies employing labels are costly and laborious. RNA microarrays for sensitive target DNA detection not requiring labels have been described. The major issue with creating RNA microarrays is that the attachment of pro
...

Use of Optical Coherence Tomography (OCT) for Use of Comprehensive Intra-oral Diagnosis

Background: In dentistry there exists a pressing need for novel diagnostic modalities. A strong consensus for reducing patient exposure to ionizing radiation is countered by the absence of other non-invasive diagnostic and monitoring tools. Diagnostic options for soft tissue pathologies are also limited and inadequate. Current technologies for intra-oral diagnostics are invasive and include radiographs, clinical examination, intra-oral staining techniques and biopsy. Disadvantages to these tech
...

Formulation of Monodisperse Contrast Agents in Microfluidic Systems for Ultrasonic Imaging

Background: Ultrasound imaging may be used to produce a 2D image of the body's internal structures. However, since blood is much less (1000x less) echogenic than tissue, small vessels, blood pool volume and blood flow all are difficult, if not impossible, to image using traditional ultrasound techniques. Researchers discovered, however, that by introducing micro-bubbles (USCAs) into the circulation many of the limitations surrounding blood imaging could be overcome. Of the recent developments i
...

Total Ankle Arthroplasty

Background: Total ankle arthroplasty (TAA) is the process of replacing a diseased ankle with a prosthetic ankle. Over the years there have been several efforts to provide a total ankle replacement solution. However, all such current solutions have significant drawbacks, including complications relating to aseptic loosening, delayed wound healing, wound dehiscence, and prosthetic subsidence. Other problems include prosthesis migration and loosening, and osteolysis at the tibial component. One com
...

Fluoro-Free Guidewire for Improved Colonscope

Background: Endoscopes with a soft insertion unit can be inserted into the lumen of a body cavity to diagnose problems located in a deep region in the body cavity without the necessity of incision and can also be used to guide treatment appliances to a desired location within the body cavity. In the past, medical practitioners have needed to use radio-opaque markers or contrast either in the patient or on the instruments (or both) in order to visualize instrument placement under fluoroscopy. Vi
...

A Diffusive Probe for Quantification of Optical Properties of Superficial Layers

Background: Diffuse optical spectroscopy (DOS) has been successfully employed for quantitative determination of in vivo optical properties and chromophore concentrations of deep tissues such as breast and brain. This invention is a method and probe design for obtaining quantitative optical properties and chromophore concentrations of tissue components "in-vivo" at superficial depths and "short" source detector separations. This domain, in which the source and detector are in relatively close pr
...

Robotic Hip Swinger

Background: Over 700,000 people in the U.S alone suffer strokes each year often resulting in an impairment of walking ability. A popular approach to locomotion rehabilitation called body weight supported (BWS) training shows promise in improving locomotion after strokes. However the technique involves suspending the patient in a harness above a treadmill and manually assisting the legs and hips in a walking pattern. Although effective, this technique is highly labor intensive and thus clinical
...

Corneal Transplantation

Background: Corneal damage due to accident or disease results in varying degrees of blindness in millions of individuals throughout the planet. In some cases it is possible to restore vision by a corneal transplant. A full-thickness transplant (penetrating keratoplasty, PK) runs a high risk of graft rejection. An alternative operation is a form of partial thickness graft (lamellar keratoplasty, LK) which involves transplanting limbal stem cells which regenerate surface corneal cells. LK transpl
...

Humidity And Temperature Sensor Device For The Determination Of Oxygen Consumption In Medical Applications

Background: The determination of oxygen consumption is an important monitor of normal cardiopulmonary and tissue function in anesthesia and critical care medicine. This requires accurate measurement of inhaled and exhaled volumes. Traditionally, it has been very difficult to measure the extra volume of exhalant (compared to inhalant) because of the difficulty in measuring the extra warmth and humidity of exhaled air. If it were possible to continuously and immediately measure temperature and hu
...

A Method And Apparatus For Use In Antifibrotic Therapy Of Ophthalmic Filtration Surgery

A Method And Apparatus For Use In Antifibrotic Therapy Of Ophthalmic Filtration Surgery
...

Tissue Viability Monitor

Background: The last decade of cardiac surgery has witnessed significant strides towards better understanding and better management of previously lethal cardiac pathology. Such developments have led to a general recognition of previously unknown conditions such as myocardial stunning and hibernation in which the injured myocardium is in a state of suspended animation. Unfortunately, such states can easily be mistaken for total necrosis. Because such tissues are actually viable and could be salv
...

Novel Device For Determining The Viability Of Human Myocardium Or Other Animal Tissues

Background: The last decade of cardiac surgery has witnessed significant strides towards better understanding and better management of previously lethal cardiac pathology. Such developments have led to a general recognition of previously unknown conditions such as myocardial stunning and hibernation in which the injured myocardium is in a state of suspended animation. Unfortunately, such states can easily be mistaken for total necrosis. Because such tissues are actually viable and could be salv
...

New Multimodal Probes Compatible with Flourescence and MRI

APPLICATIONS OF TECHNOLOGY: - Effective as multimodal probes for: - Imaging - Targeting specific cells or tissue - Therapeutics delivery and imaging in vivo or in vitro - Detects locality and size of diseased cells by MRI, PET, ESR, or deep tissue NIR with greater sensitivity than possible with existing methods. ADVANTAGES: - Increases resolution of in vivo imaging - Reduces false positive imaging (when used with MRI and fluorescence imaging in combination) - Can facilitate imaging-guided
...

Nanotube Radio for Communications and Medical Applications

APPLICATIONS OF TECHNOLOGY: - All-in-one radio receiver for cell phones/wireless networks/GPS and other electronic devices - Radio controlled devices that can exist inside the body, e.g. used as drug release triggers, diagnostic instrumentation, interfacing with muscle or brain function - Ultra small hearing aid - RF antenna, tunable pass filter, amplifier, or demodulator ADVANTAGES: - Orders of magnitude smaller than previous radios – can fit inside a living cell - Eliminates wiring/ther
...

Co-registration of PET and Transrectal Ultrasounds (TRUS) Images for Improved Prostate Imaging and Biopsy

IB-2420 Dual PET-TRUS imaging co-registers positron emission tomography and transrectal ultrasound images taken during the same patient exam. The simulated “merged PET-TRUS image” (central image), helping to pinpoint any cancer present, will be used to guide diagnosis and potential treatments, as indicated at right. APPLICATIONS OF TECHNOLOGY: • Detects prostate cancer using accurately co-registered positron emission tomography (PET) and transrectal ultrasound (TRUS) imag
...

Co-registration of PET and Transrectal Ultrasounds (TRUS) Images for Improved Prostate Imaging and Biopsy

APPLICATIONS OF TECHNOLOGY: Detects prostate cancer using accurately co-registered positron emission tomography (PET) and transrectal ultrasound (TRUS) images Guides prostate biopsy sampling Monitors response to treatment and detects local recurrence ADVANTAGES: Provides high-resolution anatomical detail in the prostate region through TRUS images, allowing tumors detected by PET to be localized precisely Compact and open prostate-optimized PET design allows convenient access for
...

Power Tester

Abstract The present invention relates to a power tester for testing reaction time and muscular power. More specifically, the present invention relates to a portable power tester which can be used to determine muscular power. The ability to exert muscle power is important in the effective performance of many sport skills where the body has to change speed and/or direction quickly. Low leg extensor power has also been identified as a primary predictor of falls in the elderly. The PowerTool is u
...

Potent Tyrosine Phosphatase Inhibitors

TECH FIELD(S) Medical Therapeutic FEATURES Protein tyrosine phosphates (PTPs) are becoming the next hot target area of drug development. The targets are believed involved in cancer, diabetes, obesity, autoimmune diseases, and infectious diseases. However, a potent drugable PTP inhibitor is yet to be found. We have developed families of compound with the structures suitable for binding with PTP, and rapid screening method for finding more potent compounds. BENEFITS * Highly potent PT
...

Percutaneous Thrombolytic Reinfusion Device

FEATURES Blood clots, such as thrombi (localized clots) and emboli (clots which have moved through the bloodstream), can pose serious health risks, including stroke, breathing difficulty, other attendant health concerns and death. As such, a safe and effective method of removing such clots is highly desirable. Researchers at Indiana University have developed a treatment system (device) and method of removing such blood clots, with re-infusion of clot-free blood back into the patient, resulting
...

Percutaneous Stent-Graft and Method for Delivery

FEATURES Over 130,000 patients undergo chronic hemodialysis in the United States each year. The procedure requires access to the patient’s vascular system, but such access may eventually fail due to the formation of scar tissue inside the vessel or due to vessel occlusion. Failure of hemodialysis access contributes to morbidity, hospitalization time and increased cost of treatment. Our novel percutaneous stent-graft and method for delivery restores blood flow between vessels. This stent-g
...

Novel Monomer-Free Light-Cured Glass-Ionomer System for Improved Dental Restoratives

FEATURES Glass-ionomer cements are one of the most promising restoratives in dentistry. Since their invention, these cements have been successfully applied in dentistry for more than 25 years. The success of these cements is attributed to the facts that they are known for their unique properties such as direct adhesion to tooth structure and base metals, anticariogenic properties due to release of fluoride, thermal compatibility with tooth enamel and dentin because of low coefficients of therm
...

Improved Intravenous Catheter and Delivery System

FEATURES A common problem faced by practitioners introducing intravenous (IV) catheters is the uncertainty as to whether the catheter is properly positioned within the vein. A major reason for this uncertainty is that the practitioner bases his judgment of proper insertion upon the observation of fluid flowing back into a flash chamber. Often this flow of fluid is more related to placement of the tip of the insertion needle rather than the catheter. These false observations usually require t
...

Disposable Two-Way Valve Filter for Use in Re-infusion After Blood Clot Removal

FEATURES Several of the current treatments for thrombotic conditions such as arterial emboli and thrombosis, deep vein thrombosis and pulmonary thromboembolytic disease, require mechanical fragmentation of clots followed by aspiration of clot fragments. During removal, moderate to large amounts of blood can be aspirated along with clot fragments. Keeping blood loss to a minimum is important in any procedure, but it is particularly important in this setting because of the frequently associate
...

Device for Digital Retinal Imaging

FEATURES A digital camera with simplified optics for imaging the retina and anterior structures. BENEFITS * The device can be produced at lower cost that current products. In addition, it will be easier to operate which will facilitate use in lesser developed regions of the world. Moreover, dilation of the pupil is not required.
...

Carrier for Medical Equipment for Motor Vehicle Transport

FEATURES The inventor’s observational surveys of children with special health care needs have shown that families transport their needed equipment unrestrained. In the event of a motor vehicle crash these objects become projectiles. This invention is a light weight carrier designed to safely transport medical equipment (ventilators, suction equipment, oxygen tanks, monitors) in a motor vehicle in such a way that in a crash the medical equipment is secured. BENEFITS Increase safety for
...

Brachytherapy Catheter Positioning Guide

FEATURES Stenosis of arteries or veins by the formation of atherosclerotic plaque is a well known and frequent medical problem. The most common procedure to treat such blockages is a technique commonly referred to as a "balloon angioplasty." In many patients the newly opened vessel undergoes restenosis, this is, reconstricting, as a healing response to the injury inflicted to the vessel wall during angioplasty One approach to preventing restenosis involves intravascular delivery of radiatio
...

Automatic Retractable Floor System for 360 Degree Rotating Gantry

FEATURES A commercial360 degree rotating gantry has a hazardous cavity for radiation technologists and nurses working in the area. Horizontal, pneumatically actuated, retractable floor plates aligned with the treatment room permanent floor are designed to cover this cavity and automatically retract to allow equipment on the rotating gantry to pass through the floor during rotation. The floor plates are retracted and repositioned automatically during gantry rotation so that only the floor pla
...

Adventitial Delivery of Agents for the Treatment and Prevention of Restenosis

FEATURES Balloon angioplasty is one of the most widely used treatments for heart and vascular disease with an estimate of nearly two million procedures performed each year. However, roughly 25% of patients treated with balloon angioplasty experience renewed narrowing of the treated arteries, or restenosis, within six months of the initial procedure, often leading to further interventions. Indiana University researchers have developed a broad method for the non-intramural, adventitial (outside li
...

Steerable Epicardial Lead to be Placed via the Subxiphoid

Congestive Heart Failure (CHF) is a significant and growing healthcare problem with almost five million patients suffering from this condition in the U.S. alone. The resulting hospitalization costs for treating these patients are $15B. While there have been numerous advances in treating CHF, few patients are cured of their symptoms and often have a diminished quality-of-life as their activities become restricted. Recent medical studies have shown that the use of a biventricular pacemaker, whi
...

Method and Means for Intracranial Implantation of Carmustine Anti-Tumoral Agents

Biodegradable wafers containing the anti-tumoral agent carmustine (BCNU) are often inserted into the surgical void in the brain following the debulking of a glioma. The timed-release of the drug and subsequent diffusion of it into the peri-tumoral region allow for an effective, although relatively short-lived, form of interstitial chemotherapy. Once fully dissolved, an additional craniotomy would be needed to reinstate the treatment, and such an approach is typically not indicated as part of the
...

Manometrically-Monitored Introducer Needle and Method of Use

Congestive Heart Failure (CHF) affects over 5,000,000 people in the U.S. alone and its incidence is growing. As the number of CHF cases grows, so will the rate of Ventricular Tachycardia (VT). Implantable Cardioverter Defibrillators (ICDs) can prevent sudden death from VT and drug therapies are often combined with ICDs for long-term patient management. However, the currently available VT drugs may have limiting side effects for such patients. Another approach to treating VT is the endocardial
...

Epicardial-Cathode Catheter for Ablation Procedures

Two million Americans suffer from atrial fibrillation, which can cause palpitations, syncope, strokes and is associated with death. Cardiac ablations are becoming a standard method of treatment utilizing radiofrequency energy to render tissue, which is electrically faulty, inactive. However, AF ablation comes with significant risks. Specifically, ablation in the posterior left atrial wall can damage adjacent structures such as the phrenic nerve and the esophagus. This has caused deaths in post-A
...

Epicardial Ablation Catheter and Access Sheath and Methods of Use

Today most electrophysiologic ablations are done from the endocardium because many superventricular tachycardias originate there. However, two of the fastest growing areas of ablation atrial fibrillation ablation and ventricular tachycardia (VT) ablation have significant contributors in the epicardium. In particular, endocardial VT ablation is only successful 50% of the time in the long-term. One reason is that 15-50% of VT is epicardial. Furthermore, endocardial VT ablations have a real risk
...

Closure Device for Skull Plates

An estimated 18,000+ people will develop brain tumors this year in the US, and over 30,000 people will develop subarachnoid hemorrhages caused by brain aneurysms. Aneurysms and brain tumors are only two of the several conditions that require neurosurgical procedures for treatment. Neurosurgical procedures, especially open craniotomies, are extremely delicate operations, and the last thing a surgeon wants to consider is the difficulties in re-securing a skull flap into the aperture successfully a
...

Innovative catheters - for dilating difficult lesions and delivering therapeutics to the Diseased Artery Wall

New Market Opportunity: Therapeutic delivery Advances in local drug delivery have proven extremely effective in the coronary arena. Drug-eluting stents have made a significant breakthrough in the prevention of instent restenosis. However, there are a number of areas where drugeluting stents cannot be used effectively; namely, chronic total occlusions, peripheral artery disease, edge restenosis and vulnerable plaque. These forms of vascular disease require a catheter based method of local drug d
...

Glass Matrix to Preserve Proteins and Biopolymers

This glass-like matrix preserves proteins without refrigeration or freezing. Appropriately plasticizing carbohydrate or polymeric glasses yields a biopreservation matrix that can provide stability enhancement for encapsulated biological agent of as much as 100-fold over current best-practice formulations. Biopreservation Glasses - Appropriately plasticizing carbohydrate or polymeric glasses yields a biopreservation matrix that can provide stability enhancement for encapsulated biological agen
...

Notify me of New Entries on this Page

You can receive an email whenever a new patent is added to this category. You can unsubscribe at any time.

PLEASE ENTER YOUR EMAIL:


Newsletter Sign Up

Join 40,000+ subscribers who receive our Innovation Newsletter each week.

I'd like to Subscribe