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Pharmaceutical

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Pharmaceutical research studies the ways to develop drugs that can cure diseases and help pain. Post your pharmaceutical technology for license or sale here.


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Cytotoxin compounds and methods of isolation

The present invention concerns groups of compounds derived from tunicates of the Synoicum species, as well as to pharmaceutical compositions comprising these compounds, and uses thereof. Extracts fro..

Oral Antidepressant Formulation

TriRima® Product Profile Summary TriRima® is an optimized, specific, high affinity, reversible inhibitor of monoamine oxidase-A (RIMA) potentially useful as monotherapy in the treatment of major..

Metadichol ® Nano particle and applications ( patent pending)

Metadichol®*(anagram METHODICAL) is a product produced from the waste of our agricultural industry and is present in small amounts in our foods we consume on a daily basis as most of it is lost in ou..

Hydroxy Ceramides and analogs thereof and their use for Preventing or Treating Cancer

Disclosed are compounds, compositions, methods of treatment and synthetic methods for making compounds related to stereoisomers of 2-hydroxy-ceramides and the use of 2-hydroxy-ceramides and their ana..

Intelligent Temperature Indicator Label and Method

Our Smart Labels or Time Temperature Indicators (TTI) are researched and designed for use in Cold Chain . The labels provide information regarding the Products Integrity. They monitor..

Intelligent Temperature Indicator Label and Method

Our Smart Labels or Time Temperature Indicators (TTI) are researched and designed for use in Cold Chain . The labels provide information regarding the Products Integrity. They monitor..

Biodegradable Self-Expanding Drug-Eluting Prosthesis

Implantable radially expandable medical prostheses for treatment of vascular diseases through percutaneous deployment.

Neuroprotective novel drugs for Parkinsons, alcoholism + other CNS disorders WO2012020170

The present invention relates to novel 6,7-disubstituted-isoquinoline derivatives and more particularly to novel 6,7-disubstituted-1-methyl-1 ,2,3,4- tetrahydro- and -3,4-dihydroisoquinoline derivativ..

Indole compounds and their use as radiation sensitizing agents and chemotherapeutic agents

Radiotherapy is the treatment of cancer and other diseases with ionizing radiation. Radiotherapy is used in curative therapy, palliative therapy, adjuvant therapy after or before surgery, simultaneous..

DEVICE FOR ORGANIZING THE ADMINISTRATION OF PILLS AT PREDETERMINED TIME INTERVALS

A device for organizing the administration of pills at predetermined time intervals, characterized in that it has a main body used as an individual tissue ring with an opening, through which tissues c..

UNIT DOSAGE OF APADENOSON

The present invention provides a unit dosage of Apadenoson, a pharmacological stress agent, and use of the same as a pharmacologic agent for myocardial perfusion imaging.

PYRIDINONE DIKETO ACIDS: INHIBITORS OF HIV REPLICATION IN COMBINATION THERAPY.

A new class of diketo acids constructed on pyridinone scaffolds, designed as inhibitors of HTV replication through inhibition of HIV integrase, is described. These compounds are useful in the preventi..

2'-FLUORO-6'-METHYLENE CARBOCYCLIC NUCLEOSIDES AND METHODS OF TREATING VIRAL INFECTIONS

The present invention relates to 2'-Fluoro-6'-methylene carbocyclic nucleosides, pharmaceutical compositions containing these nucleosides and their use in the treatment or prophylaxis of a number of v..

ANTIMICROBIAL COMPOSITION AND USE

Antimicrobial compositions are provided comprising a pharmaceutically acceptable organic acid and a pharmaceutically acceptable surfactant. This synergistic combination allows compositions to be formu..

VACCINE FOR RUNTING-STUNTING SYNDROME

The present invention includes polypeptides, polynucleotides, antibodies, and vaccines associated with Runting Stunting Syndrome (RSS) in poultry. The present invention also includes methods of protec..

COMPOSITION À BASE DE MYCOPLASMA GALLISEPTICUM

The present invention provides a formulation that prevents virulent Mycoplasma galHsepticum infection in birds of the order GaIHf ormes. The formulation comprises live Mycoplasma galHsepticum strain K..

METHODS AND COMPOSITIONS FOR OPHTHALMIC TREATMENT OF FUNGAL AND BACTERIAL INFECTIONS

The present invention provides methods and compositions for use in the methods for contacting an eye of a patient with an effective amount of therapeutic composition comprising a pharmaceutically acce..

DOSE OF AN ANGIOGENIC FACTOR AND METHOD OF ADMINISTERING TO IMPROVE MYOCARDIAL BLOOD FLOW

The present invention has multiple aspects. In one aspect, the present invention is directed to a unit dose pharmaceutical composition comprising from about 5 ng/dose to less than 135,000 ng of an ang..

APTAMER INHIBITORS OF OSTEOPONTIN AND METHODS OF USE THEREOF

The present invention polynucleotide aptamers that selectively bind to and inhibit the function of osteopontin, pharmaceutical compositions comprising the same, and methods of use for diagnostics and ..

ANTI-CD19 ANTIBODIES AND USES IN ONCOLOGY

The invention relates to immunotherapeutic compositions and methods for the treatment of B cell diseases and disorders in human subjects, such as, but not limited to, B cell malignancies, using therap..

USE OF RANOLAZINE FOR NON-CARDIOVASCULAR DISORDERS

Disclosed is a method of treating a non-cardiovascular disorder characterized by an abnormal persistent sodium current in a subject in need of treatment thereof, said method comprising administering t..

GERANYLGERANYL TRANSFERASE INHIBITORS AND METHODS OF MAKING AND USING THE SAME

The present invention is directed to compounds useful in the treatment of diseases associated with prenylation of proteins and pharmaceutically acceptable salts thereof, to pharmaceutical compositions..

INDOLES, DERIVATIVES, AND ANALOGS THEREOF AND USES THEREOF

Indole derivatives and analog compounds and pharmaceutical compositions comprising the same are provided. Also provided are methods of using these compounds to inhibit tubulin polymerization in a cell..

METHODS AND COMPOSITIONS FOR MODULATING DRUG-POLYMER ARCHITECTURE, PHARMACOKINETICS AND BIODISTRIBUTION

Drug-polymer chemotherapeutics are provided having improved therapeutic efficacy and reduced dose-limiting toxicity. Methods are also provided for modulating the architecture, pharmacokinetics and bio..

Method of modulating the activity of a nucleic acid molecule

The present invention relates, in general, to agents that modulate the pharmacological activity of nucleic acid molecules and, in particular, to agents that bind therapeutic or diagnostic nucleic acid..

SUBSTITUTED PORPHYRINS

Discloses are compounds according to Formula I. Further provided are methods of reducing oxidative stress in a cell, methods of treating a disease including cancer, and methods of treating a subject w..

MANASSANTIN COMPOUNDS AND METHODS OF MAKING AND USING SAME

Provided are manassantin compounds and methods of using the compounds. Provided are methods of treating a disease, the method comprising administering a compound according to Formula I. Further provid..

AROMATIC C16-C20 SUBSTITUTED TETRAHYDRO PROSTAGLANDINS USEFUL AS FP AGONISTS

PROBLEM TO BE SOLVED: To provide a new PGF analogs, particularly compounds useful for the treatment of various diseases and conditions such as bone disorders and glaucoma, to provide pharmaceutical co..

TRPC6 INVOLVED IN GLOMERULONEPHRITIS

Focal and segmental glomerulosclerosis (FSGS) is a kidney disorder of unknown etiology and up to 20% of patients on dialysis have this diagnosis. A large family with hereditary FSGS carries a missense..

INHIBITING EPH B-3 KINASE

EphB3 kinase inhibitor compounds, including certain pyrazolo[1,5-a]pyridine and imidazo[1,2-a]pyridine compounds, inhibit EphB3 kinase. The EphB3 kinase inhibitor compounds can have greater potency fo..

METHODS AND SYSTEMS FOR TREATING CELL PROLIFERATION DISORDERS WITH PSORALEN DERIVATIVES

Psoralen compounds of Formula (I): wherein (N+Aryl) is a member selected from the group consisting of nitrogen containing aromatic heterocycles of formulae (i)-(iii): wherein Z is a group of formula: ..

SUBSTITUTED PORPHYRINS

PROBLEM TO BE SOLVED: To provide a method for modulating physiological and pathological processes, and in particular, to provide a method for modulating the intracellular levels of oxidants and thereb..

BIOMOLECULE POLYMER CONJUGATES AND METHODS FOR MAKING THE SAME

Methods for producing biomolecule-polymer conjugates, such as polypeptide-polymer conjugates, include attachment of an initiator agent to a biomolecule and in situ polymerization of a polymer from def..

PEPTIDE ADJUVANTS, VACCINES, AND METHODS OF USE

Provided herein are peptides that have activity as mast cell activating proteins (MCAP), as well as compositions, adjuvant compositions, vaccines, and pharmaceutical formulations that include the pept..

PROCHELATORS USEFUL FOR INHIBITING METAL-ASSOCIATED TOXICITY

Prochelator compounds of Formula (I) or Formula (II) are described, along with methods of using the same and pharmaceutical formulations or compositions containing the same.

CD20-SPECIFIC ANTIBODY AND METHOD OF EMPLOYING THE SAME

The present invention provides monoclonal antibodies and antigen-binding fragments thereof that specifically bind to CD20, as well as pharmaceutical compositions comprising the same. The invention fur..

COMPOSITIONS, METHODS, AND KITS FOR DETERMINING AN ALKYL TRANSFERASE

The present invention relates to novel compounds as well as to compositions, methods, and kits comprising the compounds for determining an alkyltransferase (ATase), in particular an alkylguanine-DNA a..

BISPHOSPHONATE COMPOSITIONS AND METHODS FOR TREATING HEART FAILURE

The present invention provides for methods and compositions for treating and/or preventing cardiac dysfunction by administering to subject a therapeutically effective amount of a bisphosphonate, funct..

BETULINIC ACID DERIVATIVES AS ANTI-HIV AGENTS

The present invention provides compounds of the general structure: which are substituted at the 3 and 28 positions, along with pharmaceutical formulations containing the same and methods of treating v..

POLYVALENT VACCINE

The present invention relates, in general, to an immunogenic composition (e.g., a vaccine) and, in particular, to a polyvalent immunogenic composition, such as a polyvalent HIV vaccine, and to methods..

COMPOSITIONS AND METHODS RELATING TO HEAT SHOCK TRANSCRIPTION FACTOR ACTIVATING COMPOUNDS AND TARGETS THEREOF

The present invention relates to HSF activating compounds, methods for their discovery, and their research and therapeutic uses, as well as pharmaceutically acceptable salts, solvates, chelates, non-c..

DERIVATIVE N-THIOLATED 2-OXAZOLIDINONE ANTIBIOTICS

This invention describes the discovery and synthesis of N-thiolated 2-oxazolidinones as a new class of anti bacterial agents. These compounds can be synthesized from 2-oxazolidinones by Ndeprotection ..

Polyphenol proteasome inhibitors, synthesis, and methods of use

The present invention relates to synthetic green tea derived polyphenolic compounds, their modes of syntheses, and their use in inhibiting proteasomal activity and in treating cancers. The present inv..

Novel Polymorph of Acetylsalicylic Acid, and Methods of Making and Using the Same

A polymorph of aspirin is provided by the present invention. Methods of making and using the same are also provided.

EXO-S-MECAMYLAMINE FORMULATION AND USE IN TREATMENT

A pharmaceutical composition includes a therapeutically effective amount of exo-S-mecamylamine or a pharmaceutically acceptable salt thereof, substantially free of exo-R-mecamylamine in combination wi..

COMPOSITIONS COMPRISING ANTI-ICAM-1 ANTIBODIES

There is provided a method of preventing a respiratory infection by administering an effective amount of an agent for regulating ICAM-1 expression. Also provided is a composition for the prevention of..

ANTIBACTERIAL S-HETEROSUBSTITUTED DISULFIDES

Synthetically-derived S,S-heterodisubstituted disulfides that exhibit potent in vitro antibacterial activity against a variety of bacteria, including Staphylococcus aureus, methicillin-resistant Staph..

Pharmaceutical Co-Crystal Compositions

A pharmaceutical composition comprising a co-crystal of an API and a co-crystal former; wherein the API has at least one functional group selected from ether, thioether, alcohol, thiol, aldehyde, keto..

Fish-ribosyn for antibiotic susceptibility testing

The subject invention concerns materials and methods for evaluating the susceptibility of bacterial cells to an antibiotic or other antimicrobial compound or agent. In one embodiment, a sample compris..

BROAD SPECTRUM VACCINE AGAINST NON-TYPHOIDAL SALMONELLA

The present invention is drawn to attenuated Salmonella serovar strains S. Typhimurium and S. Enteritidis, conjugate vaccines derived from these attenuated strains of S. Typhimurium and S. Enteritidis..

MUTUAL PRODRUGS AND METHODS TO TREAT CANCER.

Mutual prodrugs comprising retinoids and histone deacetylase inhibitors, methods for production of the mutual prodnigs, and methods of treatment comprising administration of the mutual prodrugs. The r..

P53 ACTIVATOR PEPTIDES

The present invention relates to novel polypeptides that activate p53, and the polynucleotides encoding these p53 activator peptides. The present invention also relates to pharmaceutical compositions ..

KYNURENINE-AMINOTRANSFERASE INHIBITORS

Compounds of formula (I) : prodrug derivatives and/or pharmaceutically acceptable salt thereof, selectively inhibit the enzyme kynurenine aminotransferase, thereby reducing the synthesis of kynurenic ..

ATTENUATED SALMONELLA ENTERICA SEROVAR PARATYPHI A AND USES THEREOF

The present invention is drawn to a live, attenuated S. Paratyphi A strain, a live, attenuated S. Paratyphi A strain comprising a stabilized plasmid expression system, an S. Paratyphi conjugate vaccin..

PROTECTIVE VACCINE AGAINST STAPHYLOCOCCUS AUREUS BIOFILMS COMPRISING CELL WALL-ASSOCIATED IMMUNOGENS

Vaccine formulations effective against Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus (MRSA) are disclosed, as well as methods of using the vaccine formulations in the tr..

MULTIVALENT LIVE VECTOR VACCINE AGAINST CLOSTRIDIUM DIFFICILE-ASSOCIATED DISEASE

The invention relates to a multivalent Clostridium difficile vaccine comprising a Salmonella Typhi live vector comprising the cell binding domain of TcdA toxin (CBD/A) of Clostridium difficile or an a..

SULFATED PSYLLIUM DERIVATIVE FOR REDUCING THE RISK OF CHRONIC HUMAN DISEASES AND METHOD FOR PREPARING THE SAME

The invention is directed to a method for preparing sulfated psyllium derivatives for use to reduce the risk of chronic human diseases. The sulfation of psyllium was carried out with sulfur, trioxide,..

Substituted Phenyl Aziridine Precursor Analogs as Modulators of Steroid Receptor Activities

Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one ..

Kainate Receptor-Selective Epimeric Analogs of Dysiherbaine

Disclosed are compounds, pharmaceutical compositions, methods of treatment, and methods for selectively antagonizing a GluR5 receptor, a GluR6 receptor, or both receptors. The pharmaceutical compositi..

SELECTIVE POLY-N-SUBSTITUTED GLYCINE ANTIBIOTICS

Antimicrobial peptoid compounds and related compositions as can be used against bacteria effectively and selectively.

VACCINE COMPOSITONS FOR INDUCING IMMUNE RESPONSES AGAINST COMPONENTS OF DRUSEN

Disclosed are compositions and methods for treating or preventing the formation of drusen in a patient in need thereof. The compositions include an effective amount of at least one polypeptide present..

TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

The present invention relates to the identification of compounds and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis (ALS) and other neurodegenerative dise..

COMPOSITIONS AND METHODS OF VITAMIN E ADMINISTRATION

The present invention relates to compositions and methods of vitamin E administration. In particular, the present invention provides opposing effects, relative to inflammation, from the administration..

TARGETED SCHIFF BASE COMPLEXES

The present invention provides targeted Schiff base complexes. In particular the present invention provides biopolymer targeted transition metal complexes configured to inhibit the activity of targete..

PYRIMIDINE-2,4,6-TRIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

The present invention relates to the identification of inventive pyrimidine-2,4,6- triones (PYT compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclero..

CYCLOHEXANE-1,3-DIONES FOR USE IN THE TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS

The present invention relates to the identification of provided cyclohexane-1,3-diones (CHD compounds) and pharmaceutical compositions thereof for treating subjects with amyotrophic lateral sclerosis ..

VACCINE COMPOSITIONS AND USES THEREOF

The present invention relates to vaccine compositions and uses thereof. Embodiments of the present invention provide oral bacterial (e.g., probiotic lactic acid bacteria) vaccine delivery systems comp..

Pharmacological Treatment for Sleep Apnea

The present invention relates generally to pharmacological methods for the prevention of amelioration of sleep-related breathing disorders via administration of agents or combinations of agents that p..

USE OF SPECIFICALLY ENGINEERED ENZYMES TO ENHANCE THE EFFICACY OF PRODRUGS

The invention provides methods for enhancing efficiency of prodrugs by specifically engineered enzymes with altered or enhanced activity and broader substrate specificity towards nucleoside analogs us..

Ecteinascidins

The present invention is directed to several newly discovered ecteinascidin (Et) species, designated herein as Et 731, Et 815, Et 808, and Et 594. The physical properties of these compounds, their pre..

NON-SIMIAN CELLS FOR GROWTH OF PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) VIRUS.

Disclosed are compositions and methods relating to growth of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) using non-simian cells. In a particular example, porcine alveolar macrophage ce..

LIPOSOME FORMULATION HAVING HYDROPHILIC AND HYDROPHOBIC PHARMACEUTICAL COMPOUNDS CO-ENCAPSULATED THEREIN

The present invention features liposomal formulations composed of at least one hydrophilic pharmaceutical compound loaded in the aqueous core of the liposome and at least one hydrophobic pharmaceutica..

ENZYME INHIBITING COMPOUNDS AND METHODS

The invention provides compounds, compositions, and methods for studying the Rohmer pathway and for treating bacterial infections or parasitic infections. The parasitic infection can be a protozoan in..

PORTABLE ACTIVE FLUID POWERED ANKLE-FOOT ORTHOSIS

A portable active pneumatically-powered ankle foot orthosis. A lower leg mount and a foot bed are pivotally coupled at or proximate to an ankle position. A pneumatically powered rotary actuator is con..

METHOD OF REGULATING CELL GROWTH USING A PROTEASOME INHIBITOR

This invention provides methods and pharmaceutical compositions for regulating cell growth or inducing apoptosis in a cell, particularly a mammalian tumor cell. Specifically, the invention provides me..

Compositions and Methods for Treating Neurodegenerating Diseases

This invention provides agents, compositions, pharmaceutical compositions and methods for treating or slowing the progression of a neurodegenerating disease, such as Alzheimer's disease and a demyelin..

SYNERGISTIC ANTIBIOTIC COMBINATIONS AND DERIVATIVES

Improved antibiotic analogs, and synergistic combinations of antibiotics designed based on structural crystallographic analysis, are provided as well as pharmaceutical compositions comprising the impr..

METHODS AND COMPOSITIONS FOR AFFECTING CYCLOPHILIN A REGULATION OF KINASES IN MODULATING CELLULAR ACTIVITIES

The present invention relates to drug screening assays, therapeutic protocols and pharmaceutical compositions designed to target non-receptor tyrosine family kinases and components of the tyrosine kin..

AGR-MEDIATED INHIBITION OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS

The present invention involves the use of activators of bacterial Agrquoroum-sensing systems to prevent or reverse biofilm formation in methicillin resistant Staphylococcus aureus (MRSA), or to restor..

2,4,6-TRISUBSTITUTED PHENOLS HAVING ANESTHETIC PROPERTIES

Trisubstituted phenol compounds and methods of using the compounds, e.g., for anesthetizing a subject, are disclosed.

CELLULOSE CAPSULES AND METHODS FOR MAKING THEM

Disclosed are cellulose capsules, methods for preparing a cellulose capsule, and compositions comprising cellulose capsules, including sustained- or controlled-release dosage forms comprising cellulos..

METHODS OF IMPROVING VACCINE IMMUNOGENICITY

The present invention provides a process called "Immune Banking" that enhances vaccine efficacy by exploiting existing humoral responses. The process involves tagging new antigens with molecular marke..

Inhibitors of Phosphodiesterase Type 5A for Treating or Preventing Muscle Disease or the Symptoms Thereof in a Patient

Disclosed are pharmaceutical compositions and methods for treating or preventing muscle diseases or the symptoms thereof. The compositions typically include and the methods typically utilize phosphodi..

CAPPED MESOPOROUS SILICATES

The invention provides an article comprising, a mesoporous silicate matrix, such as a particle, having one or more pores; and one or more releasable caps obstructing one or more of the pores. The arti..

NOVEL ANTIBIOTIC ALTERNATIVES

The present invention relates to two recombinant colicin expression systems, one utilizing a yeast expression system that produces a protein that is inexpensive to purify, and the other utilizing a pl..

NEUROPROTECTIVE COMPOUNDS AND THEIR USE

Apocynin derivative compounds, active pharmaceutical ingredients, dosage forms, and methods of use thereof as neuroprotectants in the brain of mammals.

COMPOSITION COMPRISING beta -HYDROXY- beta -METHYLBUTYRIC ACID AND AT LEAST ONE AMINO ACID AND METHODS OF USE

The present invention provides a composition comprising HMB and at least one amino acid. The present invention also provides a method for the treatment of disease-associated wasting of an animal, a me..

Producing polyelectrolyte hydrogel bodies, useful e.g. as soft tissue implants, comprises filling a semi-permeable membrane-forming liquid and a coagulation medium in a hollow template to form hollow

Producing dimensionally stable polyelectrolyte hydrogel bodies (2) with defined three-dimensional shape, comprises: filling a semi-permeable membrane-forming liquid in a hollow template (1); separatin..

PKCdelta REGULATES NEUROINFLAMMATORY EVENTS

This invention relates to methods and pharmaceutical compositions for regulating the levels of proinflammatory substances released from activated microglia using a protein kinase C delta (PKCd) inhibi..

ANALGESIC AGENTS

he invention provides a compound of formula (I) or a salt thereof, as well as compositions comprising such compounds. The compounds and compositions are useful as analgesics.

TRIPTOLIDE PRODRUGS

The invention provides compounds of formula (I): or a salt thereof. The invention also provides pharmaceutical compositions comprising a compound of formula I, processes for preparing compounds of for..

STREPTOCOCCAL C5a PEPTIDASE VACCINE

Novel vaccines for use against beta -hemolytic Streptococcus colonization or infection are disclosed. The vaccines contain an immunogenic amount of a variant of streptococcal C5a peptidase (SCP). Also..

METHODS OF ADMINISTERING PORCINE B-DOMAINLESS FVIII

The present invention provides a method of administering porcine B-domainless factor VIII (OBI-1) to a patient having factor VIII deficiency to provide more rapid and effective protection against blee..

NUCLEOSIDE DERIVATIVES FOR TREATMENT OF CALICIVIRIDAE INFECTIONS, INCLUDING NOROVIRUS INFECTIONS

A method and composition for treating a host infected with a Caliciviridae virus, such as a Norovirus, comprising administering an effective treatment amount of a described modified nucleoside or a ph..

NON-MYELOSUPPRESSIVE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF TREATMENT

The present invention provides microtubule targeting compounds that are myelo-sparing. Particularly, the MTCs of the invention are structurally designed to exhibit specificity for inhibiting ss-tubuli..

STEROID ANALOGUES FOR NEUROPROTECTION

Provided are steroid analogues functionalized with polar substituents at the C3 and/or C20 positions of the steroid ring system that exhibit improved water solubility. Also provided are pharmaceutical..

2'-FLUORONUCLEOSIDES

The 2'-fluoronucleoside is provided to treat hepatitis type B, hepatitis type C, HIV(human immunodeficiency virus), and abnormal cell proliferation including tumor and cancer. The pharmaceutical compo..

BRANCHED DIEPOXIDE COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS

The present invention provides certain diepoxide carbocyclic compounds wherein at least one carbocyclic ring carbon includes two non-epoxide substituents, and pharmaceutical compositions containing th..

CYANINE-CONTAINING COMPOUNDS FOR CANCER IMAGING AND TREATMENT

This invention relates generally to cyanine-containing compounds; pharmaceutical compositions comprising cyanine-containing compounds; and methods of using cyanine-containing compounds for cancer cell..

METHODS AND COMPOSITIONS FOR IMPROVED DELIVERY OF THERAPEUTIC AND DIAGNOSTIC AGENTS

Among other things, this disclosure provides for compounds having a targeting moiety linked to a therapeutic moiety and/or a diagnostic moiety; the synthetic methods for making the compounds; pharmace..

CATECHOLAMINE DERIVATIVES FOR OBESITY AND NEUROLOGICAL DISORDERS

Novel compounds, compositions, and methods related to the activation of the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a co..

COMPOUNDS, COMPOSITIONS, METHODS OF SYNTHESIS, AND METHODS OF TREATMENT

Briefly described, embodiments of this disclosure include compounds as described herein, labeled compounds as described herein, pharmaceutical composition including compounds described herein, methods..

SUBUNIT SELECTIVE NMDA RECEPTOR POTENTIATORS FOR THE TREATMENT OF NEUROLOGICAL CONDITIONS

Provided are compounds, pharmaceutical compositions and methods of treating or preventing disorders associated with NMDA receptor activity, including schizophrenia, Parkinson's disease, cognitive diso..

METHODS OF NEUROPROTECTION USING NEUROPROTECTIVE STEROIDS AND A VITAMIN D

Described herein are compositions and methods for treating or preventing nervous system injury. In particular, the methods and compositions relate to the use of at least one neuroprotective steroid, s..

ENANTIOMERICALLY PURE beta -D-DIOXOLANE-NUCLEOSIDES

A method and composition for the treatment of humans infected with HIV that includes the administration of an HIV treatment amount of an enantiomerically pure (beta)-D-dioxolanyl purine nucleoside of ..

MVA EXPRESSING MODIFIED HIV ENVELOPE, GAG, AND POL GENE

PROBLEM TO BE SOLVED: To control pathogenic immunodeficiency virus. ; SOLUTION: There is provided a pharmaceutical composition comprising a recombinant MVA virus expressing an HIV env, gag, and pol ge..

CONJUGATES OF NOSCAPINE AND FOLIC ACID AND THEIR USE IN TREATING CANCER

The present invention is directed to compounds which are conjugates of two non-toxic natural products, noscapine (and various noscapine analogs) and folic acid (and various folic acid analogs), where ..

SMALL-MOLECULE INHIBITORS OF HIF AND ANGIOGENESIS

Inhibitors of Hypoxia Inducible Factor (HIF) and angiogenesis, for example 2,2-dimethylbenzopyran compounds and derivatives thereof, and methods of their use including treatment of cancer, disorders l..

NMDA RECEPTOR ANTAGONISTS FOR NEUROPROTECTION.

Provided are compounds, pharmaceutical compositions and methods of treatment or prophylaxis of disorders associated with NMDA receptor activity, including neuropathic pain, stroke, traumatic brain inj..

USE OF IMIPRAMINE BLUE AND ANALOGS THEREOF IN TREATING CANCERS

Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are triphenyl methane analogs. The compounds and compositions ca..

TREATING VARIOUS DISORDERS USING TRKB AGONISTS

Novel compounds and methods for activating the TrkB receptor are provided. The methods include administering in vivo or in vitro a therapeutically effective amount of a compound containing four six-me..

NOSCAPINE AND NOSCAPINE ANALOGS AND THEIR USE IN TREATING INFECTIOUS DISEASES BY TUBULIN BINDING INHIBITION

Compositions and methods for treating or preventing infectious diseases, and inhibiting the ability of microbes to travel within mammalian cells, and inhibiting microbial replication, are disclosed. T..

NMDA RECEPTOR ANTAGONISTS FOR THE TREATMENT OF NEUROPSYCHIATRIC DISORDERS.

Provided are pharmaceutical compositions and methods of treatment or prophylaxis of certain neuropsychiatric conditions, in particular mood disorders. The compounds are of the general Formula I-V as d..

Systems Biology Approach Predicts Immunogenicity of Vaccines

A major challenge in vaccinology is to prospectively determine vaccine efficacy. Disclosed herein are methods and compositions for identifying early expression "signatures" that predicted immune respo..

SYNERGISTIC INDUCTION OF HUMORAL AND CELLULAR IMMUNITY BY COMBINATORIAL ACTIVATION OF TOLL-LIKE RECEPTORS

Described herein are compositions that include a selected antigen, a TLR4 ligand and a TLR7/TLR8 ligand, wherein the antigen and TLR ligands are encapsulated in nanoparticles. Co-administration of bot..

COMPOSITIONS AND METHODS FOR TREATING MLV-INFECTION, AND PREVENTING AND TREATING MLV-INITIATED DISEASES

Compositions and methods for inhibiting infection by XMRV or other MLV are disclosed. Also disclosed are methods for treating cancers resulting from infection by XMRV or other MLV, and for preventing ..

RECOMBINANT ANTIBODIES AGAINST H1N1 INFLUENZA

Antibodies that bind with high affinity to swine H1N1 virus are described. In vivo experiments showed that one such antibody is able to fully protect mice challenged with a lethal dose of swine H1N1 v..

POLYMERS FOR DELIVERING A SUBSTANCE INTO A CELL

Disclosed herein are polymers that can be made cationic and used to deliver a substance into a cell. Also disclosed are pharmaceutical compositions comprising the polymers and methods of using the pol..

ANTI-CANCER VACCINE COMPOSITION

Combinations of anti-cancer vaccines and inhibitory antibodies to CD223 overcome immune suppression in cancer patients. The vaccines may be isolated antigens, groups of antigens, or whole tumor cells...

SPIPERONE DERIVATIVES AND METHODS OF TREATING DISORDERS

Described herein are spiperone derivative compounds which have been found to be useful in methods of stimulating CaCC and treating disorders (or symptoms thereof) associated with CaCC including cystic..

COMPOSITIONS AND METHODS FOR TREATMENT OF NEURODEGENERATIVE DISEASE

Compounds, compositions, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.

THERMOSTABILIZATION OF PROTEINS.

Provided are compositions comprising a cocaine esterase (CocE) and a compound that thermostabilizes the CocE. Also provided are methods of thermostabilizing a cocaine esterase. Additionally provided a..

INHIBITORS OF MRE11, RAD50 AND/OR NBS1

The invention provides, inter alia, compositions comprising an inhibitor of MRE11, RAD50 and/or NBSl and methods of using such inhibitor for modulating the cellular response to DNA damage, arresting t..

PHARMACEUTICAL COMPOSITION COMPRISING A PROTON PUMP INHIBITOR AND PROTEIN COMPONENT

The present disclosure relates to, inter alia, pharmaceutical compositions comprising a H+,K+-ATPase proton pump inhibitor and a protein component; to methods for manufacture of such compositions, and..

COMPOUNDS FOR TREATMENT OF COPPER OVERLOAD

The present invention provides compounds, pharmaceutical compositions, and methods that can be used to treat pathologies that are due to copper overload or to the presence of reactive oxygen species.

Novel substituted benzimidazole dosage forms and method of using same

The invention provides a solid oral pharmaceutical composition in capsule or powder dosage form comprising: a) omeprazole or a single enantiomer thereof, including a salt or other derivative thereof; ..

E3 LIGASE INHIBITORS

The present invention provides, e.g., compounds having the structure of formula (I): The present invention also provides pharmaceutical compositions that include such compounds, and methods for modula..

Compounds that Inhibit Production of sAPPB and AB and Uses Thereof

The present invention relates to compounds with activity as inhibitors of sAPP[beta] and A[beta] production, and methods for treating, preventing, or ameliorating neurodegenerative diseases, such as A..

RAGE FUSION PROTEINS AND METHODS OF USE

Disclosed are RAGE fusion proteins comprising RAGE polypeptide of soluble human sRAGE fragment with the certain amino acid sequence and non-RAGE polypeptide linked thereto. Said protein is used for tr..

Agents for preventing and treating disorders involving modulation of the RyR receptors

The present invention provides novel compounds of Formula I and salts, hydrates, solvates, complexes, and prodrugs thereof. The present invention further provides methods for synthesizing compounds of..

NOVEL CURCUMIN DERIVATIVES AND THEIR PHARMAEUTICAL USES THEREOF

Disclosed are methods relating to analogues, derivatives, and metabolites of curcumin. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended ..

VACCINE AGAINST BOTULISM

The invention relates to novel DNA and protein vaccines against Clostridium botulinum. The DNA vaccine includes a DNA molecule that includes a first segment encoding a fragment of a heavy chain region..

METHOD AND COMPOSITIONS FOR TREATMENT OR PREVENTION OF INFLAMMATORY CONDITIONS

Pharmaceutical compositions and methods for treating or preventing an inflammatory condition in a patient are disclosed. The pharmaceutical compositions and methods include the use of vincamine or a v..

RESPIRATORY SYNCYTIAL VIRUS VACCINE BASED ON CHIMERIC PAPILLOMAVIRUS VIRUS-LIKE PARTICLES OR CAPSOMERES

The present invention is directed to a chimeric papillomavirus virus- like particle (VLP) or capsomere including an Ll polypeptide and, optionally, an L2 polypeptide, and a respiratory syncytial virus..

USE OF ELECTROPHILIC COMPOUNDS FOR INDUCING PLATELET PRODUCTION OR MAINTAINING PLATELET FUNCTION

The present invention is directed to a method of inducing platelet production that includes contacting a megakaryocyte with an electrophilic compound under conditions effective to induce platelet prod..

SYSTEMS AND METHODS FOR ENHANCING VACCINE EFFICACY

Pharmaceutical compositions of the invention include an antigen or a nucleic acid molecule encoding the antigen; one or both of a PPAR ligand and an RxR ligand; and a pharmaceutically suitable carrier..

COMPOUNDS AND METHODS FOR ALTERING LIFESPAN OF EUKARYOTIC ORGANISMS

Provided are compounds which generally have a triketone structure. Examples of the compounds include derivatives of 1,3-cyclohexanedione, such as: 1,3-cyclohexanedione, 2-propanoyl-5-cyclohexyl-; 1,3-..

PHENAZINE DERIVATIVES AND USES THEREOF

The present invention provides compounds, pharmaceutically acceptable compositions thereof, and methods of using the same.

BIOCOMPATIBLE POLYSACCHARIDE-BASED HYDROGELS

Modified polysaccharides and crosslinked modified polysaccharide compositions are described. Methods of using the crosslinked modified polysaccharide compositions to deliver proteins, oligonucleotides..

PHOSPHOPEPTIDES AS MELANOMA VACCINES

We characterized a total of 175 HLA-DR-associated phosphopeptides using sequential affinity isolation, biochemical enrichment, mass spectrometric sequencing and comparative analysis. Many were derived..

ANTIFUNGAL AGENTS AS NEUROPROTECTANTS

Provided herein are compounds, compositions and methods for protecting neuronal and glial cells.

VACCINES TARGETING CELLULAR DEATH RECEPTORS

The invention provides therapeutics and methods to induce a mammalian host, including a human, to produce antibodies, which agonize death receptors and cause the apoptotic death of target cells within..

ANTITUMOR AGENTS

The invention provides compounds of formula I as described herein wherein Y is F, Cl or Br; or a pharmaceutically acceptable salt thereof. The compounds are effective antitumor agents. The invention a..

DENDRIMERS FOR SUSTAINED RELEASE OF COMPOUNDS

Dendrimer-based compositions and methods are provided, that are useful for administering pharmaceutical compositions to target cells and tissues for treatment of ocular diseases including macular dege..

TOPICAL STEROIDAL FORMULATIONS

The present invention relates to formulations of poorly water soluble pharmaceutical agents of Formula I and II. The present invention also relates to compositions containing compounds of Formula I or..

SUBSTITUTED STYRYL BENZYLSULFONES FOR TREATING PROLIFERATIVE DISORDERS

Styryl benzylsulfones of formula (I) are useful as antiproliferative agents, including, for example, anticancer agents. In said formula, (a) (i) at least three of R1, R2, R3, R4 and R5 are independent..

MANIPULATING SP1 ACTIVITY TO IMPROVE THERAPEUTIC CLONING

The observed over-expression of Sp1 target genes has inspired inventors to formulate a specific strategy for correcting many gene expression defects, and thus improve clone development. The invention ..

SUPPRESSION OF POSTOPERATIVE ILEUS

The invention provides a method for suppressing postoperative ileus in connection with the performance of a surgical procedure on a patient. In accordance with the inventive method, interleukin-10 (IL..

CYCLIC ADENOSINE MONOPHOSPHATES FOR REDUCING THE FORMATION OF ADHESIONS

Provided herein are methods of reducing adhesion formation in a subject, for example, post-surgical abdominal and pelvic adhesions. The methods comprise administering to the subject a compound chosen ..

COMPOUNDS FOR THE TREATMENT OF PATHOLOGIES ASSOCIATED WITH AGING AND DEGENERATIVE DISORDERS

The present invention relates to methods of inhibiting one or more signs of aging and/or degenerative disorder in a subject in need of such treatment, which comprise administering, to the subject, an ..

PREDICTION AND PREVENTION OF PREECLAMPSIA

The present disclosure relates to methods for assessing increased risk of preeclampsia in a pregnant woman. The methods described herein employ measuring relaxin levels, and optionally measuring C-rea..

ANTICANCER VACCINE AND DIAGNOSTIC METHODS AND REAGENTS

The invention provides a method for vaccinating a patient against a malignancy comprising introducing a protein or peptide comprising of all or an immunogenic fragment of a cyclin protein into the pat..

BICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF

The present invention provides bicyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, and hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, such as..

TRICYCLIC COMPOUNDS HAVING ANTIMITOTIC AND/OR ANTITUMOR ACTIVITY AND METHODS OF USE THEREOF

The present invention provides tricyclic compounds, pharmaceutically acceptable salts, prodrugs, solvates, or hydrates thereof, having antimitotic activity, anti-multidrug resistance activity, for exa..

NOVEL COMPUNDS, PHARMACEUTICAL COMPOSITIONS CONTAINING SAME, AND METHODS OF USE FOR SAME

A pharmaceutical composition comprising a phamaceurtical diluent and a compound of formula IV wherein R21= H, C1-C20 alkyl, cycloalkyl, alkenyl, aryl, arylalkyl, or alkylaryl, -CH2OR25, -C(O)R25, -CO(..

METHOD FOR TREATMENT OF TUMORS USING NORDIHYDROGUALARETIC ACID DERIVATIVES

Pharmaceutical compositions comprising nordihydroguaiaretic derivatives and uses thereof to suppress Spl regulated promoter activity, arrest cell growth, stimulate apoptosis, and treat tumors.

CHIMERIC VACCINES

The invention provides chimeric proteins and nucleic acids encoding these which can be used to generate vaccines against selected antigens. In one aspect, a chimeric protein comprises an antigen seque..

ANTITHROMBOTIC AGENTS AND METHODS OF USE THEREOF

The instant invention provides methods and compositions for the treatment, prevention and diagnosis of for example, platelet aggregation or clot formation in a subject. The invention inhibits the acti..

FUSED DIIMIDAZODIAZEPINE COMPOUNDS AND METHODS OF USE AND MANUFACTURE THEREOF

he invention encompasses novel compounds and pharmaceutically acceptable salts thereof and compositions including therapeutically or prophylactically effective amounts of such compounds or pharmaceuti..

INHIBITORS OF HUMAN METHIONINE AMINOPEPTIDASE 1 AND METHODS OF TREATING DISORDERS

Described herein are novel pyrimidine-pyridine compounds, methods of inhibiting methionine aminopeptidase and treating disorders (or symptoms thereof) associated with methionine aminopeptidase, wherei..

N-ACYLOXYSULFONAMIDE AND N-HYDROXY-N-ACYLSULFONAMIDE DERIVATIVES

The invention provides certain N-acyloxysulfonamide and N-hydroxy-N-acylsulfonamide derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such comp..

BIS-ACYLATED HYDROXYLAMINE DERIVATIVES

The invention provides certain bis-acylated hydroxylamine derivative compounds, pharmaceutical compositions and kits comprising such compounds, and methods of using such compounds or pharmaceutical co..

TRIOXANE DIMER SULFUR COMPOUNDS

The disclosure provides novel trioxane sulfur dimers having Formula I: methods for their preparation, pharmaceutical compositions containing these compounds, and methods for treating cancer, prolifera..

Pharmaceutical Formulation for Regulating the Timed Release of Biologically Active Compounds Based on a Polymer Matrix

A formulation containing a biologically active compound having a structure with hydrogen bonding sites is blended with a polymer having a structure with complementary hydrogen bonding sites, the polym..

Soybean Oil Based Oxygen Carrying Emulsion for Massive Blood Loss

VivaSure is a new treatment for shock from massive blood loss. It is based on soybean oil and is therefore biodegradable. It refills lost vascular volume, protects from free radicals, absorbs toxins a..

THERAPEUTIC COMPOUNDS.

he invention provides compounds of formula (I) wherein A, B, R<1>, F, G, n, n' and the dotted line have any values defined herein, as well as salts thereof. The compounds have activity as anti-prolife..

SOLUBILIZED TOPOISOMERASE POISON AGENTS

The invention provides compounds of formula I: wherein A, B, W, Y, Z, and R1 have any of the meanings defined in the specification and their pharmaceutically acceptable salts. The invention also provi..

MULTIPLE PHASE CROSS-LINKED COMPOSITIONS AND USES THEREOF

The present invention is directed to pharmaceutical compositions, and method for preparing pharmaceutical compositions, comprising a cross-linked matrix physically entrapping at least one therapeutic ..

PHARMACEUTICAL PREPARATIONS HAVING INDIVIDUALIZED DOSAGE AND STRUCTURE

A manufacturing device capable of creating individualized dosages of pharmaceutical preparations in which a metering system and a means of performing non-destructive chemical analysis of individual ma..

METHYLENEDIOXYBENZO [I] PHENANTHRIDINE DERIVATIVES USED TO TREAT CANCER

The invention provides compounds of formula I: wherein A, B, X, and Y have any of the values defined in the specification, as well as pharmaceutical compositions comprising such compounds, processes f..

TYPE 5 ADENYLYL CYCLASE INHIBITORS FOR PROVIDING CARDIAC PROTECTION

The invention provides a method of treating a cardiac disease by administering a pharmaceutically effective amount of at least one compound capable of inhibiting AC5 to a patient. The compound capable..

THERAPEUTIC COMPOUNDS

The invention provides compounds of formula (I) wherein u, d, v, m, n, R1, W, X, Y, and Z have any values defined herein, as well as salts thereof. The compounds have activity as anti-proliferative ag..

COMPOSITIONS AND METHODS MODULATING MG29 FOR THE TREATMENT OF DIABETES

Disclosed herein are compositions and methods for treatment of muscle dysfunction, including diabetes. In addition, the invention relates to therapeutic compositions comprising nucleotides and/or poly..

ANTIMICROBIAL AGENTS

The invention provides a compound of formula (I): or a salt or prodrug thereof, wherein Y, W, Z, Z1, Z2, Z3, Z4, and R1- R12 have any of the values described in the specification, as well as compositi..

CYTOMEGALOVIRUS VACCINES AND METHODS OF PRODUCTION.

Methods of increasing diversity in cytomegalovirus vaccines through the selection of cell type in which the virus is propagated, and the use of cytomegalovirus produced by those methods in the develop..

INHIBITION OF GLYCEROL-3-PHOSPHATE ACYLTRANSFERASE (GPAT) AND ASSOCIATED ENZYMES FOR TREATMENT OF VIRAL INFECTIONS

A method of treating or preventing a viral infection in a mammal by administering a compound or pharmaceutically acceptable derivative thereof that inhibits a phosphatidic acid synthesis enzyme

ANTIBIOTIC COMPOUNDS

Methods for identifying prodrug antibiotic compounds and direct inhibitory antibiotic compounds utilizing various screens are provided. Also provided are methods for treating infections using these co..

COMPOSITIONS FOR TREATING BACTERIAL INFECTIONS

The present invention is antibiotic compositions having the ability to disrupt a MazEF complex in S. aureus. The compositions also have the ability to inhibit growth of S. aureus and as such are usefu..

INHIBITORS OF FRUCTOSE 1,6-BISPHOSPHATASE AND METHODS OF USE THEREOF

The invention is directed to a compound according to formula (I). The compounds of formula (I) include prodrugs, pharmaceutically acceptable salts, stereoisomer mixtures, and enantiomers thereof. The ..

NOVEL HETERO PYRROLE ANALOGS ACTING ON CANNAPINOID RECEPTORS

Disclosed are biologically active hetero pyrrole analogs such as imidazoles, thiazoles, oxazoles and pyrazoles capable of interacting with the CB1 and/or CB2 cannabinoid receptors. Aspects disclose he..

METHODS AND COMPOSITIONS FOR INHIBITING ATHEROSCLEROSIS AND VASCULAR INFLAMMATION

Disclosed herein are compositions and methods for reducing inflammation associated with atherosclerosis and/or vascular inflammatory disease. The methods include administering to a subject in need of ..

CHOLERA VACCINES

The methods and compositions of the present invention are directed to a vaccine against Vibrio cholerae comprised of V. cholerae outer membrane vesicles (OMVs). Such vaccines are relatively stable, fa..

SMALL MOLECULE ANTAGONISTS OF PHOSPHATIDYLINOSITOL-3, 4, 5-TRIPHOSPHATE (PIP3) AND USES THEREOF

Disclosed are a new class of non-lipid small molecule inhibitors which interfere with the interaction between PIP3 and pleckstrin homology domains. These molecules target a broad range of PIP3 -depend..

METHOD AND COMPOSITION FOR INHIBITING MULTI-DRUG RESISTANCE BY HYALURONAN OLIGOMER

PROBLEM TO BE SOLVED: To provide a pharmaceutical composition for treating multi-drug resistant cell. ; SOLUTION: The pharmaceutical composition includes a competing agent of hyaluronan interaction wi..

METHODS AND COMPOSITIONS FOR SPORE-BASED VACCINES

Methods for immunizing a subject to an infectious agent are provided, using vegetative cytoplasmic expression of an antigen encoding an infectious agent or spore surface display of the antigen, and co..

INDOLE COMPOUNDS AND METHODS OF USE THEREOF

Novel indole compounds are disclosed. Also disclosed are methods for using the compounds to treat human and animal disease, pharmaceutical compositions of the compounds, and kits including the compoun..

ANTIFUNGAL FORMULATION AND METHOD OF PREPARATION

A pharmaceutical preparation for treating a microbial infection such as a fungal or bacterial infection in an individual comprises a peptide or a pharmaceutically acceptable salt thereof, wherein said..

COMPOSITIONS AND METHODS FOR THE TREATMENT OF CYSTIC FIBROSIS

The invention is directed to novel pharmaceutical compositions comprising chemicals agents that are useful in the treatment and prevention of cystic fibrosis and the prevention of signs and symptoms o..

TETRAHYDROPYRANONAPHTHYRIDINES DERIVATIVES, PHARMACEUTICAL COMPOSITIONS AND THERAPEUTIC TREATMENT THEREOF

This invention relates to tetrahydropyranonaphthyridines derivatives having formula (III) or IV: and analogues of the tetrahydropyranonaphthyridines derivatives. The invention also relates to pharmace..

HUMAN ANTIBODIES AGAINST HEPATITIS C VIRUS (HCV) USES THEREOF.

Isolated human monoclonal antibodies which bind to hepatitis C virus (HCV), and related antibody-based compositions and molecules, are disclosed. The human antibodies can be produced in a transfectoma..

REAGENTS FOR RECOMBINOGENIC ENGINEERING AND USE THEREOF

The present invention features homologous recombination methods and systems. The methods and systems promote highly efficient homologous recombination in cells (e.g., in prokaryotic cells). The method..

ANTIBODIES TO TREAT CANCER

Compositions and methods for the treatment of cancer, particularly melanoma, myeloma, small cell lung cancer, thymic lymphoma, T-cell lymphoma, B-cell lymphoma, osteosarcoma, and acute T-cell leukemia..

ESPFU NUCLEIC ACIDS AND PROTEINS AND USES THEREOF

Disclosed are EspFU (EspF-like polypeptide encoded by a gene of the cryptic prophage CP-933U of enterohemorrhagic E. coli) polypeptides, fragments thereof, nucleic acids that encode EspFU polypeptides..

COMPOUNDS AND METHODS FOR TREATING MAMMALIAN GASTROINTESTINAL MICROBIAL INFECTIONS

Described herein are compounds, and pharmaceutically acceptable salts and prodrugs thereof, which are useful as inhibitors of IMPDH. In certain embodiments, a compound of the invention selectively inh..

COMPOSITIONS WITH ENHANCED BIOAVAILABILITY AND FAST ACTING INHIBITOR OF GASTRIC ACID SECRETION

The present invention relates to the use of pharmaceutically acceptable zinc salts, preferably water soluble zinc salts alone or optionally, in combination with one or more of a protein pump inhibitor..

METHODS OF TREATING CANCER AND OTHER CONDITIONS OR DISEASE STATES USING LFMAU AND LDT

The present invention relates to the use of the compound according to formula (I), below for the treatment of tumors, cancer and hyperproliferative diseases, among other conditions or disease states: ..

Anti-inflammatory compounds and uses thereof

The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides met..

IMMUNOGENIC EPITOPES AS TARGETS FOR UNIVERSAL CANCER VACCINES

The present invention provides a peptide having an amino acid sequence as set forth in SEQ ID NOs: 1 through 95 and any combination there of. The peptide or combination of peptides possess 0CT4 specif..

ANTI-INFLAMMATORY COMPOUNDS AND USES THEREOF

The present invention provides anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of use thereof for treating inflammatory disorders. The present invention also provides met..

ANTI-HEPATITIS C ACTIVITY OF MESO-TETRAKIS-PORPHYRIN ANALOGUES

The present invention relates to porphyrin analogues, their use in pharmaceutical compositions alone, or combination with other agents and in the treatment and/or prophylaxis of flaviviridae viral inf..

MIF MODULATORS

The invention provides novel heterocyclic compounds, pharmaceutical compositions and methods of treatment that modulate levels of MIF expression and treat disorders associated with high or low levels ..

USE OF HSP90 PROTEIN INHIBITING COMPOUNDS AND PHARMACEUTICAL COMPOSITION INTENDED FOR ANTI-TUMOUR THERAPY

The invention relates to a method for designing an individual anti-tumour therapy for a patient based on the detection of the levels of the Hsp90 protein responsible for resistance to a drug or a mixt..

METHOD FOR MARKING AND IDENTIFYING MANUFACTURED ARTICLES, SUBSTANCES AND ORGANISMS, AND USES THEREOF

The present invention comprises a method for marking and identifying manufactured articles, substances and organisms (referred to below as "products"), based on the addition to the product to be marke..

SPIROPIPERIDYL RIFAMYCINS FOR THE TREATMENT OF MICROBACTERIAL INFECTIONS

The compounds of formula (1), their pharmaceutically acceptable salts and their solvates, wherein R 1 is a radical selected between hydrogen and alkyl; R 2 is selected from hydroxyalkyl, phenyl, pheny..

DEUTERATED TAPAZOLE AND DERIVATIVES, PREPARATION METHOD THEREFOR AND USE OF SAME

The invention relates to deuterated compounds having formula (I) in which R1, R2 and R3 represent independently a hydrogen atom or a C1-C4alkyl group, optionally substituted with: a -OR4 group, R4 rep..

RECOMBINANT ANTIGEN

The invention relates to a recombinant peptide of the catalytic subunit of the serine/threonine protein phosphatase of Angiostrongylus costaricensis and active peptides used in the production of an in..

PEPTIDES FOR THE TREATMENT OF OCULAR HYPERTENSION AND/OR GLAUCOMA

The invention relates to peptide compounds with the amino acid sequence having formula (I): Tyr-Ala-Arg-Ala-Ala-Ala-Arg-Gln-Ala-Arg-Ala-(X)-Ser-Asp-Gly-Gly-pTyr-Met- Asp-Met-Ser (I), wherein (X) is no..

BISTHIAZOLE COMPOUNDS THAT CAN BE USED TO TREAT CANCER

The invention relates to compounds having formula (I), the pharmaceutically acceptable salts thereof, or the solvates of same, wherein: Ri is selected from phenyl, optionally mono-, di- or tri-substit..

TRITERPENOID DERIVATIVES USEFUL AS ANTIPROLIFERATIVE AGENTS

Formule (I) and (II). The present invention relates to the use of a new lupane derivative of general formula (I) or (II), or a pharmaceutically acceptable salt, crystal form, complex, hydrate, or hydr..

METHOD FOR SCREENING COMPOUNDS FOR THE TREATMENT OR PREVENTION OF COLON CANCER

The invention is in the field of molecular medicine, more in particular in the field of identifying new compounds for the treatment or prevention of colorectal cancer. The invention provides a method ..

ANTAGONISTIC PEPTIDES FOR FRIZZLED-1 AND FRIZZLED-2

The invention is in the field of molecular medicine. It provides antagonistic compounds for frizzled-1and/or frizzled-2 receptors which may be useful in molecular imaging of the wound healing process ..

METHOD FOR THE TREATMENT OF ISCHEMIA REPERFUSION INJURY

The invention is in the field of thrombosis, haemostasis, cardiology, medicinal chemistry and/or pharmacology. More particularly, it relates to the use of a mutant activated protein C (APC) for the tr..

A3 ADENOSINE RECEPTOR ALLOSTERIC MODULATORS

The present invention relates to allosteric modulation of A3 adenosine receptor (A3AR) and provides for the use of an A3 adenosine receptor modulator (A3RM),for the preparation of pharmaceutical compo..

COMPOUNDS AND USES

The invention relates to a compound having the formula of structure (I): or a pharmaceutically acceptable salt thereof, for use in treating a LH receptor-related condition.

NOVEL ANTIMALARIAL 3-AZABICYCLO[3.2.2]NONANE DERIVATIVES

The present invention relates to novel 3-azabicyclo[3.2.2]nonane derivatives of the general formula (I) or a pharmaceutically acceptable salt thereof wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R10..

TRYPTAMINE-DERIVED COMPOUNDS AS ANTIBACTERIAL AGENTS

The present invention relates to a compound according to formula I, a pharmaceutically acceptable salt and/or N-oxide thereof for use as an antibacterial agent.

WATER SOLUBLE CURCUMIN COMPOSITIONS FOR USE IN ANTI-CANCER AND ANTI-INFLAMMATORY THERAPY

The present invention relates to the medical field. In a first aspect the present invention relates to novel water soluble cyclodextrin-curcumin complexes having a pharmacological activity, in particu..

METHOD FOR GENERATING ISLET BETA CELLS FROM DEDIFFERENTIATED EXOCRINE PANCREATIC CELLS

The present invention relates to an in vitro method for generating insulin-producing beta cells from a population of mammalian cells comprising dedifferentiated exocrine pancreatic cells. The method c..

IN VITRO CULTIVATION OF HELICOBACTER SPECIES.

The present invention relates to media and methods for the isolation and cultivation of "Candidatus Helicobacter suis" and isolates of "Candidatus Helicobacter suis" obtainable by these methods. The p..

Novel Vaccine Against Trypanosoma Cruzi Infection

The present invention relates to a vaccine against Trypanosoma cruzi infection, useful in the prevention and/or treatment of the Chagas disease. More specifically, the present invention relates to a r..

IMMEDIATE RELEASE PHARMACEUTICAL GRANULE COMPOSITIONS AND A CONTINUOUS PROCESS FOR MAKING THEM

A pharmaceutical or veterinary granule composition in the form of a mixture consisting essentially of: (i) at least one drug classifiable as Class II or Class IV of the Biopharmaceutical Classificatio..

VITAMIN D3 ANALOGUES FOR THE PREVENTION AND TREATMENT OF BONE DISORDERS

Novel vitamin D analogues are useful for making pharmaceutical compositions for the prevention or treatment of bone disorders such as osteoporosis

STREPTOCOCCUS PNEUMONIAE VACCINES

Streptococcus pneumoniae is a major cause of pneumoniae, meningitis, and major cause of morbidity and mortality throughout the world by bacterial otitis media, pneumoniae, meningitis, and bacteraemia...

NOVEL BICYCLIC HETEROCYCLES

The present invention relates to compound of formula I, II, III, or IV, and/or a pharmaceutical acceptable addition salt thereof and/or a stereoisomer thereof and/or a solvate thereof, wherein R1, R2,..

MORPHOLINE DERIVATIVES USED AS ANTIFUNGAL COMPOUNDS

The present invention relates to a series of novel compounds (I) which have been shown to possess antifungal activity. The invention therefore relates to the new compounds, methods for their preparati..

INDOLE AMIDE DERIVATIVES AND RELATED COMPOUNDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES

This invention provides novel compounds and the novel compounds for use as a medicine, more in particular for the prevention or treatment of neurodegenerative disorders, more specifically certain neur..

ANTI-VIRAL PYRIMIDINE NUCLEOSIDE DERIVATIVES

A compound for use in the treatment or prophylaxis of viral infections such, for example as chicken pox or shingles caused by the Varicella Zoster virus, said compound having the general formula (II):..

SYNTHESIS OF RESORCYLIC ACID LACTONES USEFUL AS THERAPEUTIC AGENTS.

Disclosed are macrocyclic compounds of formulae I, I', II, II', III, III', IV, and V, which are analogs of the pochonin resorcylic acid lactones, pharmaceutical compositions comprising the compounds, ..

ORAL GALENIC FORM, POLYMER PRODUCTION METHOD AND USE OF SAME

The polymers according to the invention comprise a polysaccharide block (17) and several hydrophobic polyacrylic blocks (18) enabling the polymer to remain intact until it reaches the colon. The polys..

HYDROXY-BISPHOSPHONIC ACID DERIVATIVES AS VECTOR FOR TARGETING BONE TISSUE

The present invention relates to hydroxy-bisphosphonic acid derivatives corresponding to general formula (I): in which: - n and m denote, independently of one another, an integer ranging from 1 to 4, ..

Piperidine derivatives, process for their preparation and pharmaceutical compositions containing them

Phenyl-carbamic acid piperidin-3-yl ester compounds (I) and their enantiomers, and addition salts with an acid or a base are new. Phenyl-carbamic acid piperidin-3-yl ester compounds of formula (I) and..

ANXIOLYTIC COMPOSITION CONTAINING ALPHAs-CASEIN -DERIVED PEPTIDES

The invention relates to pharmaceutical compositions and food products containing peptides derived from the as1-casein in milk and having benzodiazepine-type activity and particularly, anxiolytic acti..

STAMBOMYCIN AND DERIVATIVES, THEIR PRODUCTION AND THEIR USE AS DRUGS

The present invention relates to Stambomycin compounds, their derivatives and their pharmaceutically acceptable salt thereof.

Casein-Derived Peptides having Anxiolytic Activity

The invention relates to peptides and, in particular, heptapeptides derived from milk casein [alpha]s1 and having anxiolytic activity. The invention also relates to pharmaceutical and food composition..

PEPTIDES MODULATING THE ACTIVITY OF IGF-1 AND THE APPLICATIONS OF SAID PEPTIDES

The invention relates to peptides that can modulate the activity of IGF-1, to a pharmaceutical composition containing said peptides, and to the applications thereof as medicaments and agents for the i..

ANALOGS OF TEMPORIN-SHA, AND USES THEREOF

The present invention relates to novel antimicrobial peptides, to pharmaceutical compositions including said peptides, and to the uses thereof, in particular as antimicrobial drugs, disinfectants, pes..

NITROGEN HETEROCYCLE DERIVATIVES AS PROTEASOME MODULATORS

The instant invention relates to the use of at least one nitrogen heterocycle derivative of formula (I): as proteasome activity modulator in the manufacture of a pharmaceutical composition intended to..

VIRAL ENCODED PELLINO PROTEIN AND ITS USES

This invention relates to a pharmaceutical composition. In particular, it relates to a virally encoded form of a Pellino protein and its use in the regulation of signalling pathways that are associate..

GUANIDINE BASED COMPOUNDS

The adrenergic receptors or adrenoceptors are a family of G-protein coupled receptors split into a and ss subclasses. The adrenoceptors have important roles in regulating a myriad of physiological con..

MODIFIED HELICOBACTER PROTEIN

A vaccine comprising a structurally modified AhpC protein for inducing immunoreactivity against Helicobacter pylori. The structurally modified AhpC protein may have a molecular weight of between about..

TREATMENT OF MICROBIAL INFECTIONS

The present invention is directed to improved microbial antigen vaccines, pharmaceutical compositions, immunogenic compositions and antibodies and their use in the treatment of microbial infections, p..

EFFICIENT ASPIRIN PRODRUGS

Aspirin is one of the most widely used drugs in the treatment of inflammation, pain and fever. It has more recently found application in the prevention of heart attacks and stroke and is being studied..

SOLUBLE INFLUENZA VACCINE

The invention provides fusion proteins comprising: (i) a first portion comprising an influenza A M2e polypeptide, and (ii) a second portion comprising a rotaviral NSP4 polypeptide. The fusion proteins..

PDZ DOMAIN MODULATORS

This invention relates to compounds useful as PDZ domain modulators, in particular the PDZ domain of PICK1. In other aspects the invention relates to the use of these compounds in a method for therapy..

Vaccine

The invention provides a vaccine comprising secreted protein derived from Mycobacterium avium subsp paratuberculosis (M. ptb) substantially free of whole organisms of that species either dead or alive..

MULTI-COMPONENT COMPOSITIONS AND METHODS FOR DELIVERY OF ANTI-CANCER AGENTS

The present invention relates to a composition for the treatment or prevention of cancer, the composition comprising 5-fluorouracil, or a pharmaceutically acceptable salt or analogue thereof; folinic ..

GROUP A STREPTOCOCCUS PHARMACEUTICAL COMPOSITIONS AND METHODS THEREOF

Isolated proteins and immunogenic fragments thereof, for use in the treatment and prevention of a Group A Streptococcus infection are provided. In particular, the invention provides pharmaceutical com..

COMPOSITIONS AND METHODS FOR DELIVERY OF ANTI-CANCER AGENTS

The present invention relates to compositions comprising 5-fluorouracil, or a pharmaceutically acceptable salt or analogue thereof, folinic acid, or a pharmaceutically acceptable salt thereof and a cy..

ANTIMICROBIAL COMPOUNDS

The present invention relates to antimicrobial compounds and their uses, and in particular to peptide antibiotics which may be used in the treatment of Gram-negative bacterial infections.

COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE

The present invention relates to pharmaceutical compositions for the treatment and/or prophylaxis of disease associated with fibrosis in a vertebrate, said composition comprising at least one activin ..

A METHOD FOR TREATING OBESITY

A method and pharmaceutical composition for treating a disease or condition associated with elevated hypothalamic T cell protein tyrosine phosphatase (TCPTP) such as obesity, weight gain, type 2 diabe..

2-ARYLPYRAZOLO[L,5-alpha]PYRIMIDIN-3-YL ACETAMIDE DERIVATIVES AS LIGANDS FOR TRANSLOCATOR PROTEIN(18 KDA)

The invention provides compounds of formula (I) radiolabelled with 18F, 123I, 76Br, 124I or75Br and salts thereof, and a method of imaging translocator protein (18kDa) (TSPO) in a subject comprising a..

ADMINISTRABLE COMPOSITIONS

The present invention relates to a composition suitable for administration to a subject, the composition comprising pharmacologically acceptable particulate material dispersed throughout a pharmacolog..

HALOGENATED ANALOGUES OF ANTI-FIBROTIC AGENTS

The present invention relates to halogenated compounds of formula (I) with the substituents as described within the specification. The compounds may be useful as anti-fibrqtic agents. The present inve..

POROUS SILICA SHELL-MEDIATED ASSEMBLY OF MACROMOLECULAR CAPSULES

The present invention relates to a process of preparing macromolecular capsules. In particular, the invention relates to the use of a template with a permeable shell and an impermeable core for prepar..

A TEMPERATURE SENSITIVE VACCINE STRAIN OF MYCOPLASMA HYOPNEUMONIAE AND USES THEREOF

The present invention relates to a Mycoplasma hyopneumoniae vaccine strain comprising a mutation in at least one of the genes listed or as deposited with the National Measurements Institute (Australia..

Polypeptides et polynucleotides de phorphorymonas gingivalis

The present invention relates to isolated Porphorymonas gingivalis polypeptides and nucleotides. The polypeptides include; an amino acid sequence selected from the group consisting of SEQ. ID. NO. 265..

A SYNTHETIC VACCINE COMPONENT

The present invention relates generally to the field of synthetic vaccines, components thereof and methods for producing same. More particularly, the present invention provides a component of syntheti..

DINUCLEAR, QUADRUPLY-STRANDED COMPOUNDS COMPRISING PALLADIUM OR PLATINUM

The invention relates to a compound of formula (M2L4 where: M = a palladium or platinum metal ion; L = X = -O-, -S-, -NH-, or (-CH2-)n, where n = 1, 2 or 3; R2, R4, R5, R6 are each independently selec..

ANTI-CANCER COMPOSITION COMPRISING ALGINATE

The present invention relates to a biologically acceptable composition for the prophylaxis and/or treatment of colorectal cancer comprising an iron chelator, wherein the composition is adapted for the..

USE OF PHARMACEUTICAL COMPOUND CONTAINING CROTOXIN FOR THE TREATMENT OF MUSCLE DYSTONIAS

The present invention is related to the use of a pharmaceutical compound containing a toxin extracted from the rattlesnake (Crotalus durissus terrificus) venom, known as crotoxin, which can act as an ..

METHODS FOR SYNTHESIZING GLYCINOLS, GLYCEOLLINS I AND II, COMPOSITIONS OF SELECTED INTERMEDIATES, AND THERAPEUTIC USES THEREOF

Two distinct methods are disclosed and claimed for synthesizing glyceollin I plus glyceollin II as a mixture and as their pure forms. Stereochemical isomers and various synthetic intermediates are als..

THERAPEUTIC ARYL-AM I DO-ARYL COMPOUNDS AND THEIR USE

The present invention pertains generally to the field of therapeutic compounds, and more specifically to certain aryl-amido-aryl compounds of the following formula (for convenience, collectively refer..

HOT-MELT EXTRUSION OF MODIFIED RELEASE MULTI-PARTICULATES

The present invention includes compositions and methods of making a modified release pharmaceutical formulation and a method of preparation for the embedding of modified release multi-particulates int..

USE OF RIBOFLAVIN IN THE TREATMENT OF HYPERTENSION.

The invention provides the use of riboflavin in the manufacture of a medicament for the treatment or prophylaxis of elevated blood pressure in a subject homozygous or heterozygous for the MTHFR C677T ..

COMBINATIONS COMPRISING EPOTHILONE DERIVATIVES AND ALKYLATING AGENTS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM

The invention relates to a pharmaceutical combination which comprises (a) an alkylating agent and (b) an epothilone derivative of formula (I) wherein A represents O or NRN, wherein RN is hydrogen or l..

P53 TUMOR SUPPRESSOR PROTEIN ACTIVATING

The invention provides a compound of formula (I), wherein X, L1-4 and R1-4 are as defined herein, with the proviso that the compound is not (i) 4-benzoyl-3,5-dimethyl-1H-pyrrole-2-carboxylic acid ethy..

PYRIMIDE DERIVATIVES AND THEIR PHARMACEUTICAL USE

The invention provides a compound according to formula (I): wherein: X is O or S; Y is O or S; each Ar and Ar' is independently a mono-, bi- or tricyclic aryl or heteroaryl group optionally substitute..

SingleC-9 Binding Agents

The present invention relates to agents capable of binding sialic acid-binding immunoglobulin-like lectin-9 (Siglec-9) and their use in the treatment of cell proliferation and differentiation disorder..

USE OF TIAMULIN AS AN ANTIVIRAL AGENT

The invention relates to an antiviral medicament produced using an antibiotic. The invention relates to the use of an antibiotic in the preparation an antiviral medicament. The invention also relat..

METHODS FOR IDENTIFICATION

The invention relates to methods for the discovery of new chemical entities and pharmaceutical compositions with broad-spectrum chemokine inhibitor (BSCI) activity, together with the use of such agent..

IMPROVED METHODS FOR IDENTIFICATION

The invention relates to methods for the discovery of new chemical entities and pharmaceutical compositions with broad-spectrum chemokine inhibitor (BSCI) activity, together with the use of such agent..

FUSION POLYPEPTIDE COMPRISING S-ANTIGEN REPEAT UNITS

The present invention relates to a fusion polypeptide comprising a) at least one fragment of the Plasmodium falciparum S-antigen or a variant thereof, wherein the fragment comprises one or a plurality..

ANTI-INFLAMMATORY COMPOSITIONS AND COMBINATIONS

Use of broad-spectrum chemokine inhibitors (BSCIs), and in particular members of the acylaminolactam class of pharmaceutical agents, for the prevention, prophylaxis, treatment or amelioration of sympt..

Anti-inflammatory composition

The invention relates to 3-(2',2'-dimethylpropanoylamino)-tetrahydropyridin-2-one, and its pharmaceutical compositions and its use for preparing a medicament intended to prevent or treat inflammatory ..

Dimethylthiofoxins and azafoxins which may be useful as ligands for G-protein coupled receptors

The invention provides compounds of general formulae (II) or (III), or pharmaceutically acceptable salts thereof. X is -CO-(Y)k-(Z)nor -SO2-(Y)k-(Z)nwherein k is 0 or 1, each Y is a cycloalkyl, polycy..

NOVEL ANTIBIOTIC COMPOSITIONS

This invention is directed to antibiotic compositions comprising a targeting moiety covalently linked to an antibiotic moiety. This invention is also directed to pharmaceutical compositions comprising..

Anti-inflammatory agents

The invention provides compounds, pharmaceutical compositions and uses of compounds and salts thereof of general formula (I), for the preparation of a medicament for treatment of an inflammatory disor..

Magnetically-controlled micro-fluid system for e.g. 'lab-on-chip' system for determination of presence of bio-molecules, virus, biological cells

A micro-fluid system transports tiny particulate quantities of a biological or pharmaceutical liquid sample through a channel exposed to the effect of a magnetic force generated nearby. The channel is..

Quantitative Screening Assay for Protein Surface Changes

Isis Project No 3849 A new Quantitative Profiling Of biotinylation Patterns (Q-POP) assay, to enable screening for protein surface changes following protein-protein interaction. Potential applications..

High-throughput Screening of Membrane Proteins

Isis Project No 3329 A novel method for producing synthetic biological membranes has potential in new high-throughput screens of membrane protein function and drug interactions. Marketing Opportun..

Improved Physical Methods for Increasing Stereoselectivity

BACKGROUND: Since 1988, the Food & Drug Administration has required that the enantiomeric composition of all drugs be known, making stereoselective reactions essential for the pharmaceuticals industry..

Bifunctional Catalysts and Methods for Synthesis of Impermeable and Semipermeable Coatings

BACKGROUND: Fields that involve the handling of sensitive materials, such as electronics, chemicals, and biological agents need a means of safely isolating these items to protect them or the outside ..

One-Pot Organocopper Chemistry and Stereospecific Nucleoside Formation

A researcher at the University of California has made several inventions related to organic syntheses involving higher-order cuprates. Higher-order organocuprates are reagents containing copper atoms ..

DNA Binding Compounds for Genetic Regulation and Medical Diagnosis and Therapy

Compounds that bind to DNA could be used to target drugs to DNA and to regulate expression of genes. Indeed, many compounds have been discovered (e.g. Distamycin) which bind to the minor groove of DN..

RNA Nano-Constructions for Cell Detection and Drug Delivery

BACKGROUND: RNA has been previously demonstrated to assemble into nanoparticles of various shapes and sizes. These nanoparticles are able to carry various non-RNA components, including molecules for s..

Multiplexing Protein Binding Microarrays for Genetic Analysis

BACKGROUND: Our ability to understand and practically benefit from the control logic encoded in the human genome is currently limited by a lack of accurate information regarding promoter regulation. G..

Novel Agents that act in Steroid-like signaling pathways in Medicine and Agriculture

BACKGROUND: The END-2 protein of the nematode Caenorhabditis elegans is a member of the nuclear hormone receptor family. Classically, nuclear hormone receptors are thought to be localized in the cyto..

Methods for Identifying Novel Therapeutics and Diagnostics in the p53 Pathway

BACKGROUND: Current non-surgical cancer therapies rely on the use of compounds or radiation doses that are non-specific for the tumor cells and are highly toxic to humans. Although these treatments ar..

Safe and Potent Synthetic Lung Surfactant for Treating RDS and Acute Asthma

BACKGROUND: The use of lung surfactant dispersions, based on lipid and protein components extracted from animal lung tissue, has significantly reduced mortality and morbidity from respiratory distress..

Enzyme for Antimicrobial and Vaccine Development

Scientists at the University of California have shown that a specific enzyme is an essential regulator of Salmonella virulence. This enzyme is prevalent in many organisms including most enterobacteria..

Initiators for Block-Copolypeptide Synthesis

BACKGROUND: Amino acid-N-carboxyanhydride (NCA) polymerizations employing conventional initiators (e.g. hexylamine or sodium methoxide) are plagued by chain-breaking transfer and termination reactions..

Tools for the Genetic Manipulation of Fusobacterium Nucleatum

BACKGROUND: Fusobatcerium nucleatum is an anaerobic Gram-negative microorganism that is commonly found in the mouth. For example, Fusobacterium nucleatum is the most frequently isolated pathogen from..

BPM-3, a Negataive Determinant of Bone Density

BACKGROUND: Bone morphogenetic proteins (BMPs) are members of the TGFb superfamily, a large family of growth factors with varied functions. BMPs induce the formation of cartilage and bone by influenci..

EPLIN, a marker for human Cancer

BACKGROUND: EPLIN, a novel gene not previously described encodes a protein expressed in human epithelial cells. EPLIN is of significant importance because its expression is diminished in many forms of..

A Novel Tumor Suppressor Gene

BACKGROUND: Tumor suppressor genes are genes that, when damaged, fail to suppress tumorigenesis. Typically, tumor suppressor genes are genes that, in their wild-type alleles, express proteins that su..

Antibody Fusion Proteins for treating Cancer

University of California researchers have developed a family of antibody fusion proteins with a potential for various therapeutic applications. These inventions represent both novel technologies and p..

High-Speed, High-Resolution Impedance Sensor

BACKGROUND: While there has been extensive work in developing radio-frequency probes for measuring proximal impedances in air, these probes have been limited to applications using good conductors as t..

A Novel Mechanism and Target for Asthma Intervention

The Challenge Asthma is a chronic inflammatory disorder of the airways characterized by an obstruction of airflow, usually caused by mucus overproduction. Currently, most treatments for mucus hyp..

Linker Microemulsions as a Transdermal Drug Delivery Vehicle

The Challenge A key challenge in developing an effective transdermal delivery system for hydrophobic compounds, involves the creation of formulations that balance high permeability of the stratum c..

Rapid Protection from Neuronal Failure following Heat-stroke and Hyperthermia

The Technology We have identified that the down-regulation and reduced activity of certain protein kinase signaling molecules by pharmacological intervention allows the central nervous system t..

Rim 3F4 Hybridoma Cell Line

The University of British Columbia have developed a cell line for the Rim 3F4 antibody and have isolated and characterized the epitope sequence in the Rim 3F4 protein. The epitope sequence is amenable..

Rho 1D4 Antibody

Dr. Robert Molday and coworkers at The University of British Columbia, have developed a cell line for the Rho 1D4 antibody and have isolated and characterized the epitope sequence in Rho 1D4 (9 amino ..

The Ocean Surface Wave Identification and Tracking System (WITS)

APL-WAVES is a set of integrated software tools for the analysis and display of ocean surface directional wave data and related information. Custom wave partitioning and tracking tools provide compreh..

Advantages of Insulin Delivered as an Aerosol Through the Lungs

A method of delivering a protein, in particular insulin, to the lungs. The method is characterized in that an aerosolized mist of small particles is produced in an associated medicament delivery chamb..

A New Potent Irreversible Inhibitor of y-Aminobutyric Acid Aminotransferase (21058/23058)

A promising new candidate inhibitor of the enzyme gamma-aminobutyric acid aminotransferase, critical to central nervous system disorders, has been prepared. Therapeutic potential in the treatment of e..

Inhibitors of B-Lactamases and Uses Therefor (22090, et al)

Over 100 novel inhibitors to b-lactamase, an enzyme that hydrolyzes the lactam ring of the b-lactam containing antibiotics to render the antibiotic inactive, have been identified and developed at Nort..

Protein Kinase Targeted Therapeutics (26087)

A validated novel compound and medicinal chemistry refinement for bioavailable small molecule inhibitors of protein kinases or protein kinase-mediated cellular stress response pathways. ADVANTAGES..

Clock Gene and Gene Product

Pharmaceutical control of circadian rhythms, whether directly through CLOCK or through other components of the pathway, has a wide range of applications. U. S. Patent Nos. 5,874,241 ,6,057,125, 6..

Formulation of Toll-like Receptor Ligand with Whole Cell Tumor Vaccine to Enhance Anti-tumor Responses

Established reports in literature have shown that the innate immune system can modulate immune responses against cancer. Lipopolysaccharide (LPS), a Toll-like receptor ligand 4 (TLR4), was absorbed on..

Use of High-dose Oxazaphosphorine Drugs in Combination with Monoclonal Antibodies for Treating Immune Disorders

(Set) Autoimmune diseases afflict more than 8 million people in the U.S alone. Autoimmunity usually occurs when lymphocytes, which are designed to defend the body against infections and foreign agent..

Use of High Dose Cyclophosphamide in Combination with Immune Therapeutics in Anti-Cancer Therapy

Cyclophosphamide and especially high-dose cyclophosphamide has been used for the treatment of certain autoimmune diseases such as severe aplastic anemia. Low to intermediate doses of cyclophosphamide ..

Emission Ratiometric Kinase Activity Reports in High Throughput Drug Screening and Analysis

Protein phosphorylation is one of the major regulatory mechanisms controlling cellular functions and aberrant kinase activities are found to form the molecular basis for many disease phenotyes. As a r..

PS-341 Rescues Cystic Fibrosis Transmembrane Regulator (CFTR) from Endoplasmic Reticulum Mediated Degradation

Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded, damaged, or mutant proteins with abnormal conformation from the cell. The most common disease-causing protein fol..

Valosin Containing Protein (VCP)/p97 Gene Inhibition Rescues cystic Fibrosis Transmembrane Regulator (CFTR) from Endoplasmic Reticulum Mediated Degradation

Endoplasmic reticulum (ER)-associated protein degradation (ERAD) eliminates misfolded, damaged, or mutant proteins with abnormal conformation from the cell. The most common disease-causing protein fol..

Nrf2 as a Target for Intervening Pulmonary and Systemic Inflammation

Sustained inflammation is critical in the development of several pathophysiological diseases such as Chronic Obstructive Pulmonary Disease (COPD), asthma, sepsis, acute lung injury, cardiovascular di..

Inhibiting Binding of Inducible Nitric Oxide Synthase to Cyclooxygenase-2 to Treat Inflammation

Cyclooxygenase (C0X2) and inducible nitric oxide synthase (iNOS) are two major inflammatory mediators. Inducible NOS specifically binds to C0X2 and S-nitrosylates it, enhancing C0X2 catalytic activity..

Selectively Targeted Histone Deacetylase Inhibitors

Inhibitors of histone deacetylases (HDAC) are regarded as an important approach to cancer chemotherapy, since they disrupt the aberrant cellular metabolism that occurs in many tumor types. The HDAC in..

Use of Consensus Sequence as Vaccine Antigen to Enhance Recognition of Virulent Viral Variants

Vaccines for diverse viruses will be most effective when they direct the recipient?s response to recognize the most virulent form of the organism. Scientists at JHU have found that circulating strains..

Method for Targeting Motor Neurons

Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy are disorders of motor neurons for which there is presently no effective treatment. As understanding of the mechanisms of these conditions inc..

Immune Modulation Through Targeting of the MINOR Gene

this gene will induce apoptosis in dendritic cells, thereby limiting immune responses. Inhibition of the gene will prevent dendritic cell death, thereby enhancing immune responses. Dendritic cells are..

Molecular Switches and Methods for Making and Using the Same Involving the Circular Permutation of DNA

The invention provides molecular switches which couple external signals to functionality and to methods of making and using the same. The switches according to the invention can be used, for example, ..

Suppression of HIV Replication and Prevention/Treatment of HIV-Associated Dementia by Minocycline

This invention describes the addition of a tetracycline derviative to existing combinations of antiretroviral drugs for treatment of HIV-infected individuals. JHU researchers have determined that the ..

Antitumor Effects Generated by pNGVL4a-Sig/E7 (detox)/HSP70 DNA Vaccine Administered Through Gene Gun, Biojector and Syringe

DNA vaccines have emerged as an attractive approach for antigen-specific cancer immunotherapy. We have previously linked Mycobacterium tuberculosis heat shock protein 70 (HSP70) to human papillomaviru..

Use of Hedgehog Pathway Inhibitors in Small Cell Lung Cancer

We have shown that small cell lung cancer (SCLC), a highly aggressive and frequently lethal tumor, uses an embryonic signaling pathway to promote its growth. This signaling pathway is known as the Hed..

Method for producing diverse libraries of encoded polymers

With our reagents, libraries of drug-like molecules are rendered in a format where they can be subjected to evolution. This enables processing of libraries that are about 10 orders of magnitude more ..

Inhibitors of N-ethylmaleimide Sensitive Factor

JHU researchers have discovered that a previously described protein N-ethylmaleimide Sensitive Factor (NSF) regulates thrombosis. Inhibition of NSF, by certain cell permeable peptides, has been disco..

Comparison of HPV DNA Vaccines Employing Intracellular Targeting Strategies

Human papillomavirus (HPV) E6 and E7 are consistently expressed and are responsible for the malignant transformation of HPV-associated lesions. Thus, E6 and E7 represent ideal targets for therapeutic..

A Molecular Mechanism for Action of Immunophilins and a Method to Identify Novel Pharmaceuticals

The immunophilins are a family of proteins that are functionally related by their rotamase activity (ie they are peptidylprolyl isomerases, PPIase) and their ability to bind immunosuppressive drugs su..

Enhancement of Adenoviral Oncolytic Activity by Modification of the E1A Gene Product

The present invention relates to compositions and methods for enhancing the oncolytic activity of replication-competent, target cell-specific adenovirus vectors by modification of the E1A gene product..

inhibition of Tumor Growth Through Reduction of Peroxiredoxin 3 levels

The primary transforming activity of MYC is thought to arise through transcriptional regulation of numerous target genes. Scientists at Johns Hopkins have demonstrated that PRDX3, which encodes a mito..

3-BROMOPYRUVIC ACID As a Potent Anticancer Agent Delivered Intraarterially

Liver cancer is one of the most common fatal cancers in the world and may reach epidemic levels in the future due to increased viral hepatitis. Current treatment options are rarely successful indicati..

Use of Proaerolysin Toxins Modified to Contain Tissue Specific Protease Activation Sequences as Targeted Therapy For Cancer

Proaerolysin is a bacterial toxin that is normally activated by furin protease to produce the pore forming toxin aerolysin which is toxic to prostate cancer cells at picomolar concentrations. We have ..

Modulation of systemic Immune Responses by Transplantation of Hemotopoietic Stem Cells Transduced with Genes Encoding Antigens and Antigen Presenting Cell Regulatory Molecules

The initiation of T cell-dependent immune responses depends on presentation of antigens by bone marrow-derived antigen-presenting cells such as dendritic cells. Tolerance induction depends on expressi..

Oncogenic Osteomalacia-Related Gene 1: MEPE

This invention provides isolated polynucleotides encoding an oncogenic osteomalacia-related factor and polypeptides encoded by this polynucleotide. Expression systems, including gene delivery vehicles..

Phosphatonin-Related Gene: FRP - 4

This invention provides methods for modulating phosphate homeostasis and renal phosphate transport by delivering agents that alter the expression of the FRP-4 gene or alter the activity of the FRP-4 p..

Enhancement of Suicidal DNA Vaccine Potency by Linkage Mycobacterium Tuberculosis Heat Shock Protein 70 to an Antigen

Naked DNA vaccines represent an attractive approach for generating antigen-specific immunity because of their stability and simplicity of delivery. There are particular concerns, however, such as pote..

A Method for Generating Constitutively Active Transmembrane Proteins

The present invention related to methods and reagents for generating and using activating mutations of receptors and ion channels.

Enhancement of Nucleic Acid Vaccine Potency by Intercellular Spreading and Enhancement of MHC Class I Presentation of Antigen Linked to Herpesvirus VP22 Protein

The potency of naked DNA vaccines is limited by their inability to amplify and spread in vivo. VP22, a herpes simplex virus type 1 (HSV-1) protein, has demonstrated the remarkable property of interce..

Gene Responsible for Stargardt-like Dominant Macular Dystrophy

The gene responsible for Stargardt-like macular dystrophy has been identified, along with its normal allelic form. The mutant gene encodes a mutant protein containing a frameshift mutation, resulting ..

Oral Gene Delivery for Hemophilia

This invention is a non-viral trans gene delivery system developed for the long-term treatment of genetic disease. A recombinant plasmid construct with a cDNA of the gene implicated in hemophilia B wa..

The Analgesic and Anesthetic Effects of Inhibiting the Interaction of the NMDA Receptor Subunits 2A/2B with Neuronal Nitric Oxide via PDZ Domain of PSD95/SAP90

PSD-95/SAP90 is a molecular scaffold protein that, through interactions involving its PDZ domains, couples the NMDA receptor to cellular signaling pathways at neuronal synapses. PSD-95/SAP90?s mRNA an..

Enhancement of Sindbis Virus Self-Replicating RNA Vaccine Potency by Linkage of Mycobacterium Tuberculosis Heat Shock Protein 70 Gene to an Antigen Gene

Self-replicating RNA vaccines (RNA replicons) have emerged as an effective strategy for nucleic acid vaccine development. Unlike naked DNA vaccines, RNA replicons eventually cause lysis of transfected..

Enhancement of DNA Vaccine Potency by Linkage of Antigen Gene to the Extracellular Domain of FLT3-Ligand Gene

professional antigen presenting cells (APCs), particularly dendritic cells (DCs). A recombinant chimera of the extracellular domain of Flt3-ligand (FL) linked to a model antigen may potentially target..

Fusion of Calreticulun (CRT) to Antigens Enhances the Potency of DNA Vaccines

Antigen-specific cancer immunotherapy and anti-angiogenesis have emerged as two attractive strategies for cancer treatment. An innovative approach that combines both mechanisms will likely generate th..

Genetic Engineering of Autologous Vein Grafts with thrombomodulin-Expressing Vectors to Resist thrombosis, Neointimal Hyperplasia and Atherosclerosis

Autologous vein grafts are the most widely used conduits for coronary and peripheral arterial bypass surgery. Compared to arterial grafts, vein grafts suffer significantly higher failure rates that li..

Human BARX2 Gene

Surprisingly, it has been found that the Barx2 gene is mutated in ovarian cancer. The invention provides methods of diagnosis, prognosis and treatment of cancer related to the Barx2 gene. Description..

Biodegradable and Biocompatible Lactide-Phosphate Copolymers, Compositions, Articles and Methods for Making the Same

The growing need for new polymer-based drug delivery materials continues to stimulate polymer research. Although several classes of synthetic polymers have been studied for controlled drug delivery an..

Phenylalkenoic Acid-Mediated Corection of Aberant Protein Trafficking

This discovery encompasses the compound 4-phenyl-delta3-transbutenoic acid, which restores normal biosynthetic trafficking to the CFTR mutation deltaF508 The mechanism centers on butyrate-mediated dow..

Biosynthetic Engineering of Cell Surface Sialic Acids

Surrounding every cell is a halo of glycoproteins, glycolipids and proteoglycans termed the glycocalyx. On these structures, the most common terminus is the sugar sialic acid which is unique in its 9-..

A New Human p53 Homologue (p46)

Since its identification as a tumor suppressor gene, p53 has become one of the most studied genes in human cancer. Inactivation of p53 is though to represent the most common genetic event in all neopl..

Cloning of a Novel Telomerase Associated Protein from Human Cells

Telomerase activity is associated with human cancer and is often associated with the selection of cells that grow well after immortalization. Since cancer cells have high levels of telomerase, some tu..

Human Smad3 and Smad4 are Sequence-Specific Transcription Activators

Mounting evidence suggests that Smad proteins are required for TGFbeta signaling, but the way(s) in which Smad proteins propagate this signal is unclear. It was found that two human Smad proteins (Sma..

SynGAP

The PSD-95/SAP90 family of proteins have recently been implicated in the organization of synaptic structure. Here we describe the isolation of a novel ras-GTPase activating protein, GAPSYN, that speci..

Oral Delivery of Nucleic Acid Vaccines by Particulate Complexes

Nanoparticle coacervates of nucleic acids and polycations serve as effective vaccines when administered orally. They can induce immunity to a variety of disease causing agents and raise a protective r..

A Simplified System for Generating Recombinant Adenoviruses

Recombinant adenoviruses provide a versatile system for gene expression studies and therapeutic applications. A strategy, which simplifies the generation and production of such viruses is reported her..

Therapeutic Nanospheres

4-Phenylbutyrate exerts many beneficial biological effects. It appears to induce the transcription of certain promoters, as well as having a remedial effect on proteins which are aberrantly localized ..

Semaphorins

The semaphorin gene family consists of a large family of conserved proteins several members of which have been shown to function in inhibitory and repulsive axon guidance. In addition, semaphorins may..

Arachadonic Acid/Ceramide-Based Screens for Colorectal Cancer Chemopreventive Agents

Nonsteroidal antiinflammatory drugs (NSAIDS) can inhibit colorectal tumorigenesis and are one of the few agents known to be useful for the chemoprevention of neoplasia. It is shown that NSAID treatmen..

Autologous GVHD

Portions of the MHC class II invariant chain peptide, termed CLIP, exhibit immunomodulatory properties and can skew the cytokine response. In particular, the flanking regions of CLIP interact with rec..

Isolation of GRIP

The invention concerns the discovery of a novel family of proteins named as glutamate receptor interacting proteins (GRIPs). GRIPs interact with non-NMDA glutamate receptors and, in particular, intera..

Reversal of Loss of Imprinting in Tumor Cells by 5-aza-2"-deoycytidine

In order to determine whether loss of imprinting (LOI) in cancer might be reversed by altering DNA methylation, tumor cells were treated with 5-aza-2?deoxycytidine, a specific inhibitor of cytosine DN..

Therapeutic use of Ligands for CD46 for treatment of patients with disorders associate patheogenetically w/inappropriate or excess production of IL-12.

The present invention provides a method of treating a variety of disorders in a mammal characterized by dysregulated, physiologically abnormal, aberrant IL-12 production and/or overproduction of IL-12..

Use of Recombinant Bacteriophages to Monitor Ion Channel Receptor Expression im Mammalian Cells

The present invention concerns a novel method for detecting cell surface proteins utilizing a modified virus. This method combines peptide display technology and traditional immuno-amplification strat..

Discovery of Human Mad-related Genes

Resistance to the growth inhibitory effects of TGF-beta is common in human cancers. However the mechanism(s) by which tumour cells become restistant to TGF-beta are generally unknown. We have identifi..

Generation of Soluble Divalent Heterodimeric Analogs of Proteins involved in Immune Responses

This invention is directed to compositions comprising soluble divalent and multivalent heterodimeric analogs of proteins that are involved in immune regulation and methods of making and using the same..

Interferon Gamma-Gene-Based Therapy in Allergic Diseases

In vivo delivery of an interferon-y gene to mucosal cells of the lung is an effective means to treat and prevent the development of allergen-induced diseases Description (Set) Proposed Use (Set) ..

GDF -14

The present invention provides a growth and differentiation factor, GDF-14, and a polynucleotide sequence encoding GDF-14. GDF-14 is expressed at highest levels in muscle, brain, uterus, spleen, and t..

4.0 Demethyl Perclomedine

Substantially pure 3,5-dichloro-2-nethoxy-4-hydroxy-6-(trichloromethyl)pyridine or 4-demethylpenclomedine (formula I), acid addition salts thereof, pharmaceutical compositions containing the aforesai..

Enhancing Nerve Regeneration

Compounds have been identified which can stimulate neuronal growth by inhibiting the neuronal inhibitory activity of myelin-associated glycoprotein (MAG). Specifically, complex carbohydrates have been..

cDNA Cloning and Sequencing of Peptidyl-Glycine Alpha-Amidating Monooxygenasse

The sequence of bovine PAM is taught as well as new forms of PAM not known before. One new form is membrane bound and provides the basis and methods for alpha-amidating inactive precursors of peptide ..

Therapeutic Suppression of Specific Immune Responses by Administration of Oligomeric Forms of Antigen of Controlled Chemistry

The method and construct used to reduce undesired antibody response in a mammal by administering a non-immunogenic construct of which contains at least two copies of a B cell membrane immunoglobulin r..

Methods and Compositions for Creating Biopolymers with Modulatable or Novel Functionalities by Insertional Mutagenesis

The invention provides molecular switches which couple external signals to functionality and to methods of making and using the same. The switches according to the invention can be used, for example, ..

O2-Benzyl-substituted Dizeniumdiolates that Release Nitric Oxide at Controlled Rates Upon Photolysis

Nitric oxide (NO) is a critically important bioregulator, involved in a wide range of processes including neurotransmission, blood clotting, and blood pressure control. In addition, macrophages have b..

Inhibitors of Plasmepsin II, an Anti-Malarial target

Compounds and methods for the inhibition of anti-malarial target aspartyl protease plasmepsins (e.g. Plasmepsin I, Plasmepsin II, Plasmepsin IV and HAP) are provided. The compounds are based on alloph..

Modulation of Cell Survival Using E1B and Aven

The present invention relates to preventing or delaying programmed cell death by expressing one or more anti-apoptotic polypeptides in a cell such that programmed cell death in the cell is prevented o..

Structural Prediction of Allosterism

During the course of biological function, proteins interact with other proteins, ligands, substrates, inhibitors, etc. These interactions occur at precisely defined locations with the protein but thei..

Antiproliferative Vitamin D3 Hybrids

The present invention is based on the unexpected finding that certain modifications to the A-ring portion of vitamin D.sub.3 analogues produce compounds of superior biological activity. In its broades..

Formation of Oligonucleotide Triplexes with Selectively Modified Cytosines

The present invention is based on the finding that it is possible to use the bisulfite-catalyzed transamination reaction to selectively introduce aminoalkyl or carboxyalkyl linker arms at a specific d..

1, 2, 4 - Trioxanes Having Antimalarial Activity

Because of the widespread incidence of malaria in certain parts of the world and because of the increasing parasite resistance to standard anti-malarial drugs, there is an urgent need for new and effe..

Vitamin D3 Analogues

The present invention is based on the unexpected finding that the A-ring portion of vitamin D.sub.3 analogues can be modified without negatively affecting the biological activity of the resulting comp..

Identification of a new Type II Heat-labile Enterotoxin

One of the factors limiting the commercial development of mucosal vaccines is the availability of appropriate, safe and effective adjuvants and antigen delivery systems that promote the desired kinds ..

Calcium Sulfate (sulphate)-Based Nanoparticles: Synthesis and Modification Methods and Application in Bone Regenerative Therapy

Bone regeneration within critical size defects, both in the oral cavity and throughout the rest of the body, occurs very slowly in the absence of bone stabilizing agents to act as scaffolds. Though au..

Methods for Preparing Multivalent RNA-Targeting Ligands with Specific Application Towards Targeting the (CUG)n Oligomers that Cause Myotonic Dystrophy

Trinucleotide repeat disorders are genetic disorders caused by extended stretches of DNA encoded with the same trinucleotide sequence repeated many times. Some of the most notable trinucleotide repeat..

Using Selection to Define Rules for Small Molecule Targeting of RNA

Information needed to design nucleic acid-based compounds which target RNA can be as limited as knowing the Watson-Crick base pairing “code”. However, to date, the clinical success of such compoun..

Inhibition of Mechanical Ion Channels by Peptide Enantiomers

Stretch-activated cation channels (SAC) are wide-spread in the body and trigger cellular responses to mechanical stresses. They mediate the senses of touch and hearing and help to regulate organ funct..

Transgenic mouse model for neurodegenerative diseases

The study of neurodegenerative diseases such as Parkinson’s Disease (PD) and the subsequent development of therapeutic agents to combat these diseases rely upon accurate non-human models that mimic ..

Composition of Liposomal GM-CSF

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF ..

Method for Inhibiting Proteases in the Oral Cavity

Sensitive teeth, a condition which affects more than 45 million Americans each year, likely results from exposed dentinal tubules. A number of products have been developed that either occlude the expo..

Composition and method of preparation of liposomal microparticulate IL-12 for immunotherapy

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF ..

Composition of the reconstitution medium for protein and peptide formulations

Pharmaceutical scientists at the University at Buffalo have developed a rational strategy to design compositions for the reconstitution of freeze-dried protein/peptide formulations. These compositions..

Gene silencing of human c-myc oncogene by poly-DNP-RNA

Overexpression of the c-myc proto-oncogene has been implicated in the onset and progression of a wide range of cancers; in restenosis following arterial injury or intervention; and in the loss and dys..

Novel Human Gene with Immunoregulatory and Antiproliferative Properties

Abnormal or unregulated control of the body’s immune system can contribute to a variety of disorders, including but not limited to autoimmune disease and cancer. Standard treatments for autoimmune d..

Poly-DNP-RNA-21

The RIa/PKA gene is often overexpressed in cancers of the breast, lung, colon, prostate and ovary. UB researchers have synthesized a new compound, DNP-ssRNA-21, that triggers cleavage of the mRNA of R..

Use of hair follicle cells for tissue engineering of artificial organs or cell therapy

Many different tissues have been identified as stem cell sources for cell-based tissue engineering and cell therapies. However, the procurement of such cells is limited by ethical issues or the access..

Isolation of Functional Smooth Muscle Cells using Tissue Specific Promoters

Chemical engineers at the University at Buffalo have developed a method for isolating a patient’s own functional smooth muscle cells from hair follicles, bone marrow, cord blood or peripheral blood ..

Biological Vaccine Delivery System

This invention relates to methods and compositions for producing a fusion protein comprised of Haemophilus influenae P2 amino acid sequences, wherein in place of loop 5, or a portion thereof, is displ..

Use of RNA inhibitors based on IL-14 and antibodies to IL-14 for the treatment of autoimmune diseases and lymphomas

Autoimmune disorders and B cell derived lymphomas cause life-long suffering or premature death. Often the treatment for these diseases is symptomatic at best with severe side effects. An effective new..

Monoclonal antibody 3F5-5E5 and P107 diagnostic markers and putative vaccine antigen for Moraxella catarrhalis and supplemental Mab 4G5

This invention includes monoclonal antibodies, proteins, nucleic acid seqeunces and lipoologosaccharides (LOS) which are specific to Moraxella catarrhalis. These materials are useful for designing a m..

HIV antisense ORF(s) and putative protein(s)

The current invention is a gene comprising an open reading frame on the plus strand of the pro-viral DNA, and located in the region of HIV-1 long terminal repeat. The gene encodes a protein that is re..

OUTER MEMBRANE PROTEIN B1 OF MORAXELLA CATARRHALIS

The present invention includes a method for the isolation and purification of outer membrane protein B1 as well as B1 peptides from Moraxella catarrhalis, and the resulting compositions. The method in..

Novel 4-Substituted Indole compounds and methods for making same

The basic indole structure has been a structure of great interest to synthetic and medicinal chemists because of its presence in a large number of biologically active agents. For the most part, the cu..

Erogorgiaene derivatives and method for making

Marine-derived bioactive compounds hold great promise as therapeutics in the treatment of human disease. One particular family of marine-derived diterpene compounds has demonstrated anti-cancer, anti-..

Novel Chalcogenoxanthylium Dyes for Purging Blood Pathogens

Researchers at the University at Buffalo and the American Red Cross have developed a suite of chemical compounds to be used to purge pathogens found in the blood supply. There is a dire need to in..

21,23-Core-Modified Porphyrins as Sensitizers for Photodynamic Therapy

Photodynamic Therapy (PDT) is a unique approach to the treatment of cancer and other diseases. Able to differentiate cancerous and normal tissue while minimizing or eliminating many of the side effect..

Use of hair follicle cells for tissue engineering of artificial organs or cell therapy

Many different tissues have been identified as stem cell sources for cell-based tissue engineering and cell therapies. However, the procurement of such cells is limited by ethical issues or the access..

Composition and Method of preparation of Lipidic particles containing VEGF for lymphadema

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF ..

Identification of a new Type II Heat-labile Enterotoxin

One of the factors limiting the commercial development of mucosal vaccines is the availability of appropriate, safe and effective adjuvants and antigen delivery systems that promote the desired kinds ..

Method of treating bacterial infection in humans using antimicrobial nanoparticles applied in vivo and ex vivo

Method of treating bacterial infection in humans using antimicrobial nanoparticles applied in vivo and ex vivo Categories: Environment, Therapeutic and Vaccines

Composition of Liposomal GM-CSF

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF ..

Methods for Preparing Multivalent RNA-Targeting Ligands with Specific Application Towards Targeting the (CUG)n Oligomers that Cause Myotonic Dystrophy

Trinucleotide repeat disorders are genetic disorders caused by extended stretches of DNA encoded with the same trinucleotide sequence repeated many times. Some of the most notable trinucleotide repeat..

Anti-tumor compounds

Members of the inhibitor of apoptosis protein (IAP) protein family are often expressed at high levels in cancer cells. It is thought that high expression of IAP proteins leads to a disruption in the a..

Method and Composition of Less Immunogenic, Long Circulating EPO

Over one million patients in the U.S. are prescribed a therapeutic erythropoietin to treat anemia caused by kidney failure or cancer chemotherapy. It is estimated that over 80% of cancer patients and ..

Using Selection to Define Rules for Small Molecule Targeting of RNA

Information needed to design nucleic acid-based compounds which target RNA can be as limited as knowing the Watson-Crick base pairing “code”. However, to date, the clinical success of such compoun..

Calcium Sulfate (sulphate)-Based Nanoparticles: Synthesis and Modification Methods and Application in Bone Regenerative Therapy

Bone regeneration within critical size defects, both in the oral cavity and throughout the rest of the body, occurs very slowly in the absence of bone stabilizing agents to act as scaffolds. Though au..

Method for Delivering Hydrophobic Drugs Via Nanocrystal Formulations

This technology explains the formulation of a nanosized drug delivery carrier and the method of delivering photodynamic drugs, which are free from the external agents. From the results obtained for s..

Organically Modified Silica Nanoparticles Coencapsulating Photosensitizing Drug and Two-Photon Absorber for Two-photon Activated Photodynamic Therapy

Photodynamic therapy (PDT), following health agency approvals throughout the world for various cancers and other diseases, is slowly being accepted as a standard treatment for the treatment of obstruc..

Method for Inhibiting Proteases in the Oral Cavity

Sensitive teeth, a condition which affects more than 45 million Americans each year, likely results from exposed dentinal tubules. A number of products have been developed that either occlude the expo..

Chimeric TBP-Toxin Proteins as Mucosal Antigens for Vaccination against Neisseriae

Neisseria gonorrhoeae, the causative agent of the sexually transmitted disease gonorrhea, has been a burden to mankind from antiquity. Central to this bacteria's prolific nature, is its antigenic avar..

Method and Composition of Less Immunogenic, Long- Circulating Protein- Lipid Complexes

These novel compositions provide for enhanced delivery of protein therapeutics. Proteins (e.g. recombinant or full-length Factor VIII) associated with LIPRO-FORM (see R-6031 as well) exhibited markedl..

Isolation of Functional Smooth Muscle Cells using Tissue Specific Promoters

Chemical engineers at the University at Buffalo have developed a method for isolating a patient’s own functional smooth muscle cells from hair follicles, bone marrow, cord blood or peripheral blood ..

Method and composition of Pegylated protein (FVIII)-Phosphoserine complex

These novel compositions provide for enhanced delivery of protein therapeutics. Proteins (e.g. recombinant Factor VIII) associated with LIPRO-FORM exhibited improved pharmacokinetic profiles and highe..

Composition and method of preparation of liposomal microparticulate IL-12 for immunotherapy

Pharmaceutical and immunological scientists at the University at Buffalo have developed novel formulations for cytokine and growth factor drugs, including recombinant interleukin-12 (rhIL-12), GM-CSF ..

Novel 4-Substituted Indole compounds and methods for making same

The basic indole structure has been a structure of great interest to synthetic and medicinal chemists because of its presence in a large number of biologically active agents. For the most part, the cu..

Erogorgiaene derivatives and method for making

Marine-derived bioactive compounds hold great promise as therapeutics in the treatment of human disease. One particular family of marine-derived diterpene compounds has demonstrated anti-cancer, anti-..

TLR2-mediated adjuvant activities of LT-II B subunits

The present invention deals with heat-labile enterotoxins (LT-IIs) in which the toxic A-subunits are absent, leaving only the nontoxic B pentamers. Researchers found that despite the absence of toxic ..

Gene silencing of human c-myc oncogene by poly-DNP-RNA

Overexpression of the c-myc proto-oncogene has been implicated in the onset and progression of a wide range of cancers; in restenosis following arterial injury or intervention; and in the loss and dys..

Inhibition of Mechanical Ion Channels by Peptide Enantiomers

Stretch-activated cation channels (SAC) are wide-spread in the body and trigger cellular responses to mechanical stresses. They mediate the senses of touch and hearing and help to regulate organ funct..

Use of anti-T antibody to block metastasis of T antigen bearing tumors

Many cancer cells contain a carbohydrate structure on their surface known as the Thomsen-Friedenreich Antigen (TF-Ag). This antigen, which is not detectable on normal cells, plays a pivotal role in me..

Monoclonal antibody 3F5-5E5 and P107 diagnostic markers and putative vaccine antigen for Moraxella catarrhalis and supplemental Mab 4G5

This invention includes monoclonal antibodies, proteins, nucleic acid seqeunces and lipoologosaccharides (LOS) which are specific to Moraxella catarrhalis. These materials are useful for designing a m..

MUC7 12-mer-D isomer: novel and promising antimicrobial agent

This invention encompasses isomeric peptide derivatives of a naturally occurring protein found within the human body. These isomeric derivatives have been shown to possess potent antifungal activity c..

Novel Chalcogenoxanthylium Dyes for Purging Blood Pathogens

Researchers at the University at Buffalo and the American Red Cross have developed a suite of chemical compounds to be used to purge pathogens found in the blood supply. There is a dire need to in..

Adjuvant activities of a mutant LT-IIb enterotoxin lacking binding to ganglioside GD1a

UB microbiologists have developed a mutant heat-labile enterotoxin (LT-IIb) that demonstrates promising adjuvant activity and appears to overcome the limitations and concerns related to various mucosa..

Novel Human Gene with Immunoregulatory and Antiproliferative Properties

Abnormal or unregulated control of the body’s immune system can contribute to a variety of disorders, including but not limited to autoimmune disease and cancer. Standard treatments for autoimmune d..

Composition of the reconstitution medium for protein and peptide formulations

Pharmaceutical scientists at the University at Buffalo have developed a rational strategy to design compositions for the reconstitution of freeze-dried protein/peptide formulations. These compositions..

A vaccine to prevent infection by nontypeable Haemophilus influenzae infection

Currently, there is no effective vaccine to prevent infection by non-typeable Haemophilus influenzae (NTHi), a leading cause of otitis media as well as a number of other upper respiratory tract infect..

Poly-DNP-RNA-21

The RIa/PKA gene is often overexpressed in cancers of the breast, lung, colon, prostate and ovary. UB researchers have synthesized a new compound, DNP-ssRNA-21, that triggers cleavage of the mRNA of R..

Method for preparing less-immunogenic protein-lipid complexes

A novel method has been developed for preparing less immunogenic protein formulations. One composition derived from this method has demonstrated promising results in the delivery and efficacy of prote..

Organic Mixtures for the Encapsulation of Proteins in Dispersed Systems

Liposome technologies were developed to circumvent the problems associated with delivering therapeutic proteins into the human body. By encapsulating the protein of interest, the liposome allows the p..

Novel Antihemophilic (AHF) Formulations: Surface Coated Dispersion Systems as a Delivery Vehicle for AHF and its Fragments

Liposome technologies were developed to circumvent the problems associated with delivering therapeutic proteins into the human body. By encapsulating the protein of interest, the liposome allows the p..

Chimeric LT-II toxins as adjuvant-carrier molecules

One of the factors limiting the commercial development of mucosal vaccines is the availability of appropriate, safe and effective adjuvants, or delivery systems that promote the desired kinds of immun..

Protein Components of Streptococcus Pneumonae That Bind to Mucin Glycoproteins of Human Nasal and Middle Ear Secretions

Currently, there is no effective vaccine to prevent infections by Streptococcus pneumoniae, a leading cause of otitis media (OM) as well as a number of other upper respiratory tract infections that af..

Outer Membrane Protein B1 as a Vaccine for Branhamella Catarrhalis

The present invention encompasses nucleotide sequences derived from Moraxella catarrhalis which encode one or more epitopes of its outer membrane protein B1. Recombinant B1 protein or B1 peptides may ..

HIV antisense ORF(s) and putative protein(s)

The current invention is a gene comprising an open reading frame on the plus strand of the pro-viral DNA, and located in the region of HIV-1 long terminal repeat. The gene encodes a protein that is re..

Stabilization of Taxane Formulations

The clinical development of taxanes has been hampered by poor aqueous solubility, which necessitates administration of the drug in a vehicle such as Cremophor EL mixed with ethanol. Unfortunately, the..

Biological Vaccine Delivery System

This invention relates to methods and compositions for producing a fusion protein comprised of Haemophilus influenae P2 amino acid sequences, wherein in place of loop 5, or a portion thereof, is displ..

Specific glycan-modified HIV envelope proteins as vaccine immunogens against

Introduction A major obstacle in current AIDS/HIV vaccine development is the failure to induce broadly neutralizing antibodies against primary isolates of human immunodeficiency virus. Standard vaccin..

BCRP expressing cell lines

Introduction The breast cancer resistance protein (BCRP) is an ATP-binding cassette efflux transporter originally identified by its ability to confer multidrug resistance in cancer cells. BCRP mediate..

Alteration of Surface Affinities

Summary This invention claims a method for using a pulse of current in an electrochemical microdevice to change a surface from one that resists the adsorption of proteins and cells to one that promot..

Bead-based polymerase colony microarrays and nucleic acid sequencing ("Polony-FISSEQ Beads")

Summary Foundational work of Dr. George Church has enabled the production and use of replicable arrays of polymerase-amplified nucleic acid colonies (so-called "polonies") on semisolid support matrice..

Synthesis of Compounds with Peptide Characteristics

Summary Although peptides have shown some promise in clinical trials as therapeutic agents, its success has largely been limited by several factors, including rapid degradation by peptidases, poor cel..

High-Throughput Synthetic Platform for Natural Product Analog Libraries

Summary Background: In small molecule drug development, researchers typically develop biased libraries in which all members share a particular characteristic, such as an ability to interact with a par..

Calcipressins: Lead Targets for Autoimmune, Inflammatory, and Cardiovascular Disease

Summary The development of more selective immunosuppressive agents to mitigate transplant rejection and autoimmune diseases requires effective strategies of blocking signaling pathways in T cells. Cur..

Toxin-Phage Bacteriocide Antibiotic and Uses Thereof

Summary The rise of antibiotic resistant bacterial strains will necessitate the development of new strategies for treating bacterial infections. One potential alternative to conventional antibiotics i..

Mu Opioid Peptidomimetics: Lead Compounds for the Treatment of Pain

Summary Background: Although peptides have shown some promise in clinical trials as therapeutic agents, their success has largely been limited by several factors, including rapid degradation by peptid..

Liposome- Based, Intracellular Delivery of Drugs into Phagocytes, B- and T- cells and their tumor cells.

Summary Liposomes are man-made spheres, or vesicles, with an aqueous interior enclosed by one or more phospholipid bilayers. Liposomes can enhance the pharmacokinetics and efficacy of therapeutics by ..

Antisense Inhibition of Angiogenin Expression in Cancer

Summary Antisense oligonucleotides targeted to anigogenin and designed based on the known sequence of the ANG gene have been synthesized. Angiogenin is a potent positive mediator of neovascularization..

Methods and Reagents for Modulating TGF-beta Superfamily Signalling

Summary Harvard Medical School researchers have developed compositions and methods for modulating TGF-b signalling. TGF-b superfamily members regulate a wide range of normal and pathological biologica..

Novel Chemistry and Method to make Compounds Active Against Picornaviruses

Summary Picornaviruses are a large family of viruses responsible for many serious human and animal diseases, including hepatitis A, meningitis, diarrhea, summer flu, the common cold and polio. Several..

Synthesis of Compounds with Peptide Characteristics

Summary Although peptides have shown some promise in clinical trials as therapeutic agents, its success has largely been limited by several factors, including rapid degradation by peptidases, poor cel..

Compositions and Methods for Treating Papillomavirus-Infected Cells

Summary Human papillomaviruses have been linked to widespread, serious human diseases, especially cervical carcinoma. Researchers estimate that over 90% of the 500,000 cases of cervical cancer that ar..

High-Throughput Synthetic Platform for Natural Product Analog Libraries

Summary Background: In small molecule drug development, researchers typically develop biased libraries in which all members share a particular characteristic, such as an ability to interact with a par..

Small Molecule Arrays: A New Forefront in Drug Discovery

Summary Scientists from the laboratory of Professor Stuart Schreiber at Harvard University have developed a novel method of printing small molecule libraries on glass microscope slides. This method re..

Drug candidate for neurological stroke and septic shock

Summary Apoptosis is a genetically regulated cellular suicide mechanism that plays an important role in regulating normal development and tissue homeostasis as well as pathogenesis of diseases. This p..

Next Generation Diagnostics for Breast Cancer, Prostate Cancer, and Melanoma

Summary From the labs of Professor Alun Jones (inventor of CardioliteTM) and Professor Ashfaq Mahmood, comes a series of small molecule imaging probes, capable of conjugation to both SPECT-based and P..

Techniques for high yield synthesis of macrocyclic compounds

Summary Many useful pharmaceuticals, including natural products, have a macrocyclic structure that can be a challenge when exploring synthesis methods. The Walsh Laboratory has discovered a new proces..

Method of Creating Self-Assembled, Selectively-Permeable Colloidosome Structures

Summary Colloidosomes are spherical shells of micron-sized particles made by the simple technique of self-assembly onto emulsion droplets. These hollow, elastic capsules are ideal for efficiently enca..

Aminoglycosides Scaffolding Targeting Antibiotic-Resistant Bacteria

Summary This invention encompasses key modifications to the chemistry of aminoglycosides to overcome bacterial resistance. The novel chemistry leverages: (a) the weak stereospecificity of aminoglycosi..

Novel Peptide Therapeutic for Multiple Sclerosis

Summary Background: In Multiple Sclerosis, the host’s immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part a..

Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products

Summary Inhibition of bacterial septation machinery represents a promising approach for countering antibiotic-resistant bacteria. One such approach targets FtsZ, an essential protein and key mediator ..

Ephrins as Novel Targets in Neuronal Regeneration

Summary Chemokines play an intrinsic role in immunity and neural trafficking through their interactions with GPCRs. A reverse signaling mechanism of Ephrin B/EphB receptor has been discovered to inhib..

TreeDock protein docking software

Summary Predicting protein-protein and protein-ligand docking remains one of the challenging topics of structural biology. The main problems are (i) to reliably estimate the binding free energies of d..

Techniques for high yield synthesis of macrocyclic compounds

Summary Many useful pharmaceuticals, including natural products, have a macrocyclic structure that can be a challenge when exploring synthesis methods. The Walsh Laboratory has discovered a new proces..

Toxin-Phage Bacteriocide Antibiotic and Uses Thereof

Summary The rise of antibiotic resistant bacterial strains will necessitate the development of new strategies for treating bacterial infections. One potential alternative to conventional antibiotics i..

Treatment of alcoholism and substance abuse using selective inhibition of alpha 2 adrenergic receptors and dopamine D2 receptors

Summary To date, most alcohol and substance-abuse drugs have been plagued by moderate efficacy and a lack of specific target mechanisms. A new approach is proposed involving weighted inhibition of the..

Mu Opioid Peptidomimetics: Lead Compounds for the Treatment of Pain

Summary Background: Although peptides have shown some promise in clinical trials as therapeutic agents, their success has largely been limited by several factors, including rapid degradation by peptid..

In Vivo Evolution of an RNA-Based Transcriptional Activator

Summary This invention claims a method of evolving potent RNA transcriptional regulators using a combination of directed evolution and site directed mutagenesis. Also described are specifically evolve..

Manipulating Stem Cells for Repair and Drug Delivery at Various Anatomic Sites

Summary Cellular and gene therapy for chronic drug delivery and tissue repair have been explored in a range of anatomic sites including the heart, brain, bone marrow, and skeletal muscle. Mashimo and ..

Novel Avrainvillamide-like Compounds with Anti-proliferative Properties

Summary Avrainvillamide and stephacidin B, (a dimer of avrainvillamide) have been identified in culture media from various strains of the fungus Aspergillus. Both compounds demonstrate anti-proliferat..

Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products

Summary The emergence of bacterial strains resistant to current drugs has prompted a renewed effort to discover new methods for fighting infectious disease. A promising new target is FtsZ, a key media..

Novel Urazole Epoxyquinol Inhibitors of Hepatitis C Virus Replication

Summary Background: Hepatitis C virus (HCV) infects about 200 million people worldwide and frequently leads to cirrhosis, liver failure, and hepatocellular carcinoma. Currently, the best therapy for t..

Clinical Stage HIV Vaccine Candidate and Other Vaccine Vectors

Summary Replication-defective viruses integrate the safety advantages of a killed virus vaccine and the immunogenicity of a live virus vaccine. Professor David Knipe and his research team present a no..

Hydroxapatite -Antigen Conjugates AMPERSAND Methods for Generating A Poly-IG Immune Resp

Summary Issued patents 5,443,832: SUMMARY OF THE INVENTION We have discovered that hydroxylated calcium phosphate (HCP) particulate is a particularly useful carrier for antigens to be applied to..

Treating Diseases Associated with Oxidative Stress through the Metalothioneine System

Summary Since its initial discovery and characterization over 40 years ago by Vallee and colleagues, metallothionein has attracted a remarkable level of scientific attention due to its unique structur..

Genetically Attenuated Microbial Vaccines

Summary The invention, covered by U.S. Patent No. 6,254,874, provides vaccines that comprise attenuated pathogens. It also encompasses methods for the creation of attenuated microorganisms useful in s..

Novel Surfactants for Stabilizing Emulsions of Water or Hydrocarbon Oil-Based Droplets in a Fluorocarbon Oil Continuous Phase

Summary Emulsions—dispersions of two immiscible fluids—have many applications in industry and everyday life. These range from paints, to crop protection, chemical synthesis, and producti..

High-throughput hydrogels for cell culture in realistic tissue stiffness environments

Summary Markets/ Needs Addressed: The physical environment surrounding a living cell influences its ability to proliferate, metabolize, differentiate and survive. In particular, the stiffness of the ..

Targeting MEF-2 for the Treatment of Neurodegenerative Disease

Summary Post-synaptic differentiation of dendrites is an essential step in synapse formation and is intrinsic to neural reprogramming following CNS trauma or neurodegenerative disease. Investigators f..

Genetic Test for Periodontal Disease

Summary Peridontitis is a serious oral disease characterized by highly painful loss of tissue between the tooth and the gingival tissue. In the US, it is estimated that dentists perform upwards of 28...

Brainbow Mice: A Technicolor Approach to map the Neuronal Circuits

Summary Understanding how the precise interconnections of neurons account for brain functions has been a preoccupation of neuroscientists for over a century. The primary obstacle that researchers have..

Array of Micro Differential Scanning Calorimeters for Combinatorial Studies

Summary Differential scanning calorimetry (DSC) is a primary technique for measuring the thermal properties of materials. A typical DSC system requires relatively large amounts of test material, makin..

Microfluidic Platform for Constructing Tunable 3D Cellular Microenvironments for Performing Biologically Relevant Cell-Based Assays

Summary Markets/Needs Addressed: In vitro studies of living cells are commonly carried out in 2-dimensional (2D) systems involving cells grown in monolayers in glass or polystyrene Petri dishes. The ..

Brainbow Mice: A Technicolor Approach to map the Neuronal Circuits

Summary Understanding how the precise interconnections of neurons account for brain functions has been a preoccupation of neuroscientists for over a century. The primary obstacle that researchers have..

AlignAce motif searching software

Summary Developed by genomics researchers at Harvard Medical School, AlignAce employs an algorithm that scans non-coding nucleic acid sequences at high resolution for motifs that occur with non-random..

Time and concentration warping software for RNA and protein expression data

Summary The predominant strategies for drug discovery today employ high-throughput screens and microarray-based methods that generate large data sets. Increasingly, these techniques are being used to ..

TreeDock protein docking software

Summary Predicting protein-protein and protein-ligand docking remains one of the challenging topics of structural biology. The main problems are (i) to reliably estimate the binding free energies of d..

Microfluidic Arrays for Multiplex Detection of Analyts

Summary This invention is a microfluidic array apparatus and a method of performing multiple analyses on multiple samples simultaneously, utilizing nanoliter volumes of reagents. It has two embodiment..

Algorithm for Haplotype Construction of Single Nucleotide Polymorphism

Summary The Haplotyper software program utilizes a novel algorithm called Partition-Ligation to reconstruct individual haplotype phase information from unphased genoptype data. The Partition-Ligation ..

GoFish gene annotation and database query software

Summary GoFish, a genomics software tool developed at Harvard Medical School, provides methods for improved gene annotation and query of gene annotation databases. The software enables efficient analy..

Phenotype Drug Screening Platform ; Based on Quantitative Morphometric Analysis of Cells

Summary A new platform has been developed for rapid phenotypic drug screening and cytological profiling. Recent studies demonstrate the platform’s efficacy for rapidly discovering and character..

Method and Apparatus for Fluid Dispersion

Summary The invention is a microfluidic device for focusing and/or breaking fluid sections and drops. The subject fluid flows in the device's central channel as the dispersing fluid flows in the two o..

Calcipressins: Lead Targets for Autoimmune, Inflammatory, and Cardiovascular Disease

Summary The development of more selective immunosuppressive agents to mitigate transplant rejection and autoimmune diseases requires effective strategies of blocking signaling pathways in T cells. Cur..

Methods to Regulate the Duration of Th2 Activation

Summary TID1 encodes two human mitochondrial matrix localized splice variants. Expression of each of two splice variants has opposing effects on the cell's ability to respond to exogenous apoptotic st..

A Novel Class of Phospholipase A2 Preferentially Expressed in Th2 Cells

Summary This invention describes the identification of a novel, low molecular weight class of Phospholipase A2 enzyme, PLA2 Group XII, that is involved in Type 2 T helper (Th2) cell differentiation an..

Novel Peptide Therapeutic for Multiple Sclerosis

Summary Background: In Multiple Sclerosis, the host’s immune system (lead by T cells) attacks and destroys myelin basic protein, the principle component necessary for nerve transmission. Part a..

Ephrins as Novel Targets in Neuronal Regeneration

Summary Chemokines play an intrinsic role in immunity and neural trafficking through their interactions with GPCRs. A reverse signaling mechanism of Ephrin B/EphB receptor has been discovered to inhib..

A Sensitive Assay to Identify Inhibitors of HSV DNA Polymerase

Summary Investigators from Harvard Medical School have developed a novel in vitro screening assay for small molecule inhibitors of viral DNA polymerase subunits. A number of hit have been identified w..

Anti-Mitotic Eg5 Inhibitors for Treatment of Cancer and Inflammatory Disease

Summary Background: Molecules targeting mitosis and microtubule stability are important for the treatment of cancer. Unfortunately, the mechanism of action of these agents can cause undesirable toxici..

Saframycin Assay

Summary Background: Chemotherapeutic DNA-binding compounds exert their effects, in part, by preventing DNA synthesis and initiating events that leads to apoptotic death. Despite the excellent antiprol..

Small Molecule Approaches to the Management of Macular Degeneration by Short-Circuiting the Visual Cycle

Summary Age related macular degeneration (AMD) affects millions of persons worldwide and is a leading cause of vision loss and blindness in ageing populations. In this disease, daytime vision (cone do..

Novel Avrainvillamide-like Compounds with Anti-proliferative Properties

Summary Avrainvillamide and stephacidin B, (a dimer of avrainvillamide) have been identified in culture media from various strains of the fungus Aspergillus. Both compounds demonstrate anti-proliferat..

Brainbow Mice: A Technicolor Approach to map the Neuronal Circuits

Summary Understanding how the precise interconnections of neurons account for brain functions has been a preoccupation of neuroscientists for over a century. The primary obstacle that researchers have..

Method of Creating Self-Assembled, Selectively-Permeable Colloidosome Structures

Summary Colloidosomes are spherical shells of micron-sized particles made by the simple technique of self-assembly onto emulsion droplets. These hollow, elastic capsules are ideal for efficiently enca..

Nonhomologous Random Recombination of Nucleic Acids (Nucleic Acid Shuffling)

Summary This invention comprises methods for non-homologous random recombination (NRR) of nucleic acids, and their use to develop and select nucleic acids or polypeptides with novel structure and func..

Nonhomologous Random Recombination of Nucleic Acids (Nucleic Acid Shuffling)

Summary This invention comprises methods for non-homologous random recombination (NRR) of nucleic acids, and their use to develop and select nucleic acids or polypeptides with novel structure and func..

Novel Surfactants for Stabilizing Emulsions of Water or Hydrocarbon Oil-Based Droplets in a Fluorocarbon Oil Continuous Phase

Summary Emulsions—dispersions of two immiscible fluids—have many applications in industry and everyday life. These range from paints, to crop protection, chemical synthesis, and producti..

Animal Model for Benign Prostate Hyperplasia

Summary The invention provides transgenic mouse models of benign prostate hyperplasia. These animals are useful in toxicity screens, as well as in assays aimed at the development of drugs to prevent p..

Targeting MEF-2 for the Treatment of Neurodegenerative Disease

Summary Post-synaptic differentiation of dendrites is an essential step in synapse formation and is intrinsic to neural reprogramming following CNS trauma or neurodegenerative disease. Investigators f..

Purification of a Smooth Muscle Cell Mitogen from Beta Tumor Cell Conditioned Me

Summary This invention describes a novel human growth factor, sometimes referred to as "BTC-GF". BTC-GF is a mitogen for smooth muscle cells, 3T3 fibroblasts, and retinal pigment epithelial cells, but..

A New p53 Cell-Based Assay

Summary Harvard researchers developed a reliable, high-throughput screening assay to identify activators and inhibitors of p53. This cell-based luminescence assay measures the level of a reporter gene..

Dominant negative inhibitor of anthrax toxin

Summary The invention enables prevention and emergency treatment of anthrax. It provides a dominant negative inhibitor (DNI) of an essential infectivity factor of B. anthracis, a potentially lethal pa..

ras Oncogene Inhibitors

Summary Activated ras genes have been associated with a number of human cancers. An activated ras gene, H-ras-1, was the first non-viral oncogene discovered. Several other human ras proto-onco genes h..

Deglycosylating gp120

Summary This invention describes a method for producing partially deglycosylated HIV-1 envelope glycoproteins through site-directed mutagenesis. Removal of multiple carbohydrate residues by mutation o..

Selective Deposition of Cells in Microwells

Summary This invention is a method of selectively functionalizing indentations (such as wells or channels in microfluidic systems) or protrusions on a substrate such that, for example, cells selective..

Methods for Treating Arteriosclerosis

Summary Scientists at Harvard Medical School have identified imidazoles that inhibit endothelial cell, vascular smooth muscle cell and fibroblast proliferation. These imidazoles can be used to benefic..

Mediators of Chronic Allograft Rejection and DNA Molecules Encoding Them

Summary This invention provides methods of detecting and treating arterial inflammatory disease, including chronic allograft rejection subsequent to organ transplantation or chronic vascular Chlamydia..

NF-X1: Novel Target for Inhibition of MHC Class II Transcription and Autoimmune Disease

Summary The class II MHC molecules function in the presentation of processed peptides to helper T cells during an immune response. Dysregulated expression of class II major histocompatibility complex ..

EPH Receptor Ligands, and Uses Related Thereto

Summary The EPH kinases constitute the largest family of receptor tyrosine kinases. EPH receptors and their ligands (ephrins) play a central role in embryonic development and increasing evidence also ..

Novel Synthetic Mechanism to b-Lactone and Analogs: Lead Compounds for the Treatment of Proteasome-Related Diseases

Summary Background: Proteasome inhibition offers considerable promise in the therapy of a number of types of diseases, such as cancer and neurodegenerative diseases. One such proteasome inhibtor, Velc..

Liposome- Based, Intracellular Delivery of Drugs into Phagocytes, B- and T- cells and their tumor cells.

Summary Liposomes are man-made spheres, or vesicles, with an aqueous interior enclosed by one or more phospholipid bilayers. Liposomes can enhance the pharmacokinetics and efficacy of therapeutics by ..

Improved Method of Expression Cloning

Summary The human genome will soon be completely sequenced, presenting a vast new array of targets against which pharmaceutical agents can potentially be designed. However, to capitalize on this new i..

Assay and Reagents for Detecting Inhibitors of Ubiquitin-dependent Degredation o

Summary Issued US patent 5,726,025 : SUMMARY OF THE INVENTION The present invention provides a systematic and practical approach for the identification of candidate agents able to inhibit ubiqui..

In Vitro Differentiation of CD34+ Progenitor Cells into T-Lymphocytes (formerly

Summary Harvard Medical School researchers have developed a method for the production of large quantities of T lymphocytes in vitro. A monolayer of non-human primate thymic stromal cells is cocultured..

High Lead Expression of Soluble CMV UL97 and Development of an Assay to Screen Inhibitors

Summary The Coen Lab has expressed UL97 and UL97 fusion proteins and developed an assay to identify agents that inhibit or activate UL97 to be used in the treatment of human cytomegalovirus (HCMV) inf..

A Novel Tumor Suppressor Protein and Gene

Summary A novel tumor suppressor gene, doc-1, has been discovered which is structurally altered during oral carcinogenesis and which is expressed by normal and not transformed human tissues, and not b..

Herpesvirus Antiviral Drug Screen

Summary Herpesviruses continue to be a significant medical problem, causing painful chronic genital infections as well as devastating neonatal infections. To address these problems, Harvard Medical Sc..

Smooth Muscle Cell Lim Protein

Summary Summary Issued patents claim DNA encoding the SmLIM polypeptide and/or promoter sequence, and the SmLIM polypeptide. Background and Significance Cardiovascular disease is the leading cau..

Identification and Characterization of Class II HDACs: Lead Targets for Treatment of Cancer and Neurodegenerative Diseases

Summary Background: One promising target of recent cancer therapy research involves a family of proteins primarily involved in gene regulation known as histone deacetylases or HDACs. Currently there a..

Antisense Inhibition of Angiogenin Expression in Cancer

Summary Antisense oligonucleotides targeted to anigogenin and designed based on the known sequence of the ANG gene have been synthesized. Angiogenin is a potent positive mediator of neovascularization..

Methods and Reagents for Modulating TGF-beta Superfamily Signalling

Summary Harvard Medical School researchers have developed compositions and methods for modulating TGF-b signalling. TGF-b superfamily members regulate a wide range of normal and pathological biologica..

Cell Based Assay for Discovery of Glycogen Synthase Kinase Inhibitors

Summary Background: Lithium exhibits numerous physiological effects in animals. For example, lithium mimics insulin action by stimulating glycogen synthesis and is remarkably effective for the treatme..

Method for Cloning Secreted Proteins

Summary Many biologically important molecules, including many used therapeutically, are secreted proteins, such as interferons, erythropoietin and insulin. Secreted proteins have a hydrophobic signal ..

Novel Chemistry and Method to make Compounds Active Against Picornaviruses

Summary Picornaviruses are a large family of viruses responsible for many serious human and animal diseases, including hepatitis A, meningitis, diarrhea, summer flu, the common cold and polio. Several..

Surface-Bound, Bimolecular, Double-Stranded DNA Arrays

Summary The invention, developed at Harvard Medical School, achieves high array feature density and accurate feature production through enzymatic second-strand synthesis of immobilized single-stranded..

A Rapid and Inducible Method for Repressing Gene Function

Summary The Struhl lab has developed a rapid and effective mean to inactivate a target gene, including genes involved in essential pathways. This invention allows the inducible degradation of the poly..

Production and uses of polymerase colony ("polony") arrays

Summary The invention provides methods for rapid fabrication and use of replicable, high-density nucleic acid arrays. Array features are produced through amplification on a support matrix of nucleic a..

Surface-Bound Double-Stranded DNA Protein Arrays

Summary Developed at Harvard Medical School, this invention provides nucleic acid arrays specifically designed for the assay of DNA-dependent protein:protein binding and/or physical interactions betwe..

AlignAce motif searching software

Summary Developed by genomics researchers at Harvard Medical School, AlignAce employs an algorithm that scans non-coding nucleic acid sequences at high resolution for motifs that occur with non-random..

Cellular Basis of Vascular-Graft Stenosis

Summary The invention features a mouse model of vascular graft stenosis in which the stenosis develops rapidly and closely mimics the development of vascular graft stenosis in humans. Methods of surgi..

Synthesis of Compounds with Peptide Characteristics

Summary Although peptides have shown some promise in clinical trials as therapeutic agents, its success has largely been limited by several factors, including rapid degradation by peptidases, poor cel..

Systematic, condition-independent identification of essential genes of microorganisms

Summary Traditional antibiotics have been aimed at a small subset of cellular processes (such as cell wall synthesis, protein synthesis and mRNA synthesis) and targets (including DNA gyrase and the ce..

Compositions and Methods for Treating Papillomavirus-Infected Cells

Summary Human papillomaviruses have been linked to widespread, serious human diseases, especially cervical carcinoma. Researchers estimate that over 90% of the 500,000 cases of cervical cancer that ar..

Monoclonal Antibody 2F12, Anti-ITK

Summary Monoclonal antibody to the T cell signaling protein ITK (Tyrosine kinase), developed by Heather Wilcox in Dr. Leslie Berg's lab, in the department of Molecular and Cell Biology, Harvard. These..

Geminin: A Biomarker with Significant Prognostic Potential in Cancer and Neuronal Differentiation

Summary A nuclear protein known as geminin is proposed as a broadly applicable cancer biomarker. The geminin protein was initially discovered by Kirchner et al. as an inhibitor of DNA synthesis and as..

Polo-Like Kinase Polo Box: Lead Target for Cancer Therapeutics

Summary Elevated expression of mammalian polo-like kinase (Plk) 1 occurs in many different types of cancers, such as head and neck, squamous cell carcinomas, oropharyngeal carcinomas, non-small cell l..

Methods and Compositions Relating to Modulation of Cartilage Growth by Modulatio

Summary Dr. Laurie Glimcher at Harvard University has recently discovered that the transcription factor NFATp plays a critical role in regulating the formation of cartilage. Mice that lack NFATp displ..

The Cytoblot: A Miniaturized High-Throughput Immunodetection Screening Assay Kit

Summary Background: A major goal of drug discovery efforts is to develop successful high throughput assays. Current assays either detect specific protein-ligand interactions using recombinant proteins..

A Tool for the Linkage and Presentation of Multiple Protein Functional Domains

Summary Recent molecular biology research is moving beyond genetics to look at protein - protein interactions and how cells interact or communicate. These exciting areas are in need of improved tools ..

A Method to Target the Degradation of Specific Cellular Proteins

Summary In order to study the role of specific proteins in cellular processes, researchers use a variety of techniques, including gene knockout, antisense, and RNA interference technologies. These tec..

On Bead Tagging and Decoding for Combinatorial Synthesis

Summary Pharmaceutical drug discovery has been greatly impacted by the development of novel approaches to the rapid synthesis of novel compounds, including combinatorial synthesis approaches. A common..

Drug screening tool for herpes antivirals

Summary Harvard Medical School researchers have developed a genetically modified herpes simplex virus that has utility as a drug screening tool. To develop this tool, Harvard researchers engineered a ..

Small Molecule Therapeutic and Screening Assays for Drugs Active Against Chronic Neural Degenerative Diseases.

Summary Huntington's disease, as well as other ataxias, are caused by the abnormal expansion of nucleic acid CAG repeats that code a glutamine stretch. These repeats are found within several otherwise..

Direct and Practical Synthetic Route to Pseudopterosins: Important Anti-Inflammatory, Anti-Pain, and Anti-Irritant Compounds

Summary Background: The pseudopterosins are a group of diterpene glycosides isolated from the Caribbean sea whip, Pseudopterogorgia elisabethae. The pseudopterosins represent an important structural c..

Bilins as anticancer agents

Summary A remarkable discovery at Harvard Medical School has led to the recognition that a naturally-occurring small molecule and analogs thereof possess potent anticancer properties through their abi..

Inhibitors of Protein-Processivity Factor

Summary Harvard investigators have discovered that Pol interacts with a processivity factor at a site that is distinct from sites of normal interaction between known Pol family members and other cellu..

Drug candidate for neurological stroke and septic shock

Summary Apoptosis is a genetically regulated cellular suicide mechanism that plays an important role in regulating normal development and tissue homeostasis as well as pathogenesis of diseases. This p..

Small Molecule Arrays: A New Forefront in Drug Discovery

Summary Scientists from the laboratory of Professor Stuart Schreiber at Harvard University have developed a novel method of printing small molecule libraries on glass microscope slides. This method re..

Method of Detecting Compounds Utilizing Genetically Modified Lambdoid Bacterioph

Summary This invention describes a method to detet a molecule of interest in a given solution, and a method of selecting or screening for cell lines that can continuously produce desired compounds. Th..

Identification and Characterization of Class II HDACs: Lead Targets for Treatment of Cancer and Neurodegenerative Diseases

Summary Background: One promising target of recent cancer therapy research involves a family of proteins primarily involved in gene regulation known as histone deacetylases or HDACs. Currently there a..

Reaction Microarrays: Ultra Fast Method for Chiral Catalyst Discovery

Summary Background: While combinatorial chemistry has been successfully applied to the problem of chiral catalyst discovery, its utility is severely hampered by the lack of rapid, high-throughput scre..

Dominant negative inhibitor of anthrax toxin

Summary The invention enables prevention and emergency treatment of anthrax. It provides a dominant negative inhibitor (DNI) of an essential infectivity factor of B. anthracis, a potentially lethal pa..

"Teabag" Processing: An Automated, High Throughput Method for Affinity Purification

Summary A high throughput system for protein purification has been developed, whereby a “tea-bag” structure is used to house microspheres for targeted protein binding and elution. The micr..

Methods to Regulate the Duration of Th2 Activation

Summary TID1 encodes two human mitochondrial matrix localized splice variants. Expression of each of two splice variants has opposing effects on the cell's ability to respond to exogenous apoptotic st..

Aminoglycosides Scaffolding Targeting Antibiotic-Resistant Bacteria

Summary This invention encompasses key modifications to the chemistry of aminoglycosides to overcome bacterial resistance. The novel chemistry leverages: (a) the weak stereospecificity of aminoglycosi..

Targeting FtsZ Activity Using Novel Antibacterials: Screening Assays, Small Molecule Hits, and Synthetic Pathways to Potent Natural Products

Summary Inhibition of bacterial septation machinery represents a promising approach for countering antibiotic-resistant bacteria. One such approach targets FtsZ, an essential protein and key mediator ..

A Drug Discovery Platform Using Novel Labeled Uridine Analogs: Unique moieties contribute to molecular biology research

Summary Background: Uracil is a nucleic acid base that, when bound to ribose or deoxyribose, forms uridine or deoxyuridine, respectively. Certain analogs of uridine and deoxyuridine have been synthesi..

A Versatile Method for Accelerated Chromosome Walking and DNA Fingerprinting

Summary Background: A variety of DNA amplification methods deal with sequence analysis of an uncharacterized region adjacent to a known element. These methods include inverse PCR (iPCR), panhandle PCR..

Nonhomologous Random Recombination of Nucleic Acids (Nucleic Acid Shuffling)

Summary This invention comprises methods for non-homologous random recombination (NRR) of nucleic acids, and their use to develop and select nucleic acids or polypeptides with novel structure and func..

HDAC Inhibitors

HDAC Inhibitors Laura Brass Email: laura_brass@harvard.edu Telephone: (617) 495-3067

Absolute Quantification of Proteins (AQUA)

Summary This invention provides methods, reagents and kits for obtaining absolute quantification of proteins and their modifications directly from cell lysates. In particular, the invention provides p..

Tome-1, a novel cell-cycle gene required for mitotic entry

Summary This invention, out of Marc Kirschner's research group, concerns the discovery of a novel protein required for mititic entry. Harvard researchers have isolated and identified the protein and t..

Saframycin Assay

Summary Background: Chemotherapeutic DNA-binding compounds exert their effects, in part, by preventing DNA synthesis and initiating events that leads to apoptotic death. Despite the excellent antiprol..

Susceptibility to Tuberculosis 1 (sst1): Novel Target for Diagnosis and Treatment of Mycobacterium tuberculosis

Summary Background: Tuberculosis is the seventh most important cause of global premature mortality and disability. Currently there are 8 million new cases and 3 million deaths annually from tuberculos..

Monoclonal IgE anti-ovalbumin antibody

Summary A laboratory from the Harvard School of Public Health has developed a monoclonal Ig E mouse anti-ovalbumin. This antibody is useful as a positive control in ELISA assays used to measure the le..

Transgenic GFP-Rhodopsin Zebrafish Model System for Study of Retinal Disease

Summary Background: Rhodopsin is a G-protein coupled receptor that initiates the light response upon absorption of a photon in the outer segment of the retina (ROS). Rhodopsin constitutes at least 90%..

Method and Apparatus for Fluid Dispersion

Summary The invention is a microfluidic device for focusing and/or breaking fluid sections and drops. The subject fluid flows in the device's central channel as the dispersing fluid flows in the two o..

A Novel Class of Proteosome Inhibitors

Summary Harvard Medical School investigators has discovered a number of anticancer small molecules, termed ubistatins, that inhibit cell cycle machinery through interference with the ubiquitin-proteas..

Small Molecule Approaches to the Management of Macular Degeneration by Short-Circuiting the Visual Cycle

Summary Age related macular degeneration (AMD) affects millions of persons worldwide and is a leading cause of vision loss and blindness in ageing populations. In this disease, daytime vision (cone do..

Novel Candidates for Tuberculosis Therapy

Summary There is a need for new antibiotics that are useful against tuberculosis. Proteasomes of Mycobacterium tuberculosium are essential in enabling these bacteria to evade killing by macrophages of..

Fully-integrated 2D microelectromagnet coil arrays in silicon for magnetic manipulation and RF imaging of cells and magnetic particles

Summary The invention comprises a novel method and an apparatus to manipulate, segregate, detect and analyze biological samples on a microfluidic CMOS chip. This technique offers sub-micrometer precis..

Genetic Test for Periodontal Disease

Summary Peridontitis is a serious oral disease characterized by highly painful loss of tissue between the tooth and the gingival tissue. In the US, it is estimated that dentists perform upwards of 28...

Deteremination of intracellular protein-protein interactions by colocalization with cytoplasmic inclusions

Summary Viral inclusion bodies are formed in transfected mammalian cells to enable an endogenous assay for protein-protein or nucleic acid-protein interactions. Inclusion bodies are generated by trans..

Simultaneous Study of Multiple Genetic Interactions Using Multi-mutant Yeast

Summary While the Saccharomyces Genome Deletion Project succeeded in deleting many open reading frames in the S. cerevisiae genome, the possibility of multiple deletions in the same strain still repre..

Novel Cancer Target Following HDAC Track: First Histone Demethylase offers opportunity in treating resistant cancers

Summary The invention encompasses a novel target representing a potential new avenue in the treatment of cancer and other diseases, based on interference with gene regulation. The target, LSD1 (lysine..

A Novel Class of HIV Therapeutics: Monoclonal Antibodies that Neutralize Previously Resistant HIV Primary Isolates

Summary Background: Molecular studies of the genomic organization of HIV-1 show that it encodes a number of genes common to all retroviruses, such as the gag, pol, and env genes. The env gene of HIV-1..

Correlated Mutation Analysis-assisted Chimeric-Engineering/Directed-Evolution of Novel Portein/Enzyme Function

Summary Chimeric protein engineering and directed-evolution are increasingly popular methods to obtain enzymes with desired activities and substrate specificities. Chimeric-engineering goes about this..

Novel Avrainvillamide-like Compounds with Anti-proliferative Properties

Summary Avrainvillamide and stephacidin B, (a dimer of avrainvillamide) have been identified in culture media from various strains of the fungus Aspergillus. Both compounds demonstrate anti-proliferat..

Targeting the Par-4 Protein as a Novel Approach in Depression Treatment

Summary Harvard researchers have discovered methods for identifying agents that modulate the interaction between Par-4 and the dopamine D2 receptor (D2DR). The ability to screen for this interaction m..

Proteasome-Mediated Degradation of RISC: Lead Target for Treatment of Long-Term Memory Disorders

Summary Background: Breakthrough research by Professor Sam Kunes and colleagues at Harvard University demonstrates that degradative control of the miRNA RISC pathway underlies the synaptic pattern of ..

Single Cell mAB Discovery: ; Discovering Therapeutic Antibodies Invisible to Current Screening Platforms

Summary Monoclonal antibodies, including the epitope specific antibodies, represent a rapidly growing pharmaceutical segment, driven by the need for targeted therapeutics and growing knowledge of dise..

Wnt1-Cre transgenic mouse model

Summary Background: The ability to generate specific genetic modifications in mice provides a powerful approach to assess gene function. As such systems allowing conditional genetic modification have ..

Attenuated RNA Viruses for Vacine and Drug Delivery

Summary Research in the lab of Prof. Sean Whelan has revealed new compositions to attenuate non-segmented negative-sense RNA (nsNS) viruses. Successful attenuation was demonstrated on vesicular stomat..

Brainbow Mice: A Technicolor Approach to map the Neuronal Circuits

Summary Understanding how the precise interconnections of neurons account for brain functions has been a preoccupation of neuroscientists for over a century. The primary obstacle that researchers have..

Transgenic Mice with Fluorescently Tagged Neuronal Mitochondria as a New Tool to Study Axonal Transport

Summary Background: Axonal transport supplies organelles to axons and synapses but little is known about how organelles are distributed among the branches of an axon to insure adequate supply of resou..

Targeting MEF-2 for the Treatment of Neurodegenerative Disease

Summary Post-synaptic differentiation of dendrites is an essential step in synapse formation and is intrinsic to neural reprogramming following CNS trauma or neurodegenerative disease. Investigators f..

Smaller and faster biocalorimeter for ultra-sensitive temperature sensing that helps reduce drug-development cost and risk

Summary Innovation and Advantages: We have developed a novel calorimetry device for ultra-sensitive temperature sensing associated with a chemical reaction using surface plasmon-enhanced radiation. Ra..

Small Molecule Microarrays: A New Forefront in Drug Discovery

Summary Scientists from the laboratory of Professor Stuart Schreiber at Harvard University have developed a novel method of printing small molecule libraries on glass microscope slides. This method re..

Nanobioelectronics: Building functional hybrid nanoelectronic/cell circuit elements

Summary Background: The determination of electrophysiological properties is important for understanding signal propagation through individual neurons and neuronal networks as well as muscle tissue. H..

Treating Diseases Associated with Oxidative Stress through the Metalothioneine System

Summary Since its initial discovery and characterization over 40 years ago by Vallee and colleagues, metallothionein has attracted a remarkable level of scientific attention due to its unique structur..

HEK293T cells stably expressing Divalent Metal Transporter-1 (DMT1-1): Model System to Screen for Inhibitors of Iron Uptake

Summary A HEK293T cell line that stably expresses Divalent Metal Transporter-1 (DMT-1). DMT1 functions in transport of ferrous iron across the plasma membrane and/or out of the endosomal compartment. ..

Generating transgenic models via in-vitro selection of embryonic stem clones:; An accelerated route to in-vivo disease models and target validation

Summary Techniques to customize and predict transgenic animal phenotype through in-vitro pre-screening would be highly advantageous. Research from the lab of Professor David Sinclair presents a new pl..

High-throughput hydrogels for cell culture in realistic tissue stiffness environments

Summary Markets/ Needs Addressed: The physical environment surrounding a living cell influences its ability to proliferate, metabolize, differentiate and survive. In particular, the stiffness of the ..

Magnetic Resonance Force Microscope

Introduction Magnetic resonance force microscopy (MRFM) is a variant of scanning probe microscopy that combines the sensitivity and spatial resolution of atomic force microscopy with the threedimensio..

Preparative-Scale Microfabricated Capillary Electrophoresis

Introduction The demand for precise, high throughput protein separation is increasing due to both the growing number of protein based therapeutics being developed and the emphasis on proteomic analysi..

Droplet Compartmentalization for Chemical Separations and On-Line Sampling

Introduction The ability to separate complex mixtures of chemicals and biomolecules is an important component of any chemical synthesis or biological processing. To date, there is no technology availa..

BCRP expressing cell lines

Introduction The breast cancer resistance protein (BCRP) is an ATP-binding cassette efflux transporter originally identified by its ability to confer multidrug resistance in cancer cells. BCRP mediate..

IN VIVO DRUG DISCOVERY ASSAY FOR OTOPROTECTIVE COMPOUNDS

Introduction A number of commonly used drugs are known to kill hair cells in the mammalian inner ear and cause dose-dependent sensorineural hearing loss. Most notably, aminoglycoside antibiotics and p..

Fabrication of Gold Nanocages and Cubic Nanoframes for Biomedical Treatment through Etching Nanoboxes

Introduction Because of their small sizes and unique properties, nanomaterials are finding widespread use in studying complex biological systems. Gold nanostructures have been the subject of intensive..

The Multiple Drug Resistance Gene, Polymorphisms, and uses Thereof

Introduction Multiple drug resistance is a well-documented phenomenon and critical problem in the treatment of various diseases including cancer and HIV. While there are many mechanisms leading to mul..

A Yeast Ligand Sensor

Introduction The yeast ligand sensor is a novel approach for the detection and quantification of ligandbinding, an issue of great interest in drug discovery and other areas. The approach is a protein-..

Delivery of PEGylated Drugs from Bioadhesive Formulations

Introduction While significant advances have been made in the field of PEGylated drug delivery, there is still a need for novel and improved PEGylated drug delivery formulations, particularly those th..

Use of Adhesion Molecules as Shear-Induced Nanoscale Binding Switches

Introduction Methods, compositions, and devices for using shear-dependent binding switches in a variety of applications would be extremely useful in biomedical and other fields. Applications for this ..

Solubility Enhancing Fusion Proteins

Introduction Recombinant proteins having therapeutic, diagnostic or any other commercial or research applications are produced by expression in a host cell. However these proteins of interest are ofte..

NOVEL SYNTHESIS OF IDURONATE A HEPARAN SULPHATE SUBUNIT

BACKGROUND Heparan sulphate and heparin play a central role in a large number of processes including anti-coagulation, angiogenesis, cell growth and migration. A new class of medicinal drugs can be en..

A FUNCTIONAL FOOD WITH INDICATIONS FOR PEPTIC ULCERS

BACKGROUND 1 in 10 people are affected by peptic ulcers over the course of their lifetime. Incidence of the condition is set to increase as the population ages. Current treatment relies on combination..

NOVEL ANTIMICROBIAL PEPTIDES

BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-mi..

A novel antibiotic for the control of biofilm formation

Invention TA is a broad spectrum antibiotic differing from known antibiotics by virtue of its adhesiveness to synthetic materials and to biological tissues, whilst retaining its bactericidal activity..

Identification and Isolation of Osteogenic Progenitor Cells

Invention A novel gene, termed chromatin remodeling protein (ChroM1), from osteoblast progenitor cells has been cloned and sequenced. ChroM1 functions as a transcriptional regulator of genes involved..

Modulation of sperm activity in fertility and contraception

Invention Prof. Naor’s team has recently discovered that two Mitogen-Activated Protein Kinases (MAPKs) play a role in human sperm functions. The team discovered that human sperm progressive and hy..

Novel Anti Bacterial Drug

The Invention Two non-toxic short peptides were conjugated to form a novel drug candidate. One of the peptides is a polymyxin-B or polymyxin-E analog (PMBN or PMEN, respectively) while the other is..

Topical Therapy for Fungal Nail Infections (Onychomycosis)

Invention The invention comprises a two-step topical treatment for fungal nail infections combining (a) enzymatic digestion of dermatophyte hyphae by lysing enzymes to expose the growing tips and (b)..

Improved Calcitonin-based Therapeutics

Invention The aggregation site on human calcitonin has been identified, paving the way for development of specific inhibitors of calcitonin amyloid fibril formation. Such inhibitors will enable devel..

An inhibitor to the ß-secretase pathway of Aß generation in Alzheimer´s Disease

Invention Antibodies have been raised against the β-secretase cleavage site in Amyloid β precursor protein (AβPP). These antibodies can prevent the processing of AβPP and the subsequent formation..

Collagomers - Widely Applicable Drug Delivery Technology

Invention Collagomers are bioadhesive micro and macro particles generated by linking a phospholipid to collagen. Collagomers entrap a wide range of molecules and release them slowly over long period..

Single-Trigger Molecular Amplifiers

Invention Dendrimers were synthesized, whereby a single specific cleavage event releases all the functional groups at the tips of the dendrimer, via spontaneous fragmentation of the dendrimer to its..

Targeted Nanoparticles for Drug Delivery

Invention Novel particulate drug delivery technology comprises of lipidated Glycosaminoglycan, that form micro or nano particles in a controlled manner. The particles (neither a liposome nor a micros..

GSK-3 inhibitors for the Treatment of Insulin Resistance-Related Diseases

Invention Novel inhibitors of GSK-3 were identified. These inhibitors represent substrate competitors that interact specifically with the GSK-3 substrate binding site. GSK-3 modulates insulin action..

Inhibitors of Amyloid Fibril Formation for the Treatment of Type II Diabetes

Invention Novel inhibitors directed against a newly identified sequence, aimed to prevent amyloid plaque formation and beta cell death are currently being developed. These inhibitors present a novel..

Immunotherapy for the prevention and treatment of osseous metastasis

Invention A gene encoding a novel cell adhesion protein whose expression is associated with bone metastases has been identified. The gene is termed SEL-OB and codes for a selectin type protein. SEL-O..

Novel Peptides for Therapeutic Angiogenesis and lschemic Cardiovascular Diseases

Invention Novel peptides were identified that bind endothelial cells and induce angiogenesis. The peptides were demonstrated to induce proliferation, migration and vascularization of endothelial cell..

Novel anti-cancer drugs with improved potency and acitivity against drug resistant cells

Invention Antimetabolites and antineoplastic agents have been chemically modified to render them active against resistant as well as sensitive cancer cells The Need The major reason for chemotherap..

New Application for Vitamin D

Invention A new application / Use for Calcitriol - It was demonstrated, in vitro, that calcitriol and some of its synthetic analogs have the potential to reduce the damage inflicted to normal tissue ..

Genetic Screen for Hepatitis C virus (HCV) Protease Inhibitors

Invention A novel in vivo genetic screen for Hepatitis C virus (HCV) Protease Inhibitors has been developed based on the concerted co-expression of a reporter gene, recombinant Hepatitis C virus (HC..

Cell Replacement Therapy for Diabetes

Invention A novel source of surrogate insulin producing beta cells has been developed. Genetic and epigenetic manipulations are employed to induce differentiation of a number of human progenitor cel..

Cell THerapy for Diabetes: Expansion and re-differentiation of adult human pancreatic islet cells for transplantation

Invention Conditions have been discovered for efficient expansion of adult human islet cells expressing normal beta-cell function (beta-cell gene expression and insulin content) The Need Type 1 (in..

Adamantyl-OEG-fullerene Hybrids as potential therapeutic agents

The Invention A series of novel soluble adamantyl-oligoethyleneglycol-fullerene hybrids was prepared via Bingel-Hirsch functionalization of C60 fullerene with various adamantyl-oligoethyleneglycol ma..

Macrolid Induced Correction of Premature Stop Codons: A novel Treatment for Colorectal Cancer

The Invention An antibiotic of the Macrolid family was demonstrated as a new treatment for colorectal cancer and other genetic human diseases that arise from pre-mature stop codons in important codin..

TAR-1: A human single chain antibody for the treatment of cancer related to mutations in p53

The Invention TAR-1, a human single chain antibody, which recognizes the common epitope exposed in mutant p53, but not in wild type p53, has been isolated. Binding of TAR-1 to the mutant p53 common e..

Novel psychotropic agents for the treatment of both negative and positive symptoms of Schizophrenia

The Invention New Chemical Entities (NCE's) psychotropic agents have been developed, possessing anti-dopaminergic activity, along with positive modulatory glutamate NMDA receptor activity. These agen..

Serotonin Reuptake Inhibitors as Novel Anti-Platelet Drugs

The Invention Serotonin-selective reuptake inhibitors (SSRIs) were chemically modified to produce novel quaternary nitrogen derivatives having a peripheral-restricted serotonin reuptake inhibitory ..

ASSNAC: A novel treatment of oxidative stress induced by reactive oxygen

The Invention ASSNAC, S-allymercapto-N-acetylcysteine, is a small bi-functional molecule that up-regulates cellular glutathione levels, the major cellular anti-oxidant. ASSNAC dissociates in peripher..

Novel Hapatatis C Virus NS3 serine protease inhibitor

The Invention Novel single chain and single domain antibodies and peptide aptamers which inhibit NS3 protease, have been isolated The Need Hepatitis C virus (HCV) infection is a major world-wide ..

Gagomers - Novel drug delivery system for the delivery of proteins to the brain

The Invention Gagomers are novel particles (neither liposomes nor microspheres/nanospheres) composed of hyaluronan shell which is crossed linked via phospholipids. Gagomers could be generated eithe..

Novel oral formulation of Insulin

The Invention Gagomers are novel particles (neither liposomes nor microspheres/nanospheres) composed of hyaluronan shell which is crossed linked to phospholipids and can be generated either as micr..

Targeting Cancer and Bone Metastases with Novel Anti Angiogenic Polymer Therapeutics

The Invention A new strategy for cancer and bone metastases therapy was developed using combined targeted polymeric drug delivery system with angiogenesis inhibitors. The novel compounds are compose..

Cell Permeable Peptides for the Treatment of Allergy, Asthma and Inflammatory Related Diseases

The Invention Novel cell permeable peptides that fuse a membrane permeation sequence to a functional sequence were developed. These cell-permeable peptides are capable of blocking signal transduction..

Silencing of Mortalin with siRNA as Adjuvant for Cancer Immunotherapy

The Invention We suggest a novel mode of treatment by inhibition of mortalin or mortalin synthesis as an adjuvant to antibody-based immunotherapy. Novel siRNA was designed as blocker of Mortalin expr..

HDACIvir´s- Novel anticancer agents

The Invention The research teams at Tel Aviv and Bar Ilan Universities have developed novel compounds derived from known histone deacetylase inhibitory (HDACI) molecules linked to acyclovir and its a..

PRODUCTION OF NOVEL HUMAN COLLAGENS

BACKGROUND A powerful new platform technology for the production of human collagens is being developed in the Kadler Centre for Cell-Matrix Research within the Department of Life Sciences at the Unive..

ADVANCED 3D FLEXIBLE FIBRE MATERIAL FOR WOUND MANAGEMENT, ORTHOPAEDIC, SPORTS & PERSONAL PROTECTIVE EQUIPMENT APPLICATIONS

BACKGROUND Spacer structures find applications is many areas. These include automotive, sports wear, medical, mattresses and protective clothing such as gloves and body armour. Spacer structures could..

Collaboration/Licence Opportunity PAEDIATRIC ANAESTHESIA RE-BREATHING APPARATUS

BACKGROUND In the normal Jackson-Rees system that is used to provide anaesthetic gas to a patient, one part of the apparatus connects to an open tailed reservoir bag. This bag expands and contracts in..

NOVEL ANTIMICROBIAL PEPTIDES

BACKGROUND Ai2 Limited is a University of Manchester spinout company that aims to become a significant player in the global anti-infectives market. The company’s focus is on developing novel anti-mi..

CORTICOSTEROIDS WITH REDUCED SIDE EFFECTS

BACKGROUND Glucocorticoids (GCs) have been used therapeutically for many years to treat a range of inflammatory conditions as immunosuppressants and in the treatment of certain cancers. These compound..

OPTICIN A TREATMENT FOR CANCER AND ANGIOGENESIS

BACKGROUND Opticin is a protein present in the eye (in the vitreous humour) and was discovered at University of Manchester by Dr Paul Bishop. Uniquely Opticin has been found to exhibit both cytotoxic ..

NOVEL SYNTHESIS OF IDURONATE A HEPARAN SULPHATE SUBUNIT

BACKGROUND Heparan sulphate and heparin play a central role in a large number of processes including anti-coagulation, angiogenesis, cell growth and migration. A new class of medicinal drugs can be en..

A FUNCTIONAL FOOD WITH INDICATIONS FOR PEPTIC ULCERS

BACKGROUND 1 in 10 people are affected by peptic ulcers over the course of their lifetime. Incidence of the condition is set to increase as the population ages. Current treatment relies on combination..

TUMOUR VASCULAR TARGETING AGENTS

A new pharmacophore for selective targeting of tumour blood-supply BACKGROUND Cancer is a huge killer, responsible for more than 500,000 deaths in the US and 150,000 in the UK each year, thus making n..

OPTICIN A TREATMENT FOR CANCER AND ANGIOGENESIS

BACKGROUND Opticin is a protein present in the eye (in the vitreous humour) and was discovered at University of Manchester by Dr Paul Bishop. Uniquely Opticin has been found to exhibit both cytotoxic ..

NOVEL DRUGS FOR THE TREATMENT & PREVENTION OF ALLERGY

BACKGROUND There is a high and increasing incidence of allergic disorders such as asthma and hay fever. It is expected that some 300m people in the western world will suffer from allergic diseases by ..

ZEBRA FISH MODELS FOR DRUG DISCOVERY

THE TECHNOLOGY Transgenic zebrafish are becoming increasing important as models for human disease. This organism offers the drug discovery industry a number of advantages including rapid reproductive ..

Mitochondrial DNA Variants Associated with Metabolic Syndrome

Background: Over the past 25 years, the Wallace's laboratory discovered that the variation in the maternally-inherited human mtDNA forms a single mtDNA tree in which the branches of the tree are regi..

Energy-Saving Technological Method for Long-Term Storage of Bio-Degradable Tissue

Background: Currently the critical storage of bio-degradable tissue for long periods of time is done at -70" C. This temperature does provide nearly unlimited storage time. Storage at -70' C is subst..

Compound to Aid in Smoking Cessation

Background: Clinical studies have illustrated that tobacco is highly addictive. Paradoxically, nicotine, the psychoactive component in tobacco, is weakly reinforcing in animals. This phenomenon has l..

A Chemical Compound with Possible p53 Cancer Mutant Rescue Activity

Background: Mutants of the tumor suppressor protein are frequently found in human cancers. About three quarters of them have a single amino acid change in the core domain of p53 that is needed to bin..

Mouse Model of Cardiac and Muscle Disease and Cancer Caused by a Mitochondrial DNA Point Mutation

Background: It is becoming increasingly clear that mitochondrial DNA (mtDNA) base substitution mutations are a common cause of age-related degenerative diseases as well as cancer. However, no mouse m..

CPET Laboratory

Technology: UCI clinic developed a novel algorithm to analyze the results of stress tests done in patients having a new pulmonary valve implant. Application: Analysis of exercise stress tests ..

Chronic Sequential Sensorimotor Neural Probe Array

Background: The Chronic Sequential Neural Probe Array is designed for patients with an axonal injury in the peripheral nerves or spinal cord who require chronic intervention where stimulation of and/..

Novel Inhibitors of N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA)

Background: Ethanoloamides of long-chain fatty acids, termed N-acylethanolamines (NAEs) have been reported to have a variety of biological activities. NAEs are a substrate of N-acylethanolamine-hydro..

Antigens for Borrelia Infection Diagnosis and Prevention

Background: Lvme disease is the most frequently reported arthropod-borne disease in the United States and Europe. Serological assays are the most common laboratory tests used to confirm or support a ..

Prokineticin 2 and Prokineticin Receptor 2 as a Target to Treat Epilepsy and Seizures

Background: PK2 belongs to a family of secreted peptides that regulate diverse biological functions including serving as a regulatory molecule for circadian rhythms. The signaling of PK2 is mediated ..

Method for Making and Using Vascularized Tumor Spheroid to Predict Response to Antiangiogenesis Agents

Background: Angiogenesis drugs act to inhibit survival of newly formed blood vessels required for tumor growth and progression. These drugs have recently shown good activity in the clinic for breast,..

A New Mouse Model of Sjogren's Syndrome

Background: Sjogren's Syndrome is a grave autoimmune disease in which destruction of the exocrine glands leads to severe dryness of the eyes and mouth, with additional systemic complications. The pat..

A Novel 7 Base Deletion in the Gene on Chromosome 21 for Diagnostic of Keratoconus

Background: Keratoconus is a noninflammatory progressive corneal thinning disorder leading to mixed myopic and irregular astigmatism and is implicated as a major cause of cornea transplants in the We..

Hybrid Binding Proteins Against Pathological Protein Aggregates in the Central

Background: The pathological protein aggregates such as beta-amyloids, alpha-synuclein and prion protein deposits in the CNS can be removed by vaccination, i.e., immunization using specific antibodie..

Methods and Reagents for Screening New Drugs and Treating Ion Pump Associated Disorders

Background: Sodium/potassium ATPases (Na+/K+-ATPases), a family of multi-subunit ion pumps, are the most important active transporters in animal cells. They are required for maintaining the electroch..

Biomarker-Guided Prediction of Patient Adherence to Medications

Background: Adherence is one of the pivotal determinants of treatment outcomes for many medical disorders. It is estimated that 50% or more of patients with chronic conditions are noncompliant with m..

Treatment of Retinal Disorders by Transforming Growth Factor-Beta (TFG-beta ) Superfamily Proteins and Their Antagonists

Background: Retinal disorders often turn into debilitating diseases, and in most cases only few treatment options are available. With available treatment options, vision is usually not restored and t..

Rapid Multiplex Gene and mRNA Detection in Picoliter Droplets by Molecular Beacons

Background: Breast cancer is a world wide public health concern and the estimated death toll in the U.S. in 2001 was 20,000 and it also ranked first as the cause of cancer death for women between the..

New Therapy to Inhibit Plasma Cells in Autoimmune Diseases

Background: In patients suffering from multiple sclerosis (MS) B cells, stimulated by axon antigens, infiltrate central nervous system. Technology: The inventors discovered a new class of antibodi..

A New PET Radiotracer for Serotonin 5HT1A Receptors

Background: Serotonin 5-HT1A receptors are implicated in Alzheimers disease, dementia, anxiety, schizophrenia, and depression, and significant efforts have been undertaken to develop various compound..

Methods of Improving Memory and Cognition

Technology: University of California, Irvine researchers have discovered a new method of improving memory by selectively modulating nuclear receptor cell signaling. The technology has been validated ..

Methods and Compostions for the Treatment of Immune Disorders and Regulation of Cytokine and Growth Factor Signaling

Categories: Pharmaceuticals: Central Nervous System Disorders, Immune and Inflammatory Disorders Biotechnology: Assays, Diagnostics, Model Systems Background: Mgat5 is an enzyme that glycosylat..

Phage-displayed Peptide Library with Affinity for Bacterial Elongation Factor Tu

Background: The highly abundant GTP binding protein elongation factor Tu (EF-Tu) fulfills multiple roles in bacterial protein biosynthesis. EF-Tu also binds other ligands, including four structurally..

Selective Inhibitors of Monoacylglycerol Lipase as a Treatment for Neurological Disorders

Background: Acute stress elicits the rapid formation of two endocanabinoid ligands, 2-arachidonoylglycerol (2-AG) and anandamide (AEA). These endogenous lipids bind to the CB1 cannabinoid receptor an..

New Polymeric Biomaterials

Technology: The invention is on new polymeric biomaterials. The new biomaterials were created by chemical synthesis with carbohydrates and amino acids as building blocks. The biopolymers have a speci..

Somatic Mitochondrial DNA (mtDNA) Control Region (CR) Mutations Associated with Alzheimer's Disease: the Cause and Diagnosis

Background: Sporadic Alzheimer's Disease (AD) has been associated with defects in mitochondrial oxidative phosphorylation (OXPHOS) as well as inherited and somatic mitochondrial DNA (mtDNA) mutations..

Antibodies that Bind and Detect Acute Lesions in MS Brains

Background: In patients suffering from multiple sclerosis (MS) B cells, stimulated by axon antigens, infiltrate central nervous system. Technology: The inventors discovered a new class of antibodi..

Using Female Endocrine Hormones to Improve Psoriasis

Background: The most commonly prescribed medications for severe psoriasis are methotrexate and cyclosporine. Both these medications have serious side effects. The next line of treatment includes phot..

Neuropeptide S (NPS) as a Treatment for Anxiety, Sleep Disorders, Attention Deficit Hyperactivity Disorder, Attention Deficit Disorder, and Asthma

Background: Patent "WO02/31145" discloses a newly deorphanized GPCR system, Neuropeptide S (NPS), the endogenous ligand, and its cognate GPCR. However this patent does not detail the pharmacological ..

Melanin Concentrating Hormone Receptor Small Molecule Antagonists for the Treatment of Obesity and Related Metabolic Disorders

In mammals, Melanin Concentrating Hormone (MCH), a GPCR, has been shown to regulate food consumption and energy metabolism. Central administration of MCH has been shown to promote feeding while mRNA l..

Design and Synthesis of PET Radioligands for alpha 4 beta 2 Nicotinic Acetylcholine Receptors

Background: Nicotinic acetylcholine receptors (nAChRs) belong to the superfamily of ligand-gated ion channels and are distributed widely in the human and nonhuman brain. Several nAChRs have been iden..

Treatment of Bladder and Urinary Tract Cancers Using Chalcone and Flavone Derivatives

Background: About 56,000 new cases of bladder cancer are diagnosed in the United States each year and approximately 12,000 Americans will die of the disease. Drawbacks of older cisplatin based therap..

R6G9 Treatment Improves Viral-Induced Neurological Disease

Background: Multiple Sclerosis (MS) is a devastating neurological disease. MS patients often experience neurologic dysfunction believed to be the result of infiltration of immune cells, inflammation ..

An Antibody-based Method for Reducing Ocular Inflammation Which Can Aid in Corneal Transplantation

HSV keratinitis is characterized, in part, by scarring of the eye as a result of HSV reactivation. To date, corneal transplantation is the standard treatment method. A significant obstacle preventing ..

A Reduction in Sumoylation of Cellular Proteins Reduces Polyglutamine Toxicity In Vivo in a Drosophila Fruit Fly Model of Huntington's Disease

Background: Huntington's disease (HD) is a fatal, autosomal dominant, progressive neurodegenerative disorder. Clinical symptoms are progressive and include chorea, impaired voluntary movement, behavi..

Triple Transgenic Mouse Model of Alzheimer's Disease

University of California, Irvine researchers have developed a novel transgenic mouse model that contains the three major genes that contribute to the hallmark pathological features of Alzheimer's dise..

Screening and Therapeutic Methods for Promoting Wakefulness and Sleep

Background: Current drugs used to modulate sleep and wakefulness cause a number of undesirable side-effects such as anxiety, addiction, and continued sedation. AMPA and PrRP receptors are found in th..

Novel Retinoblastoma Binding Protein-Related Gene And Potential Use As Cancer Vaccine

Background: The central objective in the development of an effective immunotherapy is the identification of tumor antigens that can elicit antibody and cellular immune responses in humans. Human auto..

DRD4 , ADHD

Background: Attention Deficit Hyperactivity Disorder (ADHD) is the most prevalent disorder of early childhood. It affects an estimated 3-6% of elementary school children. ADHD individuals may have ab..

Her2/neu Vaccine Protects Against Tumor Growth

Background: Her2/neu is over-expressed in various types of tumor cells, including 20-30% of breast cancers, adenocarcinomas of the ovary, salivary gland, stomach and kidney, colon cancer, and non-sma..

Platelet Aggregation Inhibitors

Thrombin is an enzyme in the blood that plays a key role in platelet formation during injury. While blood coagulation is essential for a surface wound, platelet activation underlies various pathologic..

ADP Glucose Receptor as a Target for Disorders Involving Platelet Aggregation

Background: Recently, activation of the P2Y12 G-protein coupled receptor (GPCRs) has been shown to be central to platelet aggregation. Drugs preventing platelet aggregation are being tested, but one ..

Treatment For Prostate Cancer

Background: Polyamines are naturally synthesized by the body and are involved in many biochemical processes, including cellular proliferation, cell cycle regulation, and protein synthesis. The prosta..

A Novel Treatment For Upper Respiratory Tract Irritation And Cough

Background: Traditional cough suppression therapy has included palliatives in the form of herbal remedies, narcotics such as codeine, and local anesthetics such as benzonatate. The anesthetic compoun..

A New Process Of Adding Alkyl Groups To Organic Substrates Using TmI2(MeOCH2CH2OMe)3

Background: In the pharmaceutical industry, synthetic chemists often alkylate starting compounds to generate compounds that have more desirable properties. However, the current reagents used in this ..

Donor Organ Preservation for Transplantation Using a Hemoglobin Based Solution

During heart transplantation, the heart must be preserved while it is transported from donor to recipient. Standard techniques call for the heart to be immersed and cooled in cardioplegia or saline so..

Use Of Perillyl Alcohol In Organ Transplantation

Background: Current state of the art in the field of organ transplantation employs various immunosuppressive agents to prevent post-surgical allograft rejection by the host. However, these pharmacol..

Treatment For Circadian Performance Deficits By Upmodulation Of Central Glutamate Receptors

Background: Alertness and general physical and mental performance are impaired during normal sleep periods compared to those during normal waking periods. Unlike stimulants such as caffeine or metham..

Novel And Selective Inhibitors Of HIV-1 Integrase

In the ongoing battle against the human immunodeficiency virus (HIV), researchers at the University of California, Irvine, have synthesized novel compounds that inhibit the protein HIV Integrase and p..

Diagnostic Marker And Novel Therapeutic Target For Neurodegenerative Disorders

Scientists at the University of California, Irvine, have isolated a candidate gene that may be responsible for increasing the risk of schizophrenia and bipolar disorder. This elusive gene encodes for ..

Drugs To Improve Synaptic Transmission

About 5% of the general population over the age of 65 suffers from Alzheimer's disease for which there is no known treatment. Synaptic connections in the hippocampus, a brain region known to be import..

Silica Nanoboxes

Microporous crystalline materials (e.g. zeolites, aluminophosphates), also called molecular sieves, are widely used as catalysts, adsorbents, and membranes. Two factors largely determine the utility o..

A library containing more than 3000 new enzymes produced by 14 Fungi

Solution / invention summary : 14 fungi have been grown in various harsh conditions in order to produce a variety of enzymes. A high throughput platform is then used to isolate some 3000 new enzymes...

Novel Targets for Preterm Labour

New Market Opportunity Over 4 million births occur annually in the US, between 0.5-1 million women are treated annually with tocolytic drugs to halt early preterm labour contractions, while annual t..

Live-Cell based assay for DNA Damage Response

New Market Opportunity Cell-based assays play a decisive role in the current drug screening process, yielding safer drugs in a cost effective manner. Such assays offer the potential to screen out co..

Novel Sirtuin Activating Compounds

An improved method of synthesizing stilbene analogs, specifically resveratrol, that can activate sirtuins with increased efficiency, activity, and stability. General Information Sirtuins are NAD+ ..

Use of Equol for Treating Skin, Hair, Brain and Prostate Health and Obesity/Weight Control

General Information Dihydrotestosterone (DHT) is a metabolite of the principal male hormone testosterone. However, it is more powerful than testosterone because of its increased affinity for the an..

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