It seems more than anything that there is misinformation rather than a real problem. GMOs in agriculture have been around for centuries - only they've been called things like horticulture and selective breeding. When you buy your orange carrots at the grocery store, it's because they were modified (selectively bred) to express a gene for orange color some 500 years ago. At that time selecting for the gene for orange color was called selecting for an orange trait but the process of obtaining the orange color was no different that what's done in a test tube. Just because it wasn't done in a test tube does not mean it was not genetically modified.

And while genetic manipulation of bacteria, cells and animals occur in the laboratory, these organisms do not cross-breed with organisms in the wild. E. coli and genetically modified bacteria and cells are destroyed by routine lab procedures such as autoclaving and exposure to harsh acids, bases and detergents ensuring none of their material is transmitted to the wild. Is there a minute, infinitesimally small chance that these could escape the lab? Sure, but once out of the lab, they are no longer in optimal growing conditions - the same conditions they have been selectively bred for and would not survive. Genetically modified mice are in the same boat, they do not have immune systems capable of surviving in the wild and would succumb to even the weakest of common rodent infections.

Let's stop with the doomsday science fiction and stick to facts.