Toll-Like Receptor 9 Modulators

TLR9 is localized to endoplasmic reticulum and upon stimulation with a TLR9 ligand, is transported to a tubular lysosomal compartment as is CpG-DNA. Furthermore, it is shown that TLR9 and CpG-DNA directly bind. It was also found that the MyD88 translocates in response to activation of TLR9-mediated signaling. Methods of identifying compounds that affect translocation and activity of TLR9 and MyD88 are described.

Patents:
US 20,100,291,577

Inventor(s): LATZ EICKE [US]; VISINTIN ALBERTO [US]; GOLENBOCK DOUGLAS T [US]

Type of Offer: Sale



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