Bis-carbazole DNA intercalating agents for antitumor therapy

The present invention is a DNA intercalating agent represented by the structure Y-Z-Y, wherein Y is an anti-tumor bis-carbazole and Z is a linear arrangement of multiple aromatic rings, containing at least two aromatic rings, or at least two alicyclic rings, said rings being linked in a 1,4 or 1,3 manner. Methods of inhibiting cancer cells and treating subjects having cancer with these agents are also provided.

Patents:
US 20,100,010,033

Inventor(s): GRIBBLE GORDON W [US]; ANDROSOV DMITRY A [US]

Type of Offer: Licensing



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