Modification of Hydrogenase Activities in Thermophilic Bacteria to Enhance Ethanol Production

Bacteria consume a variety of biomass-derived substrates and produce ethanol. Hydrogenase genes have been inactivated m Thermoanaerobacterium saccharolyticum to generate mutant strains with reduced hydrogenase activities. One such mutant strain with both the ldh and hydtrA genes inactivated shows a significant increase in ethanol production. Manipulation of hydrogenase activities provides a new approach for enhancing substrate utilization and ethanol production by biomass-fermenting microorganisms.

Patents:
WO 2,009,079,584

Inventor(s): SHAW ARTHUR JOSEPHUS IV [US]; LYND LEE R [US]; HOGSETT DAVID A [US]

Type of Offer: Licensing



« More Biomass Patents

---