Type I Interferon Antagonists

Disclosed in certain embodiments is a method of preparing a Type 1 interferon antagonist comprising modifying a Type 1 interferon at the site of interaction with the interferon receptor subunit IFNAR-1 such that the binding affinity of the interferon to the IFNAR-1 subunit is reduced as compared to the native interferon, and corresponding compositions and methods of treatment thereof.

Attached files:
WO 2010030671.jpg

Patents:
WO 2,010,030,671

Inventor(s): LANGER JEROME [US]; SCHREIBER GIDEON [IL]

Type of Offer: Licensing



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