Antibodies that Specifically Bind Hedgehog-Derived Polypeptides

The present invention provides two novel polypeptides, referred to as the "N" and "C" fragments of hedgehog, or N-terminal and C-terminal fragments, respectively, which are derived after specific cleavage at a G'CF site recognized by the autoproteolytic domain in the native protein. Also included are sterol-modified hedgehog polypeptides and functional fragments thereof. Methods of identifying compositions which affect hedgehog activity based on inhibition of cholesterol modification of hedgehog protein are described.

Patents:
US 20,110,002,941

Inventor(s): BEACHY PHILIP A [US]; PORTER JEFFREY A [US]

Type of Offer: Licensing



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