Novel Inhibitors of Retroviral Reverse Transcriptase

Disclosed are nucleic acid molecules, and methods of their use, which have a specific structure including a double helical domain and a G-quadruplex domain physically connected by a linker domain which may be nucleosidic or non-nucleosidic. These aptamers demonstrate potent inhibition of phylogenetically diverse primate lentiviral reverse transcriptases, which effect is largely independent of aptamer sequence provided that the aptamer has the specified structure.

Attached files:


Patents:
WO 2,009,143,476

Inventor(s): MICHALOWSKI DANIEL [US]; BURKE-AGUERO DONALD H [US]

Type of Offer: Licensing



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