Methods for the Preparation of Thiazolidinethione Indene-Based Chiral Auxiliaries

Methods for the preparation of indene-based thiazolidinethiones are provided comprising contacting 1-amino-2,3-dihydro-1H-inden-2-ol, or a substituted derivative thereof, with an acid under suitable reaction conditions to provide a first intermediate; and contacting the first intermediate with an alkali xanthate in the presence of an alkali hydroxide under suitable reaction conditions to provide a compound of formula (III), wherein R1-R8 are defined herein.

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Patents:
US 20,100,179,330

Inventor(s): OLIVO HORACIO F [US]; OSORIO LOZADA ANTONIO VICTOR [CH]

Type of Offer: Licensing



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