Alpha-helix Mimetic Using a 2,5-oligopyrimidine Scaffold

Alpha-helix mimetics and associated methods of making are provided. These compounds are constructed using a 2,5-oligopyrimidine scaffold. The semi-rigid scaffold holds individual side chain-like residues in orientations that mimic the orientations of side chain residues of an ?-helical protein domain. The new scaffold is easier to make than previous scaffolds and has much more favorable physical properties than previous alpha-helix mimics. The amphiphilic alpha-helix mimetics have application for making libraries and for treating diseases or conditions effected by the inhibition or disruption of interactions with the alpha helix of a protein.

Attached files:
WO 2010083501.jpg

Patents:
WO 2,010,083,501

Inventor(s): MCLAUGHLIN MARK L [US]; ANDERSON LAURA [US]; ZHOU MINGZHOU [US]

Type of Offer: Licensing



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