Monoclonal Antibody Production in B Cells and Uses Therof

The presently disclosed subject matter provides methods of inhibiting a host innate response to activator-mediated proliferative signals in a primary B cell. In some embodiments a method is provided for immortalized primary B cells. In some embodiments a method is provided for increasing efficiency of EBV transformation of primary B cells. In some embodiments a method is provided for increasing proliferation of primary B cells in culture. In some embodiments a method is provided for producing a monoclonal antibody. In some embodiments a method is provided for identifying a novel broadly neutralizing antibody having a desired antigen specificity. Also provided are antibodies produced according the methods of the presently disclosed subject matter.

Attached files:
WO 2010053987.jpg

Patents:
WO 2,010,053,987

Inventor(s): HWANG KWAN-KI [US]; LUFTIG MICAH [US]

Type of Offer: Licensing



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