Radiolabled Cyclopamine Assay for the Smoothened Receptor

The present invention discloses novel methods for screening compositions for both agonist and antagonist activity on the smoothened receptor. The assay tests ligands on the activity of the receptor using a cyclopamine binding and ultra high receptor expression.

Patents:
WO 2,009,155,283

Inventor(s): CHEN WEI [US]; BARAK LAWRENCE S [US]; JIANGBO WANG [US]; LEFKOWITZ ROBERT J [US]; LEYRLY HERBERT KIM [US]

Type of Offer: Licensing



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