Deadline: 2019-05-31 Award: $50,000 Open to: US citizen or permanent resident 18+*
Integrated Chemistry Database for Translational Innovation in Pain, Opioid Use Disorder and Overdose. This Challenge aims to reward and spur innovative solutions to the development of an open-source, controlled-access database that will contain extensive chemical, biological and clinical data on currently available pain drugs, opioids and treatments for addiction and overdose.
This Challenge requires submission of only a detailed description of the design of a database, not the final working database. The database should include but not be limited to the structures of known analgesics and opioids; information on the corresponding drug targets and, if available, known/predicted mechanisms of action; information on the structure and chemical synthesis; available in vitro and in vivo biological screening data; and any clinical data relevant to the effectiveness, as well as side effects, including risk of addiction etc.
In order to serve the purpose of the NCATS ASPIRE Design Challenges, all deposited information (including chemical structures, published chemical synthesis steps and conditions, safety data, etc.) is required to be in a format that is suitable for use in training and validating advanced machine learning applications. The data can be aggregated from available public (assembled from publications and public databases) and/or private (including industry-based collaborators) sources. If using data from non-public sources, innovators must certify that they have proper freedom of operation to utilize and present the data in an open-source format (i.e., for all included datasets, innovators should provide the license and terms under which they are provided for this Challenge). It is expected that the developed database will be utilized by other innovators in other NCATS ASPIRE Design Challenges during the Reduction-to-Practice stage that is envisioned to follow the Design Challenge.
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