Novel Approaches to Combat Antibiotic Resistance in Gram-Negative Bacterial

Deadline: 2019-12-02
Award: $40,000
Open to: Everyone*

Antibiotic-resistant Gram-negative infections have emerged as major concerns in hospitals, nursing homes, and other healthcare settings. To blunt the profound impact on patients and mitigate the rising costs of treating these infections, novel approaches, targets, and mechanisms are urgently needed. Therefore, the Seeker desires proposals that will reveal novel mechanisms and targets to launch drug discovery programs targeting multidrug resistant Gram-negatives. Additionally, the Seeker desires proposals addressing insights into the factors limiting small molecule uptake and retention in Gram-negatives (“permeability and efflux”).