Problem Solver

Chris Stone

Chris Stone

Areas Chris Stone is Knowledgeable in:

Microbiology and bacteriology

Techniques Chris Stone Uses:

Collaborative meetings, international partnership

Chris Stone's Problem Solving Skills:

  1. Publishing scientific articles
  2. Type III secretion systems of Gram-negative bacteria
  3. Peptide mimetics
  4. High throughput screening
  5. Protein crystal optimization
  6. Protein expression
  7. Cloning and genetic manipulation
  8. Experimental design
  9. Enzymology
  10. Bacteriology

Chris Stone's Problem Solving Experience:

  1. - I have cloned over 25 type III secretion proteins and re-constructed them in a heterologous system to evaluate their function
  2. - I have worked extensively with a genetically intractable organism, developing novel approaches to manipulating its genome.
  3. - I have mapped protein interaction domains and targeted them for disruption with peptide mimetic compounds
  4. - I have solved the crystal structure of multiple Gram-negative virulence proteins and used these structures to develop inhibitors