Areas Chris Stone is Knowledgeable in:
Microbiology and bacteriology
Techniques Chris Stone Uses:
Collaborative meetings, international partnership
Chris Stone's Problem Solving Skills:
- Publishing scientific articles
- Type III secretion systems of Gram-negative bacteria
- Peptide mimetics
- High throughput screening
- Protein crystal optimization
- Protein expression
- Cloning and genetic manipulation
- Experimental design
- Enzymology
- Bacteriology
Chris Stone's Problem Solving Experience:
- - I have cloned over 25 type III secretion proteins and re-constructed them in a heterologous system to evaluate their function
- - I have worked extensively with a genetically intractable organism, developing novel approaches to manipulating its genome.
- - I have mapped protein interaction domains and targeted them for disruption with peptide mimetic compounds
- - I have solved the crystal structure of multiple Gram-negative virulence proteins and used these structures to develop inhibitors