Patent Holder
Alasdair Bell
Patents Pending or approved
Title PubDate Appl.No Applicant Inventor
WO/2008/030611 - ANTIBODIES TO BONE MORPHOGENIC PROTEINS AND RECEPTORS THEREFOR AND METHODS FOR THEIR USE 13.03.2008 PCT/US2007/019652 MEDAREX, INC. ZIMMERMAN, Deborah
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, which specifically bind to BMP2, BMP4, BMPRlA, BMPRlB, ACTRl, and/or BMPR2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Also provided are immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention and, optionally, one or more additional therapeutic. The invention also provides methods for treating diseases associated with abnormal bone formation and ossification mediated by BMP2, -BMP4, BMPRlA, BMPRlB, ACTRl5 and/or BMPR2.
WO/2008/021263 - METHODS OF INDENTIFYING ANTIBODIES THAT BIND OLIGOMERIC FORMS OF CHEMOKINES AND USES THEREOF 21.02.2008 PCT/US2007/017833 MEDAREX, INC. SRINIVASAN, Mohan
The present invention is directed to methods of identifying an antibody or an antigen-binding portion thereof that specifically recognizes and binds an oligomeric form of a chemokine.
WO/2008/018641 - MONOCLONAL ANTIBODIES AGAINST STROMAL DERIVED FACTOR-1 (SDF-1) 14.02.2008 PCT/JP2007/065991 ONO PHARMACEUTICAL CO., LTD. POGUE, Sarah, L.
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to SDF-1 with high affinity. Nucleic acid molecules encoding SDF-1 antibodies, expression vectors, host cells and methods for expressing the SDF-1 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the SDF-1 antibodies are also provided. Methods for detecting SDF-1, as well as methods for treating various B cell malignancies, including breast cancer, multiple myeloma and non-Hodgkin's lymphoma, and autoimmune disorders are disclosed.
WO/2007/002223 - CD19 ANTIBODIES AND THEIR USES 04.01.2007 PCT/US2006/024183 MEDAREX, INC. RAO-NAIK, Chetana
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD 19 with high affinity. Nucleic acid molecules encoding such CD 19 antibodies, expression vectors, host cells and methods for expressing the CD 19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD 19 antibodies are also provided. Methods for detecting CD 19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.
Title PubDate Appl.No Applicant Inventor
WO/2008/030611 - ANTIBODIES TO BONE MORPHOGENIC PROTEINS AND RECEPTORS THEREFOR AND METHODS FOR THEIR USE 13.03.2008 PCT/US2007/019652 MEDAREX, INC. ZIMMERMAN, Deborah
The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, which specifically bind to BMP2, BMP4, BMPRlA, BMPRlB, ACTRl, and/or BMPR2 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Also provided are immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention and, optionally, one or more additional therapeutic. The invention also provides methods for treating diseases associated with abnormal bone formation and ossification mediated by BMP2, -BMP4, BMPRlA, BMPRlB, ACTRl5 and/or BMPR2.
WO/2008/021263 - METHODS OF INDENTIFYING ANTIBODIES THAT BIND OLIGOMERIC FORMS OF CHEMOKINES AND USES THEREOF 21.02.2008 PCT/US2007/017833 MEDAREX, INC. SRINIVASAN, Mohan
The present invention is directed to methods of identifying an antibody or an antigen-binding portion thereof that specifically recognizes and binds an oligomeric form of a chemokine.
WO/2008/018641 - MONOCLONAL ANTIBODIES AGAINST STROMAL DERIVED FACTOR-1 (SDF-1) 14.02.2008 PCT/JP2007/065991 ONO PHARMACEUTICAL CO., LTD. POGUE, Sarah, L.
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to SDF-1 with high affinity. Nucleic acid molecules encoding SDF-1 antibodies, expression vectors, host cells and methods for expressing the SDF-1 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the SDF-1 antibodies are also provided. Methods for detecting SDF-1, as well as methods for treating various B cell malignancies, including breast cancer, multiple myeloma and non-Hodgkin's lymphoma, and autoimmune disorders are disclosed.
WO/2007/002223 - CD19 ANTIBODIES AND THEIR USES 04.01.2007 PCT/US2006/024183 MEDAREX, INC. RAO-NAIK, Chetana
The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to CD 19 with high affinity. Nucleic acid molecules encoding such CD 19 antibodies, expression vectors, host cells and methods for expressing the CD 19 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the CD 19 antibodies are also provided. Methods for detecting CD 19, as well as methods for treating various B cell malignancies, including non-Hodgkin's lymphoma, are disclosed.