Illimar Altosaar

CIPO 2 555 137 Canada PUROINDOLINES AS FUSION-PROTEIN CARRIERS IN MOLECULAR PHARMING: Described are methods and compositions for producing proteinated granules and isolating desired products (for example, one or more protein, peptide, remediant, cosmeceutical, or pharmaceutical compound species) in transgenic plants engineered to produce the desired product(s). The present invention provides polynucleotide and polypeptide and protein sequences from plants to serve as carriers of recombinant fusion "cargo" proteins (also called "hybrid" or "multimeric" polypeptides), methods for targeting fusion polypeptides to starch granules, methods for tethering fusion polypeptides to the lipid layer associated with starch granule surfaces, and methods for using starch granule associated polypeptides as a carrier protein for the production of recombinant biopharmaceuticals. The desired products are isolated from the transgenic plants by size reduction (also called "milling") and air classification to remove the proteinated granule away from the endogenous host proteome.;

US 7,214,862 U.S.A. Production of GM-CSF in plants: The present invention discloses a method of producing granulocyte-macrophage colony stimulating factor (GM-CSF) in a plant comprising, transforming the plant with a genetic construct comprising a regulatory region functional in the plant, operably associated with a GM-CSF coding sequence, or a fragment or a derivative thereof, operably associated with a transcriptional terminator, and expressing the GM-CSF. Also disclosed are transgenic plants, seeds and cells comprising GM-CSF coding sequences and plant optimized GM-CSF coding sequences.