Method for Synthesizing Xanthohumol
A method is provided for synthesizing xanthohumol by inserting a prenyl-group onto the aryl-ring via a para-Claisen rearrangement after using a Mitsunobu reaction to establish the key prenylether precursor. A Claisen-Schmidt condensation is used to construct the chalcone scaffold followed by removal of MOM protecting groups under acidic conditions that are optimized to prevent concomitant cyclization to the flavone.
ERHARDT PAUL W [US]; KHUPSE RAHUL S [US]
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