Method for Synthesizing Xanthohumol

A method is provided for synthesizing xanthohumol by inserting a prenyl-group onto the aryl-ring via a para-Claisen rearrangement after using a Mitsunobu reaction to establish the key prenylether precursor. A Claisen-Schmidt condensation is used to construct the chalcone scaffold followed by removal of MOM protecting groups under acidic conditions that are optimized to prevent concomitant cyclization to the flavone.

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Patents:
WO 2,009,026,206

Inventor(s): ERHARDT PAUL W [US]; KHUPSE RAHUL S [US]

Type of Offer: Sale



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