De novo Peptide Sequencing Using a Covalent Derivatization Strategy
Research Tool. The invention describes a dual labeling strategy that enhances the mass spectrometry analysis of peptides. A de novo sequencing method is described that utilizes both guanidination of lysine residues in conjunction with amidination of the N-termini of peptides to be analyzed by mass spectrometry.
* The invention facilitates identification of N- and C-terminal fragment ions.
James P. Reilly and Richard L. Beardsley
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