Antimalarial Agents That Are Inhibitors of Dihydroorotate Dehydrogenase
Inhibitors of parasitic dihydroorotate dehydrogenase enzyme (DHOD) are candidate therapeutics for treating malaria. Illustrative of such therapeutic agents include the compound: and a triazolopyrimidine class of compounds that conform to Formula (IX): and their solvates, stereoisomers, tautomers and pharmaceutically acceptable salts.
PHILLIPS MARGARET [US]; RATHOD PRADIPSINH K [US]; CHARMAN SUSAN A [AU]; FLOYD DAVID [US]; BURROWS JEREMY [GB]; MATTHEWS DAVID [U
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